ATE230992T1 - Hydromorphone-therapie - Google Patents
Hydromorphone-therapieInfo
- Publication number
- ATE230992T1 ATE230992T1 AT95924665T AT95924665T ATE230992T1 AT E230992 T1 ATE230992 T1 AT E230992T1 AT 95924665 T AT95924665 T AT 95924665T AT 95924665 T AT95924665 T AT 95924665T AT E230992 T1 ATE230992 T1 AT E230992T1
- Authority
- AT
- Austria
- Prior art keywords
- hydromorphone
- oral
- composition
- therapy
- hydromorphone therapy
- Prior art date
Links
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 title abstract 3
- 229960001410 hydromorphone Drugs 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Electronic Switches (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/271,593 US5529787A (en) | 1994-07-07 | 1994-07-07 | Hydromorphone therapy |
| PCT/US1995/007950 WO1996001629A1 (en) | 1994-07-07 | 1995-06-23 | Hydromorphone therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE230992T1 true ATE230992T1 (de) | 2003-02-15 |
Family
ID=23036244
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95924665T ATE230992T1 (de) | 1994-07-07 | 1995-06-23 | Hydromorphone-therapie |
| AT99204122T ATE227575T1 (de) | 1994-07-07 | 1995-06-23 | Hydromorphontherapie |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99204122T ATE227575T1 (de) | 1994-07-07 | 1995-06-23 | Hydromorphontherapie |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5529787A (de) |
| EP (2) | EP1025845B1 (de) |
| AT (2) | ATE230992T1 (de) |
| AU (1) | AU693910B2 (de) |
| CA (1) | CA2188451A1 (de) |
| DE (2) | DE69528852T2 (de) |
| DK (2) | DK0769949T3 (de) |
| ES (2) | ES2186724T3 (de) |
| NZ (1) | NZ289289A (de) |
| PT (1) | PT1025845E (de) |
| WO (1) | WO1996001629A1 (de) |
| ZA (1) | ZA955674B (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| US5914131A (en) * | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
| US5529787A (en) * | 1994-07-07 | 1996-06-25 | Alza Corporation | Hydromorphone therapy |
| US20020006438A1 (en) * | 1998-09-25 | 2002-01-17 | Benjamin Oshlack | Sustained release hydromorphone formulations exhibiting bimodal characteristics |
| ES2168610T3 (es) * | 1996-03-12 | 2002-06-16 | Alza Corp | Composicion y forma galenica que contiene un antagonista opioide. |
| AU3121597A (en) * | 1996-05-24 | 1997-12-09 | Alza Corporation | Nutritional support system |
| US6190351B1 (en) * | 1997-02-28 | 2001-02-20 | Alza Corporation | Nutritional support system |
| US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
| US8524277B2 (en) * | 1998-03-06 | 2013-09-03 | Alza Corporation | Extended release dosage form |
| US6224907B1 (en) * | 1998-03-06 | 2001-05-01 | Alza Corporation | Anti-asthma therapy |
| US6541021B1 (en) * | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) * | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| JP4806507B2 (ja) | 1999-10-29 | 2011-11-02 | ユーロ−セルティーク エス.エイ. | 制御放出ヒドロコドン処方 |
| KR100748913B1 (ko) * | 1999-11-22 | 2007-08-13 | 알자 코포레이션 | 제 1 및 제 2 를 함유하는 삼투성 투약 형태 |
| JP4100910B2 (ja) * | 1999-12-23 | 2008-06-11 | ファイザー・プロダクツ・インク | ヒドロゲル駆動の薬物剤形 |
| WO2001047498A2 (en) | 1999-12-23 | 2001-07-05 | Pfizer Products Inc. | Hydrogel-driven layered drug dosage form comprising sertraline |
| US7074803B2 (en) * | 2001-03-02 | 2006-07-11 | Durect Corporation | Opioid formulations |
| US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
| US20060083691A1 (en) * | 2000-05-10 | 2006-04-20 | Wermeling Daniel P | Intranasal opioid compositions, delivery devices and methods of using same |
| US6610271B2 (en) * | 2000-05-10 | 2003-08-26 | University Of Kentucky Research Foundation | System and method for intranasal administration of lorazepam |
| US6948492B2 (en) * | 2000-08-15 | 2005-09-27 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
| MXPA03003895A (es) | 2000-10-30 | 2003-07-28 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada. |
| US20040176359A1 (en) * | 2001-02-20 | 2004-09-09 | University Of Kentucky Research Foundation | Intranasal Benzodiazepine compositions |
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
| UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| ES2677769T3 (es) | 2002-09-20 | 2018-08-06 | Alpharma Pharmaceuticals Llc | Subunidad secuestrante y composiciones y procedimientos relacionados |
| WO2004026256A2 (en) * | 2002-09-20 | 2004-04-01 | Alpharma, Inc. | Sustained-release opioid formulations and methods of use |
| US20040102476A1 (en) * | 2002-11-25 | 2004-05-27 | Chan Tai Wah | High concentration formulations of opioids and opioid derivatives |
| KR20060092255A (ko) * | 2003-09-26 | 2006-08-22 | 알자 코포레이션 | 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법 |
| ATE504288T1 (de) * | 2003-09-26 | 2011-04-15 | Alza Corp | Oros-push-stick für die kontrollierte abgabe von wirkstoffen |
| KR20120106757A (ko) * | 2003-09-26 | 2012-09-26 | 알자 코포레이션 | 오피오이드 및 비오피오이드 진통제의 제어 방출 제제 |
| GB0400804D0 (en) | 2004-01-14 | 2004-02-18 | Innoscience Technology Bv | Pharmaceutical compositions |
| ES2653568T3 (es) | 2004-06-12 | 2018-02-07 | Collegium Pharmaceutical, Inc. | Formulaciones de fármacos para la prevención del abuso |
| US8541026B2 (en) * | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
| US20100172989A1 (en) * | 2006-01-21 | 2010-07-08 | Abbott Laboratories | Abuse resistant melt extruded formulation having reduced alcohol interaction |
| US20090317355A1 (en) * | 2006-01-21 | 2009-12-24 | Abbott Gmbh & Co. Kg, | Abuse resistant melt extruded formulation having reduced alcohol interaction |
| US20090022798A1 (en) * | 2007-07-20 | 2009-01-22 | Abbott Gmbh & Co. Kg | Formulations of nonopioid and confined opioid analgesics |
| US8044112B2 (en) * | 2006-03-30 | 2011-10-25 | Novartis Ag | Method for applying a coating onto a silicone hydrogel lens |
| RU2445077C2 (ru) | 2006-06-19 | 2012-03-20 | АЛФАРМА, Инк. | Фармацевтические композиции |
| US20080069871A1 (en) * | 2006-07-21 | 2008-03-20 | Vaughn Jason M | Hydrophobic abuse deterrent delivery system |
| HUE027342T2 (en) * | 2006-10-30 | 2016-09-28 | Novartis Ag | Method for applying a hydrophilic coating to a contact lens of silicone hydrogel |
| US20080275030A1 (en) | 2007-01-19 | 2008-11-06 | Sveinbjorn Gizurarson | Methods and Compositions for the Delivery of a Therapeutic Agent |
| US20090076135A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched hydromorphone |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
| EP2393484A1 (de) | 2009-02-06 | 2011-12-14 | Egalet Ltd. | Gegen missbrauch durch alkoholeinnahme widerstandsfähige zusammensetzung mit unmittelbarer freisetzung |
| CA2766179A1 (en) | 2009-06-24 | 2010-12-29 | Egalet Ltd. | Controlled release formulations |
| US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| DK2826467T3 (en) | 2010-12-22 | 2017-10-16 | Purdue Pharma Lp | INCLUDED, MANIPULATION-PROPOSED SLOW-DELIVERY DOSAGE FORMS |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4036228A (en) * | 1975-09-11 | 1977-07-19 | Alza Corporation | Osmotic dispenser with gas generating means |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4126684A (en) * | 1976-02-11 | 1978-11-21 | Ciba-Geigy Corporation | 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse |
| US4111201A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| US4111202A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4519801A (en) * | 1982-07-12 | 1985-05-28 | Alza Corporation | Osmotic device with wall comprising cellulose ether and permeability enhancer |
| US4576604A (en) * | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
| US4612008A (en) * | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| GB8521350D0 (en) * | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
| US5021053A (en) * | 1989-07-14 | 1991-06-04 | Alza Corporation | Oral osmotic device with hydrogel driving member |
| US5151093A (en) * | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| US5208037A (en) * | 1991-04-22 | 1993-05-04 | Alza Corporation | Dosage forms comprising polymers comprising different molecular weights |
| US5198229A (en) * | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
| US5529787A (en) * | 1994-07-07 | 1996-06-25 | Alza Corporation | Hydromorphone therapy |
-
1994
- 1994-07-07 US US08/271,593 patent/US5529787A/en not_active Expired - Lifetime
-
1995
- 1995-06-23 AT AT95924665T patent/ATE230992T1/de active
- 1995-06-23 ES ES95924665T patent/ES2186724T3/es not_active Expired - Lifetime
- 1995-06-23 CA CA002188451A patent/CA2188451A1/en not_active Abandoned
- 1995-06-23 WO PCT/US1995/007950 patent/WO1996001629A1/en not_active Ceased
- 1995-06-23 NZ NZ289289A patent/NZ289289A/en not_active IP Right Cessation
- 1995-06-23 DK DK95924665T patent/DK0769949T3/da active
- 1995-06-23 DE DE69528852T patent/DE69528852T2/de not_active Expired - Lifetime
- 1995-06-23 AT AT99204122T patent/ATE227575T1/de active
- 1995-06-23 EP EP99204122A patent/EP1025845B1/de not_active Expired - Lifetime
- 1995-06-23 ES ES99204122T patent/ES2186302T3/es not_active Expired - Lifetime
- 1995-06-23 PT PT99204122T patent/PT1025845E/pt unknown
- 1995-06-23 DE DE69529412T patent/DE69529412T2/de not_active Expired - Lifetime
- 1995-06-23 AU AU29083/95A patent/AU693910B2/en not_active Expired
- 1995-06-23 DK DK99204122T patent/DK1025845T3/da active
- 1995-06-23 EP EP95924665A patent/EP0769949B1/de not_active Expired - Lifetime
- 1995-07-07 ZA ZA955674A patent/ZA955674B/xx unknown
-
1996
- 1996-03-05 US US08/611,294 patent/US5702725A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2908395A (en) | 1996-02-09 |
| ES2186302T3 (es) | 2003-05-01 |
| DE69529412T2 (de) | 2003-07-31 |
| DE69529412D1 (en) | 2003-02-20 |
| DK1025845T3 (da) | 2002-12-30 |
| AU693910B2 (en) | 1998-07-09 |
| DE69528852D1 (de) | 2002-12-19 |
| NZ289289A (en) | 1997-10-24 |
| DK0769949T3 (da) | 2003-02-24 |
| EP1025845B1 (de) | 2002-11-13 |
| ZA955674B (en) | 1996-02-20 |
| EP1025845A3 (de) | 2000-12-13 |
| DE69528852T2 (de) | 2003-09-18 |
| EP0769949A1 (de) | 1997-05-02 |
| EP0769949B1 (de) | 2003-01-15 |
| PT1025845E (pt) | 2003-03-31 |
| ATE227575T1 (de) | 2002-11-15 |
| WO1996001629A1 (en) | 1996-01-25 |
| CA2188451A1 (en) | 1996-01-25 |
| US5702725A (en) | 1997-12-30 |
| ES2186724T3 (es) | 2003-05-16 |
| US5529787A (en) | 1996-06-25 |
| EP1025845A2 (de) | 2000-08-09 |
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Legal Events
| Date | Code | Title | Description |
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