SU1552605A1 - 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia - Google Patents

3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia

Info

Publication number
SU1552605A1
SU1552605A1 SU4424261/04A SU4424261A SU1552605A1 SU 1552605 A1 SU1552605 A1 SU 1552605A1 SU 4424261/04 A SU4424261/04 A SU 4424261/04A SU 4424261 A SU4424261 A SU 4424261A SU 1552605 A1 SU1552605 A1 SU 1552605A1
Authority
SU
USSR - Soviet Union
Prior art keywords
triazino
dimethylaminoethylthio
hyperthermia
methoxy
indole
Prior art date
Application number
SU4424261/04A
Other languages
Russian (ru)
Inventor
А.Б. Томчин
В.Ф. Катков
Э.Н. Сумина
Е.Б. Каткова
Л.М. Крюкова
К.Н. Зеленин
Original Assignee
А.Б. Томчин
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by А.Б. Томчин filed Critical А.Б. Томчин
Priority to SU4424261/04A priority Critical patent/SU1552605A1/en
Application granted granted Critical
Publication of SU1552605A1 publication Critical patent/SU1552605A1/en

Links

Abstract

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(2-dimethylaminoethylthio)-8-methoxy-1,2,4-triazino-[5,6-b] - indole dihydrochloride. Synthesis is carried out from 3-mercapto-1,2,4-triazino-[5,6-b] -indole and 2-dimethylthiaminoethyl-chloride hydrochloride at room temperature followed by treatment with HCl. Empirical formula is CHNOS×2HCl, yield is 42.5%, m. p. is 202 C, LD= 580 mg/kg. At hyperthermia new compound at dose 10 mg/kg provides survival in thermochamber (40 C) 75% animals as compared with 30% with known bemithyl. EFFECT: new compound showing enhanced activity. 1 tbl
SU4424261/04A 1988-05-12 1988-05-12 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia SU1552605A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4424261/04A SU1552605A1 (en) 1988-05-12 1988-05-12 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4424261/04A SU1552605A1 (en) 1988-05-12 1988-05-12 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia

Publications (1)

Publication Number Publication Date
SU1552605A1 true SU1552605A1 (en) 1996-09-10

Family

ID=60528797

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4424261/04A SU1552605A1 (en) 1988-05-12 1988-05-12 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia

Country Status (1)

Country Link
SU (1) SU1552605A1 (en)

Similar Documents

Publication Publication Date Title
MX9205542A (en) NITROGENATED HETERO-CYCLE COMPOUND.
BG104853A (en) Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
HUP0002272A2 (en) Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
SU1552605A1 (en) 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia
ES475533A1 (en) Novel propione amide derivative and its manufacture
JP2000500464A (en) Blood regulatory compounds
US3467755A (en) Compositions and methods for producing sedation and tranquilization with substituted 4,5,6,7- tetrahydro-4-oxindoles
EP0000355A1 (en) New indole derivatives, processes for their preparation, and pharmaceutical compositions containing them.
NO165635B (en) ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE QUINOLINE DERIVATIVES.
US3818033A (en) 5(4)-amino-substituted imidazoles
SU1681502A1 (en) 3-(2, 5-dimethoxybenzoyl)-4-dimethylaminomethyl-5- hydroxy-6-bromobenzofuran hydrochloride showing analgetic, local anesthetic, anticonvulsant, antiarrythmic, stimulating coronary, cerebral and renal blood circulation effects
SU1415725A1 (en) 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistance
SU1626644A1 (en) 3-(benzylaminocarbonylmethylthio)-1,2,4-triazino-[5,6-b]-indole enhancing physical endurance
US3732236A (en) 2-phenyl-indoline amidines
SU1623156A1 (en) 3-(2-diethylaminoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide hydrochloride accelerating recovery process after physical loading
SU1547281A1 (en) 3-(2-aminoethylthio)-1,2,4-triazino-[5,6-b]-indole enhancing resistance to hypercapnic hypoxia
US3682953A (en) Substituted 5-nitrofuryl-pyrazoles
US3896227A (en) 1-(3-hydroxystyryl pyridinium salts and their derivatives as whipworm control agents
SU1498021A1 (en) 3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide dihydrochloride accelerating recovery process after physical loading, enhancing resistance to hyperthermia and showing antihypoxic activity
SU1547279A1 (en) 3-(2-dimethylaminoethylthio)-8-methyl-1,2,4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia
GB2164037A (en) 6-aminomethyl-furo-(3,4-c)-pyridine derivatives
SU1596719A1 (en) 3-(morpholinocarbonylmethylthio)-1,2,4-triazino-[5,6-b]-indole enhancing resistance to hypercapnic hypoxia
SU1598431A1 (en) 3-(3-dimethylaminopropylthio)-1,2,4-triazino-[5, 6-b]-indole hydrochloride showing antihypoxic activity
SU1483895A1 (en) Hydrochloride of 3-(2-dipropylaminoethylthio)-1,2,4-triazino[5,6-b)-indole which increases resistance against hypertermia
PL245929A1 (en) Process for manufacturing novel derivatives of triazole and fungicide