TR201820053T4 - Şeker zinciri asparajin türevi üretmeye yönelik proses. - Google Patents

Şeker zinciri asparajin türevi üretmeye yönelik proses. Download PDF

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Publication number
TR201820053T4
TR201820053T4 TR2018/20053T TR201820053T TR201820053T4 TR 201820053 T4 TR201820053 T4 TR 201820053T4 TR 2018/20053 T TR2018/20053 T TR 2018/20053T TR 201820053 T TR201820053 T TR 201820053T TR 201820053 T4 TR201820053 T4 TR 201820053T4
Authority
TR
Turkey
Prior art keywords
asparagine
mixture
linked
oligosaccharide derivatives
sugar chain
Prior art date
Application number
TR2018/20053T
Other languages
English (en)
Inventor
Fukae Kazuhiro
Original Assignee
Glytech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glytech Inc filed Critical Glytech Inc
Publication of TR201820053T4 publication Critical patent/TR201820053T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Asparajin ile bağlanmış oligosakkarit türevlerini hazırlamaya yönelik bir proses olup, özelliği aşağıdaki adımları içermesidir: (a) lipitlerinden ayrılmış bir yumurta sarısının, peptit ile bağlanmış oligosakkaritleri elde etmek üzere bir proteaz ile muamele edilmesi, (b) peptit ile bağlanmış oligosakkaritlerin karışımının asparajin ile bağlanmış oligosakkaritleri elde etmek üzere bir peptidaz ile muamele edilmesi, (c) bir lipofilik koruyucu grubun asparajin ile bağlanmış oligosakkarit türevlerinin bir karışımını elde etmek üzere karışımdaki asparajin ile bağlanmış oligosakkarit türevleri içine uygulanması ve (d) asparajin ile bağlanmış oligosakkarit türevlerinin karışımının, karışımı ayrı asparajin ile bağlanmış oligosakkarit türevlerine ayırmak üzere kromatografiye tabi tutulmasıdır.
TR2018/20053T 2003-02-04 2004-02-03 Şeker zinciri asparajin türevi üretmeye yönelik proses. TR201820053T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003026609 2003-02-04

Publications (1)

Publication Number Publication Date
TR201820053T4 true TR201820053T4 (tr) 2019-01-21

Family

ID=32844148

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/20053T TR201820053T4 (tr) 2003-02-04 2004-02-03 Şeker zinciri asparajin türevi üretmeye yönelik proses.

Country Status (14)

Country Link
US (1) US7955819B2 (tr)
EP (2) EP1591532B1 (tr)
JP (1) JP4237752B2 (tr)
KR (1) KR20050095609A (tr)
CN (1) CN100378225C (tr)
AU (1) AU2004209371B2 (tr)
CA (1) CA2514337C (tr)
DK (1) DK1591532T3 (tr)
ES (1) ES2701175T3 (tr)
HU (1) HUE041502T2 (tr)
PT (1) PT1591532T (tr)
TR (1) TR201820053T4 (tr)
TW (1) TWI344819B (tr)
WO (1) WO2004070046A1 (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5004464B2 (ja) * 2005-12-02 2012-08-22 大塚化学株式会社 糖鎖修飾リポソーム
CA2694542C (en) 2007-07-31 2017-08-29 Otsuka Chemical Co., Ltd. Method for producing peptide
AU2009261441B2 (en) 2008-06-17 2013-01-10 Glytech, Inc. Oligosaccharide chain added glp-1 peptide
RU2520240C2 (ru) 2008-08-19 2014-06-20 Глитек,Инк. Способ получения гликопротеина и способ скрининга
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
US20120114595A1 (en) 2009-07-16 2012-05-10 Otsuka Chemical Co., Ltd. Sugar chain-added ailim extracellular domain and method for producing same
EP2474560B1 (en) 2009-09-03 2014-03-19 The Noguchi Institute Method for producing 11-sugar sialyloligosaccharide-peptide
US20120264684A1 (en) 2009-10-30 2012-10-18 Yasuhiro Kajihara Glycosylated Form of Antigenic GLP-1 Analogue
JP5285022B2 (ja) * 2010-04-30 2013-09-11 旭化成株式会社 糖ペプチド誘導体及びその製造方法
JP5680576B2 (ja) * 2011-03-03 2015-03-04 旭化成株式会社 １１糖シアリルオリゴ糖アスパラギンの製造方法
BR112013022941B8 (pt) 2011-03-10 2021-02-23 Glytech Inc método para fabricação de glicopeptídeo tendo cadeia de açúcar sialil e método para a fabricação de um derivado de sialilglicoasparagina
KR102031998B1 (ko) 2011-09-04 2019-10-14 가부시키가이샤 도우사 고가쿠 겐큐쇼 당쇄 부가 폴리펩티드 및 당해 폴리펩티드를 포함하는 의약 조성물
KR102175017B1 (ko) 2011-09-04 2020-11-05 가부시키가이샤 도우사 고가쿠 겐큐쇼 당쇄 부가 폴리펩티드 및 당해 폴리펩티드를 포함하는 의약 조성물
EP2924053B1 (en) 2012-11-22 2020-11-11 Glytech, Inc. Glycosylated linker, compound containing glycosylated linker moiety and physiologically active substance moiety or salt thereof, and methods for producing said compound or salt thereof
WO2014084110A1 (ja) 2012-11-30 2014-06-05 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
CA2908211C (en) 2013-03-29 2022-07-19 Glytech, Inc. Polypeptide glycosylated with sialylated sugar chain
CA2908136C (en) 2013-03-30 2021-06-29 Glytech, Inc. Sugar chain-polypeptide complex
CN113121718B (zh) * 2021-05-13 2022-09-23 东南大学 一种迷果芹多糖psgp-2及其制备方法与应用
JP7261366B1 (ja) 2021-05-31 2023-04-19 Ｋｈネオケム株式会社 糖ぺプチドを製造する方法
WO2023157924A1 (ja) * 2022-02-18 2023-08-24 Ｋｈネオケム株式会社 複合型糖アスパラギン及びその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0727216B1 (en) * 1994-07-15 2003-05-28 TAIYO KAGAKU Co., LTD. Medicinal composition containing sialic acid derivative
JPH0899988A (ja) * 1994-09-29 1996-04-16 Takehiko Yamamoto シアル酸類含有オリゴ糖の製造法
WO2003008431A1 (fr) * 2001-06-19 2003-01-30 Otsuka Chemical Co.,Ltd. Methode de production d'un derive d'asparagine de chaines des sucres
AU2002322080A1 (en) * 2001-06-20 2003-01-08 The Brigham And Women's Hospital, Inc. P53 binding protein-related protein in cardiomyopathy

Also Published As

Publication number Publication date
EP2626429A1 (en) 2013-08-14
WO2004070046A1 (ja) 2004-08-19
US20060205039A1 (en) 2006-09-14
EP1591532B1 (en) 2018-10-31
WO2004070046A8 (ja) 2005-08-25
CA2514337A1 (en) 2004-08-19
JPWO2004070046A1 (ja) 2006-05-25
TWI344819B (en) 2011-07-11
DK1591532T3 (en) 2019-01-21
EP1591532A4 (en) 2011-03-30
CN1777679A (zh) 2006-05-24
EP1591532A1 (en) 2005-11-02
US7955819B2 (en) 2011-06-07
AU2004209371B2 (en) 2008-05-01
AU2004209371A1 (en) 2004-08-19
ES2701175T3 (es) 2019-02-21
TW200420231A (en) 2004-10-16
PT1591532T (pt) 2019-01-11
CN100378225C (zh) 2008-04-02
KR20050095609A (ko) 2005-09-29
HUE041502T2 (hu) 2019-05-28
JP4237752B2 (ja) 2009-03-11
CA2514337C (en) 2010-07-13

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