TR199900153T2 - Hücre çogalmasini önlemek için ikame edilmis bisindolilmaleimitler. - Google Patents

Hücre çogalmasini önlemek için ikame edilmis bisindolilmaleimitler.

Info

Publication number
TR199900153T2
TR199900153T2 TR1999/00153T TR9900153T TR199900153T2 TR 199900153 T2 TR199900153 T2 TR 199900153T2 TR 1999/00153 T TR1999/00153 T TR 1999/00153T TR 9900153 T TR9900153 T TR 9900153T TR 199900153 T2 TR199900153 T2 TR 199900153T2
Authority
TR
Turkey
Prior art keywords
cell proliferation
prevent cell
bisindolylmaleimides
substituted
substituted bisindolylmaleimides
Prior art date
Application number
TR1999/00153T
Other languages
English (en)
Inventor
Hooda Dhingra Urvashi
Mary Huryn Donna
Dalton Keith Denn�S
Federico Weber Giuseppe
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199900153T2 publication Critical patent/TR199900153T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

R'nin alkil, alkiltio veya hidrosi oldugu formül (I)'e ait bilesikler ve ayni zamanda formül (I)'e ait bilesiklerin farmasötik açidan kabul gören tuzlari, kanser tedavisi için yararli çogalma önleyici maddelerdir.
TR1999/00153T 1996-07-29 1997-07-19 Hücre çogalmasini önlemek için ikame edilmis bisindolilmaleimitler. TR199900153T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2208096P 1996-07-29 1996-07-29

Publications (1)

Publication Number Publication Date
TR199900153T2 true TR199900153T2 (tr) 1999-04-21

Family

ID=21807715

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00153T TR199900153T2 (tr) 1996-07-29 1997-07-19 Hücre çogalmasini önlemek için ikame edilmis bisindolilmaleimitler.

Country Status (18)

Country Link
US (1) US5891901A (tr)
EP (1) EP0915871B1 (tr)
JP (1) JP2000516590A (tr)
KR (1) KR20000029627A (tr)
CN (1) CN1077572C (tr)
AR (1) AR007970A1 (tr)
AT (1) ATE347551T1 (tr)
AU (1) AU739704B2 (tr)
BR (1) BR9710902A (tr)
CA (1) CA2262088A1 (tr)
CO (1) CO4890846A1 (tr)
DE (1) DE69737060D1 (tr)
HR (1) HRP970417A2 (tr)
MA (1) MA24288A1 (tr)
PE (1) PE91498A1 (tr)
TR (1) TR199900153T2 (tr)
WO (1) WO1998004553A1 (tr)
ZA (1) ZA976487B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL195323B1 (pl) * 1998-03-17 2007-09-28 Hoffmann La Roche Podstawione bisindolilomaleimidy do hamowania proliferacji komórek
US6521658B1 (en) * 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
WO2005052193A2 (en) * 2003-11-19 2005-06-09 Applera Corporation Methods for determining the degradation state or concentration of nucleic acids
EP3169337A1 (en) 2014-07-17 2017-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
WO1993018765A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
US5891901A (en) 1999-04-06
PE91498A1 (es) 1998-12-22
AR007970A1 (es) 1999-11-24
CN1226249A (zh) 1999-08-18
HRP970417A2 (en) 1998-08-31
CO4890846A1 (es) 2000-02-28
BR9710902A (pt) 1999-08-17
EP0915871B1 (en) 2006-12-06
CN1077572C (zh) 2002-01-09
MA24288A1 (fr) 1998-04-01
WO1998004553A1 (en) 1998-02-05
KR20000029627A (ko) 2000-05-25
CA2262088A1 (en) 1998-02-05
AU739704B2 (en) 2001-10-18
ZA976487B (en) 1998-01-29
AU4296497A (en) 1998-02-20
JP2000516590A (ja) 2000-12-12
ATE347551T1 (de) 2006-12-15
DE69737060D1 (de) 2007-01-18
EP0915871A1 (en) 1999-05-19

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