TR199901978T2 - Safra asidini emme etkili çapraz baglantili vinil polimerleri. - Google Patents

Safra asidini emme etkili çapraz baglantili vinil polimerleri.

Info

Publication number
TR199901978T2
TR199901978T2 TR1999/01978T TR9901978T TR199901978T2 TR 199901978 T2 TR199901978 T2 TR 199901978T2 TR 1999/01978 T TR1999/01978 T TR 1999/01978T TR 9901978 T TR9901978 T TR 9901978T TR 199901978 T2 TR199901978 T2 TR 199901978T2
Authority
TR
Turkey
Prior art keywords
cross
bile acid
absorption effect
vinyl polymers
acid absorption
Prior art date
Application number
TR1999/01978T
Other languages
English (en)
Inventor
Von Seggern Heinke
Hoffmann Axel
Falk Eugen
Hrsch Brigitte
Heinz Linkies Adolf
Glombik Heiner
Original Assignee
Aventis Research & Technologies Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Research & Technologies Gmbh & Co.Kg filed Critical Aventis Research & Technologies Gmbh & Co.Kg
Publication of TR199901978T2 publication Critical patent/TR199901978T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/10—Esters
    • C08F20/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C08F20/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/10—Esters
    • C08F22/1006—Esters of polyhydric alcohols or polyhydric phenols, e.g. ethylene glycol dimethacrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/36—Amides or imides
    • C08F22/38—Amides
    • C08F22/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bulus, içindeki A'nin hidrojen ya da C1-9-alkil, G ve E'nin birbirinden bagimsiz olarak O ya da NH, d ve a2nin birbirinden bagimsiz olarak 2'den 10'a kadar bir tam sayi, R1 ve R2'nin birbirinden bagimsiz olarak C1-9-alkil, T'nin fenilen ya da R1 ve R2 birbirinden bagimsiz olarak C1-19-alkille beraberce 1'den 10 'a kadar kesintili olarak bitisik olan oksijen atomlari ya da gruplari-N+R1R2 tarafindan bölünmüs olan ve X-1'in bir asit anyonu anlamina geldigi C2-200-alkil anlamina geldigi genel Formül II'nin bilesikleriyle ilgilidir.Ayni zamanda bu bilesiklerden olusan polimerler ve bunlarin lipid düsürücü maddeler olarak kullanimi da dahil edilmistir.Formül(II),(a), (b), (c), (d), (e).
TR1999/01978T 1997-02-17 1998-02-17 Safra asidini emme etkili çapraz baglantili vinil polimerleri. TR199901978T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19705963A DE19705963A1 (de) 1997-02-17 1997-02-17 Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung

Publications (1)

Publication Number Publication Date
TR199901978T2 true TR199901978T2 (tr) 2000-06-21

Family

ID=7820445

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01978T TR199901978T2 (tr) 1997-02-17 1998-02-17 Safra asidini emme etkili çapraz baglantili vinil polimerleri.

Country Status (14)

Country Link
EP (1) EP0960141A1 (tr)
JP (1) JP2002515930A (tr)
KR (1) KR20000071167A (tr)
CN (1) CN1251112A (tr)
AU (1) AU728985B2 (tr)
BR (1) BR9807408A (tr)
CA (1) CA2281602A1 (tr)
CZ (1) CZ293299A3 (tr)
DE (1) DE19705963A1 (tr)
HU (1) HUP0001012A3 (tr)
PL (1) PL335106A1 (tr)
RU (1) RU99119911A (tr)
TR (1) TR199901978T2 (tr)
WO (1) WO1998036002A1 (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4369499A (en) * 1998-06-30 2000-01-17 Aventis Research & Technologies Gmbh & Co. Kg Novel method for producing cross-linked vinyl polymers based on quaternary ammonium groups exhibiting a bile acid adsorbent effect
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
AU773914B2 (en) 1999-02-01 2004-06-10 Eidgenossische Technische Hochschule Zurich Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
US7291673B2 (en) 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US8282912B2 (en) 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
JP2005054145A (ja) 2003-08-07 2005-03-03 Mitsubishi Gas Chem Co Inc ガスバリア性（メタ）アクリレート樹脂硬化物および塗料、接着剤、フィルム
CN101711168B (zh) 2007-04-13 2013-05-01 库罗斯生物外科股份公司 聚合物组织封闭剂
JP6126498B2 (ja) * 2013-02-15 2017-05-10 富士フイルム株式会社 高分子機能性膜及びその製造方法
JP6071957B2 (ja) * 2014-03-07 2017-02-01 富士フイルム株式会社 イオン交換性ポリマーおよびその製造方法、電解質膜およびその製造方法ならびにイオン交換性ポリマー製造用組成物
WO2017038328A1 (ja) * 2015-08-31 2017-03-09 富士フイルム株式会社 イオン交換ポリマー、硬化性組成物、硬化物、部材、及び、装置
US11214759B2 (en) 2017-09-15 2022-01-04 Lg Chem, Ltd. Polymerizable composition, polymer capsule and fabric softener composition comprising the same
CN110317588A (zh) * 2018-03-29 2019-10-11 中国石油化工股份有限公司 一种阳离子表面活性剂及其制备方法和起泡剂及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206115A1 (es) * 1973-06-11 1976-06-30 Merck & Co Inc Procedimiento para preparar un polimero lineal no ramificado y no reticulado
GB9123683D0 (en) * 1991-11-07 1992-01-02 Sandoz Ltd Improvements in or relating to organic compounds
WO1994001474A1 (en) * 1992-07-06 1994-01-20 Otsuka Kagaku Kabushiki Kaisha Polymerizable monomer, polymer thereof, and process for producing the same
ES2110543T3 (es) * 1992-07-22 1998-02-16 Hoechst Ag Derivados de poli(vinil-aminas) que tienen centros hidrofilos, procedimiento para su preparacion asi como la utilizacion de los compuestos como medicamentos, vehiculos de sustancias activas e ingredientes auxiliares para alimentos.
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor

Also Published As

Publication number Publication date
KR20000071167A (ko) 2000-11-25
JP2002515930A (ja) 2002-05-28
WO1998036002A1 (de) 1998-08-20
CA2281602A1 (en) 1998-08-20
AU728985B2 (en) 2001-01-25
AU6498398A (en) 1998-09-08
DE19705963A1 (de) 1998-08-20
PL335106A1 (en) 2000-04-10
CZ293299A3 (cs) 1999-12-15
HUP0001012A2 (hu) 2000-09-28
EP0960141A1 (de) 1999-12-01
BR9807408A (pt) 2000-03-14
RU99119911A (ru) 2001-06-27
CN1251112A (zh) 2000-04-19
HUP0001012A3 (en) 2001-11-28

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