SU1498021A1 - 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activity - Google Patents
3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activityInfo
- Publication number
- SU1498021A1 SU1498021A1 SU4333677/04A SU4333677A SU1498021A1 SU 1498021 A1 SU1498021 A1 SU 1498021A1 SU 4333677/04 A SU4333677/04 A SU 4333677/04A SU 4333677 A SU4333677 A SU 4333677A SU 1498021 A1 SU1498021 A1 SU 1498021A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- morpholinoethylthio
- triazino
- indolyl
- hyperthermia
- showing
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b] -indolyl-5-acetamide dihydrochloride. Synthesis is carried out by reaction of 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b] -indole sodium salt and formamide. Yield is 80.6%, empirical formula is CHClNOS, m. p. is 186 C. Protection coefficient of new compound against hypoxia is 1.4, protection degree of animals against hyperthermia is 53% as compared with 30% for bemithyl, recovery degree after physical loading is increased by 142% as compared with control. EFFECT: new compound showing enhanced activity. 4 tbl
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4333677/04A SU1498021A1 (en) | 1987-07-17 | 1987-07-17 | 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4333677/04A SU1498021A1 (en) | 1987-07-17 | 1987-07-17 | 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1498021A1 true SU1498021A1 (en) | 1996-09-10 |
Family
ID=60528165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4333677/04A SU1498021A1 (en) | 1987-07-17 | 1987-07-17 | 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activity |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1498021A1 (en) |
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1987
- 1987-07-17 SU SU4333677/04A patent/SU1498021A1/en active
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