TR201907647T4 - Solunabilir ilaç maddeleri. - Google Patents
Solunabilir ilaç maddeleri. Download PDFInfo
- Publication number
- TR201907647T4 TR201907647T4 TR2019/07647T TR201907647T TR201907647T4 TR 201907647 T4 TR201907647 T4 TR 201907647T4 TR 2019/07647 T TR2019/07647 T TR 2019/07647T TR 201907647 T TR201907647 T TR 201907647T TR 201907647 T4 TR201907647 T4 TR 201907647T4
- Authority
- TR
- Turkey
- Prior art keywords
- drug substance
- dry powder
- drug substances
- metered dose
- formulation
- Prior art date
Links
- 229940088679 drug related substance Drugs 0.000 title abstract 4
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229940124748 beta 2 agonist Drugs 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
- A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0078—Mechanical counters having a display or indicator on a strip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
- A61M15/0026—Hinged caps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/20—Flow characteristics having means for promoting or enhancing the flow, actively or passively
Abstract
Mevcut buluş, bir kuru toz formülasyonu içeren bir rezervuar ve rezervuardan ilaç maddesinin ölçülmüş bir dozunu dağıtmaya yönelik bir düzenek; kuru toz ilaç maddesinin aglomeratlarını parçalamaya yönelik bir siklon deaglomeratör; ve bir ağızlık içinden bir solunum indüklü hava akışını yönlendirmeye yönelik bir dağıtım geçiş yolunu içeren bir kuru toz solunum cihazını sağlar, burada dağıtım geçiş yolu, ilaç maddesinin ölçülü dozuna uzanır, burada formülasyon, d10 <1?m, d50 = 1-3 ?m, d90 = 3.5-6 ?m ve NLT %99 10 ?m olan bir partikül boyutu dağılımına ve bir laktoz taşıyıcıya sahip olan bir solunabilir ß2-agonisti içerir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1321717.9A GB201321717D0 (en) | 2013-12-09 | 2013-12-09 | Inhalable Medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201907647T4 true TR201907647T4 (tr) | 2019-06-21 |
Family
ID=50000403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/07647T TR201907647T4 (tr) | 2013-12-09 | 2014-11-19 | Solunabilir ilaç maddeleri. |
Country Status (20)
Country | Link |
---|---|
US (2) | US11071835B2 (tr) |
EP (3) | EP3590499B1 (tr) |
JP (2) | JP6495916B2 (tr) |
KR (2) | KR102207557B1 (tr) |
CN (1) | CN105916491B (tr) |
AR (1) | AR099364A1 (tr) |
AU (2) | AU2014361087B2 (tr) |
BR (1) | BR112016011995A2 (tr) |
CA (1) | CA2930898A1 (tr) |
DK (2) | DK3590499T3 (tr) |
EA (1) | EA034267B1 (tr) |
ES (2) | ES2929348T3 (tr) |
GB (1) | GB201321717D0 (tr) |
HU (2) | HUE060180T2 (tr) |
IL (1) | IL246045B (tr) |
MX (2) | MX2016007181A (tr) |
PL (2) | PL3079655T3 (tr) |
TR (1) | TR201907647T4 (tr) |
TW (1) | TWI590846B (tr) |
WO (1) | WO2015086278A1 (tr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
EP3552645A1 (en) * | 2016-11-18 | 2019-10-16 | Norton (Waterford) Limited | Drug delivery device with electronics |
GB201713899D0 (en) * | 2017-08-30 | 2017-10-11 | Indosys Ltd | Multi-dose medicament delivery device |
GB202012742D0 (en) * | 2020-08-14 | 2020-09-30 | Norton Waterford Ltd | An inhalable medicament |
CA3189493A1 (en) | 2020-08-14 | 2022-02-17 | Brian Paul O'NEILL | An inhalable formulation of fluticasone propionate and albuterol sulfate |
JP2023549995A (ja) * | 2021-11-29 | 2023-11-30 | 康希諾生物股▲ふん▼公司 | 霧化カップ及び霧化吸入投与におけるその使用 |
WO2023111637A1 (en) * | 2021-12-14 | 2023-06-22 | A. Nattermann & Cie Gmbh | Fluid dispensing device |
WO2023117929A1 (en) * | 2021-12-21 | 2023-06-29 | Chiesi Farmaceutici S.P.A. | Powder inhaler |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
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JP3342484B2 (ja) * | 1991-12-18 | 2002-11-11 | アストラ・アクチエボラーグ | 新規な配合 |
US6503537B2 (en) * | 1997-03-20 | 2003-01-07 | Schering Corporation | Preparation of powder agglomerates |
SE9703407D0 (sv) | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
US6212482B1 (en) * | 1998-03-06 | 2001-04-03 | Micron Technology, Inc. | Circuit and method for specifying performance parameters in integrated circuits |
PE20020075A1 (es) * | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | Dispositivo contador de dosis para inhalador de medicamento |
PE20020067A1 (es) | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | Desaglomerador para inhalador de polvo seco accionado por la respiracion |
SE0200312D0 (sv) | 2002-02-01 | 2002-02-01 | Astrazeneca Ab | Novel composition |
AU2005224030B2 (en) * | 2004-03-23 | 2008-09-25 | Novartis Ag | Pharmaceutical compositions |
GB0515584D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
CA2634984C (en) * | 2006-01-04 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of moderate persistent asthma |
TW200817047A (en) * | 2006-04-03 | 2008-04-16 | Teva Pharma | Drug microparticles |
GB0714134D0 (en) * | 2007-07-19 | 2007-08-29 | Norton Healthcare Ltd | Dry-powder medicament |
US9956170B2 (en) | 2008-06-26 | 2018-05-01 | 3M Innovative Properties Company | Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof |
GB0818476D0 (en) * | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
US10387621B2 (en) * | 2009-01-16 | 2019-08-20 | Cerner Innovation, Inc. | Matching of vibratory inhalers to patient vocal tract for optimization of particle dispersion |
US8834848B2 (en) * | 2009-02-04 | 2014-09-16 | Activaero Gmbh Research & Development | Flow and volume regulated inhalation for treatment of severe oral corticosteroid-dependent asthma |
US9463161B2 (en) | 2009-05-29 | 2016-10-11 | Pearl Therapeutics, Inc. | Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems |
TR201000680A2 (tr) * | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | Tiotropyum, formoterol ve budesonid içeren farmasötik bileşimler |
CN102946868B (zh) * | 2010-06-22 | 2014-10-29 | 奇斯药制品公司 | 包含抗毒蕈碱药的干粉制剂 |
AU2011287711B2 (en) * | 2010-08-03 | 2016-10-27 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising a phosphodiesterase inhibitor |
JOP20120023B1 (ar) * | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
TW201306842A (zh) | 2011-06-15 | 2013-02-16 | Exelixis Inc | 使用pi3k/mtor吡啶並嘧啶酮抑制劑及苯達莫司汀及/或利妥昔單抗治療惡性血液疾病之組合療法 |
US20150202297A1 (en) | 2012-07-05 | 2015-07-23 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Dry powder inhalers comprising a carrier other than lactose and a ternary component |
LT3409270T (lt) * | 2013-07-11 | 2021-07-26 | Chiesi Farmaceutici S.P.A. | Sausų miltelių kompozicija, apimanti anticholinerginį agentą, kortikosteroidą ir beta adrenerginį agentą, skirta vartoti įkvepiant |
GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
GB201321712D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Dry Powder Inhaler |
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2013
- 2013-12-09 GB GBGB1321717.9A patent/GB201321717D0/en not_active Ceased
-
2014
- 2014-11-19 EP EP19173102.5A patent/EP3590499B1/en active Active
- 2014-11-19 EP EP22199664.8A patent/EP4190309A1/en not_active Withdrawn
- 2014-11-19 DK DK19173102.5T patent/DK3590499T3/da active
- 2014-11-19 ES ES19173102T patent/ES2929348T3/es active Active
- 2014-11-19 MX MX2016007181A patent/MX2016007181A/es unknown
- 2014-11-19 BR BR112016011995A patent/BR112016011995A2/pt active Search and Examination
- 2014-11-19 KR KR1020187025408A patent/KR102207557B1/ko active IP Right Grant
- 2014-11-19 PL PL14799806T patent/PL3079655T3/pl unknown
- 2014-11-19 PL PL19173102.5T patent/PL3590499T3/pl unknown
- 2014-11-19 US US15/101,718 patent/US11071835B2/en active Active
- 2014-11-19 ES ES14799806T patent/ES2728076T3/es active Active
- 2014-11-19 JP JP2016537491A patent/JP6495916B2/ja active Active
- 2014-11-19 MX MX2021005056A patent/MX2021005056A/es unknown
- 2014-11-19 HU HUE19173102A patent/HUE060180T2/hu unknown
- 2014-11-19 CA CA2930898A patent/CA2930898A1/en not_active Withdrawn
- 2014-11-19 DK DK14799806.6T patent/DK3079655T3/da active
- 2014-11-19 TR TR2019/07647T patent/TR201907647T4/tr unknown
- 2014-11-19 KR KR1020167018153A patent/KR20160101954A/ko active Application Filing
- 2014-11-19 AU AU2014361087A patent/AU2014361087B2/en active Active
- 2014-11-19 EA EA201590734A patent/EA034267B1/ru not_active IP Right Cessation
- 2014-11-19 EP EP14799806.6A patent/EP3079655B1/en active Active
- 2014-11-19 HU HUE14799806 patent/HUE044901T2/hu unknown
- 2014-11-19 WO PCT/EP2014/075058 patent/WO2015086278A1/en active Application Filing
- 2014-11-19 CN CN201480067131.XA patent/CN105916491B/zh active Active
- 2014-12-04 TW TW103142237A patent/TWI590846B/zh not_active IP Right Cessation
- 2014-12-05 AR ARP140104540A patent/AR099364A1/es active IP Right Grant
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2016
- 2016-06-06 IL IL246045A patent/IL246045B/en unknown
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2018
- 2018-07-04 AU AU2018204860A patent/AU2018204860B2/en active Active
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2019
- 2019-03-06 JP JP2019040242A patent/JP6946363B2/ja active Active
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2021
- 2021-07-26 US US17/385,365 patent/US20210379304A1/en not_active Abandoned
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