TR199701354A2 - Lökosit adezyonu ve VLA-4-Antagonist'lerinin inhibitörleri. - Google Patents

Lökosit adezyonu ve VLA-4-Antagonist'lerinin inhibitörleri.

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Publication number
TR199701354A2
TR199701354A2 TR97/01354A TR9701354A TR199701354A2 TR 199701354 A2 TR199701354 A2 TR 199701354A2 TR 97/01354 A TR97/01354 A TR 97/01354A TR 9701354 A TR9701354 A TR 9701354A TR 199701354 A2 TR199701354 A2 TR 199701354A2
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TR
Turkey
Prior art keywords
compounds
vla
adhesion
cell
formula
Prior art date
Application number
TR97/01354A
Other languages
English (en)
Other versions
TR199701354A3 (tr
Inventor
Heinrich Ulrich Stilz Dr.
Volkmar Wehner Dr.
Jochen Knolle Dr.
Eckard Bartnik Dr.
CHRISTOPH H�LS Dr.
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of TR199701354A2 publication Critical patent/TR199701354A2/tr
Publication of TR199701354A3 publication Critical patent/TR199701354A3/tr

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    • C07D233/72—Two oxygen atoms, e.g. hydantoin
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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  • Life Sciences & Earth Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
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Abstract

I sayili formülü olan bilesikler, ki bu formülde B, D, E, R, W, Y, Z, b, c, d, e, f, g, ve h istemlerde gösterilmis olan manalara sahiptirler, integrin'ler sinifina giren adezyon reseptörlerinin VLA-4 antagonist'leri ve/veya lökositlerin adezyonu ve migrasyonu enhibitörleridirler. Ihtira I sayili formüle ait bilesiklerin ve bu bilesikleri içeren ispençiyari müstahzarlarin,istenmedik derecedeki bir lökosit adezyonunun ve/veya lökosit migrasyonunun neden oldugu veya bunlara bagli olan veya hücreden hücreye veya hücreden matrise olan karsilikli faaliyetlerin bir rol oynadiklari, yani VLA-4 reseptörlerinin ligand'lariyla karsilikli etkilesmelerine dayanan hastaliklarin, mesala iltihaplanmalarin, reumatoid artritis veya alerjik hastaliklarin tedavisi ve profilaksi için kullanilmalarini ve bu çesit hastaliklarda uygulanacak ilaçlarin üretilmesi için I sayili formüle ait bilesiklerin kullanilmalarini ilgilendirmektedir.
TR97/01354A 1996-11-15 1997-11-13 Lökosit adezyonu ve VLA-4-Antagonist'lerinin inhibitörleri. TR199701354A3 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19647380A DE19647380A1 (de) 1996-11-15 1996-11-15 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten

Publications (2)

Publication Number Publication Date
TR199701354A2 true TR199701354A2 (tr) 1998-06-22
TR199701354A3 TR199701354A3 (tr) 1998-06-22

Family

ID=7811830

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Application Number Title Priority Date Filing Date
TR97/01354A TR199701354A3 (tr) 1996-11-15 1997-11-13 Lökosit adezyonu ve VLA-4-Antagonist'lerinin inhibitörleri.

Country Status (30)

Country Link
US (1) US20040220148A1 (tr)
EP (1) EP0842943B1 (tr)
JP (1) JPH10147573A (tr)
KR (1) KR19980042457A (tr)
CN (1) CN1135236C (tr)
AR (1) AR010067A1 (tr)
AT (1) ATE233276T1 (tr)
AU (1) AU747789B2 (tr)
BR (1) BR9705727A (tr)
CA (1) CA2220784A1 (tr)
CZ (1) CZ293351B6 (tr)
DE (2) DE19647380A1 (tr)
DK (1) DK0842943T3 (tr)
ES (1) ES2190503T3 (tr)
HR (1) HRP970605B1 (tr)
HU (1) HUP9702035A3 (tr)
ID (1) ID19010A (tr)
IL (1) IL122188A0 (tr)
MX (1) MX9708782A (tr)
MY (1) MY119617A (tr)
NO (1) NO317241B1 (tr)
NZ (1) NZ329178A (tr)
PL (1) PL323128A1 (tr)
PT (1) PT842943E (tr)
RU (1) RU2229296C2 (tr)
SI (1) SI0842943T1 (tr)
SK (1) SK284377B6 (tr)
TR (1) TR199701354A3 (tr)
TW (1) TW496874B (tr)
ZA (1) ZA9710244B (tr)

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US20040220148A1 (en) 2004-11-04
HUP9702035A3 (en) 1998-12-28
ATE233276T1 (de) 2003-03-15
CA2220784A1 (en) 1998-05-15
HUP9702035A2 (hu) 1998-07-28
DE19647380A1 (de) 1998-05-20
NO975244L (no) 1998-05-18
HU9702035D0 (en) 1998-01-28
TR199701354A3 (tr) 1998-06-22
AR010067A1 (es) 2000-05-17
AU4515997A (en) 1998-05-21
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MY119617A (en) 2005-06-30
IL122188A0 (en) 1998-04-05
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TW496874B (en) 2002-08-01
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PL323128A1 (en) 1998-05-25
EP0842943A2 (de) 1998-05-20
ID19010A (id) 1998-06-04
ZA9710244B (en) 1998-05-15
MX9708782A (es) 1998-05-31
NO317241B1 (no) 2004-09-27
DE59709383D1 (de) 2003-04-03
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ES2190503T3 (es) 2003-08-01
RU2229296C2 (ru) 2004-05-27
CZ359997A3 (cs) 1998-06-17
SK284377B6 (sk) 2005-02-04
HRP970605B1 (en) 2003-08-31
EP0842943A3 (de) 1999-02-24
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PT842943E (pt) 2003-07-31
HRP970605A2 (en) 1998-08-31
BR9705727A (pt) 2000-03-21
SI0842943T1 (en) 2003-08-31

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