TN2011000220A1 - Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors - Google Patents
Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitorsInfo
- Publication number
- TN2011000220A1 TN2011000220A1 TN2011000220A TN2011000220A TN2011000220A1 TN 2011000220 A1 TN2011000220 A1 TN 2011000220A1 TN 2011000220 A TN2011000220 A TN 2011000220A TN 2011000220 A TN2011000220 A TN 2011000220A TN 2011000220 A1 TN2011000220 A1 TN 2011000220A1
- Authority
- TN
- Tunisia
- Prior art keywords
- pyridine
- phosphodiesterase
- inhibitors
- pyrimidine derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11459508P | 2008-11-14 | 2008-11-14 | |
US16621509P | 2009-04-02 | 2009-04-02 | |
PCT/US2009/064643 WO2010057126A1 (fr) | 2008-11-14 | 2009-11-16 | Derives de pyridine et de pyrimidine comme inhibiteurs de phosphodiesterase 10 |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2011000220A1 true TN2011000220A1 (en) | 2012-12-17 |
Family
ID=41557471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2011000220A TN2011000220A1 (en) | 2008-11-14 | 2011-05-05 | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
Country Status (17)
Country | Link |
---|---|
US (2) | US8318718B2 (fr) |
EP (1) | EP2364306B1 (fr) |
JP (1) | JP2012508777A (fr) |
KR (1) | KR20110086603A (fr) |
AR (1) | AR074343A1 (fr) |
AU (1) | AU2009313773B2 (fr) |
BR (1) | BRPI0921598A2 (fr) |
CA (1) | CA2742833C (fr) |
CR (1) | CR20110279A (fr) |
EA (1) | EA201100749A1 (fr) |
ES (1) | ES2413808T3 (fr) |
IL (1) | IL212670A0 (fr) |
MA (1) | MA32891B1 (fr) |
MX (1) | MX2011005093A (fr) |
TN (1) | TN2011000220A1 (fr) |
TW (1) | TW201030001A (fr) |
WO (1) | WO2010057126A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927549B2 (en) | 2008-11-21 | 2015-01-06 | High Point Pharmaceuticals, Llc | Adamantyl benzamide derivatives |
US8354411B2 (en) | 2009-02-05 | 2013-01-15 | Takeda Pharmaceutical Company Limited | 1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound |
KR101875238B1 (ko) | 2010-06-24 | 2018-07-05 | 다케다 야쿠힌 고교 가부시키가이샤 | 포스포디에스테라아제 (pdes) 저해제로서의 융합 헤테로시클릭 화합물 |
WO2012018909A1 (fr) | 2010-08-04 | 2012-02-09 | Takeda Pharmaceutical Company Limited | Composés hétérocycliques condensés |
EP2602255B1 (fr) | 2010-08-04 | 2017-04-26 | Takeda Pharmaceutical Company Limited | Composé à cycle hétérocyclique fusionné |
JP5800814B2 (ja) | 2010-08-10 | 2015-10-28 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
EP3210984B1 (fr) | 2011-01-11 | 2019-06-19 | Sunovion Pharmaceuticals Inc. | Composés hétéroaryles et procédés d'utilisation correspondants |
BR112013021180A2 (pt) | 2011-02-18 | 2019-09-24 | Allergan Inc | derivados de 6,7-dialcóxi-3-isoquinolinol substituído como inibidores de fosfodiesterase 10 (pde10a) |
JP5973990B2 (ja) * | 2011-03-16 | 2016-08-23 | 武田薬品工業株式会社 | 縮合複素環化合物 |
EA031153B1 (ru) | 2011-06-10 | 2018-11-30 | Мерк Патент Гмбх | Применение пиримидиновых соединений с btk ингибирующей активностью |
TWI570122B (zh) | 2011-06-22 | 2017-02-11 | 武田藥品工業股份有限公司 | 稠合雜環化合物之結晶 |
WO2012177896A1 (fr) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Antagonistes de trpm8 et leur utilisation dans le cadre thérapeutique |
JP2014527511A (ja) | 2011-06-24 | 2014-10-16 | アムジエン・インコーポレーテツド | Trpm8拮抗剤及び治療におけるそれらの使用 |
TWI450895B (zh) * | 2011-08-25 | 2014-09-01 | Merck Sharp & Dohme | 嘧啶pde10抑制劑 |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
WO2014071044A1 (fr) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Dérivés de 6,7-dialcoxy-3-isoquinoline substitués à titre d'inhibiteurs de phosphodiestérase 10 (pde10a) |
EP2975037A4 (fr) | 2013-03-15 | 2016-08-10 | Daiichi Sankyo Co Ltd | Dérivé du benzothiophène |
US10039764B2 (en) | 2013-07-12 | 2018-08-07 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression |
CA2925211A1 (fr) | 2013-09-27 | 2015-04-02 | Nimbus Iris, Inc. | Inhibiteurs d'irak et leurs utilisation |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
ES2795748T3 (es) | 2014-07-31 | 2020-11-24 | Pasteur Institut Korea | Derivados de 2-amino-bencimidazol como inhibidores de 5-lipoxigenasa y/o prostaglandina E sintasa para tratar enfermedades inflamatorias |
EP3351533A4 (fr) | 2015-09-18 | 2019-03-06 | Kaken Pharmaceutical Co., Ltd. | Dérivé biaryle et médicament le contenant |
CN110563664A (zh) * | 2019-07-23 | 2019-12-13 | 上海合全药物研发有限公司 | 外消旋体(4as,7s,7as)-叔丁基-7-羟基六氢环戊二烯[b][1,4]噁嗪-4(4ah)-甲酸基酯制法 |
CN117337292A (zh) * | 2021-05-12 | 2024-01-02 | 勃林格殷格翰国际有限公司 | 作为cGAS抑制剂的具有N-连接环状取代基的吡啶衍生物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4198417A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
WO2003004488A1 (fr) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Composes d'indazole benzimidazole utilises comme inhibiteurs de tyrosine et de serine/threonine kinase |
PL1635828T3 (pl) | 2003-04-04 | 2008-10-31 | H Lundbeck As | Pochodne 4-(2-fenyloksyfenylo)-piperydyny lub 1,2,3,6-tetrahydropirydyny jako inhibitory wychwytu zwrotnego serotoniny |
DE10337942A1 (de) * | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Aminobenzimidazolderivate |
DE10344223A1 (de) * | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
DE10349587A1 (de) * | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
US7470712B2 (en) | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
DE102005016634A1 (de) * | 2005-04-12 | 2006-10-19 | Merck Patent Gmbh | Neuartige Aza-Hetercyclen als Kinase-Inhibitoren |
MX2008001605A (es) | 2005-08-02 | 2008-04-14 | Irm Llc | Compuestos y composiciones de tiazol-2-il amino 5-substituido como inhibidores de cinasa proteica. |
NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
US7868177B2 (en) * | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
WO2008057280A1 (fr) | 2006-10-27 | 2008-05-15 | Amgen Inc. | Composés à cycles multiples et procédés d'utilisation |
WO2009081259A1 (fr) | 2007-12-21 | 2009-07-02 | Pfizer Inc. | Dérivés phénoxy-pyridylés |
CA2727174A1 (fr) | 2008-06-20 | 2010-01-21 | Jiangao Song | Agonistes des recepteurs gpr119 aryles et utilisations associees |
-
2009
- 2009-11-13 TW TW098138717A patent/TW201030001A/zh unknown
- 2009-11-13 AR ARP090104404A patent/AR074343A1/es not_active Application Discontinuation
- 2009-11-16 CA CA2742833A patent/CA2742833C/fr not_active Expired - Fee Related
- 2009-11-16 EA EA201100749A patent/EA201100749A1/ru unknown
- 2009-11-16 AU AU2009313773A patent/AU2009313773B2/en not_active Ceased
- 2009-11-16 JP JP2011536570A patent/JP2012508777A/ja not_active Ceased
- 2009-11-16 BR BRPI0921598A patent/BRPI0921598A2/pt not_active Application Discontinuation
- 2009-11-16 MX MX2011005093A patent/MX2011005093A/es active IP Right Grant
- 2009-11-16 EP EP09752706.3A patent/EP2364306B1/fr active Active
- 2009-11-16 WO PCT/US2009/064643 patent/WO2010057126A1/fr active Application Filing
- 2009-11-16 ES ES09752706T patent/ES2413808T3/es active Active
- 2009-11-16 US US12/619,573 patent/US8318718B2/en active Active
- 2009-11-16 KR KR1020117013477A patent/KR20110086603A/ko not_active Application Discontinuation
-
2011
- 2011-05-03 IL IL212670A patent/IL212670A0/en unknown
- 2011-05-05 TN TN2011000220A patent/TN2011000220A1/fr unknown
- 2011-05-26 CR CR20110279A patent/CR20110279A/es not_active Application Discontinuation
- 2011-06-10 MA MA33931A patent/MA32891B1/fr unknown
-
2012
- 2012-11-14 US US13/676,826 patent/US8759532B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2742833A1 (fr) | 2010-05-20 |
TW201030001A (en) | 2010-08-16 |
BRPI0921598A2 (pt) | 2016-02-10 |
MA32891B1 (fr) | 2011-12-01 |
IL212670A0 (en) | 2011-07-31 |
EA201100749A1 (ru) | 2011-10-31 |
CA2742833C (fr) | 2013-12-31 |
EP2364306B1 (fr) | 2013-04-24 |
US20130079325A1 (en) | 2013-03-28 |
AU2009313773B2 (en) | 2013-03-21 |
EP2364306A1 (fr) | 2011-09-14 |
US8759532B2 (en) | 2014-06-24 |
MX2011005093A (es) | 2011-09-27 |
AR074343A1 (es) | 2011-01-12 |
CR20110279A (es) | 2011-09-22 |
WO2010057126A1 (fr) | 2010-05-20 |
KR20110086603A (ko) | 2011-07-28 |
US20100125062A1 (en) | 2010-05-20 |
ES2413808T3 (es) | 2013-07-17 |
AU2009313773A1 (en) | 2010-05-20 |
JP2012508777A (ja) | 2012-04-12 |
US8318718B2 (en) | 2012-11-27 |
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