SU1122946A1 - Arpenal quatitative determination method - Google Patents

Abstract

THE METHOD OF QUANTITATIVE DETERMINATION OF ARPENAL by treating a solution of an analyte sample with a chemical reagent, extracting the resulting compound with chloroform followed by photometry of the extract, characterized in that, in order to increase the selectivity of the process and its accuracy, a mixture of 0.5 M sulfate solution copper and 1 M solution of sodium salitzpata, taken in a molar ratio of 0.8-1.8:: 1.0-2.2.

Description

The invention relates to analytical chemistry, in particular to methods for the extraction-photometric determination of arpenal (3-diethylaminopropyl ester of diphenylacetic acid hydrochloride). The known method of quantitative determination of arphenal by treating a sample of an analyte of sulfuric acid with brothalic acid, extracting the obtained product with benzene and treating the extract with hydrochloric acid and brilliant green sec. Is followed by photometry of the obtained solution lj. The closest to the invention in technical essence and the achieved results is a method for quantitatively determining arpenal by treating an analyte sample solution with bromophenol blue, extracting the resulting compound with chloroform followed by photometry of 2J extract. The disadvantages of the known method are in its low selectivity ( preparation, organic bases and relatively low accuracy. The aim of the invention is to increase selectively method and its accuracy. The goal is achieved by the fact that according to the method for determining arpenal by treating an analyte sample solution with a chemical reagent, extracting the resulting compound with chloroform followed by photometry of the extract, a mixture of 0.5 M copper sulfate and 1 M is used as the chemical reagent of sodium salicylate solution, taken in a molar ratio of 0.8-1.8: 1.0-2.2. Construction of the calibration curve, 0.30, 9 ml of a 0.5% standard solution of arpenal is added to the separatory funnel. coming Add 1 ml of a 0.5 M solution of copper sulfate, 1.5 ml of a 1 M solution of sodium salicylate and bring the volume to 5 ml with water and extract 5 ml of chloroform. The organic phase 461 is separated, filtered through a folded filter containing 0.5 g of anhydrous sodium sulfate. Dyed extracts photometry on FZK-56M, 1 0.5 cm at the filter number 3, against idle experience. According to the data obtained, a calibration curve is constructed. Example 1, Determination of arpenal in the preparation, 0.1250 g of the preparation (precise weighting) is dissolved in water in a 25 ml volumetric flask. To 0.6 ml of a solution of 0.5 n. 1 ml of copper sulphate thief, 1.5 ml of 1 M sodium salicylate solution, distilled water to 5 ml are added and then they proceed as described in the construction of the calibration curve. a. The content of arpenal is found on the calibration curve. The results of the quantitative determination of arpenal in the preparation are presented in Table 1, P p and M er 2, the determination of arpenal in ampoules of 1.0 ml of 2% aqueous solution. 0.2 ml of the preparation is taken from the ampoule, 1 ml of a 0.5 M solution of copper sulfate, 1.5 ml of a 1 M solution of sodium salicylate and water are added to a volume of 5 ml. and then proceed as described in the construction of the calibration curve. The content of arpenal in ampoules is found according to the calibration curve. The results of quantitative determination of arpenal in ampoules are presented in Table 2, Table 2. Figures 3-7 present the results of the quantification. arpenal in the preparation at optimal and transcendental ratios of the components in a mixture of 0.5 M copper sulfate solution and 1 M sodium salicylate solution. Accordingly, these ratios of components in the table, 3-7 rave, ml: 2.0 / 3; 0.5 / 0.7; 1.8 / 2.2; 0.8 / 1.0; 1.0 / 1.5. The relative error of the proposed method is ± 0.67%, and the known error is ± 0.78%. Using the proposed method, in contrast to the known method, allows to determine the arpenal in the presence of its hydryl products.

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Claims (1)

METHOD FOR QUANTITATIVE DETERMINATION OF ARPENAL by treating a sample solution of an analyte with a chemical reagent, extracting the resulting compound with chloroform, followed by photometric analysis of the extract, characterized in that, in order to increase the selectivity of the method and its accuracy, a mixture of a 0.5 M solution of copper sulfate and 1 M solution of sodium salicylate taken in a molar ratio of 0.8-1.8:: 1.0-2.2. '1 122946