AU2012296588B2 - Transferrin-tumstatin fusion protein and methods for producing and using the same - Google Patents

Transferrin-tumstatin fusion protein and methods for producing and using the same Download PDF

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Publication number
AU2012296588B2
AU2012296588B2 AU2012296588A AU2012296588A AU2012296588B2 AU 2012296588 B2 AU2012296588 B2 AU 2012296588B2 AU 2012296588 A AU2012296588 A AU 2012296588A AU 2012296588 A AU2012296588 A AU 2012296588A AU 2012296588 B2 AU2012296588 B2 AU 2012296588B2
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AU
Australia
Prior art keywords
tumstatin
transferrin
protein
linked
recombinant protein
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Application number
AU2012296588A
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English (en)
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AU2012296588A1 (en
Inventor
Uday B. Kompella
Robert L. Scheinman
Puneet Tyagi
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University of Colorado Colorado Springs
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University of Colorado System
University of Colorado Colorado Springs
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Publication of AU2012296588A1 publication Critical patent/AU2012296588A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2012296588A 2011-08-17 2012-08-15 Transferrin-tumstatin fusion protein and methods for producing and using the same Active AU2012296588B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161524508P 2011-08-17 2011-08-17
US61/524,508 2011-08-17
PCT/US2012/051013 WO2013025846A2 (en) 2011-08-17 2012-08-15 Transferrin-tumstatin fusion protein and methods for producing and using the same

Publications (2)

Publication Number Publication Date
AU2012296588A1 AU2012296588A1 (en) 2014-04-03
AU2012296588B2 true AU2012296588B2 (en) 2017-07-27

Family

ID=47715692

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012296588A Active AU2012296588B2 (en) 2011-08-17 2012-08-15 Transferrin-tumstatin fusion protein and methods for producing and using the same

Country Status (15)

Country Link
US (1) US9290562B2 (enExample)
EP (1) EP2744831B1 (enExample)
JP (1) JP6073888B2 (enExample)
CN (2) CN110105453A (enExample)
AU (1) AU2012296588B2 (enExample)
BR (1) BR112014008680A2 (enExample)
CA (1) CA2849015C (enExample)
DK (1) DK2744831T3 (enExample)
ES (1) ES2659161T3 (enExample)
NO (1) NO2820418T3 (enExample)
PL (1) PL2744831T3 (enExample)
PT (1) PT2744831T (enExample)
SI (1) SI2744831T1 (enExample)
TR (1) TR201802686T4 (enExample)
WO (1) WO2013025846A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2686968T3 (es) * 2013-05-06 2018-10-23 China Pharmaceutical University Proteínas de fusión bifuncionales para inhibir la angiogénesis en el microambiente tumoral y para activar las respuestas inmunitarias adaptativas y los genes y usos de las mismas
JP2016522249A (ja) * 2013-06-20 2016-07-28 ノバルティス アーゲー 脈絡膜血管新生の治療におけるｖｅｇｆアンタゴニストの使用
US11058750B2 (en) 2015-12-03 2021-07-13 Mor Research Applications Ltd. Compositions and methods for treatment of ocular diseases
KR101818151B1 (ko) 2016-03-25 2018-01-16 한국과학기술원 트렌스페린을 포함하는 허혈성망막병증 예방 및 치료용 조성물
CN109053899B (zh) * 2017-12-22 2021-11-16 湖南远泰生物技术有限公司 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060172941A1 (en) * 2004-10-14 2006-08-03 Luca Rastelli Anti-angiogenic peptides and methods of use thereof

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US5672683A (en) 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US20050192242A1 (en) 1995-10-11 2005-09-01 Neal Zane C. Therapeutic fusion protein transgenes
IL140239A0 (en) * 1998-06-17 2002-02-10 Beth Israel Hospital Anti-angiogenic proteins and methods of use thereof
JP2003517847A (ja) 1999-12-23 2003-06-03 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド トランスフェリンポリヌクレオチド、ポリペプチド、および抗体
CN1628126A (zh) 2001-08-30 2005-06-15 比奥雷克西斯药物公司 经修饰的运铁蛋白融合蛋白
US8129504B2 (en) * 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
US20060122374A1 (en) * 2002-02-07 2006-06-08 Peter Mertins Albumin-fused anti-angiogenesis peptides
WO2005034877A2 (en) 2003-10-10 2005-04-21 University Of Southern California G-csf transferrin fusion proteins
JP2007526322A (ja) * 2004-03-02 2007-09-13 マサチューセッツ インスティテュート オブ テクノロジー ナノセル薬物送達系
WO2006049983A2 (en) 2004-10-27 2006-05-11 Biorexis Pharmaceutical Corporation Peptide yy modified transferrin fusion proteins
CA2606989A1 (en) * 2005-04-29 2006-11-09 Research Development Foundation Vascular targeting of ocular neovascularization
WO2007087689A1 (en) 2006-02-03 2007-08-09 Crc For Asthma And Airways Ltd A method of modulating cellular activity and agents for use therein
CN101070349B (zh) * 2007-05-22 2010-10-13 山西康宝生物制品股份有限公司 具有选择性杀伤肿瘤新生血管内皮细胞作用的融合蛋白与应用
CN101092452A (zh) * 2007-05-23 2007-12-26 哈尔滨医科大学 肿瘤抑素抗血管生成小分子多肽、融合蛋白及两者制备方法
WO2009086132A2 (en) * 2007-12-20 2009-07-09 University Of Southern California Design of spacers to increase the expression of recombinant fusion proteins
AU2012222833B2 (en) 2011-03-03 2017-03-16 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060172941A1 (en) * 2004-10-14 2006-08-03 Luca Rastelli Anti-angiogenic peptides and methods of use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHOWERS et al. "The Iron Carrier Transferrin Is Upregulated in Retinas from Patients with Age-Related Macular Degeneration", Investigative Ophthalmology & Visual Science, 2006, Vol. 47, No. 5, Pages 2135-2140. *
FARJO et al. "The potential of nanomedicine therapies to treat neovascular disease in the retina", Journal of Angiogenesis Research, 2010, Vol. 2, Page 21. *
SUDHAKAR et al. "Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by avß3 and a5ß1 integrins", PNAS, 2003, Vol. 100, No. 8, Pages 4766-4771. *

Also Published As

Publication number Publication date
ES2659161T3 (es) 2018-03-14
JP2014526890A (ja) 2014-10-09
PL2744831T3 (pl) 2018-05-30
TR201802686T4 (tr) 2018-03-21
US9290562B2 (en) 2016-03-22
NO2820418T3 (enExample) 2018-05-05
WO2013025846A2 (en) 2013-02-21
EP2744831A4 (en) 2015-03-11
CN103998470A (zh) 2014-08-20
PT2744831T (pt) 2018-03-05
AU2012296588A1 (en) 2014-04-03
BR112014008680A2 (pt) 2017-06-13
CA2849015A1 (en) 2013-02-21
DK2744831T3 (en) 2018-03-05
US20140179612A1 (en) 2014-06-26
JP6073888B2 (ja) 2017-02-01
CA2849015C (en) 2017-08-08
EP2744831A2 (en) 2014-06-25
WO2013025846A3 (en) 2013-05-02
EP2744831B1 (en) 2017-12-06
SI2744831T1 (en) 2018-04-30
CN110105453A (zh) 2019-08-09

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