TNSN04268A1 - UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFS - Google Patents

UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFS

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Publication number
TNSN04268A1
TNSN04268A1 TNP2004000268A TNSN04268A TNSN04268A1 TN SN04268 A1 TNSN04268 A1 TN SN04268A1 TN P2004000268 A TNP2004000268 A TN P2004000268A TN SN04268 A TNSN04268 A TN SN04268A TN SN04268 A1 TNSN04268 A1 TN SN04268A1
Authority
TN
Tunisia
Prior art keywords
inhibitors
hypertensive agents
cetp
hmg
optionally
Prior art date
Application number
TNP2004000268A
Other languages
English (en)
Inventor
James Harold Revkin
Roger Benjamin Ruggeri
Tu Trung Nguyen
Charles Lester Shear
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN04268A1 publication Critical patent/TNSN04268A1/fr

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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/33Heterocyclic compounds
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    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La présente invention concerne des inhibiteurs de la protéine de transfert d'ester de cholestérol (CETP); des compositions pharmaceutiques contenant ces inhibiteurs et l'utilisation de ces inhibiteurs pour le traitement de certaines maladies/affections; éventuellement en association avec certains agents thérapeutiques; par exemple; des agents anti-hypertensifs.
TNP2004000268A 2002-07-02 2004-12-30 UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFS TNSN04268A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39339502P 2002-07-02 2002-07-02
PCT/IB2003/002792 WO2004004778A1 (fr) 2002-07-02 2003-06-18 Utilisation d'inhibiteurs cetp et eventuellement d'inhibiteurs de la hmg coa reductase et/ou d'agents anti-hypertensifs

Publications (1)

Publication Number Publication Date
TNSN04268A1 true TNSN04268A1 (fr) 2007-03-12

Family

ID=30115572

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2004000268A TNSN04268A1 (fr) 2002-07-02 2004-12-30 UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFS

Country Status (23)

Country Link
US (1) US20040053842A1 (fr)
EP (1) EP1519754A1 (fr)
JP (1) JP2005532388A (fr)
KR (1) KR20050025578A (fr)
CN (1) CN1665537A (fr)
AP (1) AP2004003189A0 (fr)
AU (1) AU2003244921A1 (fr)
BR (1) BR0312421A (fr)
CA (1) CA2488736A1 (fr)
EA (1) EA200401471A1 (fr)
EC (1) ECSP045520A (fr)
HR (1) HRP20041238A2 (fr)
IL (1) IL165328A0 (fr)
IS (1) IS7570A (fr)
MA (1) MA27311A1 (fr)
MX (1) MXPA05000015A (fr)
NO (1) NO20050497L (fr)
OA (1) OA12876A (fr)
PL (1) PL374878A1 (fr)
TN (1) TNSN04268A1 (fr)
TW (1) TW200401768A (fr)
WO (1) WO2004004778A1 (fr)
ZA (1) ZA200409582B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071210B2 (en) * 2002-07-02 2006-07-04 Pfizer Inc. CETP inhibitors in combination with antihypertensive agents and uses thereof
ATE389396T1 (de) * 2002-12-20 2008-04-15 Pfizer Prod Inc Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
EP1961419B1 (fr) * 2002-12-20 2010-03-24 Pfizer Products Inc. Formes posologiques comprenant un inhibiteur de CETP et un inhibiteur de HMG-CoA reductase
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
EP1599468B1 (fr) 2003-01-14 2007-10-03 Arena Pharmaceuticals, Inc. Derives aryles et heteroaryles tri-substitues en position 1,2,3 en tant que modulateurs de metabolisme et prophylaxie et traitement de troubles lies au metabolisme
DK1603553T3 (da) * 2003-03-17 2012-01-30 Japan Tobacco Inc Farmaceutiske præparater af CETP-inhibitorer
MXPA05009976A (es) * 2003-03-17 2005-11-04 Japan Tobacco Inc Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo].
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合
UA82698C2 (uk) * 2003-05-30 2008-05-12 Ранбакси Лабораториз Лимитед Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co
NZ544200A (en) 2003-07-14 2009-07-31 Arena Pharm Inc Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
EP1699452A2 (fr) * 2003-12-16 2006-09-13 Novartis AG Utilisation de stanines pour traiter le syndrome metabolique
BRPI0509668A (pt) * 2004-04-07 2007-10-09 Millennium Pharm Inc composto, composição farmacêutica que compreende o mesmo, método de tratamento de enfermidade, distúrbio ou sintoma inflamatório e método de preparação do composto
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
CA2588216A1 (fr) * 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Formulations d'atorvastatine stables
WO2006063048A2 (fr) 2004-12-06 2006-06-15 Avigen, Inc. Methode de traitement des douleurs neuropathiques et les syndromes associes
WO2006069162A1 (fr) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Nouveaux composes heterocycliques et leurs compositions pharmaceutiques
US20080305158A1 (en) * 2004-12-28 2008-12-11 Ranbaxy Laboratories Limited Methods For the Preparation of Stable Pharmaceutical Solid Dosage Forms of Atorvastatin and Amlodipine
US8604055B2 (en) * 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
MX2007007919A (es) * 2004-12-31 2008-01-22 Reddy Us Therapeutics Inc Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp).
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
WO2007106111A2 (fr) * 2005-07-01 2007-09-20 Elan Pharma International Limited Compositions nanoparticulaires et a liberation controlee comprenant de la nilvadipine
WO2007005941A2 (fr) 2005-07-05 2007-01-11 President And Fellows Of Harvard College Conjugues cibles sur le foie
US8026377B2 (en) * 2005-11-08 2011-09-27 Ranbaxy Laboratories, Limited Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
WO2008020314A2 (fr) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Formulations de dosage stabilisantes à base de statine
WO2007115132A2 (fr) * 2006-03-29 2007-10-11 Guilford F Timothy Produit radiopharmaceutique utilisé dans une préparation liposomale auto-formante pouvant être administrée par diverses voies, contenant d'autres ingrédients
WO2007116243A2 (fr) * 2006-04-10 2007-10-18 Mintails Limited Procede de traitement de la fibromyalgie et de pathologies apparentees
CL2007002044A1 (es) * 2006-07-14 2008-06-13 Ranbaxy Lab Ltd Polimorfo cristalino de la sal hemicalcica del acido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3,5-dihidroxiheptanoico; composicion farmaceutica; y uso para el tratamiento de la diabetes, enf
EP2131841B1 (fr) * 2007-01-30 2012-08-01 Avigen, Inc. Procédés de traitement de la douleur aiguë
US20080287402A1 (en) * 2007-05-03 2008-11-20 Johnson Kirk W Use of a glial attenuator to prevent amplified pain responses caused by glial priming
WO2008143883A1 (fr) * 2007-05-14 2008-11-27 Synvista Therapeutics, Inc. Utilisation du génotypage de l'haptoglobine pour le diagnostic et le traitement pour le transport inverse défectueux du cholestérol (rct)
WO2009021113A1 (fr) * 2007-08-09 2009-02-12 Holtzman, Jordan, L. Procédés de stimulation de l'activité de la glutathion peroxydase
EP2070520A1 (fr) * 2007-12-11 2009-06-17 LEK Pharmaceuticals D.D. Composition pharmaceutique comportant au moins un agent actif et un liant, qui gonfle dans un support acide
AU2011305525B2 (en) 2010-09-22 2016-08-18 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
EP2626351A4 (fr) * 2010-10-04 2014-03-12 Kowa Co Agent capable d'inhiber l'expression d'un arnm lié au métabolisme lipidique
WO2013024358A2 (fr) 2011-08-18 2013-02-21 Dr. Reddy's Laboratories Ltd. Composés amines hétérocycliques substitués comme inhibiteurs de la protéine de transfert d'ester cholesterylique (cetp)
CN103958511A (zh) 2011-09-27 2014-07-30 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
US10300059B2 (en) * 2014-08-28 2019-05-28 Dezima Pharma B.V. Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and HMG CoA reductase inhibitors
MX2021011472A (es) 2015-01-06 2022-08-17 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
EP3490579A1 (fr) * 2016-07-27 2019-06-05 Hartis-Pharma SA Combinaisons thérapeutiques pour traiter les troubles des globules rouges
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
CN116196314B (zh) * 2023-05-04 2023-08-15 广州市妇女儿童医疗中心 Ri-1或其盐在制备防治胃肠道疾病的药物中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6144790A (en) * 1997-02-07 2000-11-07 Bledin; Anthony G Contact fiber optic impact sensor
NZ502283A (en) * 1997-08-29 2002-05-31 Pfizer Prod Inc Cardiovascular therapy comprising amlodipine and a statin compound in amounts that are synergistically effective
GT199800126A (es) * 1997-08-29 2000-01-29 Terapia de combinacion.
GT199800127A (es) * 1997-08-29 2000-02-01 Combinaciones terapeuticas.
US6147090A (en) * 1998-09-17 2000-11-14 Pfizer Inc. 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6140342A (en) * 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
US6147089A (en) * 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
GT199900147A (es) * 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
HN2000000050A (es) * 1999-05-27 2001-02-02 Pfizer Prod Inc Sal mutua de amlodipino y atorvastatina
JP2003500487A (ja) * 1999-05-27 2003-01-07 ファイザー・プロダクツ・インク アムロジピンおよびアトルバスタチンの共通プロドラッグ
US20030092745A1 (en) * 2000-02-25 2003-05-15 Pfizer Inc. Combination therapy
US20020013334A1 (en) * 2000-06-15 2002-01-31 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
HUP0303083A3 (en) * 2000-08-15 2005-05-30 Pfizer Prod Inc Pharmaceutical compositions containing therapeutic combination of a cetp inhibitor and atorvastatin and their use
US6737430B2 (en) * 2000-11-09 2004-05-18 Pfizer, Inc. Mutual prodrug of amlodipine and atorvastatin
WO2002087556A2 (fr) * 2001-04-11 2002-11-07 Atherogenics, Inc. Procedes d'accroissement des taux de cholesterol hdl du plasma et d'amelioration de la fonctionnalite hdl avec des monoesters de probucol
US7071210B2 (en) * 2002-07-02 2006-07-04 Pfizer Inc. CETP inhibitors in combination with antihypertensive agents and uses thereof

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AU2003244921A1 (en) 2004-01-23
EP1519754A1 (fr) 2005-04-06
KR20050025578A (ko) 2005-03-14
MXPA05000015A (es) 2005-04-08
CA2488736A1 (fr) 2004-01-15
US20040053842A1 (en) 2004-03-18
BR0312421A (pt) 2005-04-19
EA200401471A1 (ru) 2005-06-30
PL374878A1 (en) 2005-11-14
ZA200409582B (en) 2006-08-30
TW200401768A (en) 2004-02-01
CN1665537A (zh) 2005-09-07
JP2005532388A (ja) 2005-10-27
AP2004003189A0 (en) 2004-12-31
IS7570A (is) 2004-11-29
ECSP045520A (es) 2005-03-10
MA27311A1 (fr) 2005-05-02
OA12876A (en) 2006-09-15
WO2004004778A1 (fr) 2004-01-15
NO20050497L (no) 2005-03-08

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