TR200400857T4 - Yeni galantamın türevleri ve analogları - Google Patents
Yeni galantamın türevleri ve analoglarıInfo
- Publication number
- TR200400857T4 TR200400857T4 TR2004/00857T TR200400857T TR200400857T4 TR 200400857 T4 TR200400857 T4 TR 200400857T4 TR 2004/00857 T TR2004/00857 T TR 2004/00857T TR 200400857 T TR200400857 T TR 200400857T TR 200400857 T4 TR200400857 T4 TR 200400857T4
- Authority
- TR
- Turkey
- Prior art keywords
- galantamine
- analogs
- derivatives
- new
- general formula
- Prior art date
Links
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 2
- 229960003980 galantamine Drugs 0.000 title 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT5462000 | 2000-03-31 | ||
| AT2382001 | 2001-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200400857T4 true TR200400857T4 (tr) | 2004-06-21 |
Family
ID=25608130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2004/00857T TR200400857T4 (tr) | 2000-03-31 | 2001-03-22 | Yeni galantamın türevleri ve analogları |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7166588B2 (OSRAM) |
| EP (1) | EP1181294B1 (OSRAM) |
| JP (1) | JP2003529602A (OSRAM) |
| CN (1) | CN1380883A (OSRAM) |
| AT (1) | ATE263171T1 (OSRAM) |
| AU (1) | AU785385B2 (OSRAM) |
| BG (1) | BG65134B1 (OSRAM) |
| BR (1) | BR0105563A (OSRAM) |
| CA (1) | CA2368966A1 (OSRAM) |
| CZ (1) | CZ300160B6 (OSRAM) |
| DE (1) | DE50101827D1 (OSRAM) |
| DK (1) | DK1181294T3 (OSRAM) |
| ES (1) | ES2215885T3 (OSRAM) |
| HK (1) | HK1049832A1 (OSRAM) |
| HU (1) | HUP0202233A3 (OSRAM) |
| IS (1) | IS2287B (OSRAM) |
| MX (1) | MXPA01012275A (OSRAM) |
| NO (1) | NO326458B1 (OSRAM) |
| NZ (1) | NZ516302A (OSRAM) |
| PL (1) | PL202463B1 (OSRAM) |
| PT (1) | PT1181294E (OSRAM) |
| RU (1) | RU2241001C2 (OSRAM) |
| SI (1) | SI1181294T1 (OSRAM) |
| SK (1) | SK285909B6 (OSRAM) |
| TR (1) | TR200400857T4 (OSRAM) |
| WO (1) | WO2001074820A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4721386B2 (ja) * | 2001-07-10 | 2011-07-13 | 第一三共株式会社 | 新規ガランタミン類縁体 |
| CN1646536A (zh) * | 2002-03-25 | 2005-07-27 | 萨诺化学萨物股份公司 | 制备降雪花胺以及其异构体、盐和水合物的方法 |
| AT414125B (de) * | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
| AT500143A1 (de) * | 2004-04-22 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung |
| US7877350B2 (en) * | 2005-06-27 | 2011-01-25 | Ab Initio Technology Llc | Managing metadata for graph-based computations |
| ATE473219T1 (de) * | 2005-09-22 | 2010-07-15 | Galantos Pharma Gmbh | Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen |
| US20090253654A1 (en) | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| WO2008022365A2 (de) * | 2006-08-24 | 2008-02-28 | Sanochemia Ltd. | Mittel zum beeinflussen der wirkungen von organophosphorverbindungen und verwendung von galanthamin, dessen derivaten und analoga zum herstellen solcher mittel |
| CN102007129B (zh) | 2008-04-14 | 2014-05-07 | 神经动力生命科学公司 | 用作治疗人类脑疾病的前药的雪花胺衍生物 |
| BG110141A (en) * | 2008-05-23 | 2009-12-31 | "Софарма" Ад | GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE |
| EP2583168B1 (en) | 2010-06-15 | 2017-11-08 | Ab Initio Technology LLC | Dynamically loading graph-based computations |
| WO2013160728A1 (en) | 2012-04-26 | 2013-10-31 | Alma Mater Studiorum - Universita' Di Bologna | Dual targeting compounds for the treatment of alzheimer's disease |
| US10108521B2 (en) * | 2012-11-16 | 2018-10-23 | Ab Initio Technology Llc | Dynamic component performance monitoring |
| CA2932763C (en) | 2013-12-05 | 2022-07-12 | Ab Initio Technology Llc | Managing interfaces for dataflow graphs composed of sub-graphs |
| EP3189418B1 (en) | 2014-09-02 | 2022-02-23 | AB Initio Technology LLC | Visually specifying subsets of components in graph-based programs through user interactions |
| CN107077364B (zh) | 2014-09-02 | 2021-06-04 | 起元科技有限公司 | 基于特定数据端口连接的识别使用图组件的自动聚类的基于图的程序规范的编译 |
| US10657134B2 (en) | 2015-08-05 | 2020-05-19 | Ab Initio Technology Llc | Selecting queries for execution on a stream of real-time data |
| US12006301B1 (en) | 2021-05-13 | 2024-06-11 | Florida A&M University | And synthesis of dual 5-HT1A and 5-HT7 receptor ligands |
| CN116082352A (zh) * | 2023-02-16 | 2023-05-09 | 西南交通大学 | 一种加兰他敏衍生物及其制备方法和用途 |
| CN118908968B (zh) * | 2024-10-09 | 2025-03-04 | 威胜生物医药(苏州)股份有限公司 | 一种加兰他敏中间体衍生物及其催化氧化制备方法 |
| CN119528922B (zh) * | 2024-11-22 | 2025-12-09 | 泰安汉威集团有限公司 | 一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947445A (en) | 1974-05-09 | 1976-03-30 | Stanford Research Institute | Diazabicyclooctanes and diazabicycloheptanes |
| US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
| JP2755403B2 (ja) * | 1987-05-04 | 1998-05-20 | デイービス、ボニー | アルツハイマー病の治療のための化合物 |
| NL8800350A (nl) | 1988-02-12 | 1989-09-01 | Stichting Biomedical Research | Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen. |
| US4954502A (en) | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| US5336675A (en) | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
| US5153193A (en) | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
| US6323196B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US5428159A (en) | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
| AT401058B (de) | 1994-10-21 | 1996-06-25 | Waldheim Pharmazeutika Gmbh | Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins |
| NZ294191A (en) * | 1994-10-21 | 1998-10-28 | Waldheim Pharmazeutika Gmbh | Process for preparing 4a,5,9,10,11,12-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine derivatives and intermediates thereof |
| US6407229B1 (en) | 1994-10-21 | 2002-06-18 | Sanochemia Pharmazeutika Ag | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine |
| GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
| GB9519268D0 (en) | 1995-09-21 | 1995-11-22 | Chiroscience Ltd | Preparation of alkaloids |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| GB9716879D0 (en) * | 1997-08-08 | 1997-10-15 | Shire Int Licensing Bv | Treatment of attention deficit disorders |
| WO2000032199A1 (de) * | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
-
2001
- 2001-03-22 PL PL352638A patent/PL202463B1/pl not_active IP Right Cessation
- 2001-03-22 TR TR2004/00857T patent/TR200400857T4/xx unknown
- 2001-03-22 NZ NZ516302A patent/NZ516302A/xx unknown
- 2001-03-22 JP JP2001572510A patent/JP2003529602A/ja active Pending
- 2001-03-22 BR BR0105563-1A patent/BR0105563A/pt not_active IP Right Cessation
- 2001-03-22 ES ES01914813T patent/ES2215885T3/es not_active Expired - Lifetime
- 2001-03-22 AT AT01914813T patent/ATE263171T1/de not_active IP Right Cessation
- 2001-03-22 CN CN01801342A patent/CN1380883A/zh active Pending
- 2001-03-22 MX MXPA01012275A patent/MXPA01012275A/es active IP Right Grant
- 2001-03-22 SI SI200130081T patent/SI1181294T1/xx unknown
- 2001-03-22 HK HK03101873.7A patent/HK1049832A1/zh unknown
- 2001-03-22 AU AU42085/01A patent/AU785385B2/en not_active Ceased
- 2001-03-22 DK DK01914813T patent/DK1181294T3/da active
- 2001-03-22 HU HU0202233A patent/HUP0202233A3/hu unknown
- 2001-03-22 PT PT01914813T patent/PT1181294E/pt unknown
- 2001-03-22 CA CA002368966A patent/CA2368966A1/en not_active Abandoned
- 2001-03-22 CZ CZ20014178A patent/CZ300160B6/cs not_active IP Right Cessation
- 2001-03-22 DE DE50101827T patent/DE50101827D1/de not_active Expired - Lifetime
- 2001-03-22 WO PCT/AT2001/000082 patent/WO2001074820A1/de not_active Ceased
- 2001-03-22 SK SK1702-2001A patent/SK285909B6/sk not_active IP Right Cessation
- 2001-03-22 EP EP01914813A patent/EP1181294B1/de not_active Expired - Lifetime
- 2001-03-22 RU RU2001135839/04A patent/RU2241001C2/ru not_active IP Right Cessation
- 2001-05-22 US US09/980,025 patent/US7166588B2/en not_active Expired - Fee Related
- 2001-11-23 IS IS6174A patent/IS2287B/is unknown
- 2001-11-28 BG BG106155A patent/BG65134B1/bg unknown
- 2001-11-30 NO NO20015857A patent/NO326458B1/no not_active IP Right Cessation
-
2006
- 2006-06-28 US US11/478,170 patent/US20070027138A1/en not_active Abandoned
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