SMT201500071B - Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi - Google Patents

Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi

Info

Publication number
SMT201500071B
SMT201500071B SM201500071T SM201500071T SMT201500071B SM T201500071 B SMT201500071 B SM T201500071B SM 201500071 T SM201500071 T SM 201500071T SM 201500071 T SM201500071 T SM 201500071T SM T201500071 B SMT201500071 B SM T201500071B
Authority
SM
San Marino
Prior art keywords
dihydro
inhibitors
antimalarial agents
orotate dehydrogenase
orotate
Prior art date
Application number
SM201500071T
Other languages
English (en)
Italian (it)
Inventor
Pradipsinh K Rathod
David Floyd
Jeremy Burrows
Alka Marwaha
Ramesh Gujjar
Jose Coteron-Lopez
Margaret Phillips
Susan A Charman
David Matthews
Original Assignee
Univ Texas
Univ Monash
Medicines Malaria Venture Mmv
Univ Washington
Glaxosmithkline Investigacion Y Desarrollo S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ Monash, Medicines Malaria Venture Mmv, Univ Washington, Glaxosmithkline Investigacion Y Desarrollo S L filed Critical Univ Texas
Publication of SMT201500071B publication Critical patent/SMT201500071B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SM201500071T 2009-09-29 2015-03-18 Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi SMT201500071B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number Publication Date
SMT201500071B true SMT201500071B (it) 2015-05-05

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500071T SMT201500071B (it) 2009-09-29 2015-03-18 Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi

Country Status (16)

Country Link
US (1) US9238653B2 (ja)
EP (1) EP2483274B1 (ja)
JP (1) JP5818266B2 (ja)
CN (1) CN102741255B (ja)
BR (1) BR112012007179B8 (ja)
CA (1) CA2775354C (ja)
DK (1) DK2483274T3 (ja)
ES (1) ES2527835T3 (ja)
HK (1) HK1174639A1 (ja)
HR (1) HRP20150066T1 (ja)
ME (1) ME02020B (ja)
PL (1) PL2483274T3 (ja)
PT (1) PT2483274E (ja)
SI (1) SI2483274T1 (ja)
SM (1) SMT201500071B (ja)
WO (1) WO2011041304A2 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE040254T2 (hu) * 2013-12-19 2019-02-28 Novartis Ag Protozoa proteaszóma inhibitor [1,2,4]triazolo[1,5-a]pirimidinszármazékok paraziták által okozott betegségek, például leishmaniasis kezelésére
EP3072894A1 (en) * 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
US20200048259A1 (en) * 2016-10-12 2020-02-13 Merck Sharp & Dohme Corp. Kdm5 inhibitors
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
CN118480009A (zh) 2017-02-06 2024-08-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
US11426420B2 (en) 2017-04-07 2022-08-30 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) * 2006-06-22 2007-12-27 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
CN101622001A (zh) * 2007-01-26 2010-01-06 Irm责任有限公司 作为激酶抑制剂用于治疗疟原虫相关疾病的嘌呤化合物和组合物
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
WO2011041304A3 (en) 2011-08-04
US20120302586A1 (en) 2012-11-29
CA2775354C (en) 2019-01-15
BR112012007179B8 (pt) 2021-05-25
ES2527835T3 (es) 2015-01-30
PT2483274E (pt) 2015-02-04
EP2483274A2 (en) 2012-08-08
JP5818266B2 (ja) 2015-11-18
EP2483274A4 (en) 2013-03-06
WO2011041304A2 (en) 2011-04-07
PL2483274T3 (pl) 2015-04-30
HK1174639A1 (en) 2013-06-14
BR112012007179B1 (pt) 2020-12-01
CN102741255A (zh) 2012-10-17
BR112012007179A2 (pt) 2017-07-25
DK2483274T3 (en) 2015-01-19
US9238653B2 (en) 2016-01-19
EP2483274B1 (en) 2014-10-29
BR112012007179A8 (pt) 2018-01-23
CA2775354A1 (en) 2011-04-07
ME02020B (me) 2015-05-20
SI2483274T1 (sl) 2015-02-27
CN102741255B (zh) 2015-10-07
HRP20150066T1 (hr) 2015-02-27
JP2013506004A (ja) 2013-02-21

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