TR201901995T4 - Evrensel kardiyoplejik çözelti (varyantlar). - Google Patents
Evrensel kardiyoplejik çözelti (varyantlar). Download PDFInfo
- Publication number
- TR201901995T4 TR201901995T4 TR2019/01995T TR201901995T TR201901995T4 TR 201901995 T4 TR201901995 T4 TR 201901995T4 TR 2019/01995 T TR2019/01995 T TR 2019/01995T TR 201901995 T TR201901995 T TR 201901995T TR 201901995 T4 TR201901995 T4 TR 201901995T4
- Authority
- TR
- Turkey
- Prior art keywords
- solution
- asystole
- cardioplegic solution
- applying
- reducing
- Prior art date
Links
- 239000008148 cardioplegic solution Substances 0.000 title abstract 3
- 208000010496 Heart Arrest Diseases 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 238000007675 cardiac surgery Methods 0.000 abstract 1
- 230000002612 cardiopulmonary effect Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002631 hypothermal effect Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 229910001425 magnesium ion Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000037000 normothermia Effects 0.000 abstract 1
- 239000006174 pH buffer Substances 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bu buluş, tıp ile, daha spesifik olarak, kalp ameliyatı ile ilgilidir ve kardiyoplejiyi normotermi veya hipotermide uygularken, kalbin iskemiden korunması için kullanılabilir. Genel amaçlı kardiyoplejik çözelti, farmasötik olarak kabul edilebilir potasyum iyonları; magnezyum iyonları; 7.1-8.9 aralığında bir pH tamponu sağlayan bir baz ve bir asit; 275-460 mOsmol/kg aralığında bir ozmolalite sağlayan bir diüretik içerir. Söz konusu çözelti, asistoli elde etmenin ve elde edilen asistoli korumanın yanı sıra kardiyopulmoner bypassta kardiyak koruması için kullanılır. Genel amaçlı kardiyoplejik çözeltiyi uygulama prosedürü, söz konusu çözeltinin başlangıç bileşenlerinin akış hızını, otomatik kanın akış hızına göre azaltarak ve böylece çözeltinin otomatik kan oranını azaltarak elde edilen asistolün korunmasını içerir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014128455/15A RU2574957C1 (ru) | 2014-07-11 | Кардиоплегический раствор (варианты) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201901995T4 true TR201901995T4 (tr) | 2019-03-21 |
Family
ID=55064554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/01995T TR201901995T4 (tr) | 2014-07-11 | 2015-06-05 | Evrensel kardiyoplejik çözelti (varyantlar). |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10646511B2 (tr) |
| EP (1) | EP3167874B1 (tr) |
| JP (1) | JP6629850B2 (tr) |
| CN (2) | CN106659677A (tr) |
| BR (1) | BR112017000052B1 (tr) |
| EA (1) | EA035702B1 (tr) |
| ES (1) | ES2713434T3 (tr) |
| MX (1) | MX2017000438A (tr) |
| TR (1) | TR201901995T4 (tr) |
| WO (1) | WO2016007041A1 (tr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2713434T3 (es) | 2014-07-11 | 2019-05-21 | Llc Cardiosystempharma Llc Csp | Solución cardiopléjica universal (variantes) |
| IT201600120839A1 (it) * | 2016-12-01 | 2018-06-01 | Valentina Valenti | Soluzione cardioplegica con attivatori dell'autofagia per l'arresto diastolico del cuore in corso di interventi cardiochirurgici |
| US11998564B2 (en) | 2018-12-14 | 2024-06-04 | National Taiwan University | Stable cardioplegic solution for cardiac surgery |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG52177B2 (en) * | 1986-02-11 | 1998-06-30 | Стефан Н. Найденов | Cardioplegic solution |
| CA2066374C (en) * | 1991-04-19 | 2002-01-29 | Paul E. Segall | Solution for perfusing primates |
| US5306711A (en) | 1992-06-24 | 1994-04-26 | Georgetown University | Organ preservative solution |
| US5405742A (en) | 1993-07-16 | 1995-04-11 | Cyromedical Sciences, Inc. | Solutions for tissue preservation and bloodless surgery and methods using same |
| US5554497A (en) | 1994-12-12 | 1996-09-10 | Charlotte-Mecklenburg Hospital Authority | Cardioplegic solution for arresting an organ |
| US5656420A (en) | 1995-02-24 | 1997-08-12 | University Of Kentucky Research Foundation | Method for employing the delta opioid dadle to extend tissue survival time during ischemia |
| RU2145843C1 (ru) * | 1997-06-16 | 2000-02-27 | Вольгушев Валентин Евгеньевич | Нормотермический кардиоплегический раствор |
| US6492103B1 (en) | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| SE0002832D0 (sv) * | 2000-08-07 | 2000-08-07 | Jostra Ab | Cardioplegic solution |
| RU2195878C2 (ru) | 2000-09-21 | 2003-01-10 | Областная клиническая больница № 1 Свердловской области | Способ защиты больного при проведении операций аортокоронарного шунтирования |
| RU2226093C1 (ru) * | 2002-11-05 | 2004-03-27 | Российский кардиологический научно-производственный комплекс Министерства здравоохранения РФ | Кардиоплегический раствор "инфузол" |
| US20110020475A1 (en) | 2006-03-15 | 2011-01-27 | Universitat Bern | Cardioplegic solution |
| AU2009215884A1 (en) * | 2008-02-15 | 2009-08-27 | President And Fellows Of Harvard College | Cardioplegia solution for cardiac surgery |
| RU2413502C1 (ru) * | 2009-07-24 | 2011-03-10 | Учреждение Российской академии медицинских наук Научный центр сердечно-сосудистой хирургии им. А.Н. Бакулева РАМН | Кардиоплегический раствор "асн-бокерия-болдырева" |
| ES2713434T3 (es) | 2014-07-11 | 2019-05-21 | Llc Cardiosystempharma Llc Csp | Solución cardiopléjica universal (variantes) |
-
2015
- 2015-06-05 ES ES15819585T patent/ES2713434T3/es active Active
- 2015-06-05 TR TR2019/01995T patent/TR201901995T4/tr unknown
- 2015-06-05 JP JP2017522314A patent/JP6629850B2/ja active Active
- 2015-06-05 US US15/325,501 patent/US10646511B2/en active Active
- 2015-06-05 WO PCT/RU2015/000353 patent/WO2016007041A1/ru active Application Filing
- 2015-06-05 BR BR112017000052-0A patent/BR112017000052B1/pt active IP Right Grant
- 2015-06-05 MX MX2017000438A patent/MX2017000438A/es unknown
- 2015-06-05 EA EA201700032A patent/EA035702B1/ru unknown
- 2015-06-05 CN CN201580037619.2A patent/CN106659677A/zh active Pending
- 2015-06-05 EP EP15819585.9A patent/EP3167874B1/en active Active
- 2015-06-05 CN CN202211187936.0A patent/CN115813947A/zh active Pending
-
2020
- 2020-04-08 US US16/843,376 patent/US10987378B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3167874B1 (en) | 2018-12-26 |
| BR112017000052A2 (pt) | 2017-11-07 |
| MX2017000438A (es) | 2017-08-16 |
| CN115813947A (zh) | 2023-03-21 |
| EP3167874A4 (en) | 2017-12-27 |
| US10987378B2 (en) | 2021-04-27 |
| JP2017520629A (ja) | 2017-07-27 |
| JP6629850B2 (ja) | 2020-01-15 |
| CN106659677A (zh) | 2017-05-10 |
| US20200230171A1 (en) | 2020-07-23 |
| RU2014128455A (ru) | 2016-02-10 |
| WO2016007041A1 (ru) | 2016-01-14 |
| EA201700032A1 (ru) | 2017-05-31 |
| US10646511B2 (en) | 2020-05-12 |
| EP3167874A1 (en) | 2017-05-17 |
| EA035702B1 (ru) | 2020-07-28 |
| ES2713434T3 (es) | 2019-05-21 |
| BR112017000052B1 (pt) | 2022-09-13 |
| US20170143760A1 (en) | 2017-05-25 |
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