SK94398A3 - Novel fused pyrrolecarboxamides; a new class of gaba brain receptor ligands - Google Patents

Novel fused pyrrolecarboxamides; a new class of gaba brain receptor ligands Download PDF

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Publication number
SK94398A3
SK94398A3 SK943-98A SK94398A SK94398A3 SK 94398 A3 SK94398 A3 SK 94398A3 SK 94398 A SK94398 A SK 94398A SK 94398 A3 SK94398 A3 SK 94398A3
Authority
SK
Slovakia
Prior art keywords
oxo
indole
carboxamide
compound according
tetrahydro
Prior art date
Application number
SK943-98A
Other languages
English (en)
Slovak (sk)
Inventor
Pamela Albaugh
Gang Liu
Kenneth Shaw
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of SK94398A3 publication Critical patent/SK94398A3/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
SK943-98A 1996-01-19 1997-01-14 Novel fused pyrrolecarboxamides; a new class of gaba brain receptor ligands SK94398A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/588,711 US5804686A (en) 1996-01-19 1996-01-19 fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
PCT/US1997/000519 WO1997026243A1 (en) 1996-01-19 1997-01-14 Novel fused pyrrolecarboxamides; a new class of gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
SK94398A3 true SK94398A3 (en) 1999-02-11

Family

ID=24354983

Family Applications (1)

Application Number Title Priority Date Filing Date
SK943-98A SK94398A3 (en) 1996-01-19 1997-01-14 Novel fused pyrrolecarboxamides; a new class of gaba brain receptor ligands

Country Status (26)

Country Link
US (2) US5804686A (de)
EP (1) EP1019372B1 (de)
JP (1) JP2000503321A (de)
KR (1) KR100490108B1 (de)
CN (1) CN1209805A (de)
AP (1) AP1015A (de)
AT (1) ATE322480T1 (de)
AU (1) AU1746697A (de)
BG (1) BG102634A (de)
BR (1) BR9707051A (de)
CA (1) CA2243317C (de)
CZ (1) CZ215498A3 (de)
DE (1) DE69735647T2 (de)
ES (1) ES2263170T3 (de)
HU (1) HUP9901018A3 (de)
IL (1) IL125391A (de)
IS (1) IS4798A (de)
MX (1) MX9805701A (de)
NO (1) NO312670B1 (de)
NZ (1) NZ330861A (de)
OA (1) OA10811A (de)
PL (1) PL327936A1 (de)
RU (1) RU2167151C2 (de)
SK (1) SK94398A3 (de)
UA (1) UA49001C2 (de)
WO (1) WO1997026243A1 (de)

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US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US6211365B1 (en) 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
EP0888300A1 (de) 1996-03-22 1999-01-07 Neurogen Corporation Kondensierte pyrrolcarboxamide als gaba-gehirn-rezeptor-liganden
US5723462A (en) * 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
YU27300A (sh) * 1997-11-13 2002-10-18 Pfizer Products Inc. Postupak sinteze pirolnih amida
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
WO1999043660A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
WO2000012492A1 (en) * 1998-09-01 2000-03-09 Nissan Chemical Industries, Ltd. Benzoxazine derivatives
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
MXPA02001709A (es) * 1999-08-31 2002-10-23 Neurogen Corp Pirrolocarboxamidas fusionadas: ligandos receptores de acido gaba-aminobutirico cerebral.
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
WO2002020492A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor
US6743817B2 (en) 2000-09-06 2004-06-01 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
MXPA03004939A (es) * 2000-12-04 2003-09-10 Pfizer Prod Inc Sintesis de pirrolamidas.
MXPA04007606A (es) * 2002-02-07 2004-11-10 Neurogen Corp Arilamidas de acido pirazolcarboxilico fusionadas substituidas y compuestos relacionados.
JP2006502974A (ja) 2002-05-17 2006-01-26 ニューロジェン コーポレイション 置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド
EP2258358A3 (de) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2275095A3 (de) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
DK2074123T3 (da) 2006-10-16 2013-01-14 Bionomics Ltd Nye anxiolytiske forbindelser
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
KR101442445B1 (ko) 2010-08-31 2014-09-22 메이지 세이카 파루마 가부시키가이샤 유해 생물 방제제
WO2012116415A1 (en) 2011-03-02 2012-09-07 Bionomics Limited Novel small-molecules as therapeutics
JP6055817B2 (ja) 2011-05-12 2016-12-27 バイオノミックス リミテッド ナフチリジンの調製方法

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DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3147276A1 (de) * 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
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DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
CA2091986C (en) * 1990-10-09 1995-11-28 Andrew Thurkauf Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
EP0626966A1 (de) * 1992-02-19 1994-12-07 PHARMACIA & UPJOHN COMPANY 3-substituierte lumidazo(1,5-a)-chinoxaline und chinozoline mit zns wirksamkeit
US5266698A (en) * 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
AU6098194A (en) * 1993-01-29 1994-08-15 Ariad Pharmaceuticals, Inc. Analogs of receptor tyrosine activation motifs and therapeutic uses thereof
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
KR100490108B1 (ko) 2005-11-25
KR19990077300A (ko) 1999-10-25
BG102634A (en) 1999-08-31
BR9707051A (pt) 1999-07-20
IL125391A (en) 2004-07-25
ES2263170T3 (es) 2006-12-01
NO983315L (no) 1998-09-03
DE69735647D1 (de) 2006-05-18
CA2243317A1 (en) 1997-07-24
AU1746697A (en) 1997-08-11
HUP9901018A2 (hu) 1999-07-28
CZ215498A3 (cs) 1999-09-15
AP1015A (en) 2001-09-28
HUP9901018A3 (en) 1999-11-29
EP1019372B1 (de) 2006-04-05
WO1997026243A1 (en) 1997-07-24
RU2167151C2 (ru) 2001-05-20
PL327936A1 (en) 1999-01-04
UA49001C2 (uk) 2002-09-16
US5804686A (en) 1998-09-08
AP9801297A0 (en) 1998-09-30
NZ330861A (en) 2000-03-27
JP2000503321A (ja) 2000-03-21
DE69735647T2 (de) 2007-05-03
IS4798A (is) 1998-07-16
OA10811A (en) 2001-07-05
CA2243317C (en) 2007-09-25
ATE322480T1 (de) 2006-04-15
EP1019372A1 (de) 2000-07-19
NO983315D0 (no) 1998-07-17
NO312670B1 (no) 2002-06-17
US6080873A (en) 2000-06-27
IL125391A0 (en) 1999-03-12
MX9805701A (es) 1998-11-30
CN1209805A (zh) 1999-03-03

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