SU1737335A1 - Method of determining intravascular blood coagulation - Google Patents
Method of determining intravascular blood coagulation Download PDFInfo
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- SU1737335A1 SU1737335A1 SU884447510A SU4447510A SU1737335A1 SU 1737335 A1 SU1737335 A1 SU 1737335A1 SU 884447510 A SU884447510 A SU 884447510A SU 4447510 A SU4447510 A SU 4447510A SU 1737335 A1 SU1737335 A1 SU 1737335A1
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Abstract
Изобретение относитс к области медицины , используетс в клинической коагул ции . Цель изобретени - повышение точности способа. Сущность изобретени : бестромбоцитарную плазму прогревают при 56 °С в течение 5 мин и при образовании гел в пробирке определ ют наличие внутрисосудистого свертывани крови. Изобретение позвол ет повысить точность определени внутрисосудистого свертывани крови.The invention relates to the field of medicine, used in clinical coagulation. The purpose of the invention is to improve the accuracy of the method. Summary of the invention: platelet-free plasma is heated at 56 ° C for 5 minutes and the presence of intravascular coagulation of blood is determined during the formation of a gel in a test tube. The invention makes it possible to increase the accuracy of the determination of intravascular coagulation of blood.
Description
Изобретение относитс к медицине, а именно к способам лабораторной диагностики нарушений свертывани крови.The invention relates to medicine, in particular to methods for the laboratory diagnosis of coagulation disorders.
Известен способ определени внутри- сосудистого свертывани крови, основанный на полимеризации продуктов деградации фибриногена этанолом.There is a known method for the determination of intravascular coagulation of blood, based on the polymerization of fibrinogen degradation products with ethanol.
Однако этаноловый тест дает в р де случаев отрицательный результат при внутри- сосудистом свертывании крови.However, the ethanol test gives a negative result in a number of cases with intravascular coagulation of blood.
Целью изобретени вл етс повышение точности способа.The aim of the invention is to improve the accuracy of the method.
Поставленна цель достигаетс тем, что прогревают плазму при 56°С в течение 5 мин и при образовании гел в пробирках определ ют наличие внутрисосудистого свертывани крови.This goal is achieved by heating the plasma at 56 ° C for 5 minutes and the formation of intravascular coagulation of the blood is determined during the formation of the gel in test tubes.
Способ осуществл ют следующим образом .The method is carried out as follows.
Венозную кровь обследуемого берут в силиконированную пробирку с 3,8%-ным раствором цитрата натри в соотношении 9:1, центрифугируют при 1200 об/мин 20 мин и полученную плазму помещают в стекл нную пробирку, которую прогревают 5 мин на вод ной бане при 56°С.The patient's venous blood is taken into a siliconized tube with a 3.8% sodium citrate solution in a 9: 1 ratio, centrifuged at 1200 rpm for 20 minutes and the resulting plasma is placed into a glass test tube, which is heated for 5 minutes in a water bath at 56 ° s
При образовании гел в пробирке тест на наличие внутрисосудистого свертывани крови считаетс положительным, при отсутствии гел - отрицательным.When a gel is formed in a test tube, the test for the presence of intravascular coagulation of blood is considered positive, and in the absence of gel it is considered negative.
П р и м е р 1. Б-на С. Диагноз: микро- тромбоваскулит. Результаты лабораторного анализа: АПТВ 42 с, протромбиновое врем 21 с, тромбиновое врем 16с, этаноловый тест (-), протамин-сульфатный тест (-), продукты деградации фибриногена 6,4 мг%, предложенный тест положителен (+).PRI me R 1. B-c. Diagnosis: micro-thrombovasculitis. Laboratory analysis results: APTT 42 s, prothrombin time 21 s, thrombin time 16s, ethanol test (-), protamine-sulphate test (-), fibrinogen degradation products 6.4 mg%, the proposed test is positive (+).
П р и м е р 2. Б-на Ж. Диагноз: болезнь Вилленбранда. Результаты лабораторного анализа до и после плазмафореза: АПТВ 47 и 49 с, протромбиновое врем 25 и 25 с, тромбиновое врем 15 и 15 с, этаноловый тест (-) и (-), протрамин-сульфатный тест (-) и (+), предложенный тест (-) и (+).PRI mme R 2. Б-on J. Diagnosis: Willenbrand's disease. The results of laboratory analysis before and after plasmapheresis: APTT 47 and 49 s, prothrombin time 25 and 25 s, thrombin time 15 and 15 s, ethanol test (-) and (-), protramine-sulfate test (-) and (+), proposed test (-) and (+).
Использование способа позвол ет повысить в 1,5 раза точность определени внутрисосудистого свертывани крови.The use of the method makes it possible to increase the accuracy of determining intravascular blood coagulation by a factor of 1.5.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU884447510A SU1737335A1 (en) | 1988-06-24 | 1988-06-24 | Method of determining intravascular blood coagulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU884447510A SU1737335A1 (en) | 1988-06-24 | 1988-06-24 | Method of determining intravascular blood coagulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1737335A1 true SU1737335A1 (en) | 1992-05-30 |
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ID=21384288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU884447510A SU1737335A1 (en) | 1988-06-24 | 1988-06-24 | Method of determining intravascular blood coagulation |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1737335A1 (en) |
-
1988
- 1988-06-24 SU SU884447510A patent/SU1737335A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Scand. J. Haematol, 1971, 813, p. 819. * |
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