SU472501A3 - Способ получени замещенных бигуанида - Google Patents
Способ получени замещенных бигуанидаInfo
- Publication number
- SU472501A3 SU472501A3 SU1907667A SU1907667A SU472501A3 SU 472501 A3 SU472501 A3 SU 472501A3 SU 1907667 A SU1907667 A SU 1907667A SU 1907667 A SU1907667 A SU 1907667A SU 472501 A3 SU472501 A3 SU 472501A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nitrate
- hydrochloride
- ethyl
- saturated
- methyl
- Prior art date
Links
- 229940123208 Biguanide Drugs 0.000 title description 2
- 150000004283 biguanides Chemical class 0.000 title description 2
- 238000004519 manufacturing process Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- 229910002651 NO3 Inorganic materials 0.000 description 14
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 229920006395 saturated elastomer Polymers 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 125000001183 hydrocarbyl group Chemical group 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- -1 isolropanol Chemical compound 0.000 description 5
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 125000001153 fluoro group Chemical group F* 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 229910052736 halogen Chemical group 0.000 description 3
- 150000002367 halogens Chemical group 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 229930195734 saturated hydrocarbon Natural products 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- MBXZPFLUPOKREA-UHFFFAOYSA-N 1-chloro-3-(diaminomethylidene)-1-phenylguanidine Chemical compound NC(N)=NC(=N)N(Cl)C1=CC=CC=C1 MBXZPFLUPOKREA-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 229940095674 pellet product Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C1/00—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
- A61C1/02—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools
- A61C1/05—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools with turbine drive
- A61C1/057—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools with turbine drive with means for preventing suction effect in turbine after deactivation of the drive air
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712117015 DE2117015A1 (de) | 1971-04-02 | 1971-04-02 | 1,2-Biguanide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU472501A3 true SU472501A3 (ru) | 1975-05-30 |
Family
ID=5804148
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1907667A SU472501A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
| SU1767915A SU535903A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанидов |
| SU1907668A SU493959A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени 1,2-бигуанидов |
| SU1907665A SU465784A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1767915A SU535903A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанидов |
| SU1907668A SU493959A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени 1,2-бигуанидов |
| SU1907665A SU465784A3 (ru) | 1971-04-02 | 1972-03-31 | Способ получени замещенных бигуанида |
Country Status (19)
| Country | Link |
|---|---|
| AR (3) | AR194360A1 (enExample) |
| AT (4) | AT317240B (enExample) |
| AU (1) | AU468307B2 (enExample) |
| BE (1) | BE781590A (enExample) |
| CA (1) | CA988084A (enExample) |
| CH (1) | CH579534A5 (enExample) |
| CS (3) | CS161936B2 (enExample) |
| DD (1) | DD95228A5 (enExample) |
| DE (1) | DE2117015A1 (enExample) |
| DK (1) | DK129651B (enExample) |
| ES (1) | ES401124A1 (enExample) |
| FR (1) | FR2132396B1 (enExample) |
| GB (1) | GB1386130A (enExample) |
| HU (1) | HU162902B (enExample) |
| NL (1) | NL7204493A (enExample) |
| NO (1) | NO135418C (enExample) |
| SE (1) | SE377332B (enExample) |
| SU (4) | SU472501A3 (enExample) |
| ZA (1) | ZA722183B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008007314A1 (de) | 2008-02-02 | 2009-08-06 | Merck Patent Gmbh | Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR940304A (fr) * | 1946-01-07 | 1948-12-09 | Ici Ltd | Procédé de fabrication de dérivés de biguanides |
-
1971
- 1971-04-02 DE DE19712117015 patent/DE2117015A1/de not_active Withdrawn
-
1972
- 1972-03-15 CS CS6963*A patent/CS161936B2/cs unknown
- 1972-03-15 CS CS6964*A patent/CS161937B2/cs unknown
- 1972-03-15 CS CS1724A patent/CS161935B2/cs unknown
- 1972-03-22 DK DK134572AA patent/DK129651B/da unknown
- 1972-03-23 ES ES401124A patent/ES401124A1/es not_active Expired
- 1972-03-27 CH CH454672A patent/CH579534A5/xx not_active IP Right Cessation
- 1972-03-27 GB GB1416272A patent/GB1386130A/en not_active Expired
- 1972-03-29 AR AR241248A patent/AR194360A1/es active
- 1972-03-29 SE SE7204127A patent/SE377332B/xx unknown
- 1972-03-29 NO NO1084/72A patent/NO135418C/no unknown
- 1972-03-30 ZA ZA722183A patent/ZA722183B/xx unknown
- 1972-03-30 AT AT00785/73A patent/AT317240B/de not_active IP Right Cessation
- 1972-03-30 AT AT00784/73A patent/AT317239B/de not_active IP Right Cessation
- 1972-03-30 AT AT00786/73A patent/AT321318B/de not_active IP Right Cessation
- 1972-03-30 AT AT279272A patent/AT313301B/de not_active IP Right Cessation
- 1972-03-30 DD DD161938A patent/DD95228A5/xx unknown
- 1972-03-30 AU AU40661/72A patent/AU468307B2/en not_active Expired
- 1972-03-30 HU HUSC383A patent/HU162902B/hu unknown
- 1972-03-31 BE BE781590A patent/BE781590A/xx unknown
- 1972-03-31 SU SU1907667A patent/SU472501A3/ru active
- 1972-03-31 SU SU1767915A patent/SU535903A3/ru active
- 1972-03-31 SU SU1907668A patent/SU493959A3/ru active
- 1972-03-31 SU SU1907665A patent/SU465784A3/ru active
- 1972-04-04 CA CA138,838A patent/CA988084A/en not_active Expired
- 1972-04-04 FR FR7211727A patent/FR2132396B1/fr not_active Expired
- 1972-04-04 NL NL7204493A patent/NL7204493A/xx not_active Application Discontinuation
- 1972-11-13 AR AR245080A patent/AR192485A1/es active
- 1972-11-13 AR AR245079A patent/AR194285A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA722183B (en) | 1972-12-27 |
| DK129651B (da) | 1974-11-04 |
| AT317239B (de) | 1974-08-26 |
| AR194285A1 (es) | 1973-06-29 |
| DK129651C (enExample) | 1975-04-07 |
| DD95228A5 (enExample) | 1973-01-20 |
| SE377332B (enExample) | 1975-06-30 |
| CS161935B2 (enExample) | 1975-06-10 |
| SU465784A3 (ru) | 1975-03-30 |
| AR192485A1 (es) | 1973-02-21 |
| NL7204493A (enExample) | 1972-10-04 |
| HU162902B (enExample) | 1973-04-28 |
| DE2117015A1 (de) | 1972-10-26 |
| AU4066172A (en) | 1973-10-04 |
| AR194360A1 (es) | 1973-07-13 |
| NO135418B (enExample) | 1976-12-27 |
| AT317240B (de) | 1974-08-26 |
| AT321318B (de) | 1975-03-25 |
| CS161937B2 (enExample) | 1975-06-10 |
| NO135418C (enExample) | 1977-04-05 |
| FR2132396B1 (enExample) | 1975-10-10 |
| CS161936B2 (enExample) | 1975-06-10 |
| AU468307B2 (en) | 1973-10-04 |
| ES401124A1 (es) | 1975-02-16 |
| SU535903A3 (ru) | 1976-11-15 |
| CH579534A5 (enExample) | 1976-09-15 |
| FR2132396A1 (enExample) | 1972-11-17 |
| GB1386130A (en) | 1975-03-05 |
| BE781590A (fr) | 1972-10-02 |
| SU493959A3 (ru) | 1975-11-28 |
| CA988084A (en) | 1976-04-27 |
| AT313301B (de) | 1974-02-11 |
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