TN2009000268A1 - Substituted isoquinoline and isoquinolinone derivatives - Google Patents
Substituted isoquinoline and isoquinolinone derivativesInfo
- Publication number
- TN2009000268A1 TN2009000268A1 TNP2009000268A TN2009000268A TN2009000268A1 TN 2009000268 A1 TN2009000268 A1 TN 2009000268A1 TN P2009000268 A TNP2009000268 A TN P2009000268A TN 2009000268 A TN2009000268 A TN 2009000268A TN 2009000268 A1 TN2009000268 A1 TN 2009000268A1
- Authority
- TN
- Tunisia
- Prior art keywords
- substituted isoquinoline
- isoquinolinone derivatives
- derivatives
- rho
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06026896 | 2006-12-27 | ||
PCT/EP2007/011165 WO2008077552A1 (fr) | 2006-12-27 | 2007-12-19 | Dérivés d'isoquinoline et d'isoquinolinone substitués |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2009000268A1 true TN2009000268A1 (en) | 2010-10-18 |
Family
ID=38001966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2009000268A TN2009000268A1 (en) | 2006-12-27 | 2009-06-25 | Substituted isoquinoline and isoquinolinone derivatives |
Country Status (22)
Country | Link |
---|---|
US (1) | US8748614B2 (fr) |
EP (1) | EP2114920A1 (fr) |
JP (1) | JP5405315B2 (fr) |
KR (1) | KR20090094338A (fr) |
CN (1) | CN101573353B (fr) |
AU (1) | AU2007338408B2 (fr) |
BR (1) | BRPI0720986A2 (fr) |
CA (1) | CA2673918C (fr) |
CO (1) | CO6210826A2 (fr) |
CR (1) | CR10814A (fr) |
DO (1) | DOP2009000162A (fr) |
EC (1) | ECSP099470A (fr) |
IL (1) | IL199537A (fr) |
MA (1) | MA31022B1 (fr) |
MX (1) | MX2009006517A (fr) |
MY (1) | MY155279A (fr) |
NO (1) | NO20092424L (fr) |
RU (1) | RU2009128693A (fr) |
SV (1) | SV2009003312A (fr) |
TN (1) | TN2009000268A1 (fr) |
WO (1) | WO2008077552A1 (fr) |
ZA (1) | ZA200903552B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007008926A1 (fr) | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Composes isoquinoliniques |
WO2008036540A2 (fr) | 2006-09-20 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Inhibiteurs de la rho-kinase |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
RU2532481C2 (ru) * | 2008-06-24 | 2014-11-10 | Санофи-Авентис | Би- и полициклические замещенные производные изохинолина и изохинолинона, полезные в качестве ингибиторов rho-киназы |
PT2303846E (pt) * | 2008-06-24 | 2015-09-04 | Sanofi Sa | Isoquinolinas e isoquinolinonas substituídas como inibidores de rho-quinase |
AU2009262516B8 (en) * | 2008-06-24 | 2014-01-30 | Sanofi | 6-substituted isoquinolines and isoquinolinones |
US8299096B2 (en) * | 2008-06-26 | 2012-10-30 | Inspire Pharmaceuticals, Inc. | Method for treating pulmonary diseases using rho kinase inhibitor compounds |
US8410147B2 (en) | 2008-06-26 | 2013-04-02 | Inspire Pharmaceuticals, Inc. | Method for treating diseases associated with alterations in cellular integrity using Rho kinase inhibitor compounds |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
CA2760562C (fr) | 2009-05-01 | 2016-07-19 | Aerie Pharmaceuticals, Inc. | Inhibiteurs a mecanisme double pour le traitement de maladie |
AU2014228790B2 (en) | 2013-03-15 | 2018-06-07 | Aerie Pharmaceuticals, Inc. | Combination therapy |
CN105829287B (zh) | 2013-12-20 | 2019-08-27 | 埃斯蒂文制药股份有限公司 | 具有抗疼痛的多重模式活性的哌嗪衍生物 |
FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
RU2017107558A (ru) | 2014-09-15 | 2018-10-18 | Руджен Холдингс (Кайман) Лимитед | Производные пирролопиримидина в качестве антагонистов nmda-рецептора nr2b |
EP3253761A4 (fr) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | Dérivés 3,3-difluoro-pipéridine en tant qu'antagonistes des récepteurs nmda nr2b |
US10584127B2 (en) | 2015-06-01 | 2020-03-10 | Rugen Holdings (Cayman) Limited | 3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists |
CN105237474B (zh) * | 2015-09-30 | 2017-08-29 | 沈阳药科大学 | 6‑羟基‑7‑芳甲酰基喹啉酮类化合物的制备及其应用 |
EP3376870B1 (fr) | 2015-11-17 | 2021-08-11 | Aerie Pharmaceuticals, Inc. | Procédé de préparation d'inhibiteurs de kinase et de leurs intermédiaires |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
WO2018098128A1 (fr) | 2016-11-22 | 2018-05-31 | Rugen Holdings (Cayman) Limited | Traitement de troubles du spectre autistique, de troubles obsessivo-compulsifs et de troubles de l'anxiété |
AU2018243687C1 (en) | 2017-03-31 | 2020-12-24 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
CN109180586B (zh) * | 2018-10-10 | 2022-03-08 | 成都理工大学 | 作为Rho激酶抑制剂的六氢氮杂卓-4-基氧基苯甲酰胺类化合物 |
IL282535B2 (en) | 2018-10-31 | 2024-05-01 | Gilead Sciences Inc | Transformed 6-azabanzimidazole compounds as HPK1 inhibitors |
CA3116347A1 (fr) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Composes 6-azabenzimidazole substitues ayant une activite inhibitrice de hpk1 |
US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
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GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
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SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
US20030095958A1 (en) | 2001-04-27 | 2003-05-22 | Bhisetti Govinda R. | Inhibitors of bace |
JPWO2002100833A1 (ja) * | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Rhoキナーゼ阻害剤 |
GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
WO2003024450A1 (fr) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methodes de traitement des maladies a prions |
SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
EP1541559A4 (fr) | 2002-07-22 | 2007-08-22 | Asahi Kasei Pharma Corp | Derive d'isoquinoline 5-substituee |
CA2502583A1 (fr) | 2002-09-12 | 2004-03-25 | Kirin Beer Kabushiki Kaisha | Derives d'isoquinoline d'inhibition des kinases et medicaments contenant ceux-ci |
US20050014783A1 (en) | 2003-05-29 | 2005-01-20 | Schering Aktiengesellschaft | Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
US20070021404A1 (en) | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CN1856476A (zh) | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉酮钾通道抑制剂 |
AU2004275720B2 (en) | 2003-09-23 | 2008-04-24 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
US20070060595A1 (en) * | 2003-10-10 | 2007-03-15 | Toshio Yoshizawa | Novel fused heterocyclic compound and use thereof |
WO2005054202A1 (fr) | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | Derives de 7-phenyl-isoquinoline-5-sulfonylamino en tant qu'inhibiteurs de akt (proteine kinase b) |
JP2005232175A (ja) * | 2004-01-21 | 2005-09-02 | Asahi Kasei Pharma Kk | 5−置換イソキノリン医薬 |
WO2005074535A2 (fr) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Inhibiteurs de cholinesterase pour des troubles de la colonne vertebrale |
EP1729761A4 (fr) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | Traitement de cadasil avec des inhibiteurs de la cholinesterase |
SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
NZ565669A (en) | 2005-07-26 | 2010-05-28 | Sanofi Aventis | Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors |
KR101373535B1 (ko) | 2005-07-26 | 2014-03-12 | 사노피 | Rho-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 |
TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
US7618985B2 (en) * | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
US7511063B2 (en) * | 2006-08-16 | 2009-03-31 | Schering Corporation | High affinity quinoline-based kinase ligands |
US7893088B2 (en) | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
NZ577984A (en) | 2006-12-27 | 2011-03-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
CA2673921C (fr) | 2006-12-27 | 2015-10-20 | Sanofi-Aventis | Nouvelle isoquinoline substituee et derives d'isoquinolinone |
-
2007
- 2007-12-19 AU AU2007338408A patent/AU2007338408B2/en not_active Ceased
- 2007-12-19 RU RU2009128693/04A patent/RU2009128693A/ru not_active Application Discontinuation
- 2007-12-19 KR KR1020097013517A patent/KR20090094338A/ko active IP Right Grant
- 2007-12-19 CN CN200780048282.0A patent/CN101573353B/zh not_active Expired - Fee Related
- 2007-12-19 MY MYPI20092505A patent/MY155279A/en unknown
- 2007-12-19 MX MX2009006517A patent/MX2009006517A/es active IP Right Grant
- 2007-12-19 JP JP2009543373A patent/JP5405315B2/ja not_active Expired - Fee Related
- 2007-12-19 EP EP07856888A patent/EP2114920A1/fr not_active Withdrawn
- 2007-12-19 BR BRPI0720986-0A patent/BRPI0720986A2/pt not_active IP Right Cessation
- 2007-12-19 WO PCT/EP2007/011165 patent/WO2008077552A1/fr active Application Filing
- 2007-12-19 CA CA2673918A patent/CA2673918C/fr not_active Expired - Fee Related
-
2009
- 2009-05-20 CR CR10814A patent/CR10814A/es not_active Application Discontinuation
- 2009-05-22 ZA ZA200903552A patent/ZA200903552B/xx unknown
- 2009-06-16 CO CO09062102A patent/CO6210826A2/es not_active Application Discontinuation
- 2009-06-18 US US12/487,455 patent/US8748614B2/en not_active Expired - Fee Related
- 2009-06-23 SV SV2009003312A patent/SV2009003312A/es unknown
- 2009-06-24 MA MA32037A patent/MA31022B1/fr unknown
- 2009-06-24 IL IL199537A patent/IL199537A/en not_active IP Right Cessation
- 2009-06-25 TN TNP2009000268A patent/TN2009000268A1/fr unknown
- 2009-06-25 NO NO20092424A patent/NO20092424L/no not_active Application Discontinuation
- 2009-06-26 DO DO2009000162A patent/DOP2009000162A/es unknown
- 2009-06-26 EC EC2009009470A patent/ECSP099470A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2009006517A (es) | 2009-06-26 |
CN101573353B (zh) | 2014-08-06 |
US20100105650A1 (en) | 2010-04-29 |
EP2114920A1 (fr) | 2009-11-11 |
JP5405315B2 (ja) | 2014-02-05 |
CO6210826A2 (es) | 2010-10-20 |
KR20090094338A (ko) | 2009-09-04 |
RU2009128693A (ru) | 2011-02-10 |
CA2673918A1 (fr) | 2008-07-03 |
CN101573353A (zh) | 2009-11-04 |
IL199537A0 (en) | 2010-03-28 |
MA31022B1 (fr) | 2009-12-01 |
CA2673918C (fr) | 2015-02-17 |
ECSP099470A (es) | 2009-07-31 |
DOP2009000162A (es) | 2009-07-31 |
MY155279A (en) | 2015-09-30 |
AU2007338408A1 (en) | 2008-07-03 |
AU2007338408B2 (en) | 2012-07-26 |
US8748614B2 (en) | 2014-06-10 |
WO2008077552A1 (fr) | 2008-07-03 |
IL199537A (en) | 2013-11-28 |
BRPI0720986A2 (pt) | 2014-03-11 |
ZA200903552B (en) | 2010-04-28 |
SV2009003312A (es) | 2010-02-05 |
NO20092424L (no) | 2009-09-18 |
CR10814A (es) | 2009-08-12 |
JP2010514717A (ja) | 2010-05-06 |
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