TR199800645T1 - Apoptoz oraninin arttirilmasi için bir y-RAR-özgü agonist ligandinin kullanimi. - Google Patents
Apoptoz oraninin arttirilmasi için bir y-RAR-özgü agonist ligandinin kullanimi.Info
- Publication number
- TR199800645T1 TR199800645T1 TR1998/00645T TR9800645T TR199800645T1 TR 199800645 T1 TR199800645 T1 TR 199800645T1 TR 1998/00645 T TR1998/00645 T TR 1998/00645T TR 9800645 T TR9800645 T TR 9800645T TR 199800645 T1 TR199800645 T1 TR 199800645T1
- Authority
- TR
- Turkey
- Prior art keywords
- apoptosis
- agonist ligand
- rar
- caused
- ligand
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Abstract
En azindan bir hücre popülasyonunda apoptoz oraninin arttirilmasi için bir farmasötik bilesimin hazirlanmasi için en azindan bir y-RAR reseptörüne-özgü agonist ligandinin kullanimi olup, burada apoptozun y-RAR reseptörlerinin aktive edilmesiyle uyarilabildigi anlatilmistir.Bilesim, özellikle,apoptozun y-RAR reseptörlerinin aktive edilmesiyle uyarilabildigi, en azindan bir hücre popülasyonunda yetersiz bir apoptoz orani ile iliskili bir hastalik ya da düzensizligin iyilestirilmesi için yararlidir.Bir kozmetik bilesimi içinde apoptoz uyarica olarak en azindan bir y-RAR reseptöre-özgü agonist ligandinin kullanimi da anlatilmistir. Bahsedilen bilesim, derinin kronolojik yaslanmasi ve isikla yaslanmanin kontrol edilmesi ve/veya engellenmesi için kullanilabilecektir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9512179A FR2739557B1 (fr) | 1995-10-09 | 1995-10-09 | Utilisation d'un ligand agoniste specifique rar-gamma |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199800645T1 true TR199800645T1 (tr) | 1998-06-22 |
Family
ID=9483613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/00645T TR199800645T1 (tr) | 1995-10-09 | 1996-10-08 | Apoptoz oraninin arttirilmasi için bir y-RAR-özgü agonist ligandinin kullanimi. |
Country Status (16)
Country | Link |
---|---|
US (4) | US6593359B1 (tr) |
EP (1) | EP0854710A2 (tr) |
JP (1) | JP3135266B2 (tr) |
KR (1) | KR19990064139A (tr) |
CN (1) | CN1121857C (tr) |
AU (1) | AU705993B2 (tr) |
BR (1) | BR9610967A (tr) |
CA (1) | CA2231561A1 (tr) |
FR (1) | FR2739557B1 (tr) |
HU (1) | HUP9900453A3 (tr) |
NO (1) | NO981592L (tr) |
NZ (1) | NZ319646A (tr) |
PL (1) | PL185826B1 (tr) |
RU (1) | RU2188037C2 (tr) |
TR (1) | TR199800645T1 (tr) |
WO (1) | WO1997013505A2 (tr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040266715A1 (en) * | 1999-03-31 | 2004-12-30 | Wong Liang Fong | Neurite regeneration |
US20030053991A1 (en) * | 2000-10-04 | 2003-03-20 | Kingsman Alan John | Retinoic acid receptor beta-2, its agonists, and gene theraphy vectors for the treatment of neurological disorders |
US20070213290A1 (en) * | 1996-10-17 | 2007-09-13 | Kingsman Alan J | Neurite regeneration |
GB9907461D0 (en) * | 1999-03-31 | 1999-05-26 | King S College London | Neurite regeneration |
FR2757852B1 (fr) | 1996-12-31 | 1999-02-19 | Cird Galderma | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
DE69835441T2 (de) * | 1997-11-12 | 2007-08-02 | F. Hoffmann-La Roche Ag | Behandlung von t-helfer zell typ 2 vermittelten immunkrankheiten mit retinoid antagonisten |
US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
US6949528B1 (en) * | 1998-03-18 | 2005-09-27 | Goddard John G | Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof |
JO2178B1 (en) * | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of invasive diseases, using selected anti-PAR materials |
AU2003294757A1 (en) * | 2002-11-29 | 2004-06-23 | Axxima Pharmaceuticals Ag | Formulations useful against hepatitis c virus infections |
US20050202055A1 (en) | 2004-03-11 | 2005-09-15 | Koichi Shudo, Tokyo, Japan | Anti-wrinkle agent |
JP4921351B2 (ja) * | 2004-03-26 | 2012-04-25 | ディーエスエム アイピー アセッツ ビー.ブイ. | レチノイドと組み合せたhdacインヒビターを含む組成物 |
US7713266B2 (en) | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US7850683B2 (en) * | 2005-05-20 | 2010-12-14 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US9254162B2 (en) | 2006-12-21 | 2016-02-09 | Myoscience, Inc. | Dermal and transdermal cryogenic microprobe systems |
US8409185B2 (en) | 2007-02-16 | 2013-04-02 | Myoscience, Inc. | Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling |
WO2009065061A1 (en) | 2007-11-14 | 2009-05-22 | Myoscience, Inc. | Pain management using cryogenic remodeling |
ES2427980T3 (es) | 2008-12-22 | 2013-11-05 | Myoscience, Inc. | Sistema crioquirúrgico integrado con refrigerante y fuente de energía eléctrica |
CN103200937B (zh) | 2010-09-01 | 2020-07-03 | 托马斯杰弗逊大学 | 用于肌肉修复和再生的组合物和方法 |
BR112013033309B1 (pt) | 2011-06-24 | 2022-07-05 | Gri Bio, Inc | Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i |
CA2860893A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
CA2861116A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Cryogenic probe filtration system |
EP2802279B1 (en) | 2012-01-13 | 2017-08-16 | Myoscience, Inc. | Cryogenic needle with freeze zone regulation |
US9017318B2 (en) | 2012-01-20 | 2015-04-28 | Myoscience, Inc. | Cryogenic probe system and method |
US9295512B2 (en) | 2013-03-15 | 2016-03-29 | Myoscience, Inc. | Methods and devices for pain management |
US9610112B2 (en) | 2013-03-15 | 2017-04-04 | Myoscience, Inc. | Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis |
US20140350536A1 (en) | 2013-03-15 | 2014-11-27 | Myoscience, Inc. | Cryogenic Blunt Dissection Methods and Devices |
WO2014146127A1 (en) | 2013-03-15 | 2014-09-18 | Myoscience, Inc. | Methods and systems for treatment of spasticity |
WO2015069792A1 (en) | 2013-11-05 | 2015-05-14 | Myoscience, Inc. | Secure cryosurgical treatment system |
PL3380086T3 (pl) | 2015-11-25 | 2022-02-21 | Io Therapeutics, Inc. | Oporne na cyp26 agonisty selektywne względem rar-alfa w leczeniu nowotworu |
EP3454762B1 (en) | 2016-05-13 | 2024-04-03 | Pacira CryoTech, Inc. | Systems for locating and treating with cold therapy |
EP3468600A4 (en) | 2016-06-10 | 2019-11-13 | IO Therapeutics, Inc. | RETINOID COMPOUNDS AND RELECTIVE REXINOIDS OF THE RECEPTOR AND IMMUNE MODULATORS FOR IMMUNOTHERAPY OF CANCER |
KR20200029544A (ko) | 2017-07-13 | 2020-03-18 | 아이오 테라퓨틱스, 인크. | 암 면역요법을 위해 면역 조절제와 조합된 면역조절 레티노이드 및 렉시노이드 화합물 |
SG11202001479RA (en) | 2017-08-31 | 2020-03-30 | Io Therapeutics Inc | Rar selective agonists in combination with immune modulators for cancer immunotherapy |
EP3709918A4 (en) | 2017-11-15 | 2021-08-11 | Pacira CryoTech, Inc. | INTEGRATED COLD THERAPY AND ELECTRIC STIMULATION SYSTEMS FOR LOCALIZATION AND TREATMENT OF NERVE AND RELATED PROCEDURES |
US11135236B2 (en) * | 2018-04-10 | 2021-10-05 | Northwestern University | Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5786391A (en) * | 1995-01-11 | 1998-07-28 | Cornell Research Foundation, Inc. | Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position |
EP0850067A4 (en) * | 1995-07-17 | 1999-12-15 | Cird Galderma | METHOD FOR CANCER TREATMENT USING 6- (3- (1-ADAMANTYL) -4-HYDROXYPHENYL) 2 NAPHTALINE CARBONIC ACID |
-
1995
- 1995-10-09 FR FR9512179A patent/FR2739557B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-08 NZ NZ319646A patent/NZ319646A/xx unknown
- 1996-10-08 RU RU98108590/14A patent/RU2188037C2/ru not_active IP Right Cessation
- 1996-10-08 TR TR1998/00645T patent/TR199800645T1/tr unknown
- 1996-10-08 PL PL96326077A patent/PL185826B1/pl not_active IP Right Cessation
- 1996-10-08 EP EP96933502A patent/EP0854710A2/fr not_active Withdrawn
- 1996-10-08 KR KR1019980702620A patent/KR19990064139A/ko not_active Application Discontinuation
- 1996-10-08 CA CA002231561A patent/CA2231561A1/fr not_active Abandoned
- 1996-10-08 BR BR9610967A patent/BR9610967A/pt not_active Application Discontinuation
- 1996-10-08 AU AU72209/96A patent/AU705993B2/en not_active Ceased
- 1996-10-08 US US09/051,407 patent/US6593359B1/en not_active Expired - Fee Related
- 1996-10-08 CN CN96198769A patent/CN1121857C/zh not_active Expired - Fee Related
- 1996-10-08 JP JP09514767A patent/JP3135266B2/ja not_active Expired - Fee Related
- 1996-10-08 WO PCT/FR1996/001568 patent/WO1997013505A2/fr not_active Application Discontinuation
- 1996-10-08 HU HU9900453A patent/HUP9900453A3/hu unknown
-
1998
- 1998-04-07 NO NO981592A patent/NO981592L/no not_active Application Discontinuation
-
1999
- 1999-11-02 US US09/431,920 patent/US6686386B1/en not_active Expired - Fee Related
-
2000
- 2000-07-25 US US09/624,771 patent/US6506796B1/en not_active Expired - Fee Related
-
2001
- 2001-03-09 US US09/801,664 patent/US20010018456A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6686386B1 (en) | 2004-02-03 |
AU7220996A (en) | 1997-04-30 |
NO981592L (no) | 1998-06-09 |
US6506796B1 (en) | 2003-01-14 |
WO1997013505A3 (fr) | 1997-05-29 |
NO981592D0 (no) | 1998-04-07 |
FR2739557A1 (fr) | 1997-04-11 |
US20010018456A1 (en) | 2001-08-30 |
HUP9900453A2 (hu) | 1999-05-28 |
WO1997013505A2 (fr) | 1997-04-17 |
CN1121857C (zh) | 2003-09-24 |
CN1203528A (zh) | 1998-12-30 |
RU2188037C2 (ru) | 2002-08-27 |
JP3135266B2 (ja) | 2001-02-13 |
AU705993B2 (en) | 1999-06-03 |
PL326077A1 (en) | 1998-08-17 |
KR19990064139A (ko) | 1999-07-26 |
JPH11501661A (ja) | 1999-02-09 |
US6593359B1 (en) | 2003-07-15 |
PL185826B1 (pl) | 2003-08-29 |
HUP9900453A3 (en) | 1999-11-29 |
EP0854710A2 (fr) | 1998-07-29 |
BR9610967A (pt) | 1999-03-02 |
FR2739557B1 (fr) | 1997-11-14 |
CA2231561A1 (fr) | 1997-04-17 |
NZ319646A (en) | 2000-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR199800645T1 (tr) | Apoptoz oraninin arttirilmasi için bir y-RAR-özgü agonist ligandinin kullanimi. | |
DE69421778D1 (de) | Verwendung von wirksamen Mengen von aktiven Stoffen zur Behandlung von Mischhaut | |
ATE236921T1 (de) | L-ribavirin und dessen verwendung | |
TR199901973T2 (tr) | Insanin cinsel tepkisini modülasyonu için yöntem ve formülasyonlar. | |
CY1115521T1 (el) | Σχηματισμοi οι οποiοι περιλαμβανουν αντι-κωδικευσης νουκλεοτιδια σε συνδετινες | |
BR9206630A (pt) | Gel cosmético aquoso de baixo pH contendo derivados não iônicos de poliacrilamida | |
DE59609235D1 (de) | Verwendung von aerogelen in der landwirtschaft | |
ATE140483T1 (de) | Natürlicher killerzellen-stimulationsfaktor | |
IT1191989B (it) | Composizione cosmetica filtrante contenente un filtro uv associato ad un polimero ottenuto mediante polimerizzazione sequenziale in emulsione e suo impiego per la protezione dell epidermide umana contro le radiazioni ultraviolette | |
ES2197500T3 (es) | Uso de cloruro de n,n-bis(fenilcarbamoilmetil)dimetilamonio y sus usos derivados en el tratamiento del dolor cronico. | |
DE69735848D1 (de) | Dosisform mit ansteigender dosisfreisetzung | |
ES2133329T3 (es) | Variantes de il-3 humana. | |
DE50007706D1 (de) | Verwendung von melatonin zur behandlung der androgenetischen und diffusen alopezie vom weiblichen typ | |
IT1180156B (it) | Composizione cosmetica a base di glicoproteine per il trattamento della pelle | |
ATE213630T1 (de) | Verwendung vonsisovaleramid als mildes anxiolytisches und sedatives mittel | |
ES2176495T3 (es) | Utilizacion de un antagonista de la bradiquinina, destinada a inducir y/o estimular el crecimiento de los cabellos y/o frenar su caida. | |
MX9302378A (es) | Antagonistas de serotonina. | |
ATE63815T1 (de) | Verwendung von zinn-protoporphyrin und zinnmesoporphyrin zur herstellung eines arzneimittels fuer die behandlung von psoriasis. | |
ES2057004T3 (es) | N-alcoxialquilamidas de hidroxiacidos y composiciones a base de las mismas para el tratamiento de la piel. | |
DE68906198D1 (de) | Lichterregbarer leuchtstoff und dessen verwendung in der radiographie. | |
ATE293986T1 (de) | Schmerzlindernde verwendung von n-l-alpha- aspartyl-l-phenylalanine-1-methylester | |
DE69903137D1 (de) | Oleamid-glycyl-glycine derivate für die kosmetik und/oder dermatologie | |
FI904144A0 (fi) | Etanolipolttoaine ja sen käyttö dieselpolttoaineena | |
DE69326188D1 (de) | Verwendung von N-Acylderivaten von Aminoalkoholen zur Herstellung eines Arzneimittels zur Behandlung von neurogenen endoneuralen Ödemen der peripheren Nerven | |
ATE79022T1 (de) | Verwendung von 2,4-monofurfuryliden-sorbitol und dessen tetraalkyl-derivaten in kosmetika und in der dermatologie. |