SV2017005467A - Formas sólidas de un inhibidor ask1. - Google Patents

Formas sólidas de un inhibidor ask1.

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Publication number
SV2017005467A
SV2017005467A SV2017005467A SV2017005467A SV2017005467A SV 2017005467 A SV2017005467 A SV 2017005467A SV 2017005467 A SV2017005467 A SV 2017005467A SV 2017005467 A SV2017005467 A SV 2017005467A SV 2017005467 A SV2017005467 A SV 2017005467A
Authority
SV
El Salvador
Prior art keywords
solid forms
ask1 inhibitor
crystal forms
ask1
inhibitor
Prior art date
Application number
SV2017005467A
Other languages
English (en)
Inventor
Mark Andres
Ernest A Carra
Chan Brenda J Burke
Anna Chiu
Olga Viktorovna Lapina
Stephen P Lathrop
Valeriya Smolenskaya
Lok Him Yu
Gregory Notte
Original Assignee
Gilead Sciences Inc
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Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of SV2017005467A publication Critical patent/SV2017005467A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
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    • C07—ORGANIC CHEMISTRY
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    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/06—Glycolic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

FORMAS CRISTALINAS DE 5-(4-CICLOPROPIL-1H-IMIDAZOL-1-IL)-N-(6-(4-ISOPROPIL-4H-1,2,4-TRIAZOL-3-IL)PIRIDIN-2-IL)-2-FLUORO-4-METILBENZAMIDA (COMPUESTO I) FUERON PREPARADAS Y CARACTERIZADAS EN ESTADO SÓLIDO: (VER FORMULA); TAMBIÉN SE PROPORCIONAN PROCEDIMIENTOS DE FABRICACIÓN Y MÉTODOS DE UTILIZACIÓN DE LAS FORMAS CRISTALINAS
SV2017005467A 2014-12-23 2017-06-19 Formas sólidas de un inhibidor ask1. SV2017005467A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096406P 2014-12-23 2014-12-23
US201562269066P 2015-12-17 2015-12-17

Publications (1)

Publication Number Publication Date
SV2017005467A true SV2017005467A (es) 2017-10-17

Family

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SV2017005467A SV2017005467A (es) 2014-12-23 2017-06-19 Formas sólidas de un inhibidor ask1.

Country Status (29)

Country Link
US (4) US9643956B2 (es)
EP (2) EP4265250A3 (es)
JP (3) JP2017538774A (es)
KR (1) KR101971387B1 (es)
CN (1) CN107108574A (es)
AU (2) AU2015371629B2 (es)
BR (1) BR102015032466A2 (es)
CA (1) CA2972012C (es)
CL (1) CL2017001617A1 (es)
CO (1) CO2017006099A2 (es)
CR (1) CR20170266A (es)
CU (1) CU20170087A7 (es)
DO (1) DOP2017000145A (es)
EA (1) EA201791066A1 (es)
EC (1) ECSP17038512A (es)
ES (1) ES2955208T3 (es)
GT (1) GT201700136A (es)
HK (1) HK1246277A1 (es)
IL (1) IL252756A0 (es)
MA (1) MA41252A (es)
MX (1) MX2017008416A (es)
MY (1) MY194953A (es)
NZ (1) NZ732441A (es)
PE (1) PE20171105A1 (es)
PH (1) PH12017550028A1 (es)
SG (1) SG11201704834UA (es)
SV (1) SV2017005467A (es)
TW (2) TWI689504B (es)
WO (1) WO2016105453A1 (es)

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