TR27016A - Bir yeni sefalosporin c asilaz. - Google Patents

Bir yeni sefalosporin c asilaz.

Info

Publication number
TR27016A
TR27016A TR00192/93A TR19293A TR27016A TR 27016 A TR27016 A TR 27016A TR 00192/93 A TR00192/93 A TR 00192/93A TR 19293 A TR19293 A TR 19293A TR 27016 A TR27016 A TR 27016A
Authority
TR
Turkey
Prior art keywords
acylase
amino acid
ala
native
acid sequence
Prior art date
Application number
TR00192/93A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of TR27016A publication Critical patent/TR27016A/tr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
TR00192/93A 1992-02-27 1993-02-24 Bir yeni sefalosporin c asilaz. TR27016A (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929204439A GB9204439D0 (en) 1992-02-27 1992-02-27 A new cephalosporin c acylase

Publications (1)

Publication Number Publication Date
TR27016A true TR27016A (tr) 1994-09-15

Family

ID=10711322

Family Applications (1)

Application Number Title Priority Date Filing Date
TR00192/93A TR27016A (tr) 1992-02-27 1993-02-24 Bir yeni sefalosporin c asilaz.

Country Status (15)

Country Link
US (1) US5336613A (tr)
EP (1) EP0558241B1 (tr)
JP (1) JPH0614777A (tr)
KR (1) KR100276541B1 (tr)
CN (1) CN1062903C (tr)
AT (1) ATE121784T1 (tr)
CA (1) CA2090571A1 (tr)
DE (1) DE69300123T2 (tr)
DK (1) DK0558241T3 (tr)
ES (1) ES2071527T3 (tr)
GB (1) GB9204439D0 (tr)
GR (1) GR3015943T3 (tr)
HU (1) HU220460B1 (tr)
TR (1) TR27016A (tr)
TW (1) TW274565B (tr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE167520T1 (de) * 1990-04-18 1998-07-15 Gist Brocades Nv Mutierte beta-lactamacylasegene
ZA932809B (en) * 1992-04-24 1994-10-21 Lilly Co Eli Process for preparing cephalosporins.
TW400384B (en) * 1993-11-01 2000-08-01 Fujisawa Pharmaceutical Co A new cephalosporin C acylase
EP0775210B1 (en) * 1994-08-12 2000-02-02 Dsm N.V. Mutated penicillin g acylase genes
CN1065278C (zh) * 1994-08-27 2001-05-02 中国科学院上海植物生理研究所 一步两酶法制造7-氨基头孢烷酸
GB9423212D0 (en) 1994-11-17 1995-01-04 Glaxo Group Ltd Industrial enzymes
US6153429A (en) * 1996-04-05 2000-11-28 Vera Genics Ltd. Cell lines useful for in vitro assay for indentification of carcinogens
US5821049A (en) * 1996-04-05 1998-10-13 Viratest Carcinogen Monitoring, Ltd In vitro assay for identification of carcinogens
HU226348B1 (en) 1996-11-05 2008-09-29 Bristol Myers Squibb Co Mutant penicillin g acylases
KR100530299B1 (ko) * 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 c 아실라제 및 이를 이용한 7-aca 제조방법
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
BRPI0621278A2 (pt) * 2005-12-28 2011-12-06 Dsm Ip Assests Bv acilases mutantes
CN109913436B (zh) * 2017-12-12 2023-05-23 石药集团圣雪葡萄糖有限责任公司 含有一个或几个点突变的头孢菌素c酰化酶突变体及其制备方法
CN112662655B (zh) * 2020-12-29 2022-05-03 山东金城柯瑞化学有限公司 头孢菌素c酰化酶突变体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152286A (ja) * 1984-12-27 1986-07-10 Asahi Chem Ind Co Ltd セフアロスポリンcアシラ−ゼ産生遺伝情報を担うdna断片

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
IL87276A (en) 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152286A (ja) * 1984-12-27 1986-07-10 Asahi Chem Ind Co Ltd セフアロスポリンcアシラ−ゼ産生遺伝情報を担うdna断片

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. FERMENT. BIOENG. vol. 72, no. 4, 1991, pages 227 - 231 ICHIRO ARAMORI E AL. 'ISOLATION OF SOIL STRAINS PRODUCING NEW CEPHALOSPORIN ACYLASE S' *
J. FERMENT. BIOENG. vol. 72, no. 4, 1991, pages 232 - 243 ICHIRO ARAMORI ET AL. 'CLONING AND NUCLEOTIDE SEQUENCING ...' *
The search has been performed among the documents dated prior to 24th February 1993. *

Also Published As

Publication number Publication date
JPH0614777A (ja) 1994-01-25
ATE121784T1 (de) 1995-05-15
DE69300123D1 (de) 1995-06-01
EP0558241A3 (en) 1993-12-01
EP0558241A2 (en) 1993-09-01
DE69300123T2 (de) 1996-03-28
DK0558241T3 (da) 1995-07-03
ES2071527T3 (es) 1995-06-16
HU220460B1 (hu) 2002-02-28
CN1062903C (zh) 2001-03-07
EP0558241B1 (en) 1995-04-26
CN1085252A (zh) 1994-04-13
HU9300557D0 (en) 1993-05-28
KR930017918A (ko) 1993-09-20
GR3015943T3 (en) 1995-07-31
TW274565B (tr) 1996-04-21
GB9204439D0 (en) 1992-04-15
HUT65664A (en) 1994-07-28
CA2090571A1 (en) 1993-08-28
US5336613A (en) 1994-08-09
KR100276541B1 (ko) 2000-12-15

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