SU1547253A1 - Maleic acid trifluoroacetylhydrazide showing antiviral activity - Google Patents

Maleic acid trifluoroacetylhydrazide showing antiviral activity

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Publication number
SU1547253A1
SU1547253A1 SU4465455/04A SU4465455A SU1547253A1 SU 1547253 A1 SU1547253 A1 SU 1547253A1 SU 4465455/04 A SU4465455/04 A SU 4465455/04A SU 4465455 A SU4465455 A SU 4465455A SU 1547253 A1 SU1547253 A1 SU 1547253A1
Authority
SU
USSR - Soviet Union
Prior art keywords
trifluoroacetylhydrazide
antiviral activity
maleic acid
synthesis
type
Prior art date
Application number
SU4465455/04A
Other languages
Russian (ru)
Inventor
Ю.С. Андрейчиков
В.О. Козьминых
В.И. Ильенко
В.Г. Платонов
Н.А. Калинина
Original Assignee
Пермский фармацевтический институт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пермский фармацевтический институт filed Critical Пермский фармацевтический институт
Priority to SU4465455/04A priority Critical patent/SU1547253A1/en
Application granted granted Critical
Publication of SU1547253A1 publication Critical patent/SU1547253A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FIELD: organic chemistry. SUBSTANCE: product: maleic acid trifluoroacetylhydrazide. Synthesis is carried out by reaction of trifluoroacetic acid hydrazide and maleic anhydride in ethyl acetate medium. Yield is 82% m. p. is 178-179 C, empirical formula is CHFNO, toxicity LD= 1600 mg/kg, efficacy index is 41 and 50 as compared with that for remantadin and adapromin. Synthesized compound shows antiviral activity against influenza viruses type A, B and parainfluenza 3 type and can be used in medicine. EFFECT: synthesis of new active compounds of class indicated above. 3 tbl
SU4465455/04A 1988-07-26 1988-07-26 Maleic acid trifluoroacetylhydrazide showing antiviral activity SU1547253A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4465455/04A SU1547253A1 (en) 1988-07-26 1988-07-26 Maleic acid trifluoroacetylhydrazide showing antiviral activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4465455/04A SU1547253A1 (en) 1988-07-26 1988-07-26 Maleic acid trifluoroacetylhydrazide showing antiviral activity

Publications (1)

Publication Number Publication Date
SU1547253A1 true SU1547253A1 (en) 1995-10-20

Family

ID=60528838

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4465455/04A SU1547253A1 (en) 1988-07-26 1988-07-26 Maleic acid trifluoroacetylhydrazide showing antiviral activity

Country Status (1)

Country Link
SU (1) SU1547253A1 (en)

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