SMT201600474T1 - Procedimento per la preparazione di pemetrexed e suo sale di lisina - Google Patents
Procedimento per la preparazione di pemetrexed e suo sale di lisinaInfo
- Publication number
- SMT201600474T1 SMT201600474T1 SM20160474T SMT201600474T SMT201600474T1 SM T201600474 T1 SMT201600474 T1 SM T201600474T1 SM 20160474 T SM20160474 T SM 20160474T SM T201600474 T SMT201600474 T SM T201600474T SM T201600474 T1 SMT201600474 T1 SM T201600474T1
- Authority
- SM
- San Marino
- Prior art keywords
- pemetrexed
- procedure
- preparation
- lysine salt
- lysine
- Prior art date
Links
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 title 1
- 229960005079 pemetrexed Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000398A ITRM20120398A1 (it) | 2012-08-08 | 2012-08-08 | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| PCT/IB2013/056497 WO2014024164A1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
| EP13777144.0A EP2882753B1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600474T1 true SMT201600474T1 (it) | 2017-03-08 |
Family
ID=47018368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20160474T SMT201600474T1 (it) | 2012-08-08 | 2013-08-08 | Procedimento per la preparazione di pemetrexed e suo sale di lisina |
| SM201600474T SMT201600474B (it) | 2012-08-08 | 2016-12-28 | Procedimento per la preparazione di pemetrexed e suo sale di lisina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600474T SMT201600474B (it) | 2012-08-08 | 2016-12-28 | Procedimento per la preparazione di pemetrexed e suo sale di lisina |
Country Status (23)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107641124A (zh) * | 2016-07-22 | 2018-01-30 | 上海创诺制药有限公司 | 一种培美曲塞二酸新晶型及其制备方法 |
| CN109836425B (zh) * | 2017-11-24 | 2023-01-24 | 江苏创诺制药有限公司 | 一种合成培美酸的制备工艺 |
| CN110128427A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞缬氨酸盐 |
| CN110128426B (zh) * | 2018-02-09 | 2021-12-14 | 鲁南制药集团股份有限公司 | 培美曲塞谷氨酸盐 |
| CN110128428A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞丙氨酸盐 |
| CN111333658A (zh) * | 2020-05-06 | 2020-06-26 | 贵州联科中贝制药科技有限公司 | 一种培美曲塞二钠水合物的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005128A1 (en) | 1988-10-31 | 1990-05-17 | Mitsui Toatsu Chemicals, Inc. | Process for preparing organic group-substituted sodium aluminum hydride |
| KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| US5416211A (en) | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| HUT70208A (en) * | 1992-09-25 | 1995-09-28 | Lilly Co Eli | Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines |
| DE19725647A1 (de) | 1997-06-18 | 1998-12-24 | Basf Ag | Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme |
| ZA987550B (en) | 1997-09-26 | 2000-02-21 | Lilly Co Eli | Processes and intermediates useful to make antifolates. |
| WO2001062760A2 (en) | 2000-02-25 | 2001-08-30 | Eli Lilly And Company | A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR |
| EP1957497B1 (en) * | 2006-08-14 | 2015-09-30 | Sicor, Inc. | Processes for preparing intermediates of pemetrexed |
| WO2008021410A2 (en) * | 2006-08-14 | 2008-02-21 | Sicor Inc. | Highly pure pemetrexed diacid and processes for the preparation thereof |
| CN101591247B (zh) * | 2008-05-30 | 2012-09-05 | 上海希迪制药有限公司 | 合成4-(4-甲酯基苯基)丁醛的方法 |
| IT1401677B1 (it) * | 2010-07-22 | 2013-08-02 | Chemi Spa | Nuovo processo per la sintesi di pemetrexed sale disodico |
| CA2804855A1 (en) | 2010-07-28 | 2012-02-02 | Eagle Pharmaceuticals, Inc. | Pharmaceutical compositions containing pemetrexed having extended storage stability |
| WO2012056285A1 (en) * | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
-
2012
- 2012-08-08 IT IT000398A patent/ITRM20120398A1/it unknown
-
2013
- 2013-08-06 TW TW102128058A patent/TWI609017B/zh active
- 2013-08-08 RS RS20161202A patent/RS55515B1/sr unknown
- 2013-08-08 EP EP13777144.0A patent/EP2882753B1/en active Active
- 2013-08-08 HR HRP20170011TT patent/HRP20170011T1/hr unknown
- 2013-08-08 AU AU2013301156A patent/AU2013301156B2/en active Active
- 2013-08-08 IN IN833DEN2015 patent/IN2015DN00833A/en unknown
- 2013-08-08 PL PL13777144T patent/PL2882753T3/pl unknown
- 2013-08-08 SI SI201330427A patent/SI2882753T1/sl unknown
- 2013-08-08 KR KR1020157005932A patent/KR102288417B1/ko active Active
- 2013-08-08 RU RU2015108042A patent/RU2609006C2/ru active
- 2013-08-08 ES ES13777144.0T patent/ES2607890T3/es active Active
- 2013-08-08 HU HUE13777144A patent/HUE032304T2/en unknown
- 2013-08-08 MX MX2015001712A patent/MX362858B/es active IP Right Grant
- 2013-08-08 CN CN201380041935.8A patent/CN104736540B/zh active Active
- 2013-08-08 WO PCT/IB2013/056497 patent/WO2014024164A1/en active Application Filing
- 2013-08-08 PT PT137771440T patent/PT2882753T/pt unknown
- 2013-08-08 SM SM20160474T patent/SMT201600474T1/it unknown
- 2013-08-08 LT LTEP13777144.0T patent/LT2882753T/lt unknown
- 2013-08-08 DK DK13777144.0T patent/DK2882753T3/en active
- 2013-08-08 BR BR112015002429A patent/BR112015002429A8/pt not_active Application Discontinuation
-
2015
- 2015-03-06 ZA ZA2015/01549A patent/ZA201501549B/en unknown
-
2016
- 2016-12-28 CY CY20161101351T patent/CY1118514T1/el unknown
- 2016-12-28 SM SM201600474T patent/SMT201600474B/it unknown
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