TR199902700T2 - Seçici estrojen reseptör modülatörleri ile merkezi sinir sistemi düzensizliklerinin iyilestirilmesi. - Google Patents

Seçici estrojen reseptör modülatörleri ile merkezi sinir sistemi düzensizliklerinin iyilestirilmesi.

Info

Publication number
TR199902700T2
TR199902700T2 TR1999/02700T TR9902700T TR199902700T2 TR 199902700 T2 TR199902700 T2 TR 199902700T2 TR 1999/02700 T TR1999/02700 T TR 1999/02700T TR 9902700 T TR9902700 T TR 9902700T TR 199902700 T2 TR199902700 T2 TR 199902700T2
Authority
TR
Turkey
Prior art keywords
estrogen receptor
selective estrogen
amelioration
nervous system
central nervous
Prior art date
Application number
TR1999/02700T
Other languages
English (en)
Inventor
Renee Bales Kelly
Uhlman Bryant Henry
Marc Paul Steven
Patricia Knadler Mary
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR199902700T2 publication Critical patent/TR199902700T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bu bulus, bu tür bir tedaviye ihtiyaç duyan bir hastada depresyon, ruh hali salinimlari ya da Alzheimer hastaliginin iyilestirilmesi için bir yöntem temin etmektedir, bu yöntem, (a9 formülünün bir seçici estrojen reseptör modüle edici bilesiginin tatbik edilmesini içermektedir, bu formülde, R ve R bagimsiz olarak hidroksi ve bir ila dört karbon atomlu alkoksidir; R ve R4 bagimsiz olarak metil ya da etildir, ya da R ve R4, bagli olduklari azot atomu ile birlikte alindiginda, bir pirolidino, metil- pirolidino, dimetilpirolidino, piperidino, morfolino ya da heksametilenmino halkasini olusturmaktadir.
TR1999/02700T 1997-04-09 1998-04-07 Seçici estrojen reseptör modülatörleri ile merkezi sinir sistemi düzensizliklerinin iyilestirilmesi. TR199902700T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4311797P 1997-04-09 1997-04-09

Publications (1)

Publication Number Publication Date
TR199902700T2 true TR199902700T2 (tr) 2000-06-21

Family

ID=21925589

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02700T TR199902700T2 (tr) 1997-04-09 1998-04-07 Seçici estrojen reseptör modülatörleri ile merkezi sinir sistemi düzensizliklerinin iyilestirilmesi.

Country Status (19)

Country Link
US (2) US6077852A (tr)
EP (1) EP0986556A4 (tr)
JP (1) JP2001518898A (tr)
KR (1) KR20010006219A (tr)
CN (1) CN1260792A (tr)
AU (1) AU733421B2 (tr)
BR (1) BR9809389A (tr)
CA (1) CA2286455A1 (tr)
EA (1) EA002360B1 (tr)
HU (1) HUP0002031A3 (tr)
ID (1) ID27986A (tr)
IL (1) IL132278A0 (tr)
NO (1) NO994901L (tr)
NZ (2) NZ500175A (tr)
PL (1) PL336701A1 (tr)
TR (1) TR199902700T2 (tr)
TW (1) TW479056B (tr)
WO (1) WO1998045287A1 (tr)
ZA (1) ZA982877B (tr)

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US6610706B1 (en) 1999-07-29 2003-08-26 Eli Lilly And Company Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
EP1204656A2 (en) * 1999-07-29 2002-05-15 Eli Lilly And Company A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride
DE60005693T2 (de) * 1999-07-29 2004-07-29 Eli Lilly And Co., Indianapolis Eine kristalline form von 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophen-hydrochlorid
EP1757291A3 (en) * 2000-05-08 2009-07-15 Eli Lilly & Company Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
WO2001085147A2 (en) * 2000-05-08 2001-11-15 Eli Lilly And Company STABILIZED FORMULATIONS OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL) BENZO[b]THIOPHENE AND SALTS THEREOF
KR20030037690A (ko) * 2000-10-20 2003-05-14 일라이 릴리 앤드 캄파니 6-히드록시-3-(4-[2-(피페리딘-1-일)에톡시]페녹시)-2-(4-메톡시페닐)벤조[ｂ]티오펜 히드로클로라이드의 신규 결정형
US8124776B2 (en) * 2007-03-16 2012-02-28 Eli Lilly And Company Process and intermediates for preparing arzoxifene
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GB201311888D0 (en) * 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
CN104829568B (zh) * 2015-05-12 2017-03-01 广州中医药大学 一种2‑苯基‑苯骈五元杂环类化合物及其衍生物的医药应用
CN104829569B (zh) * 2015-05-12 2017-04-26 广州中医药大学 一种2‑苯基‑苯骈五元杂环类化合物及其衍生物的应用
US11633382B2 (en) 2015-11-10 2023-04-25 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
US20180072711A1 (en) 2016-09-15 2018-03-15 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
US10647698B2 (en) 2016-12-01 2020-05-12 Arvinas Operations, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
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CN112839646A (zh) * 2018-08-16 2021-05-25 G1治疗公司 用于治疗医学疾病的苯并噻吩雌激素受体调节剂

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Also Published As

Publication number Publication date
ID27986A (id) 2001-05-03
WO1998045287A1 (en) 1998-10-15
NO994901L (no) 1999-12-09
AU7104998A (en) 1998-10-30
US20020013342A1 (en) 2002-01-31
NO994901D0 (no) 1999-10-08
AU733421B2 (en) 2001-05-17
NZ514146A (en) 2001-09-28
JP2001518898A (ja) 2001-10-16
HUP0002031A2 (hu) 2001-06-28
CA2286455A1 (en) 1998-10-15
ZA982877B (en) 1999-10-04
KR20010006219A (ko) 2001-01-26
EA199900913A1 (ru) 2000-04-24
EP0986556A4 (en) 2001-03-21
TW479056B (en) 2002-03-11
US6077852A (en) 2000-06-20
EA002360B1 (ru) 2002-04-25
CN1260792A (zh) 2000-07-19
BR9809389A (pt) 2002-03-19
IL132278A0 (en) 2001-03-19
PL336701A1 (en) 2000-07-03
NZ500175A (en) 2001-10-26
EP0986556A1 (en) 2000-03-22
HUP0002031A3 (en) 2003-01-28

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