SU166673A1 - - Google Patents

Info

Publication number

SU166673A1

SU166673A1 SU825569A SU825569A SU166673A1 SU 166673 A1 SU166673 A1 SU 166673A1 SU 825569 A SU825569 A SU 825569A SU 825569 A SU825569 A SU 825569A SU 166673 A1 SU166673 A1 SU 166673A1

Authority

SU

USSR - Soviet Union

Prior art keywords

derivatives

cyclic

ketoesters

yield

mixture

Prior art date

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• 125000004122 cyclic group Chemical group 0.000 claims description 5
• KPJPHPFMCOKUMW-UHFFFAOYSA-N iodomethane Chemical group I[CH2] KPJPHPFMCOKUMW-UHFFFAOYSA-N 0.000 claims description 3
• KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 3
• 229910052708 sodium Inorganic materials 0.000 claims description 3
• 239000011734 sodium Substances 0.000 claims description 3
• 239000008096 xylene Substances 0.000 claims description 3
• NZZFYRREKKOMAT-UHFFFAOYSA-N Diiodomethane Chemical compound ICI NZZFYRREKKOMAT-UHFFFAOYSA-N 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000003385 sodium Chemical class 0.000 claims 1
• 239000000203 mixture Substances 0.000 description 5
• RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• 238000006243 chemical reaction Methods 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• 230000015572 biosynthetic process Effects 0.000 description 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
• PMZURENOXWZQFD-UHFFFAOYSA-L na2so4 Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
• 230000001264 neutralization Effects 0.000 description 2
• 238000000746 purification Methods 0.000 description 2
• 229910052938 sodium sulfate Inorganic materials 0.000 description 2
• 235000011152 sodium sulphate Nutrition 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• -1 2- (iodomethyl) -2-carbethoxycyclohexanone Chemical compound 0.000 description 1
• XNLICIUVMPYHGG-UHFFFAOYSA-N 2-Pentanone Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 1
• 229960000583 Acetic Acid Drugs 0.000 description 1
• 210000002683 Foot Anatomy 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating Effects 0.000 description 1
• 230000001476 alcoholic Effects 0.000 description 1
• 150000001649 bromium compounds Chemical class 0.000 description 1
• 239000003518 caustics Substances 0.000 description 1
• RDJCIKZLXHKBPH-SEPHDYHBSA-L disodium;5-[2-(4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-[(E)-2-[4-[2-(4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-sulfonatophenyl]ethenyl]benzenesulfonate Chemical compound [Na+].[Na+].C=1C=C(\C=C\C=2C(=CC(NN=C3C=CC(=O)C=C3)=CC=2)S([O-])(=O)=O)C(S(=O)(=O)[O-])=CC=1NN=C1C=CC(=O)C=C1 RDJCIKZLXHKBPH-SEPHDYHBSA-L 0.000 description 1
• 238000004821 distillation Methods 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 229940079593 drugs Drugs 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• JJOYCHKVKWDMEA-UHFFFAOYSA-N ethyl cyclohexanecarboxylate Chemical compound CCOC(=O)C1CCCCC1 JJOYCHKVKWDMEA-UHFFFAOYSA-N 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 238000005755 formation reaction Methods 0.000 description 1
• 239000012362 glacial acetic acid Substances 0.000 description 1
• 239000005457 ice water Substances 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 239000010410 layer Substances 0.000 description 1
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
• 229910052759 nickel Inorganic materials 0.000 description 1
• PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
• 239000012044 organic layer Substances 0.000 description 1
• 159000000001 potassium salts Chemical class 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 230000002194 synthesizing Effects 0.000 description 1
• DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1