SU1646256A1 - 2-(para-bromobenzoyl) or 2-(para-chlorobenzoyl)-aminoadamantanes increasing organism resistance to environment inhabitation extremal factor effect and showing immunostimulating activity - Google Patents

2-(para-bromobenzoyl) or 2-(para-chlorobenzoyl)-aminoadamantanes increasing organism resistance to environment inhabitation extremal factor effect and showing immunostimulating activity

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Publication number
SU1646256A1
SU1646256A1 SU4735457/04A SU4735457A SU1646256A1 SU 1646256 A1 SU1646256 A1 SU 1646256A1 SU 4735457/04 A SU4735457/04 A SU 4735457/04A SU 4735457 A SU4735457 A SU 4735457A SU 1646256 A1 SU1646256 A1 SU 1646256A1
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SU
USSR - Soviet Union
Prior art keywords
para
aminoadamantanes
bromobenzoyl
chlorobenzoyl
extremal
Prior art date
Application number
SU4735457/04A
Other languages
Russian (ru)
Inventor
И.С. Морозов
Н.Г. Арцимович
Н.В. Климова
Т.А. Фадеева
Н.М. Зайцева
Т.С. Галушина
Н.П. Быков
Б.М. Пятин
Н.И. Авдюнина
О.В. Щербакова
Г.В. Пушкарь
В.В. Каштанова
Т.Г. Хлопушина
Г.А. Кузнецова
И.А. Иванова
А.С. Лосев
Л.П. Ефимова
В.Г. Барчуков
С.А. Сергеева
Т.Д. Карпова
О.В. Агафонова
О.М. Краснова
С.Б. Середенин
Б.А. Бадыштов
Original Assignee
Научно-исследовательский институт фармакологии АМН СССР
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Priority to SU4735457/04A priority Critical patent/SU1646256A1/en
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Publication of SU1646256A1 publication Critical patent/SU1646256A1/en

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Abstract

FIELD: organic chemistry. SUBSTANCE: invention relates to adamantane derivatives, in part, 2-(p-bromobenzoyl) or 2-(p-chlorobenzoyl)-aminoadamantanes. Synthesis is carried out by reaction of 2-aminoadamantane chlorohydrate with corresponding benzoic acid chloroanhydride in toluene at boiling. Yield, %; m. p. C; empirical formula: a) 90.7; 185-187; CHBrNO; b) 93.2; 180-182; CHClNO.. New compounds in contrast to bromantane show protective action at overheating, under conditions of acute hypobaric hypoxia, at water depivation. Except for, new substances increase operant rat activity at fatigue development at background of nervous-psychic stress. Toxicity LD; a) 5420 mg/kg; b) 9200 mg/kg. EFFECT: improved method of synthesis, enhanced effectiveness, high yield. 2 tbl
SU4735457/04A 1989-07-13 1989-07-13 2-(para-bromobenzoyl) or 2-(para-chlorobenzoyl)-aminoadamantanes increasing organism resistance to environment inhabitation extremal factor effect and showing immunostimulating activity SU1646256A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4735457/04A SU1646256A1 (en) 1989-07-13 1989-07-13 2-(para-bromobenzoyl) or 2-(para-chlorobenzoyl)-aminoadamantanes increasing organism resistance to environment inhabitation extremal factor effect and showing immunostimulating activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4735457/04A SU1646256A1 (en) 1989-07-13 1989-07-13 2-(para-bromobenzoyl) or 2-(para-chlorobenzoyl)-aminoadamantanes increasing organism resistance to environment inhabitation extremal factor effect and showing immunostimulating activity

Publications (1)

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SU1646256A1 true SU1646256A1 (en) 1996-06-10

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SU4735457/04A SU1646256A1 (en) 1989-07-13 1989-07-13 2-(para-bromobenzoyl) or 2-(para-chlorobenzoyl)-aminoadamantanes increasing organism resistance to environment inhabitation extremal factor effect and showing immunostimulating activity

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SU (1) SU1646256A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2496504C1 (en) * 2012-03-22 2013-10-27 Федеральное государственное бюджетное учреждение "Научный центр биомедицинских технологий" Российской академии медицинских наук Agent for extreme performance stimulation, method for preparing and using it
RU2660654C1 (en) * 2017-06-09 2018-07-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный технический университет" (ВолгГТУ) N-(adamantan-2-yl)- and n-[(adamantan-1-yl)methyl]- derivatives of 2-(4-allyl-2-methoxyphenoxy)acetic acid amide, which are potential synthetic adaptogens of emergency action
RU2704126C2 (en) * 2016-11-28 2019-10-24 Российская Федерация, от имени которой выступает Министерство обороны Российской Федерации Pharmaceutical composition based on chlorobenzoylaminoadamantane, which increases physical performance in high and low temperatures

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2496504C1 (en) * 2012-03-22 2013-10-27 Федеральное государственное бюджетное учреждение "Научный центр биомедицинских технологий" Российской академии медицинских наук Agent for extreme performance stimulation, method for preparing and using it
RU2704126C2 (en) * 2016-11-28 2019-10-24 Российская Федерация, от имени которой выступает Министерство обороны Российской Федерации Pharmaceutical composition based on chlorobenzoylaminoadamantane, which increases physical performance in high and low temperatures
RU2660654C1 (en) * 2017-06-09 2018-07-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный технический университет" (ВолгГТУ) N-(adamantan-2-yl)- and n-[(adamantan-1-yl)methyl]- derivatives of 2-(4-allyl-2-methoxyphenoxy)acetic acid amide, which are potential synthetic adaptogens of emergency action

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