EA200601753A1 - Синтетические "мембранные якори" - Google Patents

Синтетические "мембранные якори"

Info

Publication number
EA200601753A1
EA200601753A1 EA200601753A EA200601753A EA200601753A1 EA 200601753 A1 EA200601753 A1 EA 200601753A1 EA 200601753 A EA200601753 A EA 200601753A EA 200601753 A EA200601753 A EA 200601753A EA 200601753 A1 EA200601753 A1 EA 200601753A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthetic
membrane anchors
molecules
relates
anchors
Prior art date
Application number
EA200601753A
Other languages
English (en)
Other versions
EA013183B1 (ru
Inventor
Николай Бовин
Лисса Гилливер
Стивен Генри
Елена Корчагина
Original Assignee
Коуд Байотек Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Коуд Байотек Лимитед filed Critical Коуд Байотек Лимитед
Publication of EA200601753A1 publication Critical patent/EA200601753A1/ru
Publication of EA013183B1 publication Critical patent/EA013183B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

Abstract

Изобретение относится к синтетическим молекулам, которые спонтанно и стабильно включаются в липидные бислои, в том числе клеточные мембраны. Конкретно, хотя и не исключительно, изобретение относится к применению этих молекул в качестве синтетических мембранных якорей или синтетических молекулярных конструкций для осуществления качественных и количественных изменений в экспрессии клеточных поверхностных антигенов.
EA200601753A 2004-03-22 2005-03-22 Синтетические молекулярные конструкции EA013183B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ53186604 2004-03-22
NZ53794105 2005-01-28
PCT/NZ2005/000052 WO2005090368A1 (en) 2004-03-22 2005-03-22 Synthetic membrane anchors

Publications (2)

Publication Number Publication Date
EA200601753A1 true EA200601753A1 (ru) 2007-04-27
EA013183B1 EA013183B1 (ru) 2010-02-26

Family

ID=34993634

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601753A EA013183B1 (ru) 2004-03-22 2005-03-22 Синтетические молекулярные конструкции

Country Status (12)

Country Link
US (5) US8013131B2 (ru)
EP (1) EP1735323B1 (ru)
JP (1) JP5456250B2 (ru)
CN (1) CN1938325B (ru)
AU (3) AU2005223715A1 (ru)
CA (1) CA2560781C (ru)
DK (1) DK1735323T3 (ru)
EA (1) EA013183B1 (ru)
ES (1) ES2654578T3 (ru)
IL (1) IL178008A (ru)
NZ (2) NZ550705A (ru)
WO (1) WO2005090368A1 (ru)

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AU2011202876B2 (en) * 2006-09-06 2011-09-01 Kode Biotech Limited Fluorescent cell markers
US20100203637A1 (en) * 2006-09-06 2010-08-12 Elena Korchagina Fluorescent cell markers
US20080160003A1 (en) * 2006-10-31 2008-07-03 University Of Delaware Fertility Enhancement Using Lipid Carriers and Bioactive Molecules
US8211860B2 (en) * 2007-04-27 2012-07-03 Kode Biotech Limited Carbohydrate-lipid constructs and their use in preventing or treating viral infection
NZ584558A (en) 2007-09-11 2012-10-26 Kode Biotech Ltd Peptide-lipid constructs and their use in diagnostic and therapeutic applications
CN101918841B (zh) * 2007-09-11 2013-09-11 科德生物工程有限公司 肽-脂构造及其在诊断和治疗用途中的应用
AU2013201431B2 (en) * 2007-10-12 2015-02-19 Kode Biotech Limited Functional lipid constructs
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WO2010039049A1 (en) * 2008-10-02 2010-04-08 Kode Biotech Limited Method of modifying the immune response
US11052141B1 (en) 2008-10-02 2021-07-06 Kode Biotech Limited Method of modifying the immune response
US8674061B2 (en) 2008-10-13 2014-03-18 Smiotik LLC Multiligand constructs
CN102656461B (zh) * 2009-06-29 2015-09-30 尼古拉·弗拉基米罗维奇·鲍文 Fsl构建体的打印
US10408717B2 (en) 2009-06-29 2019-09-10 Nicolai Vladimirovich Bovin Printing of FSL constructs
GB2500854B (en) * 2011-01-06 2019-04-17 Vladimirovich Bovin Nicolai Biosurface engineering
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
BR112015009138A2 (pt) 2012-10-23 2020-10-20 Caris Life Sciences Switzerland Holdings, S.A.R.L. métodos para caracterizar um câncer
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
US9814786B2 (en) 2013-12-02 2017-11-14 Nicolai Bovin Functionalizing nanofibres
WO2016080850A1 (en) 2014-11-21 2016-05-26 Nicolai Vladimirovich Bovin Multivalent ligand-lipid constructs
US10544842B2 (en) * 2017-03-24 2020-01-28 Ford Global Technologies, Llc One-way clutch for a vehicle
WO2019229745A1 (en) 2018-05-27 2019-12-05 Biolinerx Ltd. Agi-134 combined with a checkpoint inhibitor for the treatment of solid tumors

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Also Published As

Publication number Publication date
ES2654578T3 (es) 2018-02-14
AU2010203099B2 (en) 2012-12-06
US20110213134A1 (en) 2011-09-01
CA2560781C (en) 2011-10-11
IL178008A (en) 2011-10-31
US20070197466A1 (en) 2007-08-23
AU2010203098A1 (en) 2010-08-12
AU2010203098B2 (en) 2012-07-12
US20160333044A1 (en) 2016-11-17
NZ550705A (en) 2010-12-24
US9353349B2 (en) 2016-05-31
EA013183B1 (ru) 2010-02-26
WO2005090368A1 (en) 2005-09-29
US8637473B2 (en) 2014-01-28
AU2005223715A1 (en) 2005-09-29
US8013131B2 (en) 2011-09-06
US10414786B2 (en) 2019-09-17
EP1735323A4 (en) 2009-11-04
JP2007530532A (ja) 2007-11-01
DK1735323T3 (en) 2017-12-11
US20180057518A1 (en) 2018-03-01
EP1735323A1 (en) 2006-12-27
JP5456250B2 (ja) 2014-03-26
CN1938325A (zh) 2007-03-28
US20140186950A1 (en) 2014-07-03
CA2560781A1 (en) 2005-09-29
NZ587442A (en) 2012-02-24
AU2010203099A1 (en) 2010-08-12
US9809614B2 (en) 2017-11-07
EP1735323B1 (en) 2017-08-30
CN1938325B (zh) 2015-07-15
IL178008A0 (en) 2006-12-31

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