BR9909853A - Processo para a conversão da classe de peptìdeos equinocandina em seus análogos c4-homotirosina monodesóxi - Google Patents

Processo para a conversão da classe de peptìdeos equinocandina em seus análogos c4-homotirosina monodesóxi

Info

Publication number
BR9909853A
BR9909853A BR9909853-9A BR9909853A BR9909853A BR 9909853 A BR9909853 A BR 9909853A BR 9909853 A BR9909853 A BR 9909853A BR 9909853 A BR9909853 A BR 9909853A
Authority
BR
Brazil
Prior art keywords
analogs
peptide class
monodesoxy
homothyrosine
echinocandin
Prior art date
Application number
BR9909853-9A
Other languages
English (en)
Inventor
Triptikumar Mukhopadhyay
Kenia Jayvanti
Erra Koteswara Satya Vij Kumar
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR9909853A publication Critical patent/BR9909853A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Abstract

Patente de Invenção: <B>"PROCESSO PARA A CONVERSãO DA CLASSE DE PEPTìDEOS EQUINOCANDINA EM SEUS ANáLOGOS C4-HOMOTIROSINA MONODESóXI"<D>. A presente invenção refere-se a um processo pra a conversão da classe de peptídeos equinocandina aos seus análogos C4-homotirosina monodesóxi, particularmente mulundocandina à desoximulundocandina, que consiste em uma etapa simples de redução seletiva do grupo C4-htir (homo-tirosina) hidroxila de equinocandinas em seus análogos monodesóxi, sob condições neutras sem proteção/desproteção antes do grupo C5-orn (orniti-na) hidroxila e purificação do comosto monodesóxi a partir da mistura reacional bruta.
BR9909853-9A 1998-04-23 1999-04-22 Processo para a conversão da classe de peptìdeos equinocandina em seus análogos c4-homotirosina monodesóxi BR9909853A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107397 1998-04-23
PCT/EP1999/002715 WO1999055727A1 (en) 1998-04-23 1999-04-22 A process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues

Publications (1)

Publication Number Publication Date
BR9909853A true BR9909853A (pt) 2000-12-19

Family

ID=8231807

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909853-9A BR9909853A (pt) 1998-04-23 1999-04-22 Processo para a conversão da classe de peptìdeos equinocandina em seus análogos c4-homotirosina monodesóxi

Country Status (34)

Country Link
US (1) US6809177B1 (pt)
EP (1) EP1073675B1 (pt)
JP (1) JP2002513033A (pt)
KR (1) KR20010042916A (pt)
CN (1) CN1298410A (pt)
AP (1) AP1111A (pt)
AT (1) ATE350392T1 (pt)
AU (1) AU758395B2 (pt)
BG (1) BG104772A (pt)
BR (1) BR9909853A (pt)
CA (1) CA2327474A1 (pt)
CY (1) CY1106456T1 (pt)
CZ (1) CZ293547B6 (pt)
DE (1) DE69934683T2 (pt)
DK (1) DK1073675T3 (pt)
EA (1) EA002909B1 (pt)
EE (1) EE200000611A (pt)
ES (1) ES2280119T3 (pt)
GE (1) GEP20032900B (pt)
HR (1) HRP20000719A2 (pt)
HU (1) HUP0102491A3 (pt)
ID (1) ID27026A (pt)
IL (1) IL138432A0 (pt)
NO (1) NO20005258D0 (pt)
NZ (1) NZ506667A (pt)
PL (1) PL343484A1 (pt)
PT (1) PT1073675E (pt)
SI (1) SI1073675T1 (pt)
SK (1) SK15642000A3 (pt)
TR (1) TR200003058T2 (pt)
UA (1) UA64787C2 (pt)
WO (1) WO1999055727A1 (pt)
YU (1) YU65000A (pt)
ZA (1) ZA200004600B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101993477B (zh) * 2009-08-18 2014-03-26 上海医药工业研究院 一种棘白菌素b的脱氧类似物的制备方法
US9399664B2 (en) * 2010-03-29 2016-07-26 Biocon Limited Process for purification of pneumocandin
CN102464704B (zh) * 2010-11-05 2013-12-11 上海医药工业研究院 一种化合物及其制备方法和用途
CN116925187A (zh) * 2022-04-07 2023-10-24 浙江大学 棘白菌素类化合物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159059A (en) 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
US5348940A (en) * 1991-10-01 1994-09-20 Merck & Co., Inc. Cyclohexapeptidyl hydroxypropionitrile compounds
US5939384A (en) * 1991-10-01 1999-08-17 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU681119B2 (en) 1993-05-17 1997-08-21 Fujisawa Pharmaceutical Co., Ltd. New polypeptide compound and a process for preparation thereof
WO1996006109A1 (en) * 1994-08-23 1996-02-29 Merck & Co., Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
AU692308B2 (en) 1994-09-16 1998-06-04 Merck Sharp & Dohme Corp. Aza cyclohexapeptide compounds
CA2205369A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction

Also Published As

Publication number Publication date
AU758395B2 (en) 2003-03-20
US6809177B1 (en) 2004-10-26
ID27026A (id) 2001-02-22
HRP20000719A2 (en) 2001-10-31
WO1999055727A1 (en) 1999-11-04
CY1106456T1 (el) 2011-10-12
CZ20003903A3 (en) 2001-05-16
ES2280119T3 (es) 2007-09-01
IL138432A0 (en) 2001-10-31
DE69934683D1 (de) 2007-02-15
JP2002513033A (ja) 2002-05-08
NO20005258L (no) 2000-10-19
HUP0102491A3 (en) 2001-12-28
EA200001099A1 (ru) 2001-04-23
AP2000001894A0 (en) 2000-09-30
BG104772A (en) 2001-04-30
AU3709699A (en) 1999-11-16
KR20010042916A (ko) 2001-05-25
UA64787C2 (en) 2004-03-15
EA002909B1 (ru) 2002-10-31
NO20005258D0 (no) 2000-10-19
CA2327474A1 (en) 1999-11-04
EP1073675B1 (en) 2007-01-03
NZ506667A (en) 2003-02-28
HUP0102491A2 (hu) 2001-11-28
PL343484A1 (en) 2001-08-27
AP1111A (en) 2002-10-23
SI1073675T1 (sl) 2007-04-30
PT1073675E (pt) 2007-03-30
EE200000611A (et) 2002-04-15
ATE350392T1 (de) 2007-01-15
YU65000A (sh) 2003-10-31
DE69934683T2 (de) 2007-10-18
CZ293547B6 (cs) 2004-06-16
CN1298410A (zh) 2001-06-06
SK15642000A3 (sk) 2001-09-11
DK1073675T3 (da) 2007-05-07
EP1073675A1 (en) 2001-02-07
ZA200004600B (en) 2002-01-30
GEP20032900B (en) 2003-02-25
TR200003058T2 (tr) 2001-01-22

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.