SU677664A3 - Способ получени стабильных растворов производных алкалоидов спорыньи или их солей - Google Patents
Способ получени стабильных растворов производных алкалоидов спорыньи или их солейInfo
- Publication number
- SU677664A3 SU677664A3 SU762362650A SU2362650A SU677664A3 SU 677664 A3 SU677664 A3 SU 677664A3 SU 762362650 A SU762362650 A SU 762362650A SU 2362650 A SU2362650 A SU 2362650A SU 677664 A3 SU677664 A3 SU 677664A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solution
- mixture
- salts
- alkaloids
- ergot
- Prior art date
Links
- 150000003797 alkaloid derivatives Chemical class 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 4
- 150000003839 salts Chemical class 0.000 title claims 3
- 239000000203 mixture Substances 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 229960004290 dihydroergocornine Drugs 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- SEALOBQTUQIVGU-QNIJNHAOSA-N dihydroergocornine Chemical compound C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1 SEALOBQTUQIVGU-QNIJNHAOSA-N 0.000 claims description 8
- PBUNVLRHZGSROC-VTIMJTGVSA-N dihydro-alpha-ergocryptine Chemical compound C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1 PBUNVLRHZGSROC-VTIMJTGVSA-N 0.000 claims description 7
- LIMAOLZSWRJOMG-HJPBWRTMSA-N dihydroergocristine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C(C)C)C1=CC=CC=C1 LIMAOLZSWRJOMG-HJPBWRTMSA-N 0.000 claims description 7
- 229960004318 dihydroergocristine Drugs 0.000 claims description 7
- 229960002032 dihydroergocryptine Drugs 0.000 claims description 7
- 229960004704 dihydroergotamine Drugs 0.000 claims description 3
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 claims description 2
- 229930013930 alkaloid Natural products 0.000 claims 3
- 229960003133 ergot alkaloid Drugs 0.000 claims 3
- 239000011261 inert gas Substances 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
- 238000001914 filtration Methods 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 238000007664 blowing Methods 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- -1 dihydroergocornine methanesulfonates Chemical class 0.000 description 1
- ADYPXRFPBQGGAH-UMYZUSPBSA-N dihydroergotamine mesylate Chemical compound CS(O)(=O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C)C1=CC=CC=C1 ADYPXRFPBQGGAH-UMYZUSPBSA-N 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2524184 | 1975-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU677664A3 true SU677664A3 (ru) | 1979-07-30 |
Family
ID=5947910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762362650A SU677664A3 (ru) | 1975-05-31 | 1976-05-31 | Способ получени стабильных растворов производных алкалоидов спорыньи или их солей |
| SU762362650D SU952106A3 (ru) | 1975-05-31 | 1976-05-31 | Способ получени стабильных растворов, производных алкалоидов спорыньи или их солей |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762362650D SU952106A3 (ru) | 1975-05-31 | 1976-05-31 | Способ получени стабильных растворов, производных алкалоидов спорыньи или их солей |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS585167B2 (enExample) |
| AT (1) | AT355725B (enExample) |
| AU (1) | AU508625B2 (enExample) |
| BE (1) | BE842348A (enExample) |
| CA (1) | CA1069438A (enExample) |
| CS (1) | CS205023B2 (enExample) |
| DD (1) | DD125597A5 (enExample) |
| DK (1) | DK154606C (enExample) |
| ES (1) | ES448372A1 (enExample) |
| FI (1) | FI761461A7 (enExample) |
| FR (1) | FR2313059A1 (enExample) |
| GB (1) | GB1539083A (enExample) |
| GR (1) | GR60264B (enExample) |
| HK (1) | HK15383A (enExample) |
| HU (1) | HU171514B (enExample) |
| IE (1) | IE42999B1 (enExample) |
| IL (1) | IL49668A (enExample) |
| MY (1) | MY8300013A (enExample) |
| NL (1) | NL172616C (enExample) |
| NO (1) | NO145262C (enExample) |
| NZ (1) | NZ180984A (enExample) |
| PT (1) | PT65151B (enExample) |
| SE (1) | SE426782B (enExample) |
| SU (2) | SU677664A3 (enExample) |
| YU (1) | YU133076A (enExample) |
| ZA (1) | ZA763138B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2935515A1 (de) * | 1979-09-03 | 1981-03-19 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Arzneipraeparat |
| FR2483235A1 (fr) * | 1980-05-28 | 1981-12-04 | Fabre Sa Pierre | Compositions a usage topique contenant des alcaloides de l'ergot de seigle et de vinca rosea destinees au traitement des hyperseborrhees |
| DE3227122A1 (de) * | 1982-07-20 | 1984-01-26 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Stabile loesungen von mutterkornalkaloiden |
| HU192050B (en) * | 1983-04-22 | 1987-05-28 | Sandoz Ag | Process for production of medical preparative containing co-dergocrin and one piridin-dicarbonic acid diesthertype calcium-antagonist |
| IT1200609B (it) * | 1985-04-04 | 1989-01-27 | Poli Ind Chimica Spa | Composizione farmaceutice per il trattamento delle turbe cerebrovascolari e del cervello anziano |
| AT381232B (de) * | 1985-05-13 | 1986-09-10 | Kwizda Fa F Johann | Verfahren zur herstellung stabiler fluessiger loesungen von ergolinderivaten |
| DE102007014947B4 (de) | 2007-03-23 | 2010-05-27 | Axxonis Pharma Ag | Stabilisierte wässrige Lösungen von Ergolinverbindungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD43402A (enExample) * | ||||
| US2033921A (en) * | 1931-08-28 | 1936-03-17 | Squibb & Sons Inc | Solution of ergot alkaloids |
| US1969382A (en) * | 1932-05-21 | 1934-08-07 | Squibb & Sons Inc | Preparation of a stable hydro-alcoholic extract of ergot |
-
1976
- 1976-05-24 DK DK228676A patent/DK154606C/da not_active IP Right Cessation
- 1976-05-24 NO NO761760A patent/NO145262C/no unknown
- 1976-05-24 FI FI761461A patent/FI761461A7/fi not_active Application Discontinuation
- 1976-05-24 SE SE7605841A patent/SE426782B/xx not_active IP Right Cessation
- 1976-05-25 FR FR7615744A patent/FR2313059A1/fr active Granted
- 1976-05-26 ZA ZA00763138A patent/ZA763138B/xx unknown
- 1976-05-26 GB GB21809/76A patent/GB1539083A/en not_active Expired
- 1976-05-27 IL IL49668A patent/IL49668A/xx unknown
- 1976-05-28 BE BE167442A patent/BE842348A/xx not_active IP Right Cessation
- 1976-05-28 IE IE1138/76A patent/IE42999B1/en unknown
- 1976-05-28 AU AU14422/76A patent/AU508625B2/en not_active Expired
- 1976-05-28 NL NLAANVRAGE7605745,A patent/NL172616C/xx not_active IP Right Cessation
- 1976-05-28 CA CA253,612A patent/CA1069438A/en not_active Expired
- 1976-05-28 AT AT390476A patent/AT355725B/de not_active IP Right Cessation
- 1976-05-28 PT PT65151A patent/PT65151B/pt unknown
- 1976-05-28 NZ NZ180984A patent/NZ180984A/xx unknown
- 1976-05-28 JP JP51062848A patent/JPS585167B2/ja not_active Expired
- 1976-05-28 DD DD193077A patent/DD125597A5/xx unknown
- 1976-05-29 ES ES448372A patent/ES448372A1/es not_active Expired
- 1976-05-29 GR GR50841A patent/GR60264B/el unknown
- 1976-05-31 HU HU76SA00002923A patent/HU171514B/hu not_active IP Right Cessation
- 1976-05-31 CS CS763620A patent/CS205023B2/cs unknown
- 1976-05-31 YU YU01330/76A patent/YU133076A/xx unknown
- 1976-05-31 SU SU762362650A patent/SU677664A3/ru active
- 1976-05-31 SU SU762362650D patent/SU952106A3/ru active
-
1983
- 1983-05-12 HK HK153/83A patent/HK15383A/xx unknown
- 1983-12-30 MY MY13/83A patent/MY8300013A/xx unknown
Also Published As
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