TR200003058T2 - Ekinokandin sınıfından peptitlerin kendi C4-homotirozin analoglarına dönüştürülmesi için işlem - Google Patents

Ekinokandin sınıfından peptitlerin kendi C4-homotirozin analoglarına dönüştürülmesi için işlem

Info

Publication number
TR200003058T2
TR200003058T2 TR2000/03058T TR200003058T TR200003058T2 TR 200003058 T2 TR200003058 T2 TR 200003058T2 TR 2000/03058 T TR2000/03058 T TR 2000/03058T TR 200003058 T TR200003058 T TR 200003058T TR 200003058 T2 TR200003058 T2 TR 200003058T2
Authority
TR
Turkey
Prior art keywords
homotyrosine
analogs
echinocandin
class
monodeoxy
Prior art date
Application number
TR2000/03058T
Other languages
English (en)
Inventor
Mukhopadhyay Triptikumar
Jayvanti Kenia
Koteswara Satya Vijaya Kumar Erra
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200003058T2 publication Critical patent/TR200003058T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Bulus, ekinokandin sinifindan peptitlerin, kendi C4-homotirozin monodeoksi analoglarina, özellikle de mulundokandinin deoksi-mulundokandine dönüstürülmesine yönelik bir isleme iliskindir; sözkonusu islem, ekinokandinlerin C4-htyr (homotirozin) hidroksil grubunun, ayni derecede kolay C5-Orn (ornitin) hidroksil grubu önceden korunmadan/koruma grubu giderilmeden, nötr kosullar altinda, kendi monodeoksi analoglarina tek bir asamayla, seçici olarak indirgenmesine ve monodeoksi bilesigin ham tepkime karisimindan saflastirilmasina dayanir.
TR2000/03058T 1998-04-23 1999-04-22 Ekinokandin sınıfından peptitlerin kendi C4-homotirozin analoglarına dönüştürülmesi için işlem TR200003058T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98107397 1998-04-23

Publications (1)

Publication Number Publication Date
TR200003058T2 true TR200003058T2 (tr) 2001-01-22

Family

ID=8231807

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03058T TR200003058T2 (tr) 1998-04-23 1999-04-22 Ekinokandin sınıfından peptitlerin kendi C4-homotirozin analoglarına dönüştürülmesi için işlem

Country Status (34)

Country Link
US (1) US6809177B1 (tr)
EP (1) EP1073675B1 (tr)
JP (1) JP2002513033A (tr)
KR (1) KR20010042916A (tr)
CN (1) CN1298410A (tr)
AP (1) AP1111A (tr)
AT (1) ATE350392T1 (tr)
AU (1) AU758395B2 (tr)
BG (1) BG104772A (tr)
BR (1) BR9909853A (tr)
CA (1) CA2327474A1 (tr)
CY (1) CY1106456T1 (tr)
CZ (1) CZ293547B6 (tr)
DE (1) DE69934683T2 (tr)
DK (1) DK1073675T3 (tr)
EA (1) EA002909B1 (tr)
EE (1) EE200000611A (tr)
ES (1) ES2280119T3 (tr)
GE (1) GEP20032900B (tr)
HR (1) HRP20000719A2 (tr)
HU (1) HUP0102491A3 (tr)
ID (1) ID27026A (tr)
IL (1) IL138432A0 (tr)
NO (1) NO20005258L (tr)
NZ (1) NZ506667A (tr)
PL (1) PL343484A1 (tr)
PT (1) PT1073675E (tr)
SI (1) SI1073675T1 (tr)
SK (1) SK15642000A3 (tr)
TR (1) TR200003058T2 (tr)
UA (1) UA64787C2 (tr)
WO (1) WO1999055727A1 (tr)
YU (1) YU65000A (tr)
ZA (1) ZA200004600B (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101993477B (zh) * 2009-08-18 2014-03-26 上海医药工业研究院 一种棘白菌素b的脱氧类似物的制备方法
US9399664B2 (en) * 2010-03-29 2016-07-26 Biocon Limited Process for purification of pneumocandin
CN102464704B (zh) * 2010-11-05 2013-12-11 上海医药工业研究院 一种化合物及其制备方法和用途
CN116925187A (zh) * 2022-04-07 2023-10-24 浙江大学 棘白菌素类化合物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
US5348940A (en) 1991-10-01 1994-09-20 Merck & Co., Inc. Cyclohexapeptidyl hydroxypropionitrile compounds
US5939384A (en) 1991-10-01 1999-08-17 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
IL109615A (en) * 1993-05-17 2000-12-06 Fujisawa Pharmaceutical Co Cyclic polypeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
CA2195975C (en) * 1994-08-23 2001-05-15 James M. Balkovec An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
ES2181790T3 (es) 1994-09-16 2003-03-01 Merck & Co Inc Compuestos azaciclohexapeptidicos.
EP0787140A4 (en) * 1994-11-15 1999-04-14 Lilly Co Eli PROCESS FOR EXECUTING A RETRO-ALDOL REACTION

Also Published As

Publication number Publication date
AP1111A (en) 2002-10-23
AU758395B2 (en) 2003-03-20
EP1073675A1 (en) 2001-02-07
ATE350392T1 (de) 2007-01-15
EA002909B1 (ru) 2002-10-31
JP2002513033A (ja) 2002-05-08
SI1073675T1 (sl) 2007-04-30
EP1073675B1 (en) 2007-01-03
YU65000A (sh) 2003-10-31
IL138432A0 (en) 2001-10-31
CZ20003903A3 (en) 2001-05-16
AP2000001894A0 (en) 2000-09-30
GEP20032900B (en) 2003-02-25
WO1999055727A1 (en) 1999-11-04
CA2327474A1 (en) 1999-11-04
CN1298410A (zh) 2001-06-06
HUP0102491A2 (hu) 2001-11-28
NO20005258D0 (no) 2000-10-19
CZ293547B6 (cs) 2004-06-16
NZ506667A (en) 2003-02-28
SK15642000A3 (sk) 2001-09-11
BG104772A (en) 2001-04-30
AU3709699A (en) 1999-11-16
US6809177B1 (en) 2004-10-26
DK1073675T3 (da) 2007-05-07
ID27026A (id) 2001-02-22
DE69934683T2 (de) 2007-10-18
KR20010042916A (ko) 2001-05-25
PL343484A1 (en) 2001-08-27
ES2280119T3 (es) 2007-09-01
HUP0102491A3 (en) 2001-12-28
NO20005258L (no) 2000-10-19
CY1106456T1 (el) 2011-10-12
EA200001099A1 (ru) 2001-04-23
DE69934683D1 (de) 2007-02-15
EE200000611A (et) 2002-04-15
UA64787C2 (en) 2004-03-15
BR9909853A (pt) 2000-12-19
HRP20000719A2 (en) 2001-10-31
ZA200004600B (en) 2002-01-30
PT1073675E (pt) 2007-03-30

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