HUP9900453A2 - RAR-gamma specifikus agonista ligandum alkalmazása apoptózis arányának növelésére - Google Patents

RAR-gamma specifikus agonista ligandum alkalmazása apoptózis arányának növelésére

Info

Publication number
HUP9900453A2
HUP9900453A2 HU9900453A HUP9900453A HUP9900453A2 HU P9900453 A2 HUP9900453 A2 HU P9900453A2 HU 9900453 A HU9900453 A HU 9900453A HU P9900453 A HUP9900453 A HU P9900453A HU P9900453 A2 HUP9900453 A2 HU P9900453A2
Authority
HU
Hungary
Prior art keywords
rar
gamma
apoptosis rate
specific agonist
agonist ligand
Prior art date
Application number
HU9900453A
Other languages
English (en)
Inventor
László Fésüs
Uwe Reichert
Zsuzsa Szondy
Original Assignee
Centre International De Recherches Dermatologiques Galderma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre International De Recherches Dermatologiques Galderma filed Critical Centre International De Recherches Dermatologiques Galderma
Publication of HUP9900453A2 publication Critical patent/HUP9900453A2/hu
Publication of HUP9900453A3 publication Critical patent/HUP9900453A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
HU9900453A 1995-10-09 1996-10-08 Use of a gamma-rar-specific agonist ligand to increase apoptosis rate HUP9900453A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9512179A FR2739557B1 (fr) 1995-10-09 1995-10-09 Utilisation d'un ligand agoniste specifique rar-gamma

Publications (2)

Publication Number Publication Date
HUP9900453A2 true HUP9900453A2 (hu) 1999-05-28
HUP9900453A3 HUP9900453A3 (en) 1999-11-29

Family

ID=9483613

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900453A HUP9900453A3 (en) 1995-10-09 1996-10-08 Use of a gamma-rar-specific agonist ligand to increase apoptosis rate

Country Status (16)

Country Link
US (4) US6593359B1 (hu)
EP (1) EP0854710A2 (hu)
JP (1) JP3135266B2 (hu)
KR (1) KR19990064139A (hu)
CN (1) CN1121857C (hu)
AU (1) AU705993B2 (hu)
BR (1) BR9610967A (hu)
CA (1) CA2231561A1 (hu)
FR (1) FR2739557B1 (hu)
HU (1) HUP9900453A3 (hu)
NO (1) NO981592L (hu)
NZ (1) NZ319646A (hu)
PL (1) PL185826B1 (hu)
RU (1) RU2188037C2 (hu)
TR (1) TR199800645T1 (hu)
WO (1) WO1997013505A2 (hu)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040266715A1 (en) * 1999-03-31 2004-12-30 Wong Liang Fong Neurite regeneration
US20030053991A1 (en) * 2000-10-04 2003-03-20 Kingsman Alan John Retinoic acid receptor beta-2, its agonists, and gene theraphy vectors for the treatment of neurological disorders
US20070213290A1 (en) * 1996-10-17 2007-09-13 Kingsman Alan J Neurite regeneration
GB9907461D0 (en) * 1999-03-31 1999-05-26 King S College London Neurite regeneration
FR2757852B1 (fr) 1996-12-31 1999-02-19 Cird Galderma Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
DE69835441T2 (de) * 1997-11-12 2007-08-02 F. Hoffmann-La Roche Ag Behandlung von t-helfer zell typ 2 vermittelten immunkrankheiten mit retinoid antagonisten
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
US6949528B1 (en) * 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
AU2003294757A1 (en) * 2002-11-29 2004-06-23 Axxima Pharmaceuticals Ag Formulations useful against hepatitis c virus infections
US20050202055A1 (en) 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
JP4921351B2 (ja) * 2004-03-26 2012-04-25 ディーエスエム アイピー アセッツ ビー．ブイ． レチノイドと組み合せたｈｄａｃインヒビターを含む組成物
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7850683B2 (en) * 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US8409185B2 (en) 2007-02-16 2013-04-02 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
WO2009065061A1 (en) 2007-11-14 2009-05-22 Myoscience, Inc. Pain management using cryogenic remodeling
ES2427980T3 (es) 2008-12-22 2013-11-05 Myoscience, Inc. Sistema crioquirúrgico integrado con refrigerante y fuente de energía eléctrica
CN103200937B (zh) 2010-09-01 2020-07-03 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
BR112013033309B1 (pt) 2011-06-24 2022-07-05 Gri Bio, Inc Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i
CA2860893A1 (en) 2012-01-13 2013-07-18 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
CA2861116A1 (en) 2012-01-13 2013-07-18 Myoscience, Inc. Cryogenic probe filtration system
EP2802279B1 (en) 2012-01-13 2017-08-16 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US20140350536A1 (en) 2013-03-15 2014-11-27 Myoscience, Inc. Cryogenic Blunt Dissection Methods and Devices
WO2014146127A1 (en) 2013-03-15 2014-09-18 Myoscience, Inc. Methods and systems for treatment of spasticity
WO2015069792A1 (en) 2013-11-05 2015-05-14 Myoscience, Inc. Secure cryosurgical treatment system
PL3380086T3 (pl) 2015-11-25 2022-02-21 Io Therapeutics, Inc. Oporne na cyp26 agonisty selektywne względem rar-alfa w leczeniu nowotworu
EP3454762B1 (en) 2016-05-13 2024-04-03 Pacira CryoTech, Inc. Systems for locating and treating with cold therapy
EP3468600A4 (en) 2016-06-10 2019-11-13 IO Therapeutics, Inc. RETINOID COMPOUNDS AND RELECTIVE REXINOIDS OF THE RECEPTOR AND IMMUNE MODULATORS FOR IMMUNOTHERAPY OF CANCER
KR20200029544A (ko) 2017-07-13 2020-03-18 아이오 테라퓨틱스, 인크. 암 면역요법을 위해 면역 조절제와 조합된 면역조절 레티노이드 및 렉시노이드 화합물
SG11202001479RA (en) 2017-08-31 2020-03-30 Io Therapeutics Inc Rar selective agonists in combination with immune modulators for cancer immunotherapy
EP3709918A4 (en) 2017-11-15 2021-08-11 Pacira CryoTech, Inc. INTEGRATED COLD THERAPY AND ELECTRIC STIMULATION SYSTEMS FOR LOCALIZATION AND TREATMENT OF NERVE AND RELATED PROCEDURES
US11135236B2 (en) * 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786391A (en) * 1995-01-11 1998-07-28 Cornell Research Foundation, Inc. Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position
EP0850067A4 (en) * 1995-07-17 1999-12-15 Cird Galderma METHOD FOR CANCER TREATMENT USING 6- (3- (1-ADAMANTYL) -4-HYDROXYPHENYL) 2 NAPHTALINE CARBONIC ACID

Also Published As

Publication number Publication date
US6686386B1 (en) 2004-02-03
AU7220996A (en) 1997-04-30
NO981592L (no) 1998-06-09
TR199800645T1 (xx) 1998-06-22
US6506796B1 (en) 2003-01-14
WO1997013505A3 (fr) 1997-05-29
NO981592D0 (no) 1998-04-07
FR2739557A1 (fr) 1997-04-11
US20010018456A1 (en) 2001-08-30
WO1997013505A2 (fr) 1997-04-17
CN1121857C (zh) 2003-09-24
CN1203528A (zh) 1998-12-30
RU2188037C2 (ru) 2002-08-27
JP3135266B2 (ja) 2001-02-13
AU705993B2 (en) 1999-06-03
PL326077A1 (en) 1998-08-17
KR19990064139A (ko) 1999-07-26
JPH11501661A (ja) 1999-02-09
US6593359B1 (en) 2003-07-15
PL185826B1 (pl) 2003-08-29
HUP9900453A3 (en) 1999-11-29
EP0854710A2 (fr) 1998-07-29
BR9610967A (pt) 1999-03-02
FR2739557B1 (fr) 1997-11-14
CA2231561A1 (fr) 1997-04-17
NZ319646A (en) 2000-08-25

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