TR200100450T2 - Salvia türlerinden elde edilen ve virüslere karşı etkili olan bileşikler - Google Patents

Salvia türlerinden elde edilen ve virüslere karşı etkili olan bileşikler

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Publication number
TR200100450T2
TR200100450T2 TR2001/00450T TR200100450T TR200100450T2 TR 200100450 T2 TR200100450 T2 TR 200100450T2 TR 2001/00450 T TR2001/00450 T TR 2001/00450T TR 200100450 T TR200100450 T TR 200100450T TR 200100450 T2 TR200100450 T2 TR 200100450T2
Authority
TR
Turkey
Prior art keywords
compounds
effective against
compounds derived
against viruses
tetramers
Prior art date
Application number
TR2001/00450T
Other languages
English (en)
Inventor
K. Han Myun
Lee Paul
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of TR200100450T2 publication Critical patent/TR200100450T2/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Formül (1), Salvia bitki cinsinin ekstratlarinda bulunan Beta-(3,4-dihidroksifenil) laktik asit ve/veya kafeik asitten olusan en azindan bir kisma sahip moleküller içeren bilesimler saglanmistir; bu kisimlar, formül (I)'e sahiptirler; aktif maddeler, en azindan 190 daltonluk bir moleküler agirliga sahiptirler. Tercih edilen maddelerin bir sinifi, bahsedilen kisimlari içeren dimerler, trimerler, tetramerler ve daha büyük polimerler olusturmak için birlesmis maddelerdir; en çok tercih edilenler, salvianolik asidin dimerleri, trimerleri, tetramerleri ve daha büyük polimerleridir. Bilesikler ve bilesimler, virüs enfeksiyonlarinin tedavi edilmesi için sistemik veya lokal olarak farmasötik olarak kabul edilebilir tasiyicilarda ve eksipiyanlarda uygulanirlar.
TR2001/00450T 1998-06-25 1999-06-25 Salvia türlerinden elde edilen ve virüslere karşı etkili olan bileşikler TR200100450T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/104,363 US6037369A (en) 1998-06-25 1998-06-25 Compounds obtained from salvia species having antiviral Activity

Publications (1)

Publication Number Publication Date
TR200100450T2 true TR200100450T2 (tr) 2001-07-23

Family

ID=22300096

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00450T TR200100450T2 (tr) 1998-06-25 1999-06-25 Salvia türlerinden elde edilen ve virüslere karşı etkili olan bileşikler

Country Status (18)

Country Link
US (1) US6037369A (tr)
EP (1) EP1089747A1 (tr)
JP (1) JP2002518455A (tr)
KR (1) KR20010071580A (tr)
CN (1) CN1312722A (tr)
AU (1) AU740698B2 (tr)
BR (1) BR9912218A (tr)
CA (1) CA2335956A1 (tr)
CZ (1) CZ20004858A3 (tr)
HU (1) HUP0103398A2 (tr)
ID (1) ID28792A (tr)
IL (1) IL140483A0 (tr)
IS (1) IS5792A (tr)
MX (1) MXPA01000195A (tr)
NO (1) NO20006631L (tr)
PL (1) PL345086A1 (tr)
TR (1) TR200100450T2 (tr)
WO (1) WO1999066942A1 (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024460A1 (en) * 1996-12-05 1998-06-11 Georgetown University Extracts of salvia species having antiviral activity
US6043276A (en) * 1998-06-25 2000-03-28 Georgetown University School Of Medicine Compounds obtained from salvia species having antiviral activity
EP1278531B1 (de) * 2000-05-05 2005-09-21 Parsenn-Produkte AG Verwendung einer zubereitung zur topischen behandlung von durch virusinfektionen verursachten manifestationen
SG98409A1 (en) * 2000-06-21 2003-09-19 Chi Chiang Yang Pharmaceutical compositions and combinations for the treatment or prophylaxis of disorders related to hiv and retrovirus
JP2002020283A (ja) * 2000-06-22 2002-01-23 Yang Chi-Chiang Ｈｉｖおよびレトロウイルスに関連する障害の処置または予防のための薬学的組成物および組み合わせ
KR20020005222A (ko) * 2000-06-28 2002-01-17 치-치앙 양 Ｈｉｖ 또는 레트로바이러스에 관련된 질환의 치료 또는예방용 약학적 조성물 및 조합물
AU2001293048A1 (en) * 2000-09-26 2002-04-08 The Johns Hopkins University Antiviral compositions and methods of use
US20070027209A1 (en) * 2005-08-01 2007-02-01 Lee Hyun C Prevention and treatment of atherosclerosis with lithospermate B
WO2008117901A1 (en) * 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University A method for isolation of high concentration of magnesium lithospermate b from salviae miltiorrhizae
KR20120006029A (ko) * 2009-03-30 2012-01-17 티안진 타슬리 파마슈티컬 컴퍼니 리미티드 신규한 화합물 살비아놀릭산 ｌ, 이의 제조방법 및 용도
CN101919836A (zh) * 2009-06-17 2010-12-22 山东绿叶天然药物研究开发有限公司 迷迭香酸的新用途
CN103054976B (zh) * 2011-10-21 2014-09-24 上海中医药大学 一种治疗血小板减少症的中药组合物及其制备方法和应用
CN103845403B (zh) * 2014-02-27 2016-10-05 河南大学 丹参配方颗粒在制备预防和治疗艾滋病脑病药物方面的应用
CN104974119B (zh) * 2014-04-01 2018-10-19 中国科学院上海药物研究所 一种高纯度丹酚酸b镁及其制备方法
CN108042524A (zh) * 2017-12-21 2018-05-18 南方医科大学 丹酚酸b及其结构类似物在制备抗hpv病毒感染药物中的应用
CN109771410B (zh) * 2019-03-06 2020-11-24 湖北大学 紫草酸在制备抗乙肝病毒药物中的用途
CN109771407B (zh) * 2019-03-29 2021-11-26 成都医学院 迷迭香酸在制备抑制水痘-带状疱疹病毒的药物中的用途
CN110922286B (zh) * 2019-11-23 2022-08-16 上海化工研究院有限公司 一种非对称芳基取代富烯化合物及其制备方法与应用
EP4144353A1 (en) * 2020-04-30 2023-03-08 FUJIFILM Toyama Chemical Co., Ltd. Coronavirus infection therapeutic agent formed through combination of pyrazine derivative and another coronavirus infection therapeutic drug
CN114712342B (zh) * 2022-05-10 2023-04-21 湖北大学 紫草酸在制备抗流感病毒药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5178865A (en) * 1990-06-19 1993-01-12 Cedars-Sinai Medical Center Chinese herbal extracts in the treatment of hiv related disease in vitro
US5346695A (en) * 1991-03-27 1994-09-13 Tampa Bay Research Institute Methods of inhibiting HIV replication in vitro using polymers of p-hydroxylated cinnamic acids
WO1998024460A1 (en) * 1996-12-05 1998-06-11 Georgetown University Extracts of salvia species having antiviral activity

Also Published As

Publication number Publication date
KR20010071580A (ko) 2001-07-28
HUP0103398A2 (hu) 2002-01-28
PL345086A1 (en) 2001-12-03
BR9912218A (pt) 2002-07-23
JP2002518455A (ja) 2002-06-25
US6037369A (en) 2000-03-14
WO1999066942A9 (en) 2000-06-22
NO20006631D0 (no) 2000-12-22
MXPA01000195A (es) 2002-04-24
CN1312722A (zh) 2001-09-12
ID28792A (id) 2001-07-05
EP1089747A1 (en) 2001-04-11
NO20006631L (no) 2001-02-26
CZ20004858A3 (cs) 2001-09-12
AU740698B2 (en) 2001-11-15
WO1999066942A1 (en) 1999-12-29
CA2335956A1 (en) 1999-12-29
AU4714999A (en) 2000-01-10
IS5792A (is) 2000-12-22
IL140483A0 (en) 2002-02-10

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