TR201906038T4 - Her bir faktör VII molekülünün tanımlanan glikan motifleri ile iki N-glikosilasyon yerine sahip olduğu rekombinant veya transgenik faktör VII bileşimi. - Google Patents

Her bir faktör VII molekülünün tanımlanan glikan motifleri ile iki N-glikosilasyon yerine sahip olduğu rekombinant veya transgenik faktör VII bileşimi. Download PDF

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Publication number
TR201906038T4
TR201906038T4 TR2019/06038T TR201906038T TR201906038T4 TR 201906038 T4 TR201906038 T4 TR 201906038T4 TR 2019/06038 T TR2019/06038 T TR 2019/06038T TR 201906038 T TR201906038 T TR 201906038T TR 201906038 T4 TR201906038 T4 TR 201906038T4
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Prior art keywords
factor vii
composition
recombinant
glycosylation sites
transgenic
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TR2019/06038T
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English (en)
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Sami Chtourou Abdessatar
Nony Emmanuel
Bihoreau Nicolas
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Lab Francais Du Fractionnement
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Application filed by Lab Francais Du Fractionnement filed Critical Lab Francais Du Fractionnement
Publication of TR201906038T4 publication Critical patent/TR201906038T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
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  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Buluş bir rekombinant veya transgenik faktör VII bileşimi ile ilgilidir, bileşimin her bir faktör VII molekülü iki N-glikosilasyon yerine sahiptir, burada bileşimin tüm FVII molekülleri arasından Ga1alpha1,3Ga1 glikan motiflerinin oranı %0 ile 4 arasında bulunur. Buluş aynı zamanda bu tür bir FVII bileşimini hazırlamaya yönelik bir proses ile ilgilidir.
TR2019/06038T 2006-05-31 2007-05-31 Her bir faktör VII molekülünün tanımlanan glikan motifleri ile iki N-glikosilasyon yerine sahip olduğu rekombinant veya transgenik faktör VII bileşimi. TR201906038T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0604872A FR2901707B1 (fr) 2006-05-31 2006-05-31 Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis

Publications (1)

Publication Number Publication Date
TR201906038T4 true TR201906038T4 (tr) 2019-05-21

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ID=37714417

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/06038T TR201906038T4 (tr) 2006-05-31 2007-05-31 Her bir faktör VII molekülünün tanımlanan glikan motifleri ile iki N-glikosilasyon yerine sahip olduğu rekombinant veya transgenik faktör VII bileşimi.

Country Status (15)

Country Link
US (2) US10344272B2 (tr)
EP (1) EP2037955B1 (tr)
JP (3) JP5943536B2 (tr)
KR (1) KR101312390B1 (tr)
CN (2) CN101460189B (tr)
AR (1) AR061430A1 (tr)
AU (1) AU2007266952B2 (tr)
BR (1) BRPI0710706A2 (tr)
CA (2) CA2820391A1 (tr)
ES (1) ES2725081T3 (tr)
FR (1) FR2901707B1 (tr)
IL (3) IL195184A (tr)
TR (1) TR201906038T4 (tr)
TW (1) TWI386221B (tr)
WO (1) WO2007138199A2 (tr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3594222B1 (en) 2003-12-01 2022-08-03 Novo Nordisk Health Care AG Virus filtration of liquid factor vii compositions
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
JP2011517562A (ja) * 2008-03-25 2011-06-16 バイオプロテイン テクノロジーズ エスエー ヒト第ｖｉｉ因子を産生するトランスジェニックウサギ
WO2009141384A2 (en) * 2008-05-21 2009-11-26 Novo Nordisk A/S Process for the purification of factor vii polypeptides using affinity resins comprising specific ligands
FR2933496B1 (fr) * 2008-07-02 2012-10-05 Lfb Biotechnologies Procede de mesure du taux de facteur vii active dans un echantillon
FR2958496A1 (fr) * 2010-04-09 2011-10-14 Bioprotein Technologies Sa Preparation de proteine plasmatique de transfert des phospholipides (pltp) humaine recombinante a partir du lait d'animaux transgeniques.
CN103025757A (zh) * 2010-04-29 2013-04-03 巴克斯特国际有限公司 二价阳离子结合蛋白在阴离子交换树脂上的纯化方法
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
CA2823005C (en) 2010-12-30 2019-07-09 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Glycols as pathogen inactivating agents
WO2012133127A1 (ja) * 2011-03-31 2012-10-04 株式会社グライエンス ブドウ球菌属内の菌種を判別する方法
WO2013017555A1 (en) 2011-08-01 2013-02-07 Lfb-Biotechnologies Factor vii compositions with specific glycosylation for controlled half-life
EP2554161A1 (en) 2011-08-02 2013-02-06 LFB Biotechnologies Pharmaceutical composition comprising factor VII encapsulated in micelles
WO2013053888A1 (en) 2011-10-14 2013-04-18 Baxter International Inc. Protein purification by anion exchange chromatography
JP6236008B2 (ja) 2011-10-14 2017-11-22 バクスアルタ ゲーエムベーハー アニオン交換クロマトグラフィーによるタンパク質の精製
EP2687595B1 (en) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII
ES2936485T3 (es) 2012-12-24 2023-03-17 Coagulant Therapeutics Corp Polipéptidos del Factor VII de acción corta
JP2016508515A (ja) 2013-02-13 2016-03-22 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ 高ガラクトシル化抗ＴＮＦ−α抗体およびその使用
US20160002330A1 (en) * 2013-02-13 2016-01-07 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Cetuximab with modified glycosylation and uses thereof
SI2970376T1 (sl) 2013-03-15 2018-09-28 Baxalta Incorporated Metoda čiščenja za vitamin k odvisne proteine z anionsko izmenjevalno kromatografijo
FR3006591B1 (fr) * 2013-06-11 2016-05-06 Lab Francais Du Fractionnement Composition de facteur vii presentant un point isoelectrique substantiellement homogene
FR3082427B1 (fr) 2018-06-14 2020-09-25 Lab Francais Du Fractionnement Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x
WO2020053661A1 (en) 2018-09-13 2020-03-19 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Methods of purifying antibodies from the milk of transgenic non-human mammals comprising the use of chitosan
US20230133641A1 (en) * 2021-10-25 2023-05-04 Fios Therapeutics, Llc Viable galactosyltransferase knock-out sheep and related methods

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS504587A (tr) 1973-04-03 1975-01-17
US4229342A (en) 1977-05-18 1980-10-21 Rhone-Poulenc Industries Process for extracting proteins from milk using silica and anion exchange resins
NL8204923A (nl) 1982-12-21 1984-07-16 Stichting Nl I Zuivelonderzoek Werkwijze voor het bereiden van een precipitaat van caseine en wei-eiwit alsmede aldus bereid precipitaat.
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
FR2632524B1 (fr) * 1988-06-09 1992-03-13 Fondation Nale Transfusion San Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament
DE4028800A1 (de) 1990-09-11 1992-03-12 Behringwerke Ag Gentechnische sialylierung von glykoproteinen
US6984772B1 (en) 1994-02-18 2006-01-10 Virginia Tech Intellectual Properties, Inc. Transgenic non-human mammals producing fibrinogen in their milk
US5997864A (en) * 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
FR2677652B1 (fr) 1991-06-12 2005-05-27 Agronomique Inst Nat Rech Procede de preparation d'une proteine d'interet dans le lait d'un animal transgenique, produit obtenu et cellule eucaryote utilisee.
FR2684999A1 (fr) 1991-12-16 1993-06-18 Aquitaine Dev Transf Sanguine Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
GB9408717D0 (en) 1994-05-03 1994-06-22 Biotech & Biolog Scien Res DNA sequences
US6713662B1 (en) 1994-07-27 2004-03-30 Pharming Intellectual Property B.V. Production of collagen in the milk of transgenic mammals
US5880327A (en) 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
US6268487B1 (en) * 1996-05-13 2001-07-31 Genzyme Transgenics Corporation Purification of biologically active peptides from milk
ATE263841T1 (de) * 1997-01-16 2004-04-15 Neose Technologies Inc Praktische in vitro sialylierung von rekombinanten glykpproteinen
US6183803B1 (en) 1999-06-11 2001-02-06 Biosante Pharmaceuticals, Inc. Method for processing milk
EP1252184B1 (en) 2000-01-31 2008-01-02 Pharming Intellectual Property B.V. Human c1 inhibitor produced in the milk of transgenic mammals
US7067713B2 (en) * 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
DE60138364D1 (de) 2000-02-11 2009-05-28 Bayer Healthcare Llc Gerinnungsfaktor vii oder viia konjugate
HUP0301245A3 (en) * 2000-10-02 2005-12-28 Novo Nordisk Healthcare Ag Tmethod for the production of vitamin k-dependent proteins
AU2002318066B2 (en) 2001-07-20 2007-10-11 Campina B.V. Process for obtaining growth factor (TGF-BETA and IGF-1), lactoperoxidase and immunoglobulins preparations from milk products having low mutual cross-contamination
US20040117862A1 (en) 2002-03-11 2004-06-17 Cooper Julian D. Production of high levels of transgenic factor VII with engineered stability and its therapeutic uses
FR2841747B1 (fr) 2002-07-02 2004-08-20 Cie Laitiere Europeenne Isolat de proteines de lait et procede pour sa preparation
JP2006515227A (ja) 2003-02-24 2006-05-25 ジーティーシー バイオセラピューティックス インコーポレイテッド 十字流濾過の方法およびそのための装置
EP1664291B1 (en) * 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Coagulation factor vii polypeptides
WO2005089040A2 (en) 2004-03-23 2005-09-29 Chr. Hansen A/S Method of producing chymosin c and uses thereof
EP1786827A4 (en) 2004-05-14 2008-10-29 Kirin Holdings Kk PROCESS FOR IMMUNOGLOBULINE CLEANING
AU2005260004A1 (en) 2004-06-25 2006-01-12 Altor Bioscience Corporation Production of tissue factor in plants
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
FR2901796A1 (fr) 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR2904558B1 (fr) 2006-08-01 2008-10-17 Lab Francais Du Fractionnement "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
FR2910786B1 (fr) 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "procede d'extraction d'une proteine presente dans du lait"

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Publication number Publication date
CN103408655B (zh) 2016-10-05
EP2037955A2 (fr) 2009-03-25
TW200817032A (en) 2008-04-16
JP5943536B2 (ja) 2016-07-05
KR20090031676A (ko) 2009-03-27
KR101312390B1 (ko) 2013-10-10
BRPI0710706A2 (pt) 2011-08-16
JP2015143247A (ja) 2015-08-06
AR061430A1 (es) 2008-08-27
FR2901707A1 (fr) 2007-12-07
CA2652496C (en) 2017-05-16
US20090311239A1 (en) 2009-12-17
WO2007138199A2 (fr) 2007-12-06
AU2007266952B2 (en) 2012-10-18
IL195184A0 (en) 2011-08-01
US10344272B2 (en) 2019-07-09
US20140093491A1 (en) 2014-04-03
JP2009538885A (ja) 2009-11-12
US10364425B2 (en) 2019-07-30
CN101460189A (zh) 2009-06-17
CA2820391A1 (en) 2007-12-06
IL240318A0 (en) 2015-09-24
JP2013177440A (ja) 2013-09-09
ES2725081T3 (es) 2019-09-19
WO2007138199A3 (fr) 2008-01-17
CN101460189B (zh) 2013-10-30
FR2901707B1 (fr) 2017-09-29
CN103408655A (zh) 2013-11-27
AU2007266952A1 (en) 2007-12-06
TWI386221B (zh) 2013-02-21
JP6006823B2 (ja) 2016-10-12
IL225748A0 (en) 2013-06-27
EP2037955B1 (fr) 2019-03-06
IL195184A (en) 2017-03-30
CA2652496A1 (en) 2007-12-06

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