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Organic Low-Molecular-Weight Compounds And Preparation Thereof
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Acyclic And Carbocyclic Compounds In Medicinal Compositions
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Abstract
FIELD: organic chemistry. SUBSTANCE: product: maleic acid trifluoroacetylhydrazide. Synthesis is carried out by reaction of trifluoroacetic acid hydrazide and maleic anhydride in ethyl acetate medium. Yield is 82% m. p. is 178-179 C, empirical formula is CHFNO, toxicity LD= 1600 mg/kg, efficacy index is 41 and 50 as compared with that for remantadin and adapromin. Synthesized compound shows antiviral activity against influenza viruses type A, B and parainfluenza 3 type and can be used in medicine. EFFECT: synthesis of new active compounds of class indicated above. 3 tbl
Derivatives of 2-(fluorenylidene-9-hydrazono)-thiazolidone-4 showing antiviral effect with relation to coxsackie b4 virus and vesicular stomatitis virus