SU604489A3 - Способ получени замещенных 2-карбалкоксиаминобензимидазолов или их солей - Google Patents
Способ получени замещенных 2-карбалкоксиаминобензимидазолов или их солейInfo
- Publication number
- SU604489A3 SU604489A3 SU762373708A SU2373708A SU604489A3 SU 604489 A3 SU604489 A3 SU 604489A3 SU 762373708 A SU762373708 A SU 762373708A SU 2373708 A SU2373708 A SU 2373708A SU 604489 A3 SU604489 A3 SU 604489A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- carbalkoxyaminobenzimidazoles
- salts
- preparing substituted
- substituted
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ 2 -КАРБАЛКОКСИАМИНОБЕНЗИМИДАЗОЛОВ ИЛИ ИХ СОЛЕЙ
Изобретение относитс к способу получени новых соединений, конкретно к способу получени замещенных 2-карбалкоксиаминобензимидазолов формулы хЧО Ы-Y-0 с -NHCQOR, где РЗ - алкильный радикал Ci -€4; X - атом кислорода, атом, серы или группа С-0; У - неразветвленна или разветвленна апкильна группа Cj -€4; RI и Rj - алкил , причем оба радикала RI и RI вместе с атомом азота могут означать так № пирролидиновое, пиперидиновое, морфолиновое или тиоморфолиновое кольцо, или их солей, обладающим биологической активностью . Известен способ образовани бензимида:юльно го цикла из О-фенилендиаминов или замещенных О-феш-шендиамкнОв и кислот или их производных 1J. Цель изобретени - синтез соединений, обдалающих биологической активностью. Это достигаетс предаагаемым способом, основанным на известной реакции образовани бензимидазольного цикла, заключающимс Ъо взаимодействии производного ортофеиапендиаминаформулы i/-V z где RI, Rj, X и У имеют указанные значени , подвергают взаимодействию со сложным зфиром б«с-алкил- или бис- арилтиометиленаминомуравьиной кислоты формулы d N- 3-OR,, где РЗ имеет вышеуказанные значени , R4 и RS - одинаковые или разные и означают водород и метил, в инертном растворителе, при 60-100° С, с выделением целевого прюдукта в свободном виде или в виде соли. Пример 1. 17,8 г метилового эфира бисметилтиометилена .миномуравьиной кислоты и 32,7 г
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2443297A DE2443297A1 (de) | 1974-09-10 | 1974-09-10 | Anthelminthisch wirksame basisch substituierte 2-carbalkoxy-amino-benzimidazolyl-5(6)-phenylaether und -ketone sowie verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU604489A3 true SU604489A3 (ru) | 1978-04-25 |
Family
ID=5925336
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7502169464A SU576932A3 (ru) | 1974-09-10 | 1975-09-09 | Способ получени замещенных 2-карбалкоксиаминобензимидазолов |
| SU762373708A SU604489A3 (ru) | 1974-09-10 | 1976-06-21 | Способ получени замещенных 2-карбалкоксиаминобензимидазолов или их солей |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7502169464A SU576932A3 (ru) | 1974-09-10 | 1975-09-09 | Способ получени замещенных 2-карбалкоксиаминобензимидазолов |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4010272A (ru) |
| JP (1) | JPS51125079A (ru) |
| AT (1) | AT347936B (ru) |
| AU (1) | AU497922B2 (ru) |
| BE (1) | BE833272A (ru) |
| BG (3) | BG24671A3 (ru) |
| CA (1) | CA1054598A (ru) |
| CS (1) | CS197255B2 (ru) |
| DD (1) | DD123337A5 (ru) |
| DE (1) | DE2443297A1 (ru) |
| DK (1) | DK136646C (ru) |
| ES (1) | ES440713A1 (ru) |
| FI (1) | FI752513A (ru) |
| FR (1) | FR2284324A1 (ru) |
| GB (1) | GB1484658A (ru) |
| HU (1) | HU172145B (ru) |
| IE (1) | IE41680B1 (ru) |
| IL (1) | IL48067A (ru) |
| IT (1) | IT1048487B (ru) |
| LU (1) | LU73345A1 (ru) |
| NL (1) | NL7510490A (ru) |
| NO (1) | NO140593C (ru) |
| SE (1) | SE7510045L (ru) |
| SU (2) | SU576932A3 (ru) |
| ZA (1) | ZA755742B (ru) |
| ZM (1) | ZM13475A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323707A (en) * | 1975-10-28 | 1982-04-06 | Eli Lilly And Company | Antifertility compounds |
| US4152522A (en) * | 1978-01-03 | 1979-05-01 | Ethyl Corporation | Process for the preparation of 2-benzimidazole carbamates |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6506876B1 (en) * | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| CN110845345B (zh) * | 2019-11-26 | 2021-11-09 | 中国科学院长春应用化学研究所 | 一种芳香型二胺单体及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2048150A5 (en) * | 1969-06-02 | 1971-03-19 | Aries Robert | Carbamate derivs of benzimidazole |
| US3657267A (en) * | 1969-06-20 | 1972-04-18 | Janssen Pharmaceutica Nv | Benzimidazole carbamates |
| FR2071334A5 (en) * | 1969-12-24 | 1971-09-17 | Aries Robert | 1-morpholino alkyl carbamoyl n-2-benzimidazolyl carbamic esters - - antifungals, anthelmintics insecticides nematocides |
| DE2230182A1 (de) * | 1972-06-21 | 1974-01-31 | Hoechst Ag | Neue benzimidazole |
| DE2348104A1 (de) * | 1973-09-25 | 1975-04-03 | Hoechst Ag | Anthelmintisch wirksame 2-carbalkoxyamino-benzimidazolyl-5(6)-amino-phenylaether und verfahren zu ihrer herstellung |
-
1974
- 1974-09-10 DE DE2443297A patent/DE2443297A1/de active Pending
-
1975
- 1975-09-04 ES ES440713A patent/ES440713A1/es not_active Expired
- 1975-09-05 BG BG031730A patent/BG24671A3/xx unknown
- 1975-09-05 BG BG031729A patent/BG24670A3/xx unknown
- 1975-09-05 CS CS756069A patent/CS197255B2/cs unknown
- 1975-09-05 BG BG030926A patent/BG26375A3/xx unknown
- 1975-09-05 NL NL7510490A patent/NL7510490A/xx not_active Application Discontinuation
- 1975-09-08 ZM ZM134/75A patent/ZM13475A1/xx unknown
- 1975-09-08 DD DD188241A patent/DD123337A5/xx unknown
- 1975-09-08 FI FI752513A patent/FI752513A/fi not_active Application Discontinuation
- 1975-09-08 IT IT27010/75A patent/IT1048487B/it active
- 1975-09-08 IL IL48067A patent/IL48067A/xx unknown
- 1975-09-08 LU LU73345A patent/LU73345A1/xx unknown
- 1975-09-08 US US05/611,325 patent/US4010272A/en not_active Expired - Lifetime
- 1975-09-08 AU AU84628/75A patent/AU497922B2/en not_active Expired
- 1975-09-09 FR FR7527554A patent/FR2284324A1/fr not_active Withdrawn
- 1975-09-09 AT AT696275A patent/AT347936B/de not_active IP Right Cessation
- 1975-09-09 HU HU75HO00001834A patent/HU172145B/hu unknown
- 1975-09-09 GB GB37026/75A patent/GB1484658A/en not_active Expired
- 1975-09-09 SU SU7502169464A patent/SU576932A3/ru active
- 1975-09-09 IE IE1965/75A patent/IE41680B1/en unknown
- 1975-09-09 DK DK402675A patent/DK136646C/da active
- 1975-09-09 ZA ZA00755742A patent/ZA755742B/xx unknown
- 1975-09-09 CA CA235114A patent/CA1054598A/en not_active Expired
- 1975-09-09 SE SE7510045A patent/SE7510045L/xx unknown
- 1975-09-09 NO NO753083A patent/NO140593C/no unknown
- 1975-09-10 BE BE159915A patent/BE833272A/xx unknown
- 1975-09-10 JP JP50109072A patent/JPS51125079A/ja active Pending
-
1976
- 1976-06-21 SU SU762373708A patent/SU604489A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| BG24670A3 (en) | 1978-04-12 |
| IT1048487B (it) | 1980-11-20 |
| FR2284324A1 (fr) | 1976-04-09 |
| AU8462875A (en) | 1977-03-17 |
| IL48067A0 (en) | 1975-11-25 |
| NO140593C (no) | 1979-10-03 |
| AT347936B (de) | 1979-01-25 |
| FI752513A (ru) | 1976-03-11 |
| SU576932A3 (ru) | 1977-10-15 |
| BG24671A3 (en) | 1978-04-12 |
| IL48067A (en) | 1978-08-31 |
| LU73345A1 (ru) | 1977-05-11 |
| CA1054598A (en) | 1979-05-15 |
| BE833272A (fr) | 1976-03-10 |
| DK136646C (da) | 1978-04-17 |
| ZA755742B (en) | 1976-09-29 |
| JPS51125079A (en) | 1976-11-01 |
| NO753083L (ru) | 1976-03-11 |
| GB1484658A (en) | 1977-09-01 |
| BG26375A3 (bg) | 1979-03-15 |
| SE7510045L (sv) | 1976-03-11 |
| NO140593B (no) | 1979-06-25 |
| DE2443297A1 (de) | 1976-03-18 |
| CS197255B2 (en) | 1980-04-30 |
| DK402675A (da) | 1976-03-11 |
| IE41680B1 (en) | 1980-02-27 |
| ATA696275A (de) | 1978-06-15 |
| IE41680L (en) | 1976-03-10 |
| ZM13475A1 (en) | 1976-12-21 |
| DD123337A5 (ru) | 1976-12-12 |
| NL7510490A (nl) | 1976-03-12 |
| HU172145B (hu) | 1978-06-28 |
| AU497922B2 (en) | 1979-01-25 |
| ES440713A1 (es) | 1977-03-16 |
| US4010272A (en) | 1977-03-01 |
| DK136646B (da) | 1977-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1466839A (en) | Substituted phenylguanidines a process for their preparation and their use as medicaments | |
| PT65019B (de) | Phenylalkancarbonsaure-derivate und verfahren zu ihrer herstellung | |
| SU604489A3 (ru) | Способ получени замещенных 2-карбалкоксиаминобензимидазолов или их солей | |
| GB1434323A (en) | N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation | |
| ES426586A1 (es) | Procedimiento de fabricacion de nuevos derivados. | |
| ES429959A1 (es) | Procedimiento para la preparacion de nuevos compuestos analogos de acidos prostanoicos, no presentes en la naturaleza | |
| GB1377352A (en) | 2-trifluoromethylimino derivatives of heterocyclic compounds with five-membered rings a process for their production and their use as fungicides insecticides or acaricides | |
| JPS54128591A (en) | Cephalosporin analog | |
| ES485361A1 (es) | Procedimiento para preparar derivados de pirrolidina | |
| ES449817A1 (es) | Procedimiento para producir 2-fenilamino-tiazolinas susti- tuidas. | |
| GB1436502A (en) | Amide derivatives of 3-benzoylphenyl-alkanoic acids | |
| ES454267A1 (es) | Un procedimiento para la produccion de un nuevo derivado de aminoacidos. | |
| ES440398A1 (es) | Procedimiento para la preparacion de triazapentadienos. | |
| US3308132A (en) | 6, 8-dithiooctanoyl amides and intermediates | |
| ES440270A1 (es) | Procedimiento para preparar imidas de esteres de acidos n- (aminometiliden)-tiolfosforicos y tionofosforicos. | |
| SE7611953L (sv) | Forfarande for framstellning av aroyl-fenyl-naftalenderivat anvendbara sasom antifertilitets- och antitumormedel | |
| SU659091A3 (ru) | Способ получени производных 5-нитроимидазола | |
| IE42039L (en) | Cycloalkanothiophenes | |
| SU694012A1 (ru) | Производные -нитроалкановых кислот в качестве полупродуктовпОлНОгО СиНТЕзА пРОСТАглАНдиНОВ и иХ АНАлОгОВ | |
| US2806852A (en) | Process fgh preparing j-pyridinols | |
| SU743580A3 (ru) | Способ получени 2-аминоциклопент-1-ен -1-тиокарбонилдисульфидов | |
| GB1452724A (en) | O-triazolyl-thiono-phosphoric-phosphonic phosphinic-acid esters and ester-amides process for their preparation and their use as insecticides acaricides or nematocides | |
| TH2335B (th) | อนุพันธ์ของ1,3-ออกซาโซลิดีน -2-โอนและกระบวนการสำหรับเตรียมสารเหล่านี้ | |
| SU525686A1 (ru) | Способ получени производных 2,4диоксо-1,2,3,4-тетрагидропиридо (2,3- )пиримидина | |
| SU437764A1 (ru) | Способ получени 5 (4)-тиопроизводных имидазола |