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FIELD: organic chemistry, 1,2,4-triazino-[5,6-b]-indole derivatives. SUBSTANCE: product: 3-(2-dimethylaminoethylthio)-1,2,4-triazino-[5,6-b] -indolyl-5- acetamide. Synthesis is carried out by reaction of 3-(2-dimethylaminoethylthio)-1,2,4-triazino-[5,6-b] -indole with α-chloroacetamide in anhydrous dimethylformamide. Yield is 50%, m. p. is 146 C, empirical formula is CHNOS, toxicity LD= 1720 mg/kg, therapeutic index is 275.2. New compound can protect living organism against acute toxic lung edema while 3-(3-dimethylaminopropylthio)-1,2,4-triazino-[5,6-b] -indole shows antihypoxic action only. Synthesized compound can be used in medicine. EFFECT: new compound showing specific activity. 2 tbl
SU4696099/04A1989-04-041989-04-043-(2-dimethylaminoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide protecting against acute toxic lung edema
SU1674533A1
(en)
BICYCLE HYGIENEOUS HETEROCYCLIC COMPOUNDS CONTAINING BENZENE, CYCLOHEXAN OR PYRIDINE AND PYRIMIDINE, PYRIDINE OR IMIDAZOLE SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activity
Derivatives of 2-(fluorenylidene-9-hydrazono)-thiazolidone-4 showing antiviral effect with relation to coxsackie b4 virus and vesicular stomatitis virus