SU719480A3 - Способ получени таблеток - Google Patents
Способ получени таблеток Download PDFInfo
- Publication number
- SU719480A3 SU719480A3 SU762427754A SU2427754A SU719480A3 SU 719480 A3 SU719480 A3 SU 719480A3 SU 762427754 A SU762427754 A SU 762427754A SU 2427754 A SU2427754 A SU 2427754A SU 719480 A3 SU719480 A3 SU 719480A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solvent
- tablets
- mixture
- pressing
- cyclohexane
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- 239000002904 solvent Substances 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000003825 pressing Methods 0.000 claims abstract description 7
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
- 238000007710 freezing Methods 0.000 claims abstract description 3
- 230000008014 freezing Effects 0.000 claims abstract description 3
- 239000012442 inert solvent Substances 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 102000003929 Transaminases Human genes 0.000 claims description 3
- 108090000340 Transaminases Proteins 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- UPLLQJUZZIYKHI-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;2-oxobutanedioic acid Chemical compound OC(=O)CC(=O)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O UPLLQJUZZIYKHI-DFWYDOINSA-N 0.000 claims description 2
- QJQZRLXDLORINA-UHFFFAOYSA-N 2-cyclohexylethanol Chemical compound OCCC1CCCCC1 QJQZRLXDLORINA-UHFFFAOYSA-N 0.000 claims description 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 2
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 2
- 108010046334 Urease Proteins 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract description 6
- 238000004108 freeze drying Methods 0.000 abstract description 3
- 239000002826 coolant Substances 0.000 abstract description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- KTUQUZJOVNIKNZ-UHFFFAOYSA-N butan-1-ol;hydrate Chemical compound O.CCCCO KTUQUZJOVNIKNZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011148 porous material Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 235000021395 porridge Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- JYVHOGDBFNJNMR-UHFFFAOYSA-N hexane;hydrate Chemical compound O.CCCCCC JYVHOGDBFNJNMR-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2556561A DE2556561C2 (de) | 1975-12-16 | 1975-12-16 | Verfahren zur Herstellung von porösen Tabletten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU719480A3 true SU719480A3 (ru) | 1980-02-29 |
Family
ID=5964516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762427754A SU719480A3 (ru) | 1975-12-16 | 1976-12-13 | Способ получени таблеток |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4134943A (enExample) |
| JP (2) | JPS5276420A (enExample) |
| AT (1) | AT348133B (enExample) |
| BE (1) | BE849438A (enExample) |
| CH (1) | CH609563A5 (enExample) |
| DE (1) | DE2556561C2 (enExample) |
| FR (1) | FR2335205A2 (enExample) |
| GB (1) | GB1502580A (enExample) |
| IE (1) | IE44571B1 (enExample) |
| IT (1) | IT1124797B (enExample) |
| NL (1) | NL7613818A (enExample) |
| SE (1) | SE423967B (enExample) |
| SU (1) | SU719480A3 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2216319C1 (ru) * | 1999-11-30 | 2003-11-20 | Панацея Биотек Лимитед | Быстрорастворимая фармацевтическая композиция в виде твердой лекарственной формы с пролонгированным сладким вкусом и способ ее получения |
| US8518421B2 (en) | 2000-04-12 | 2013-08-27 | Bristol-Myers Squibb Company | Flashmelt oral dosage formulation |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| IE45770B1 (en) * | 1976-10-06 | 1982-11-17 | Wyeth John & Brother Ltd | Pharmaceutical dosage forms |
| CH637014A5 (de) * | 1978-09-29 | 1983-07-15 | Sandoz Ag | Verfahren zur herstellung von suppositorien. |
| HU179442B (en) * | 1978-10-30 | 1982-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process and equipment for preparing tablets |
| DE2925009A1 (de) * | 1979-06-21 | 1981-01-08 | Basf Ag | Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung |
| US4357312A (en) * | 1981-07-16 | 1982-11-02 | The Children's Hospital Medical Center | Method of making prolonged release body |
| GB8624628D0 (en) * | 1986-10-14 | 1986-11-19 | Scras | Soluble/splitable tablets |
| US5510115A (en) * | 1987-11-16 | 1996-04-23 | Baxter Travenol Laboratories, Inc. | Method and composition for administration of beneficial agent by controlled dissolution |
| US5030203A (en) * | 1987-11-16 | 1991-07-09 | Baxter International Inc. | Ampule for controlled administration of beneficial agent |
| AU620253B2 (en) * | 1989-05-01 | 1992-02-13 | Alkermes Controlled Therapeutics, Inc. | Process for producing small particles of biologically active molecules |
| EP0617613B1 (en) * | 1991-12-20 | 1996-05-29 | Pfizer Inc. | Porous shaped delivery devices and method of producing thereof |
| DK0620728T3 (da) * | 1992-01-13 | 1997-07-07 | Pfizer | Fremstilling af tabletter med forøget styrke |
| DE69331839T2 (de) * | 1992-01-29 | 2002-12-12 | Takeda Chemical Industries, Ltd. | Schnellösliche Tablette und ihre Herstellung |
| HUT75616A (en) * | 1992-03-17 | 1997-05-28 | Pfizer | Method for prooucing porous delivery devices |
| US5593824A (en) * | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| US5565318A (en) * | 1994-09-02 | 1996-10-15 | Pharmacia Biotech, Inc. | Room temperature stable reagent semi-spheres |
| US20040023948A1 (en) * | 1997-03-24 | 2004-02-05 | Green Richard David | Fast-dispersing dosage form containing 5-HT1 agonists |
| GB2328154B (en) * | 1997-09-03 | 1999-06-23 | Asoka Malinga Ratwatte Hiran | A method of tabletting comprising forming a mixture, containing active agent & free-flowing ice particles, into a tablet & removing the ice from the tablet |
| US20040265377A1 (en) * | 1997-10-27 | 2004-12-30 | Harry Seager | Solid dispersing vaccine composition for oral delivery |
| GB9908014D0 (en) | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| KR20010107754A (ko) * | 2000-05-26 | 2001-12-07 | 민경윤 | 경구투여용 속용정의 제조 방법 |
| GB0028709D0 (en) * | 2000-11-24 | 2001-01-10 | S P A | Process |
| US6544552B2 (en) | 2001-01-11 | 2003-04-08 | Particle And Coating Technologies, Inc. | Method of producing porous tablets with improved dissolution properties |
| KR20030074810A (ko) * | 2001-02-08 | 2003-09-19 | 파마시아 코포레이션 | 성 기능장애의 치료를 위한 신속-발현 약 |
| US6509040B1 (en) | 2001-06-22 | 2003-01-21 | R.P. Scherer Corporation | Fast dispersing dosage forms essentially free of mammalian gelatin |
| WO2003026610A2 (en) * | 2001-09-25 | 2003-04-03 | Ranbaxy Laboratories Limited | Process for the preparation of fast dissolving dosage form |
| TWI324074B (en) * | 2001-10-09 | 2010-05-01 | Bristol Myers Squibb Co | Flashmelt oral dosage formulation |
| WO2004000262A1 (ja) * | 2002-06-20 | 2003-12-31 | Kansai Koso Co., Ltd. | 有形物含有固体入浴剤の製造法及び加湿・冷却装置 |
| US20040001885A1 (en) * | 2002-06-27 | 2004-01-01 | Unchalee Kositprapa | Rapidly disintegrating antihistamine formulation |
| EP1545521A2 (en) * | 2002-10-04 | 2005-06-29 | Pharmacia Corporation | Compositions and methods for treating sexual dysfunction |
| WO2004041244A2 (en) * | 2002-10-30 | 2004-05-21 | Pharmacia Corporation | Oral extended release tablets and methods of making and using the same |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| US20070248666A1 (en) * | 2004-06-30 | 2007-10-25 | Rijkers Marinus Petrus W M | Granules Comprising a Beta-Lactam Antibiotic |
| GB0516604D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Rapidly dispersing/disintegrating compositions |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| WO2009002084A2 (en) * | 2007-06-27 | 2008-12-31 | Hanmi Pharm. Co., Ltd. | Method for preparing rapidly disintegrating formulation for oral administration and apparatus for preparing and packing the same |
| WO2011086194A1 (en) * | 2010-01-18 | 2011-07-21 | Cephalon France | Improved oral lysophilisates containing pvp/va |
| RU2013127593A (ru) | 2010-12-02 | 2015-01-10 | Апталис Фарматек, Инк. | Быстродиспергирующиеся гранулы, перорально распадающиеся таблетки и способы |
| TWI438011B (zh) * | 2011-03-04 | 2014-05-21 | Kureha Corp | 錠劑型之經口投與用組合物及其製造方法 |
| US8192659B1 (en) | 2011-09-12 | 2012-06-05 | On Demand Therapeutics, Inc. | Methods of making microtablets for drug delivery |
| PL2719373T3 (pl) | 2012-10-12 | 2017-10-31 | Omya Int Ag | Preparat szybko rozpadającej się stałej postaci dawkowanej zawierający funkcjonalizowany węglan wapnia i sposób ich wytwarzania |
| CN110822822B (zh) | 2014-06-09 | 2021-08-24 | 泰尔茂比司特公司 | 冻干法 |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | 凍結乾燥方法 |
| US11609042B2 (en) | 2019-03-14 | 2023-03-21 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2877159A (en) * | 1957-04-26 | 1959-03-10 | Ciba Pharm Prod Inc | Method for preparing tablet granulations |
| US3607753A (en) * | 1967-11-16 | 1971-09-21 | Us Army | Method of making lithium ferrite powders |
| US3812224A (en) * | 1969-05-05 | 1974-05-21 | Polysar Ltd | Process for the production of porous polymeric materials |
| US3789119A (en) * | 1971-06-01 | 1974-01-29 | Parke Davis & Co | Stabilized molded sublingual nitroglycerin tablets |
| DE2246013A1 (de) * | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
-
1975
- 1975-12-16 DE DE2556561A patent/DE2556561C2/de not_active Expired
-
1976
- 1976-12-03 US US05/747,263 patent/US4134943A/en not_active Expired - Lifetime
- 1976-12-13 GB GB51908/76A patent/GB1502580A/en not_active Expired
- 1976-12-13 IT IT30363/76A patent/IT1124797B/it active
- 1976-12-13 SE SE7613971A patent/SE423967B/xx not_active IP Right Cessation
- 1976-12-13 NL NL7613818A patent/NL7613818A/xx not_active Application Discontinuation
- 1976-12-13 SU SU762427754A patent/SU719480A3/ru active
- 1976-12-13 CH CH1564776A patent/CH609563A5/xx not_active IP Right Cessation
- 1976-12-15 FR FR7637711A patent/FR2335205A2/fr active Granted
- 1976-12-15 IE IE2744/76A patent/IE44571B1/en unknown
- 1976-12-15 JP JP51150709A patent/JPS5276420A/ja active Pending
- 1976-12-15 BE BE173288A patent/BE849438A/xx not_active IP Right Cessation
- 1976-12-15 AT AT927076A patent/AT348133B/de not_active IP Right Cessation
-
1981
- 1981-02-16 JP JP56020250A patent/JPS5824410B2/ja not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2216319C1 (ru) * | 1999-11-30 | 2003-11-20 | Панацея Биотек Лимитед | Быстрорастворимая фармацевтическая композиция в виде твердой лекарственной формы с пролонгированным сладким вкусом и способ ее получения |
| US8518421B2 (en) | 2000-04-12 | 2013-08-27 | Bristol-Myers Squibb Company | Flashmelt oral dosage formulation |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1124797B (it) | 1986-05-14 |
| IE44571L (en) | 1977-06-16 |
| SE7613971L (sv) | 1977-06-17 |
| JPS56120617A (en) | 1981-09-22 |
| GB1502580A (en) | 1978-03-01 |
| FR2335205B1 (enExample) | 1981-05-29 |
| SE423967B (sv) | 1982-06-21 |
| BE849438A (fr) | 1977-06-15 |
| IE44571B1 (en) | 1982-01-13 |
| DE2556561C2 (de) | 1983-04-14 |
| CH609563A5 (enExample) | 1979-03-15 |
| US4134943A (en) | 1979-01-16 |
| ATA927076A (de) | 1978-06-15 |
| NL7613818A (nl) | 1977-06-20 |
| FR2335205A2 (fr) | 1977-07-15 |
| JPS5276420A (en) | 1977-06-27 |
| DE2556561A1 (de) | 1977-06-30 |
| AT348133B (de) | 1979-01-25 |
| JPS5824410B2 (ja) | 1983-05-20 |
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