SU384822A1 - - Google Patents

Info

Publication number

SU384822A1

SU384822A1 SU1666111A SU1666111A SU384822A1 SU 384822 A1 SU384822 A1 SU 384822A1 SU 1666111 A SU1666111 A SU 1666111A SU 1666111 A SU1666111 A SU 1666111A SU 384822 A1 SU384822 A1 SU 384822A1

Authority

SU

USSR - Soviet Union

Prior art keywords

alkyl

hydrogen

lower alkyl

solvent

thiopurine

Prior art date

1971-06-03

Links

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• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
• 125000000217 alkyl group Chemical group 0.000 claims description 12
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
• 239000001257 hydrogen Substances 0.000 claims description 10
• 239000002904 solvent Substances 0.000 claims description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
• 238000000034 method Methods 0.000 claims description 5
• 235000011121 sodium hydroxide Nutrition 0.000 claims description 5
• 125000001475 halogen functional group Chemical group 0.000 claims description 4
• -1 nitroimidazolyl Chemical group 0.000 claims description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
• 125000001769 aryl amino group Chemical group 0.000 claims description 2
• 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 2
• 238000002360 preparation method Methods 0.000 claims description 2
• 150000002431 hydrogen Chemical group 0.000 claims 4
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical group 0.000 claims 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
• 239000011259 mixed solution Substances 0.000 claims 1
• 238000000926 separation method Methods 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 description 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
• 239000002244 precipitate Substances 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• OSJUNMSWBBOTQU-UHFFFAOYSA-N 5-chloro-1-methyl-4-nitroimidazole Chemical compound CN1C=NC([N+]([O-])=O)=C1Cl OSJUNMSWBBOTQU-UHFFFAOYSA-N 0.000 description 1
• FBGNWVFKAYFTRV-UHFFFAOYSA-N 7-methyl-3h-purine-6-thione Chemical compound N1C=NC(=S)C2=C1N=CN2C FBGNWVFKAYFTRV-UHFFFAOYSA-N 0.000 description 1
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 239000003518 caustics Substances 0.000 description 1
• 239000000460 chlorine Substances 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000005494 condensation Effects 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
• 125000005429 oxyalkyl group Chemical group 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1