SU203678A1 - Method of producing dichloroanhydrides of mixed sulfonamides amides - Google Patents
Method of producing dichloroanhydrides of mixed sulfonamides amidesInfo
- Publication number
- SU203678A1 SU203678A1 SU1103811A SU1103811A SU203678A1 SU 203678 A1 SU203678 A1 SU 203678A1 SU 1103811 A SU1103811 A SU 1103811A SU 1103811 A SU1103811 A SU 1103811A SU 203678 A1 SU203678 A1 SU 203678A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- amides
- mixed
- dichloroanhydrides
- producing
- sulfonamides
- Prior art date
Links
- 229940093912 Gynecological Sulfonamides Drugs 0.000 title 1
- 229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 title 1
- 229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 title 1
- -1 sulfonamides amides Chemical class 0.000 title 1
- 229940026752 topical Sulfonamides Drugs 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 10
- 150000001408 amides Chemical class 0.000 description 4
- FAIAAWCVCHQXDN-UHFFFAOYSA-N Phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003385 sodium Chemical class 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- MXJFCEUELIHFNV-UHFFFAOYSA-N C1(=CC=CC=C1)S(=O)(=O)O.CN(C)[Na] Chemical class C1(=CC=CC=C1)S(=O)(=O)O.CN(C)[Na] MXJFCEUELIHFNV-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical class [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
Description
Изобретение касаетс способа получени дихлорангидридов смешанных амидов сульфоновых и фосфористых кислот общей формулы RS02NRPCl2, которые могут быть использованы в качестве физиологически активных веществ.The invention concerns a process for the preparation of dichlorides of mixed amides of sulfonic and phosphorous acids of the general formula RS02NRPCl2, which can be used as physiologically active substances.
Предлагаемый способ состоит в том, что натриевые производные амидов сульфоновых кислот подвергают взаимодействию с треххлористым фосфором в среде органического растворител , например бензола.The proposed method consists in the fact that sodium derivatives of sulfonic acid amides are reacted with phosphorus trichloride in an organic solvent medium, for example benzene.
Пример. В трехгорлую колбу емкостью 250 мл с мешалкой, термометром, охлаждаемую проточной водой, помещают 13,8 г (0,1 г-моль) треххлористого фосфора в 50 мл абсолютного бензола. При сильном перемешивании присыпают 19,3 г (10,1 г-моль) натриевого производного метиламида бензолсульфоновой кислоты порци ми по 2-3 г. После внесени всего натриевого производного метиламида бензолсульфоновой кислоты охлаждение проточной водой прекращают и реакционную смесь перемешивают при комнатнойExample. In a three-necked flask with a capacity of 250 ml with a stirrer and a thermometer, cooled with running water, 13.8 g (0.1 g-mol) of phosphorus trichloride are placed in 50 ml of absolute benzene. Under strong stirring, 19.3 g (10.1 g-mol) of sodium benzymesulfonic acid methylamide derivative are poured in 2-3 g portions. After all sodium methyl methylamide benzenesulfonic acid derivative is added, cooling with running water is stopped and the reaction mixture is stirred at room temperature.
температуре еще примерно в течение 1 час дл полноты реакции. После этого выпавший на дно колбы хлористый натрий отфильтровывают и промывают 25 мл абсолютного бензола . От фильтрата отгон ют бензол, остаток перегон ют при 158-159°С (1 мм рт. ст.), вес продукта 19,3 г (71% от теоретического); По° 1,5492; dl° 1,35717.temperature for about 1 more hour to complete the reaction. After that, sodium chloride that fell to the bottom of the flask is filtered off and washed with 25 ml of absolute benzene. Benzene is distilled off from the filtrate, the residue is distilled at 158-159 ° C (1 mm Hg), product weight 19.3 g (71% of the theoretical); In ° 1,5492; dl ° 1.35717.
Найдено, %: С1 25,81.Found%: C1 25.81.
Вычислено, %: С1 26,1.Calculated,%: C1 26.1.
Полученный продукт представл ет собой густую маслообразную бесцветную жидкость, дым щуюс на воздухе.The resulting product is a thick, oily, colorless liquid that smokes in air.
Предмет изобретени Subject invention
Способ получени дихлорангидридов смешанных амидов сульфоновых и фосфористых кислот, отличающийс тем, что натриевые производные амидов сульфоновых кислот подвергают взаимодействию с треххлористым фосфором в среде органического растворител , например бензола.The method of producing dichloroanhydrides of mixed amides of sulfonic and phosphorous acids, characterized in that sodium derivatives of amides of sulfonic acids are reacted with phosphorus trichloride in an organic solvent, for example benzene.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU203678A1 true SU203678A1 (en) |
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