SU440840A1 - - Google Patents

Info

Publication number

SU440840A1

SU440840A1 SU1815879A SU1815879A SU440840A1 SU 440840 A1 SU440840 A1 SU 440840A1 SU 1815879 A SU1815879 A SU 1815879A SU 1815879 A SU1815879 A SU 1815879A SU 440840 A1 SU440840 A1 SU 440840A1

Authority

SU

USSR - Soviet Union

Prior art keywords

naphthyl

piperazine

propyl

hydrochloride

methylenedioxyphenyl

Prior art date

1974-08-25

Links

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• -1 aromatic radical Chemical class 0.000 description 17
• 150000001875 compounds Chemical class 0.000 description 11
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
• 238000000034 method Methods 0.000 description 7
• 150000003839 salts Chemical class 0.000 description 7
• 239000002253 acid Substances 0.000 description 6
• 150000003254 radicals Chemical class 0.000 description 6
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 5
• 150000007513 acids Chemical class 0.000 description 3
• 125000000217 alkyl group Chemical group 0.000 description 3
• 150000001412 amines Chemical class 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 238000000354 decomposition reaction Methods 0.000 description 3
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 125000003118 aryl group Chemical group 0.000 description 2
• 125000005279 aryl sulfonyloxy group Chemical group 0.000 description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
• 125000005843 halogen group Chemical group 0.000 description 2
• 125000000623 heterocyclic group Chemical group 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• CKFGINPQOCXMAZ-UHFFFAOYSA-N methanediol Chemical compound OCO CKFGINPQOCXMAZ-UHFFFAOYSA-N 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
• 239000000047 product Substances 0.000 description 2
• 239000007858 starting material Substances 0.000 description 2
• 125000005877 1,4-benzodioxanyl group Chemical group 0.000 description 1
• VNICFCQJUVFULD-UHFFFAOYSA-N 1-(1-naphthalenyl)piperazine Chemical compound C1CNCCN1C1=CC=CC2=CC=CC=C12 VNICFCQJUVFULD-UHFFFAOYSA-N 0.000 description 1
• WADJLAVWIMPNPC-UHFFFAOYSA-N 2,3-dibenzoyloxy-2,3-dihydroxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)OC(O)(C(O)=O)C(O)(C(=O)O)OC(=O)C1=CC=CC=C1 WADJLAVWIMPNPC-UHFFFAOYSA-N 0.000 description 1
• XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 229940117927 ethylene oxide Drugs 0.000 description 1
• 235000019256 formaldehyde Nutrition 0.000 description 1
• 238000001640 fractional crystallisation Methods 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 150000002926 oxygen Chemical class 0.000 description 1
• 229960002195 perazine Drugs 0.000 description 1
• 150000004885 piperazines Chemical class 0.000 description 1
• 229910000027 potassium carbonate Inorganic materials 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 150000003141 primary amines Chemical class 0.000 description 1
• 238000010992 reflux Methods 0.000 description 1
• 238000007363 ring formation reaction Methods 0.000 description 1
• 238000005185 salting out Methods 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1