TNSN04268A1 - UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFS - Google Patents
UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFSInfo
- Publication number
- TNSN04268A1 TNSN04268A1 TNP2004000268A TNSN04268A TNSN04268A1 TN SN04268 A1 TNSN04268 A1 TN SN04268A1 TN P2004000268 A TNP2004000268 A TN P2004000268A TN SN04268 A TNSN04268 A TN SN04268A TN SN04268 A1 TNSN04268 A1 TN SN04268A1
- Authority
- TN
- Tunisia
- Prior art keywords
- inhibitors
- hypertensive agents
- cetp
- hmg
- optionally
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 239000002220 antihypertensive agent Substances 0.000 title abstract 2
- 229940030600 antihypertensive agent Drugs 0.000 title abstract 2
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title 1
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 2
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La présente invention concerne des inhibiteurs de la protéine de transfert d'ester de cholestérol (CETP); des compositions pharmaceutiques contenant ces inhibiteurs et l'utilisation de ces inhibiteurs pour le traitement de certaines maladies/affections; éventuellement en association avec certains agents thérapeutiques; par exemple; des agents anti-hypertensifs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39339502P | 2002-07-02 | 2002-07-02 | |
PCT/IB2003/002792 WO2004004778A1 (fr) | 2002-07-02 | 2003-06-18 | Utilisation d'inhibiteurs cetp et eventuellement d'inhibiteurs de la hmg coa reductase et/ou d'agents anti-hypertensifs |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN04268A1 true TNSN04268A1 (fr) | 2007-03-12 |
Family
ID=30115572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2004000268A TNSN04268A1 (fr) | 2002-07-02 | 2004-12-30 | UTILISATION D'INHIBITEURS CETP ET FACULTATIVEMENT D'INHIBITEURS DE HMG -CoA - REDUCTASE ET/OU D'AGENTS ANTI-HYPERTENSIFS |
Country Status (23)
Country | Link |
---|---|
US (1) | US20040053842A1 (fr) |
EP (1) | EP1519754A1 (fr) |
JP (1) | JP2005532388A (fr) |
KR (1) | KR20050025578A (fr) |
CN (1) | CN1665537A (fr) |
AP (1) | AP2004003189A0 (fr) |
AU (1) | AU2003244921A1 (fr) |
BR (1) | BR0312421A (fr) |
CA (1) | CA2488736A1 (fr) |
EA (1) | EA200401471A1 (fr) |
EC (1) | ECSP045520A (fr) |
HR (1) | HRP20041238A2 (fr) |
IL (1) | IL165328A0 (fr) |
IS (1) | IS7570A (fr) |
MA (1) | MA27311A1 (fr) |
MX (1) | MXPA05000015A (fr) |
NO (1) | NO20050497L (fr) |
OA (1) | OA12876A (fr) |
PL (1) | PL374878A1 (fr) |
TN (1) | TNSN04268A1 (fr) |
TW (1) | TW200401768A (fr) |
WO (1) | WO2004004778A1 (fr) |
ZA (1) | ZA200409582B (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7071210B2 (en) * | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
ATE389396T1 (de) * | 2002-12-20 | 2008-04-15 | Pfizer Prod Inc | Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer |
EP1961419B1 (fr) * | 2002-12-20 | 2010-03-24 | Pfizer Products Inc. | Formes posologiques comprenant un inhibiteur de CETP et un inhibiteur de HMG-CoA reductase |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
EP1599468B1 (fr) | 2003-01-14 | 2007-10-03 | Arena Pharmaceuticals, Inc. | Derives aryles et heteroaryles tri-substitues en position 1,2,3 en tant que modulateurs de metabolisme et prophylaxie et traitement de troubles lies au metabolisme |
DK1603553T3 (da) * | 2003-03-17 | 2012-01-30 | Japan Tobacco Inc | Farmaceutiske præparater af CETP-inhibitorer |
MXPA05009976A (es) * | 2003-03-17 | 2005-11-04 | Japan Tobacco Inc | Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo]. |
TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
UA82698C2 (uk) * | 2003-05-30 | 2008-05-12 | Ранбакси Лабораториз Лимитед | Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co |
NZ544200A (en) | 2003-07-14 | 2009-07-31 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
EP1699452A2 (fr) * | 2003-12-16 | 2006-09-13 | Novartis AG | Utilisation de stanines pour traiter le syndrome metabolique |
BRPI0509668A (pt) * | 2004-04-07 | 2007-10-09 | Millennium Pharm Inc | composto, composição farmacêutica que compreende o mesmo, método de tratamento de enfermidade, distúrbio ou sintoma inflamatório e método de preparação do composto |
US20060063803A1 (en) * | 2004-09-23 | 2006-03-23 | Pfizer Inc | 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds |
CA2588216A1 (fr) * | 2004-11-22 | 2006-05-26 | Dexcel Pharma Technologies Ltd. | Formulations d'atorvastatine stables |
WO2006063048A2 (fr) | 2004-12-06 | 2006-06-15 | Avigen, Inc. | Methode de traitement des douleurs neuropathiques et les syndromes associes |
WO2006069162A1 (fr) * | 2004-12-20 | 2006-06-29 | Reddy Us Therapeutics, Inc. | Nouveaux composes heterocycliques et leurs compositions pharmaceutiques |
US20080305158A1 (en) * | 2004-12-28 | 2008-12-11 | Ranbaxy Laboratories Limited | Methods For the Preparation of Stable Pharmaceutical Solid Dosage Forms of Atorvastatin and Amlodipine |
US8604055B2 (en) * | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
MX2007007919A (es) * | 2004-12-31 | 2008-01-22 | Reddy Us Therapeutics Inc | Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp). |
MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
WO2007106111A2 (fr) * | 2005-07-01 | 2007-09-20 | Elan Pharma International Limited | Compositions nanoparticulaires et a liberation controlee comprenant de la nilvadipine |
WO2007005941A2 (fr) | 2005-07-05 | 2007-01-11 | President And Fellows Of Harvard College | Conjugues cibles sur le foie |
US8026377B2 (en) * | 2005-11-08 | 2011-09-27 | Ranbaxy Laboratories, Limited | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
WO2008020314A2 (fr) * | 2006-03-14 | 2008-02-21 | Ranbaxy Laboratories Limited | Formulations de dosage stabilisantes à base de statine |
WO2007115132A2 (fr) * | 2006-03-29 | 2007-10-11 | Guilford F Timothy | Produit radiopharmaceutique utilisé dans une préparation liposomale auto-formante pouvant être administrée par diverses voies, contenant d'autres ingrédients |
WO2007116243A2 (fr) * | 2006-04-10 | 2007-10-18 | Mintails Limited | Procede de traitement de la fibromyalgie et de pathologies apparentees |
CL2007002044A1 (es) * | 2006-07-14 | 2008-06-13 | Ranbaxy Lab Ltd | Polimorfo cristalino de la sal hemicalcica del acido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3,5-dihidroxiheptanoico; composicion farmaceutica; y uso para el tratamiento de la diabetes, enf |
EP2131841B1 (fr) * | 2007-01-30 | 2012-08-01 | Avigen, Inc. | Procédés de traitement de la douleur aiguë |
US20080287402A1 (en) * | 2007-05-03 | 2008-11-20 | Johnson Kirk W | Use of a glial attenuator to prevent amplified pain responses caused by glial priming |
WO2008143883A1 (fr) * | 2007-05-14 | 2008-11-27 | Synvista Therapeutics, Inc. | Utilisation du génotypage de l'haptoglobine pour le diagnostic et le traitement pour le transport inverse défectueux du cholestérol (rct) |
WO2009021113A1 (fr) * | 2007-08-09 | 2009-02-12 | Holtzman, Jordan, L. | Procédés de stimulation de l'activité de la glutathion peroxydase |
EP2070520A1 (fr) * | 2007-12-11 | 2009-06-17 | LEK Pharmaceuticals D.D. | Composition pharmaceutique comportant au moins un agent actif et un liant, qui gonfle dans un support acide |
AU2011305525B2 (en) | 2010-09-22 | 2016-08-18 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
EP2626351A4 (fr) * | 2010-10-04 | 2014-03-12 | Kowa Co | Agent capable d'inhiber l'expression d'un arnm lié au métabolisme lipidique |
WO2013024358A2 (fr) | 2011-08-18 | 2013-02-21 | Dr. Reddy's Laboratories Ltd. | Composés amines hétérocycliques substitués comme inhibiteurs de la protéine de transfert d'ester cholesterylique (cetp) |
CN103958511A (zh) | 2011-09-27 | 2014-07-30 | 雷迪博士实验室有限公司 | 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物 |
US10300059B2 (en) * | 2014-08-28 | 2019-05-28 | Dezima Pharma B.V. | Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and HMG CoA reductase inhibitors |
MX2021011472A (es) | 2015-01-06 | 2022-08-17 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
PL3310760T3 (pl) | 2015-06-22 | 2023-03-06 | Arena Pharmaceuticals, Inc. | Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1 |
EP3490579A1 (fr) * | 2016-07-27 | 2019-06-05 | Hartis-Pharma SA | Combinaisons thérapeutiques pour traiter les troubles des globules rouges |
CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
CN116196314B (zh) * | 2023-05-04 | 2023-08-15 | 广州市妇女儿童医疗中心 | Ri-1或其盐在制备防治胃肠道疾病的药物中的应用 |
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US6144790A (en) * | 1997-02-07 | 2000-11-07 | Bledin; Anthony G | Contact fiber optic impact sensor |
NZ502283A (en) * | 1997-08-29 | 2002-05-31 | Pfizer Prod Inc | Cardiovascular therapy comprising amlodipine and a statin compound in amounts that are synergistically effective |
GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
GT199800127A (es) * | 1997-08-29 | 2000-02-01 | Combinaciones terapeuticas. | |
US6147090A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6140342A (en) * | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
US6147089A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
GT199900147A (es) * | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
HN2000000050A (es) * | 1999-05-27 | 2001-02-02 | Pfizer Prod Inc | Sal mutua de amlodipino y atorvastatina |
JP2003500487A (ja) * | 1999-05-27 | 2003-01-07 | ファイザー・プロダクツ・インク | アムロジピンおよびアトルバスタチンの共通プロドラッグ |
US20030092745A1 (en) * | 2000-02-25 | 2003-05-15 | Pfizer Inc. | Combination therapy |
US20020013334A1 (en) * | 2000-06-15 | 2002-01-31 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
HUP0303083A3 (en) * | 2000-08-15 | 2005-05-30 | Pfizer Prod Inc | Pharmaceutical compositions containing therapeutic combination of a cetp inhibitor and atorvastatin and their use |
US6737430B2 (en) * | 2000-11-09 | 2004-05-18 | Pfizer, Inc. | Mutual prodrug of amlodipine and atorvastatin |
WO2002087556A2 (fr) * | 2001-04-11 | 2002-11-07 | Atherogenics, Inc. | Procedes d'accroissement des taux de cholesterol hdl du plasma et d'amelioration de la fonctionnalite hdl avec des monoesters de probucol |
US7071210B2 (en) * | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
-
2003
- 2003-06-10 US US10/459,683 patent/US20040053842A1/en not_active Abandoned
- 2003-06-18 IL IL16532803A patent/IL165328A0/xx unknown
- 2003-06-18 CA CA002488736A patent/CA2488736A1/fr not_active Abandoned
- 2003-06-18 AP AP2004003189A patent/AP2004003189A0/xx unknown
- 2003-06-18 PL PL03374878A patent/PL374878A1/xx not_active Application Discontinuation
- 2003-06-18 BR BR0312421-5A patent/BR0312421A/pt not_active IP Right Cessation
- 2003-06-18 WO PCT/IB2003/002792 patent/WO2004004778A1/fr not_active Application Discontinuation
- 2003-06-18 EP EP03738394A patent/EP1519754A1/fr not_active Withdrawn
- 2003-06-18 CN CN038155753A patent/CN1665537A/zh active Pending
- 2003-06-18 OA OA1200400342A patent/OA12876A/en unknown
- 2003-06-18 KR KR1020057000061A patent/KR20050025578A/ko not_active Application Discontinuation
- 2003-06-18 JP JP2004519080A patent/JP2005532388A/ja not_active Withdrawn
- 2003-06-18 EA EA200401471A patent/EA200401471A1/ru unknown
- 2003-06-18 MX MXPA05000015A patent/MXPA05000015A/es not_active Application Discontinuation
- 2003-06-18 AU AU2003244921A patent/AU2003244921A1/en not_active Abandoned
- 2003-07-01 TW TW092117985A patent/TW200401768A/zh unknown
-
2004
- 2004-11-26 ZA ZA200409582A patent/ZA200409582B/en unknown
- 2004-11-29 IS IS7570A patent/IS7570A/is unknown
- 2004-12-17 MA MA28016A patent/MA27311A1/fr unknown
- 2004-12-30 TN TNP2004000268A patent/TNSN04268A1/fr unknown
- 2004-12-30 EC EC2004005520A patent/ECSP045520A/es unknown
- 2004-12-30 HR HR20041238A patent/HRP20041238A2/xx not_active Application Discontinuation
-
2005
- 2005-01-28 NO NO20050497A patent/NO20050497L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL165328A0 (en) | 2006-01-15 |
HRP20041238A2 (en) | 2005-06-30 |
AU2003244921A1 (en) | 2004-01-23 |
EP1519754A1 (fr) | 2005-04-06 |
KR20050025578A (ko) | 2005-03-14 |
MXPA05000015A (es) | 2005-04-08 |
CA2488736A1 (fr) | 2004-01-15 |
US20040053842A1 (en) | 2004-03-18 |
BR0312421A (pt) | 2005-04-19 |
EA200401471A1 (ru) | 2005-06-30 |
PL374878A1 (en) | 2005-11-14 |
ZA200409582B (en) | 2006-08-30 |
TW200401768A (en) | 2004-02-01 |
CN1665537A (zh) | 2005-09-07 |
JP2005532388A (ja) | 2005-10-27 |
AP2004003189A0 (en) | 2004-12-31 |
IS7570A (is) | 2004-11-29 |
ECSP045520A (es) | 2005-03-10 |
MA27311A1 (fr) | 2005-05-02 |
OA12876A (en) | 2006-09-15 |
WO2004004778A1 (fr) | 2004-01-15 |
NO20050497L (no) | 2005-03-08 |
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