SU493959A3 - Способ получени 1,2-бигуанидов - Google Patents
Способ получени 1,2-бигуанидовInfo
- Publication number
- SU493959A3 SU493959A3 SU1907668A SU1907668A SU493959A3 SU 493959 A3 SU493959 A3 SU 493959A3 SU 1907668 A SU1907668 A SU 1907668A SU 1907668 A SU1907668 A SU 1907668A SU 493959 A3 SU493959 A3 SU 493959A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nitrate
- acetonitrile
- methyl
- hydrochloride
- ethyl
- Prior art date
Links
- 229940123208 Biguanide Drugs 0.000 title description 5
- 238000004519 manufacturing process Methods 0.000 title description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 66
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- 229910002651 NO3 Inorganic materials 0.000 description 8
- -1 1,2-diisopropylbiguanide bromohydrate Chemical compound 0.000 description 7
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 6
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 229930195734 saturated hydrocarbon Natural products 0.000 description 3
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 3
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 2
- FNMJZTGQHUXSHY-UHFFFAOYSA-N 1-(diaminomethylidene)-3-ethyl-2-methylguanidine;nitric acid Chemical compound O[N+]([O-])=O.CCNC(=NC)N=C(N)N FNMJZTGQHUXSHY-UHFFFAOYSA-N 0.000 description 2
- UAJWDGACDQVTAI-UHFFFAOYSA-N 1-(diaminomethylidene)-3-ethyl-2-pentylguanidine;hydrochloride Chemical compound Cl.CCCCCN=C(NCC)N=C(N)N UAJWDGACDQVTAI-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- VSMCRKMWTXMDRF-UHFFFAOYSA-N 1,1-dibutyl-3-(diaminomethylidene)-2-methylguanidine;nitric acid Chemical compound O[N+]([O-])=O.CCCCN(CCCC)C(NC(N)=N)=NC VSMCRKMWTXMDRF-UHFFFAOYSA-N 0.000 description 1
- BWBKOTRFVFLABK-UHFFFAOYSA-N 1,2-dibutyl-3-(diaminomethylidene)guanidine;hydrochloride Chemical compound Cl.CCCCNC(NC(N)=N)=NCCCC BWBKOTRFVFLABK-UHFFFAOYSA-N 0.000 description 1
- LJGATPJRVGFZNA-UHFFFAOYSA-N 1-(diaminomethylidene)-2-methyl-3-(2-methylbutyl)guanidine;nitric acid Chemical compound O[N+]([O-])=O.CCC(C)CN=C(NC)NC(N)=N LJGATPJRVGFZNA-UHFFFAOYSA-N 0.000 description 1
- BVRAQWLCQBWZOE-UHFFFAOYSA-N 1-(diaminomethylidene)-2-methyl-3-propylguanidine;hydrochloride Chemical compound Cl.CCCNC(=NC)N=C(N)N BVRAQWLCQBWZOE-UHFFFAOYSA-N 0.000 description 1
- JQNCYDBXNOSNKM-UHFFFAOYSA-N 1-(diaminomethylidene)-3-ethyl-2-(2-methoxyethyl)guanidine;hydrochloride Chemical compound Cl.CCNC(N=C(N)N)=NCCOC JQNCYDBXNOSNKM-UHFFFAOYSA-N 0.000 description 1
- AQMOSMBZXGPTME-UHFFFAOYSA-N 1-(diaminomethylidene)-3-ethyl-2-(3-methoxypropyl)guanidine;hydrochloride Chemical compound Cl.CCNC(N=C(N)N)=NCCCOC AQMOSMBZXGPTME-UHFFFAOYSA-N 0.000 description 1
- LLOOCEDSSBQBON-UHFFFAOYSA-N 1-(diaminomethylidene)-3-ethyl-2-heptylguanidine;hydrochloride Chemical compound Cl.CCCCCCCN=C(NCC)N=C(N)N LLOOCEDSSBQBON-UHFFFAOYSA-N 0.000 description 1
- JJEDMQKJOVKGSX-UHFFFAOYSA-N 1-(diaminomethylidene)-3-ethyl-2-hexylguanidine;hydrochloride Chemical compound Cl.CCCCCCN=C(NCC)N=C(N)N JJEDMQKJOVKGSX-UHFFFAOYSA-N 0.000 description 1
- DXMHLHCOCQTHEF-UHFFFAOYSA-N 1-(diaminomethylidene)-3-heptyl-2-methylguanidine;hydrochloride Chemical compound Cl.CCCCCCCNC(=NC)N=C(N)N DXMHLHCOCQTHEF-UHFFFAOYSA-N 0.000 description 1
- VBWLMIYYNSQZBZ-UHFFFAOYSA-N 1-(diaminomethylidene)-3-hexyl-2-methylguanidine;hydrochloride Chemical compound Cl.CCCCCCNC(=NC)N=C(N)N VBWLMIYYNSQZBZ-UHFFFAOYSA-N 0.000 description 1
- PCAUSEZGTJUFRH-UHFFFAOYSA-N 1-cyano-3-ethyl-2-methylguanidine Chemical compound CCN=C(NC)NC#N PCAUSEZGTJUFRH-UHFFFAOYSA-N 0.000 description 1
- CRQCUCJQWVEPNV-UHFFFAOYSA-N 1-cyclopropyl-3-(diaminomethylidene)-2-methylguanidine;hydrochloride Chemical compound Cl.NC(N)=NC(=NC)NC1CC1 CRQCUCJQWVEPNV-UHFFFAOYSA-N 0.000 description 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- KGKMETLQCMSQNT-UHFFFAOYSA-N 2-butyl-1-(diaminomethylidene)-3-ethylguanidine;hydrochloride Chemical compound Cl.CCCCN=C(NCC)N=C(N)N KGKMETLQCMSQNT-UHFFFAOYSA-N 0.000 description 1
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
- GDRQZRNRJFTTLA-UHFFFAOYSA-N 3-(diaminomethylidene)-1,1,2-triethylguanidine;nitric acid Chemical compound O[N+]([O-])=O.CCN=C(NC(N)=N)N(CC)CC GDRQZRNRJFTTLA-UHFFFAOYSA-N 0.000 description 1
- ZOVRUQSBAMPRHW-UHFFFAOYSA-N 3-(diaminomethylidene)-1,2-dimethyl-1-phenylguanidine;nitric acid Chemical compound O[N+]([O-])=O.NC(=N)NC(=NC)N(C)C1=CC=CC=C1 ZOVRUQSBAMPRHW-UHFFFAOYSA-N 0.000 description 1
- NMMFFCOAYIITAN-UHFFFAOYSA-N 3-(diaminomethylidene)-2-ethyl-1-methyl-1-propan-2-ylguanidine;nitric acid Chemical compound O[N+]([O-])=O.CCN=C(NC(N)=N)N(C)C(C)C NMMFFCOAYIITAN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GANYMSDHMBJFIL-UHFFFAOYSA-N acetonitrile;ethoxyethane Chemical compound CC#N.CCOCC GANYMSDHMBJFIL-UHFFFAOYSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229960004111 buformin Drugs 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 229910052736 halogen Chemical group 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C1/00—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
- A61C1/02—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools
- A61C1/05—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools with turbine drive
- A61C1/057—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools with turbine drive with means for preventing suction effect in turbine after deactivation of the drive air
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712117015 DE2117015A1 (de) | 1971-04-02 | 1971-04-02 | 1,2-Biguanide |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1767915A Division SU535903A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанидов |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU493959A3 true SU493959A3 (ru) | 1975-11-28 |
Family
ID=5804148
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1907668A SU493959A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени 1,2-бигуанидов |
| SU1907667A SU472501A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
| SU1767915A SU535903A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанидов |
| SU1907665A SU465784A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1907667A SU472501A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
| SU1767915A SU535903A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанидов |
| SU1907665A SU465784A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
Country Status (19)
| Country | Link |
|---|---|
| AR (3) | AR194360A1 (OSRAM) |
| AT (4) | AT317240B (OSRAM) |
| AU (1) | AU468307B2 (OSRAM) |
| BE (1) | BE781590A (OSRAM) |
| CA (1) | CA988084A (OSRAM) |
| CH (1) | CH579534A5 (OSRAM) |
| CS (3) | CS161936B2 (OSRAM) |
| DD (1) | DD95228A5 (OSRAM) |
| DE (1) | DE2117015A1 (OSRAM) |
| DK (1) | DK129651B (OSRAM) |
| ES (1) | ES401124A1 (OSRAM) |
| FR (1) | FR2132396B1 (OSRAM) |
| GB (1) | GB1386130A (OSRAM) |
| HU (1) | HU162902B (OSRAM) |
| NL (1) | NL7204493A (OSRAM) |
| NO (1) | NO135418C (OSRAM) |
| SE (1) | SE377332B (OSRAM) |
| SU (4) | SU493959A3 (OSRAM) |
| ZA (1) | ZA722183B (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008007314A1 (de) | 2008-02-02 | 2009-08-06 | Merck Patent Gmbh | Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR940304A (fr) * | 1946-01-07 | 1948-12-09 | Ici Ltd | Procédé de fabrication de dérivés de biguanides |
-
1971
- 1971-04-02 DE DE19712117015 patent/DE2117015A1/de not_active Withdrawn
-
1972
- 1972-03-15 CS CS6963*A patent/CS161936B2/cs unknown
- 1972-03-15 CS CS1724A patent/CS161935B2/cs unknown
- 1972-03-15 CS CS6964*A patent/CS161937B2/cs unknown
- 1972-03-22 DK DK134572AA patent/DK129651B/da unknown
- 1972-03-23 ES ES401124A patent/ES401124A1/es not_active Expired
- 1972-03-27 CH CH454672A patent/CH579534A5/xx not_active IP Right Cessation
- 1972-03-27 GB GB1416272A patent/GB1386130A/en not_active Expired
- 1972-03-29 AR AR241248A patent/AR194360A1/es active
- 1972-03-29 NO NO1084/72A patent/NO135418C/no unknown
- 1972-03-29 SE SE7204127A patent/SE377332B/xx unknown
- 1972-03-30 AT AT00785/73A patent/AT317240B/de not_active IP Right Cessation
- 1972-03-30 AT AT279272A patent/AT313301B/de not_active IP Right Cessation
- 1972-03-30 AU AU40661/72A patent/AU468307B2/en not_active Expired
- 1972-03-30 AT AT00786/73A patent/AT321318B/de not_active IP Right Cessation
- 1972-03-30 ZA ZA722183A patent/ZA722183B/xx unknown
- 1972-03-30 AT AT00784/73A patent/AT317239B/de not_active IP Right Cessation
- 1972-03-30 DD DD161938A patent/DD95228A5/xx unknown
- 1972-03-30 HU HUSC383A patent/HU162902B/hu unknown
- 1972-03-31 BE BE781590A patent/BE781590A/xx unknown
- 1972-03-31 SU SU1907668A patent/SU493959A3/ru active
- 1972-03-31 SU SU1907667A patent/SU472501A3/ru active
- 1972-03-31 SU SU1767915A patent/SU535903A3/ru active
- 1972-03-31 SU SU1907665A patent/SU465784A3/ru active
- 1972-04-04 CA CA138,838A patent/CA988084A/en not_active Expired
- 1972-04-04 NL NL7204493A patent/NL7204493A/xx not_active Application Discontinuation
- 1972-04-04 FR FR7211727A patent/FR2132396B1/fr not_active Expired
- 1972-11-13 AR AR245079A patent/AR194285A1/es active
- 1972-11-13 AR AR245080A patent/AR192485A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| CS161935B2 (OSRAM) | 1975-06-10 |
| AR192485A1 (es) | 1973-02-21 |
| AT317239B (de) | 1974-08-26 |
| AT321318B (de) | 1975-03-25 |
| CA988084A (en) | 1976-04-27 |
| DK129651C (OSRAM) | 1975-04-07 |
| HU162902B (OSRAM) | 1973-04-28 |
| ES401124A1 (es) | 1975-02-16 |
| NO135418C (OSRAM) | 1977-04-05 |
| ZA722183B (en) | 1972-12-27 |
| SU472501A3 (ru) | 1975-05-30 |
| AU4066172A (en) | 1973-10-04 |
| FR2132396B1 (OSRAM) | 1975-10-10 |
| FR2132396A1 (OSRAM) | 1972-11-17 |
| CH579534A5 (OSRAM) | 1976-09-15 |
| AR194360A1 (es) | 1973-07-13 |
| SU465784A3 (ru) | 1975-03-30 |
| AT313301B (de) | 1974-02-11 |
| NL7204493A (OSRAM) | 1972-10-04 |
| AR194285A1 (es) | 1973-06-29 |
| GB1386130A (en) | 1975-03-05 |
| CS161936B2 (OSRAM) | 1975-06-10 |
| DE2117015A1 (de) | 1972-10-26 |
| SE377332B (OSRAM) | 1975-06-30 |
| AT317240B (de) | 1974-08-26 |
| DD95228A5 (OSRAM) | 1973-01-20 |
| DK129651B (da) | 1974-11-04 |
| CS161937B2 (OSRAM) | 1975-06-10 |
| SU535903A3 (ru) | 1976-11-15 |
| NO135418B (OSRAM) | 1976-12-27 |
| AU468307B2 (en) | 1973-10-04 |
| BE781590A (fr) | 1972-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Durant et al. | Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine | |
| SU1176834A3 (ru) | Способ получени производных мочевины | |
| RU2124008C1 (ru) | Производные пиразина и их кислотно-аддитивные соли | |
| EP0210574B1 (de) | N-Substituierte 5-Nitroanthranilsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen | |
| Ukrainets et al. | 4-Hydroxy-2-quinolones 144. Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido [1, 2-a] pyrimidine-3-carboxylic acid and their diuretic properties | |
| FI57414C (fi) | Foerfarande foer framstaellning av i 6-,7-,8- och/eller 9-staellning substituerade 4-(substituerad amino)-1,3-dimetyl-1h-pyrazolo(3,4b)kinoliner med antiviral verkan | |
| HU187478B (en) | Process for preparing new imidazolyl-phenyl-amidines and pharmaceutical compositions containing thereof | |
| CZ2015601A3 (cs) | Způsob výroby 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)močoviny a jejích deuterovaných analog neobsahujících dimerické nečistoty | |
| SU493959A3 (ru) | Способ получени 1,2-бигуанидов | |
| SU677655A3 (ru) | Способ получени -циклоалкилметил-2-фениламиноимидазолинов-2или их солей | |
| FI97294C (fi) | Menetelmä bis(3,5-dioksopiperatsinyyli)alkaanien tai -alkeenien valmistamiseksi | |
| US3935266A (en) | N-substituted guanidino acid derivatives | |
| EP0179408B1 (de) | Neue Amidoalkylmelamine und Aminoalkylmelamine und Verfahren zu ihrer Herstellung | |
| US3131218A (en) | N-amino guanidine derivatives | |
| JP2690749B2 (ja) | ベンズイミダゾール誘導体、その製造方法およびその医薬への応用 | |
| Molina et al. | Reactivity of 1, 3-diaryl-2, 4-bis (heteroarylimino)-1, 3-diazetidines. Formation of N1, N2, N3, N4, N5-pentasubstituted biguanides | |
| US3398155A (en) | 2, 6-dichloro-isonicotinamide derivatives and a method for their preparation | |
| US3449356A (en) | 2-((halophenoxy)methyl)-2-imidazolines | |
| US3843636A (en) | 1-(5-(p-methoxyphenyl)furfurylidene)amino)hydantoin | |
| US3299081A (en) | Chemical processes for preparing nu-substituted amidines | |
| DE2114884A1 (de) | Basisch substituierte Derivate des 1(2H)-Phthalazinons | |
| HU188074B (en) | Process for the preparation of cimetidin | |
| Speziale et al. | Pyranylation of Amides | |
| NAGASE | Studies on fungicides. XXV. Addition reaction of dithiocarbamates to fumaronitrile, bis (alkylthio) maleonitrile, 2, 3-dicyano-5, 6-dihydro-1, 4-dithiin and 4, 5-dicyano-2-oxo-1, 4-dithiole | |
| Shiba et al. | The Preparation and Properties of Mesoionic 5-Iminothiazole Derivatives |