TR201802686T4 - Transferrin-tumstatin füzyon proteini ve bu proteinin üretilmesine ve kullanılmasına yönelik yöntemler. - Google Patents

Transferrin-tumstatin füzyon proteini ve bu proteinin üretilmesine ve kullanılmasına yönelik yöntemler. Download PDF

Info

Publication number
TR201802686T4
TR201802686T4 TR2018/02686T TR201802686T TR201802686T4 TR 201802686 T4 TR201802686 T4 TR 201802686T4 TR 2018/02686 T TR2018/02686 T TR 2018/02686T TR 201802686 T TR201802686 T TR 201802686T TR 201802686 T4 TR201802686 T4 TR 201802686T4
Authority
TR
Turkey
Prior art keywords
tumstatin
transferrin
protein
recombinant protein
recombinant
Prior art date
Application number
TR2018/02686T
Other languages
English (en)
Turkish (tr)
Inventor
B Kompella Uday
I Scheinman Robert
Tyagi Puneet
Original Assignee
Univ Colorado Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado Regents filed Critical Univ Colorado Regents
Publication of TR201802686T4 publication Critical patent/TR201802686T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TR2018/02686T 2011-08-17 2012-08-15 Transferrin-tumstatin füzyon proteini ve bu proteinin üretilmesine ve kullanılmasına yönelik yöntemler. TR201802686T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161524508P 2011-08-17 2011-08-17

Publications (1)

Publication Number Publication Date
TR201802686T4 true TR201802686T4 (tr) 2018-03-21

Family

ID=47715692

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/02686T TR201802686T4 (tr) 2011-08-17 2012-08-15 Transferrin-tumstatin füzyon proteini ve bu proteinin üretilmesine ve kullanılmasına yönelik yöntemler.

Country Status (15)

Country Link
US (1) US9290562B2 (enExample)
EP (1) EP2744831B1 (enExample)
JP (1) JP6073888B2 (enExample)
CN (2) CN110105453A (enExample)
AU (1) AU2012296588B2 (enExample)
BR (1) BR112014008680A2 (enExample)
CA (1) CA2849015C (enExample)
DK (1) DK2744831T3 (enExample)
ES (1) ES2659161T3 (enExample)
NO (1) NO2820418T3 (enExample)
PL (1) PL2744831T3 (enExample)
PT (1) PT2744831T (enExample)
SI (1) SI2744831T1 (enExample)
TR (1) TR201802686T4 (enExample)
WO (1) WO2013025846A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2686968T3 (es) * 2013-05-06 2018-10-23 China Pharmaceutical University Proteínas de fusión bifuncionales para inhibir la angiogénesis en el microambiente tumoral y para activar las respuestas inmunitarias adaptativas y los genes y usos de las mismas
JP2016522249A (ja) * 2013-06-20 2016-07-28 ノバルティス アーゲー 脈絡膜血管新生の治療におけるvegfアンタゴニストの使用
US11058750B2 (en) 2015-12-03 2021-07-13 Mor Research Applications Ltd. Compositions and methods for treatment of ocular diseases
KR101818151B1 (ko) 2016-03-25 2018-01-16 한국과학기술원 트렌스페린을 포함하는 허혈성망막병증 예방 및 치료용 조성물
CN109053899B (zh) * 2017-12-22 2021-11-16 湖南远泰生物技术有限公司 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672683A (en) 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US20050192242A1 (en) 1995-10-11 2005-09-01 Neal Zane C. Therapeutic fusion protein transgenes
IL140239A0 (en) * 1998-06-17 2002-02-10 Beth Israel Hospital Anti-angiogenic proteins and methods of use thereof
JP2003517847A (ja) 1999-12-23 2003-06-03 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド トランスフェリンポリヌクレオチド、ポリペプチド、および抗体
CN1628126A (zh) 2001-08-30 2005-06-15 比奥雷克西斯药物公司 经修饰的运铁蛋白融合蛋白
US8129504B2 (en) * 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
US20060122374A1 (en) * 2002-02-07 2006-06-08 Peter Mertins Albumin-fused anti-angiogenesis peptides
WO2005034877A2 (en) 2003-10-10 2005-04-21 University Of Southern California G-csf transferrin fusion proteins
JP2007526322A (ja) * 2004-03-02 2007-09-13 マサチューセッツ インスティテュート オブ テクノロジー ナノセル薬物送達系
US20080207502A1 (en) 2004-10-14 2008-08-28 Sopherion Therapeutics, Inc. Anti-Angiogenic Peptides and Methods of Use Thereof
WO2006049983A2 (en) 2004-10-27 2006-05-11 Biorexis Pharmaceutical Corporation Peptide yy modified transferrin fusion proteins
CA2606989A1 (en) * 2005-04-29 2006-11-09 Research Development Foundation Vascular targeting of ocular neovascularization
WO2007087689A1 (en) 2006-02-03 2007-08-09 Crc For Asthma And Airways Ltd A method of modulating cellular activity and agents for use therein
CN101070349B (zh) * 2007-05-22 2010-10-13 山西康宝生物制品股份有限公司 具有选择性杀伤肿瘤新生血管内皮细胞作用的融合蛋白与应用
CN101092452A (zh) * 2007-05-23 2007-12-26 哈尔滨医科大学 肿瘤抑素抗血管生成小分子多肽、融合蛋白及两者制备方法
WO2009086132A2 (en) * 2007-12-20 2009-07-09 University Of Southern California Design of spacers to increase the expression of recombinant fusion proteins
AU2012222833B2 (en) 2011-03-03 2017-03-16 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs

Also Published As

Publication number Publication date
ES2659161T3 (es) 2018-03-14
JP2014526890A (ja) 2014-10-09
PL2744831T3 (pl) 2018-05-30
US9290562B2 (en) 2016-03-22
NO2820418T3 (enExample) 2018-05-05
WO2013025846A2 (en) 2013-02-21
EP2744831A4 (en) 2015-03-11
CN103998470A (zh) 2014-08-20
PT2744831T (pt) 2018-03-05
AU2012296588A1 (en) 2014-04-03
BR112014008680A2 (pt) 2017-06-13
CA2849015A1 (en) 2013-02-21
DK2744831T3 (en) 2018-03-05
US20140179612A1 (en) 2014-06-26
AU2012296588B2 (en) 2017-07-27
JP6073888B2 (ja) 2017-02-01
CA2849015C (en) 2017-08-08
EP2744831A2 (en) 2014-06-25
WO2013025846A3 (en) 2013-05-02
EP2744831B1 (en) 2017-12-06
SI2744831T1 (en) 2018-04-30
CN110105453A (zh) 2019-08-09

Similar Documents

Publication Publication Date Title
CN106255699B (zh) 细胞穿透肽和使用其输送生物活性物质的方法
CN107207577B (zh) 用于治疗和预防炎症的组合物和方法
KR101258279B1 (ko) 세포 투과능을 개선한 개량형 신규 거대 분자 전달 도메인 개발 및 이의 이용방법
Wang et al. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells
Sidman et al. The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease
JP6709831B2 (ja) 血液脳関門を通過して輸送するための組成物及び方法
KR20230074076A (ko) 개질된 미토콘드리아 및 이의 용도
JP2015530358A (ja) 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物
CN101883786A (zh) 人源化的notch融合蛋白组合物及治疗方法
JP6717725B2 (ja) 遺伝子操作した成長因子変異体
JP2019196364A (ja) 線維性疾患を処置するためのエンドグリンポリペプチド
CN111303300A (zh) 一种降解crept多肽抑制剂及其在抑制胰腺癌细胞增殖与肿瘤发生过程中的应用
DK2744831T3 (en) TRANSFERRIN-TUMSTATIN-FUSION PROTEIN AND PROCEDURES FOR PREPARING AND USING THE SAME
Yin et al. Novel multi-targeted inhibitors suppress ocular neovascularization by regulating unique gene sets
JP2003518929A (ja) 基底側部選別シグナル、およびその阻害物質
US20230128981A1 (en) Cd24-loaded vesicles for treatment of cytokine storm and other conditions
TWI914375B (zh) 含有補體路徑抑制物及血管生成抑制物的融合蛋白及其用途
Piroozmand et al. MiRGD peptideticle targeted delivery of hinge-truncated soluble VEGF receptor 1 fusion protein to the retinal pigment epithelium cell line and newborn mice retina
Kumar-singh Platform for Rapid Delivery of Biologics and Drugs to Ocular Cells and Tissues Following Combat Associated Trauma
EP3096769A1 (en) Therapeutic use of vegfr-3 ligands
Cirillo Short cationic peptides for gene delivery into cancer cells