SK7112001A3 - Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system - Google Patents

Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system Download PDF

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SK7112001A3
SK7112001A3 SK711-2001A SK7112001A SK7112001A3 SK 7112001 A3 SK7112001 A3 SK 7112001A3 SK 7112001 A SK7112001 A SK 7112001A SK 7112001 A3 SK7112001 A3 SK 7112001A3
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azabicyclo
exo
ethyl
fluorophenyl
heptan
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Gerd Steiner
Rainer Munschauer
Gerhard Gross
Martin Traut
Liliane Unger
Hans-Jurgen Teschendorf
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Basf Ag
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Indole Compounds (AREA)

Abstract

The invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula (I), wherein B, R<1>, R<2> and n have the meanings given in the description, for combating diseases of addiction and other diseases of the central nervous system.

Description

Oblasť technikyTechnical field

Predložený vynález sa týka N-substituovaných 3-azabicykíoalkánových derivátov, ktoré sú vhodné ako liečivá na liečenie návykových ochorení a iných ochorení centrálnej nervovej sústavy.The present invention relates to N-substituted 3-azabicycloalkane derivatives useful as medicaments for the treatment of addictive diseases and other diseases of the central nervous system.

Doterajší stav technikyBACKGROUND OF THE INVENTION

N-substituované azabicykloalkánové deriváty sú už známe ako neuroleptiká (WO 95/13276, WO 95/15327, WO 96/04272, US 5,475,105, US 5,521,209, US 5,616,705, US 5,753,690). Teraz sa zistilo, že tieto látky sú tiež vhodné na liečenie návykových ochorení a iných ochorení centrálnej nervovej sústavy.N-substituted azabicycloalkane derivatives are already known as neuroleptics (WO 95/13276, WO 95/15327, WO 96/04272, US 5,475,105, US 5,521,209, US 5,616,705, US 5,753,690). It has now been found that these agents are also useful in the treatment of addictive diseases and other diseases of the central nervous system.

Podstata vynálezuSUMMARY OF THE INVENTION

Predložený vynález sa týka použitia N-substituovaných 3azabicykloalkánových derivátov všeobecného vzorca IThe present invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula I

v ktoromin which

B B znamená 4-, 5- alebo 6-členný kruh, ktorý môže obsahovať dvojitú väzbu, means a 4-, 5- or 6-membered ring which may contain a double bond, R1 R 1 predstavuje fenylovú, naftylovú, fenantrylovú alebo tienylovú skupinu, z ktorých každá môže byť nesubstituovaná alebo mono- alebo disubstítuovaná substituentami, ako je atóm halogénu, Ci.4-alkyiová skupina, trifluórmetylová skupina, hydroxylová skupina, Ci.4-alkoxylová skupina, aminoskupina, monometylaminoskupina, dimetylaminoskupina, kyanoskupina alebo nitroskupina,represents a phenyl, naphthyl, phenanthryl or thienyl group, each of which may be unsubstituted or mono- or disubstituted with substituents such as a halogen atom; 4- alkyl, trifluoromethyl, hydroxyl, C 1-6 alkyl; 4- alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro;

• • ···· ···· ·· · · ·· · · ·· · ·· · • · • · • • • • • • • · • · • • • • • · • · • • • • • • • • ·· · · • • • • • • • • • • • • • • • • • • • • • · • · • • • • • • ··· · · · • • • · • · ·· · · • · • · • · · • · ·

n znamená číslo 0,1, 2, 3 alebo 4, an is 0, 1, 2, 3 or 4, and

R2 predstavuje naftylovú skupinu, ktorá je nesubstituovaná alebo substituovaná jedným alebo dvoma atómami halogénu, alebo znamená jeden z nasledujúcich zvyškov:R 2 is naphthyl which is unsubstituted or substituted by one or two halogen atoms, or represents one of the following radicals:

B B R3 | R3 | 0 II 0 II - - --c—RS , - --c — RS, - — NR6--C--R7 t -- NR 6 - C - R 7 t - — SO2—(Q)- SO 2 - (Q) R« R ' \__f \ __ f

oror

O2SO 2 S

II

--K--K

-3v ktorom-3 in which

R3 R 3

R4 R 4

R3 a R4 R 3 and R 4

R5 R 5

R6 R 6

R8 R 8

R9 R 9

R10 R 10

R9 a R10 znamená atóm vodíka, hydroxylovú skupinu alebo fenylový zvyšok, ktorý je nesubstituovaný alebo substituovaný atómom fluóru, chlóru alebo brómu, predstavuje atóm vodíka alebo spoločne znamenajú atóm kyslíka, predstavuje fenylovú, naftylovú alebo tienylovú skupinu, z ktorých každá môže byť nesubstituovaná alebo mono- alebo disubstituovaná substituentom, ako je atóm fluóru, chlóru alebo brómu alebo hydroxylová skupina, nitroskupina, aminoskupina, Ci_4-alkanoylaminoskupina, C1.4alkylaminoskupina, CA-alkylová skupina alebo metoxyskupina, znamená atóm vodíka alebo metylovú skupinu, predstavuje fenylovú, naftylovú, benzofurylovú, benzotienylovú, tienylovú, indolylovú, N-metylindolylovú alebo indenylovú skupinu, z ktorých každá môže byť nesubstituovaná alebo mono- alebo disubstituovaná substituentom, ako je atóm fluóru, chlóru alebo brómu alebo C-w-alkylová skupina, hydroxylová skupina, metoxyskupina, nitroskupina, kyanoskupina, trifluórmetylová skupina, aminoskupina alebo di-C-M-alkylaminoskupina, alebo znamená C3.7-cykloalkylovú skupinu, znamená atóm vodíka alebo atóm fluóru alebo chlóru alebo CA-alkylovú skupinu, metoxyskupinu alebo aminoskupinu, predstavuje atóm vodíka alebo metylovú skupinu a znamená atóm vodíka alebo metylovú skupinu alebo spoločne s atómom uhlíka kruhu predstavujú spirocyklopropánový kruh,R 9 and R 10 represent a hydrogen atom, a hydroxyl group or a phenyl radical which is unsubstituted or substituted by a fluorine, chlorine or bromine atom, represents a hydrogen atom or together represents an oxygen atom, represents a phenyl, naphthyl or thienyl group, each of which may be unsubstituted or mono- or disubstituted with a substituent such as a fluorine, chlorine or bromine atom or a hydroxyl, nitro, amino, C 1-4 -alkanoylamino, C 1-4 alkylamino, CA-alkyl or methoxy group, represents a hydrogen atom or a methyl group, represents phenyl, naphthyl, naphthyl, naphthyl, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl, each of which may be unsubstituted or mono- or disubstituted with a substituent such as a fluorine, chlorine or bromine atom or a C 1-6 alkyl group, a hydroxyl group, a methoxy group, a nitro group, a nitro group, a nitro group upina, trifluoromethyl, amino or di-C 1-4 -alkylamino, or is C3. 7 -cycloalkyl, represents a hydrogen atom or a fluorine or chlorine atom or a C-alkyl, methoxy or amino group, represents a hydrogen atom or a methyl group and represents a hydrogen atom or a methyl group or together with the ring carbon atom they represent a spirocyclopropane ring,

···· ···· ·· · · ·· · · ·· · · • • • · • · • · • · • · « • · « • • • · • · ·· · · • · • · • • • · • · • · • · • · • · • · • · ·· · · ·· · · ·· 4 ·· 4

R11 znamená atóm vodíka, hydroxylovú skupinu, Ci^-alkylovú skupinu alebo C^-alkoxylovú skupinu, alebo spolu s priľahlým atómom uhlíka predstavuje skupinu C=O- alebo skupinu C=S,R 11 represents a hydrogen atom, a hydroxyl group, a C 1-6 -alkyl group or a C 1-6 -alkoxy group or together with an adjacent carbon atom it represents a C = O- or C = S group,

X a Y znamenajú atóm uhlíka, CH, CH2, NH skupinu alebo skupinu Ci^-alkyl-N alebo atóm dusíka,X and Y are carbon, CH, CH 2 , NH or C 1-6 -alkyl-N or a nitrogen atom,

Z predstavuje priamu väzbu, skupinu CO, skupinu CS alebo skupinu CH alebo skupinu CH2, v ktorých atóm vodíka môže byť nahradený hydroxylovou skupinou, aminoskupinou alebo CM-alkoxyskupinou alebo atómom halogénu, aZ represents a direct bond, a CO group, a CS group or a CH group or a CH 2 group in which the hydrogen atom can be replaced by a hydroxyl group, an amino group or a C 1-4 alkoxy group or a halogen atom, and

A znamená atóm vodíka, hydroxylovú skupinu, aminoskupinu, merkaptoskupinu, C^-alkylaminoskupinu, di-Ci^-alkylaminoskupinu, C^-alkyltioskupinu alebo Ci-4-alkoxylovú skupinu alebo spolu s priľahlým atómom uhlíka predstavuje skupinu C=O, aleboA represents a hydrogen atom, a hydroxyl group, an amino group, a mercapto group, a C 1-4 -alkylamino group, a di-C 1-4 -alkylamino group, a C 1-4 -alkylthio group or a C 1-4 -alkoxy group or together with an adjacent carbon atom represents C = O, or

A predstavuje Y-viazanú C3-C4-alkylénovú skupinu, ktorá môže obsahovať jednu alebo dve nekumulované dvojité väzby a v ktorej jedna CH alebo CH2 skupina môže byť nahradená atómom dusíka alebo síry alebo NH alebo N-CH3 skupinou a kde kruh je buď monosubstituovaný atómom fluóru alebo atómom chlóru alebo metylovou skupinou, metoxyskupinou, nitroskupinou alebo aminoskupinou, alebo, v prípade benzénového kruhu, tento môže byť mono-, di- alebo trisubstituovaný atómami fluóru alebo chlóru alebo skupinami, ako je metylová skupina, trifluórmetylová skupina, nitroskupina, hydroxylová skupina, metoxyskupina, aminoskupina, monometyl- alebo dimetylaminoskupina, a v ktorom X-, Y- and Z-obsahujúci kruh môže na atóme dusíka č. 1 niesť C1-C4alkylovú skupinu, alylovú skupinu alebo benzylovú skupinu a môže obsahovať 1 až 3 nekumulované dvojité väzby, a ich soli s fyziologicky prijateľnými kyselinami na prípravu liečiv na liečenie závislostí, na liečenie porúch koncentrácie (nedostatok pozornosti), hyperaktivity u detí (nedostatok pozornosti z hyperaktivity), oslabenia schopnosti učenia a oslabenia pamäte (zhoršená kognitívna funkcia).A represents a Y-linked C 3 -C 4 -alkylene group which may contain one or two non-accumulated double bonds and in which one CH or CH 2 group may be replaced by a nitrogen or sulfur atom or an NH or N-CH 3 group and wherein the ring is either monosubstituted a fluorine or chlorine atom or a methyl, methoxy, nitro or amino group, or, in the case of a benzene ring, this may be mono-, di- or trisubstituted by fluorine or chlorine atoms or by groups such as methyl, trifluoromethyl, nitro, hydroxyl a group, methoxy, amino, monomethyl- or dimethylamino group, in which the X-, Y- and Z-containing ring may be present on the nitrogen atom of the nitrogen atom. 1 carry a C 1 -C 4 alkyl group, an allyl group or a benzyl group and may contain 1 to 3 non-accumulated double bonds, and their salts with physiologically acceptable acids for the preparation of medicaments for the treatment of addictions, for the treatment of concentration disorders (lack of attention), hyperactivity in children hyperactivity), learning disability and memory impairment (impaired cognitive function).

···· ···· ·· · · ·· · · ·· · · • • • • • • • • • • • • • « • « • • • • • • ·· · · • • • • • • • • • • • • • • • • • • • · • · • · • · • · • · ·· e ·· e

Použitie podľa predloženého vynálezu sa týka všetkých návykových ochorení, či už sú pôsobené zneužívaním látok alebo inými návykovými ochoreniami, ako je napríklad závislosť na hazardných hrách. Návykovými látkami môžu byť:The use according to the present invention relates to all addictive diseases, whether they are caused by substance abuse or other addictive diseases, such as gambling addiction. Addictive substances may be:

opiáty, ako je napríklad morfín alebo heroín, nikotín, alkohol, látky, ktoré sa navzájom ovplyvňujú s komplexom benzodiazínového receptora, sedatívami alebo trankvilizérmi, ako sú napríklad benzodiazíny.opiates such as morphine or heroin, nicotine, alcohol, substances that interact with a benzodiazine receptor complex, sedatives or tranquilizers such as benzodiazines.

Možnými návykovými látkami podľa predloženého vynálezu sú predovšetkým kokaín alebo amfetamín a amfetamínu podobné látky.Possible addictive substances according to the present invention are in particular cocaine or amphetamine and amphetamine-like substances.

Zlúčeniny vzorca I sa môžu použiť ako vo forme svojich racemátov tak i vo forme svojich optických izomérov.The compounds of the formula I can be used both in the form of their racemates and in the form of their optical isomers.

Pri novej indikácii sa zlúčeniny môžu podávať zvyčajným spôsobom orálne alebo parenterálne, intravenózne alebo intramuskulárne.In a new indication, the compounds may be administered orally or parenterally, intravenously or intramuscularly.

Dávka závisí od veku, stavu a hmotnosti pacienta a od spôsobu podávania. Vo všeobecnosti predstavuje denná dávka účinnej zlúčeniny medzi približne 1 a 100 mg/kg telesnej hmotnosti v prípade orálneho podávania a medzi 0,1 a 10 mg/kg telesnej hmotnosti v prípade parenterálneho podávania.The dose depends on the age, condition and weight of the patient and the route of administration. In general, the daily dose of active compound is between about 1 and 100 mg / kg body weight for oral administration and between 0.1 and 10 mg / kg body weight for parenteral administration.

Zlúčeniny sa môžu používať vo zvyčajných farmaceutických dávkových formách, v pevnej alebo kvapalnej forme, napríklad ako tablety, filmom-poťahované tablety, kapsule, prášky, granule, cukrom-poťahované tablety, čipky, roztoky, masti, krémy alebo spreje. Tieto sa pripravia zvyčajným spôsobom. Na tento účel sa účinné zlúčeniny môžu spracovať so zvyčajnými farmaceutickými pomocnými látkami, ako sú spojivá tabliet, plnidlá, konzervačné látky, dezintegrátory tabliet, regulátory tečenie, plastifikátory, zmáčacie činidlá, dispergačné činidlá, emulgačné činidlá, rozpúšťadlá, činidlá s oneskoreným uvoľňovaním, antioxidanty a/alebo hnacie plyny (porovnaj B. Sucker a kol.: Pharmazeutische Technológie ThiemeVerlag, Stuttgart, 1978). Výsledné formy podávania zvyčajne obsahujú účinnú zlúčeninu v množstve od 1 do 99 % hmotnostných.The compounds may be used in conventional pharmaceutical dosage forms, in solid or liquid form, for example, as tablets, film-coated tablets, capsules, powders, granules, sugar-coated tablets, lace, solutions, ointments, creams or sprays. These are prepared in the usual manner. For this purpose, the active compounds may be formulated with the usual pharmaceutical excipients such as tablet binders, fillers, preservatives, tablet disintegrators, flow regulators, plasticizers, wetting agents, dispersing agents, emulsifying agents, solvents, delayed-release agents, antioxidants and the like. and / or propellants (cf. B. Sucker et al., Pharmazeutische Technologie ThiemeVerlag, Stuttgart, 1978). The resulting forms of administration usually contain the active compound in an amount of from 1 to 99% by weight.

···· • • ···· • • ·· · · ·· • · ·· · · • · · · ·· • • · · • • • · • • · • • • • • • • • • • • • • • • • · • · • • • • • · • · ·· · · ·· · · ·· · · 4 4

Príklady uskutočnenia vynálezuDETAILED DESCRIPTION OF THE INVENTION

Ako príklad zlúčenín vzorca I sa môžu uviesť nasledujúce látky:Examples of compounds of formula I include the following:

1. 1-(4-fluórfenyl)-4-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

2. 1-fenyl-4-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]-butan-1-ón2. 1-Phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

3. 1-(4-fluórfenyl)-4-[exo-6,7-difenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón3. 1- (4-Fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

4.1- (4-fluórfenyl)-4-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]bután4.1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

5.1- fenyl-2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etan-1-ón5.1-Phenyl-2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethan-1-one

6. 1-(4-fluórfenyl)-4-(exo_6‘P-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]bután6. 1- (4-fluorophenyl) -4- (exo_ 6'P - fl at cholorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] butane

7.1- (4-fluórfenyl)-4-[exo-6-m-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón7.1- (4-fluorophenyl) -4- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

8. 1-(4-fluórfenyl)-4-[exo-6-o-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón8. 1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

9.1 -(4-fluórfenyl)-4-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1 -ón9.1- (4-fluorophenyl) -4- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

10.1- (4-fluórfenyl)-4-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón10.1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

11. 1 -(4-fluórfenyl)-4-[exo-6-p-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1 ón11. 1- (4-Fluorophenyl) -4- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

12. 1 -(4-fluórfenyl)-4-[exo-6-m,p-dichlórfenyl-3-azabicyklo-[3.2.0]heptan-3-yl]butan-12. 1- (4-Fluorophenyl) -4- [exo-6-m, p-dichlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane-

1-ón1-one

13.1- (4-fluórfenyl)-4-[exo-6-m,p-dimetoxyfenyl-3-azabicyklo[3.2.0]heptan-3- yl]butan-1-ón13.1- (4-Fluorophenyl) -4- [exo-6-m, p-dimethoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

14. 1-(4-fluórfenyl)-4-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón14. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

15.1- fenyl-4-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1 -ón15.1-Phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

16.1- (4-fluórfenyl)-4-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]bután16.1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

17.1 -(4-fluórfenyl)-4-[exo-6-p-nitrofenyl-3-azabicyklo-[3.2.0]heptan-3-yl]butan-1 -ón17.1- (4-Fluorophenyl) -4- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

18.1- (4-fluórfenyl)-4-[exo-6-m-nitrofenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón18.1- (4-Fluorophenyl) -4- [exo-6-m-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

19. 1-(4-fluórfenyl)-4-[exo-6-p-trifluórmetylfenyl-3azabicyklo[3.2.0]heptan-3- yl]butan-1-ón19. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

20. 1-(4-fluórfenyl)-4-[exo-6-p-kyanofenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ón20. 1- (4-Fluorophenyl) -4- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

• ···· • ···· ·· · · ·· · · ·· · · • · • · • • • • • • • • • • • • ·· · · • · • · • • • • ·· · · • • • • • · • · • • • • • • • • • • • • • · · • · · ·· · · ·· · · ·· · · • · • ·

21.1 -(4-fluórfenyl)-4-[exo-6-tien-3-yl-3-azabicyklo-[3.2.0]heptan-3-yl]butan-1 -ón21.1- (4-Fluorophenyl) -4- [exo-6-thien-3-yl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

22.1- (4-fluórfenyl)-4-[exo-6-pyrid-3-yl-3-azabicyklo-[3.2.0]heptan-3-yl]butan-1-ón22.1- (4-Fluorophenyl) -4- [exo-6-pyrid-3-yl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

23.1- (4-fluórfenyl)-3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]propan-1 -ón ·23.1- (4-fluorophenyl) -3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propan-1-one ·

24.1- (bis-4-fluórfenyl)-4-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]bután24.1- (bis-4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

25.1- (bis-4-fluórfenyl)-4-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]biitán25.1- (bis-4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] biitane

26.1- (4-fluórfenyl)-4-[exo-6-fenyl-3-azabicyklo(3.2.0]heptan-3-yl]butan-1-ol26.1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo (3.2.0) heptan-3-yl] butan-1-ol

27.1- (4-fluórfenyl)-4-[exo-6-p-fluórfenyl-3-azabicyklo-[3.2.0]heptan-3-yl]butan-1-ol27.1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

28.1- (4-fiuórfenyl)-4-[exo-6,7-difenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ol28.1- (4-Fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

29.1- fenyl-4-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ol29.1-Phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

30.1- fenyl-4-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ol30.1-Phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

31.1- (4-fluórfenyl)-4-[exo-6-o-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ol31.1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

32.1- (4-fluórfenyl)-4-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butan-1-ol32.1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

33.1- (4-fluórfenyl)-4-[exo-6-p-trifluórmetylfenyl-3-azabicyklo[3.2.0]heptan-3yl]butan-1-ol33.1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

34. l-(4-fluórfenyl)-4-[exo-6-p-aminofenyl-3-azabicyklo[3.2.0]heptan-3-yl]bĽtan-1ón34. 1- (4-Fluorophenyl) -4- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

35. N-(3-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)-4-fluórbenzamid35. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-fluorobenzamide

36. N-(3-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)benzamid36. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) benzamide

37. N-(2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4-fluórbenzamid37. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorobenzamide

38. N-(2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzamid38. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

39. N-(2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-N-metyl-4-fluórbenzamid39. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-fluorobenzamide

40. N-(2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-N-metylbenzamid40. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methylbenzamide

41. N-(2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-N-metyl-4izopropylbenzamid41. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-isopropylbenzamide

42. N-(3-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)-4-chlórbenzamid42. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-chlorobenzamide

43. N-(2-[exo-6-p-trifliiórmetylfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4chlórbenzamid43. N- (2- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorobenzamide

···· ···· ·· · · · · ·· · · • • • • • • • · • · • • • 4 • 4 • • • • • • ·· · · • • • • • • • • • • • · • · • • • • • · • · ·· · · ·· · · • · fl • · fl

44. N-(3-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)-3-metoxybenzamid44. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-methoxybenzamide

45. N-(3-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)-3-nitrobenzamid45. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-nitrobenzamide

46. N-(3-[exo-6-p-fluórfenyl-3-azabÍcyklo[3.2.0Iheptan3-yl]propyl)-4-fluórbenzamid46. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-fluorobenzamide

47. N-(3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)benzamid47. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) benzamide

48. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl)-4-fluórbenzamid48. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorobenzamide

49. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl)benzamid49. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

50. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl)-N-metyl-4fluórbenzamid50. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-fluorobenzamide

51. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl)-N-metylbenzamid51. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methylbenzamide

52. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-N-metyl-4izopropyl-benzamid52. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-isopropylbenzamide

53. N-(3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]propyl)-4-chlórbenzamid53. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-chlorobenzamide

54. N-(3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)-3metoxybenzamid54. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-methoxybenzamide

55. N-(3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl)-3-nitrobenzamid55. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-nitrobenzamide

56. N-(2-[exo-6-m-chlórfenyl-3-azabicykío[3.2.0]heptan3-yl]etyl)-4-chlórbenzamíd56. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorobenzamide

57. N-(2-[exo-6-o-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4-chlórbenzamid57. N- (2- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorobenzamide

58. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl)-2-hydroxybenzamid58. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -2-hydroxybenzamide

59. N-(2-[exo-6-m-hydroxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4chlórbenzamid59. N- (2- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorobenzamide

60. exo-3-n-butyl-6-fenyl-3-azabicyklo[3.2.0]heptán60. Exo-3-n-butyl-6-phenyl-3-azabicyclo [3.2.0] heptane

61. exo-3-metyl-6-fenyl-3-azabicyklo[3.2.0]heptán61. Exo-3-methyl-6-phenyl-3-azabicyclo [3.2.0] heptane

62. exo-3-metyl-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptán62. Exo-3-methyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

63. exo-3-n-propyl-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptán63. Exo-3-n-propyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

64. exo-3-metyl-6,7-difenyl-3-azabicyklo[3.2.0]heptán64. Exo-3-methyl-6,7-diphenyl-3-azabicyclo [3.2.0] heptane

65. exo-3-n-propyl-6-m-hydroxyfenyl-3-azabicyklo[3.2.0]heptán65. Exo-3-n-propyl-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptane

66. exo-3-alyl-6-m-metoxyfenyl-3-azabicyklo[3.2.0]heptán66. Exo-3-allyl-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptane

···· ···· ·· · · ·· · · ·· · · B · B · • • • • • • • · • · • • • « • « • • « « • • ·· · · • • • • • • • • • · • · • • • • ··· · · · • • ·· · · • · • · ·· 1 ·· 1

67. exo-3-(3,4-dimetoxy)fenetyl-6-fenyl-3-azabicyklo[3.2.0]heptán67. exo-3- (3,4-dimethoxy) phenethyl-6-phenyl-3-azabicyclo [3.2.0] heptane

68. exo-3-(3,4-dimetoxy)fenetyl-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptán68. Exo-3- (3,4-dimethoxy) phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

69. exo-3-(3,4-dihydroxy)fenetyl-3-azabicyklo[3.2.0]heptán69. exo-3- (3,4-dihydroxy) phenethyl-3-azabicyclo [3.2.0] heptane

70. exo-3-fenetyl-6-p-fluórfenyl-3-azabicyklo[3.2.Ojheptán70. exo-3-phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2] octane

71.6^-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón71.6 ^ - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl-7-methyl-5Htiazolo [3,2-a] pyrimidin-5-one

72. (+)-6-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5H-tiazoloP^-aJyrimidin-S-ón72. (+) - 6-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo-4 &apos; -a-pyrimidin-S-one

73. (-)-6-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin-5-ón73. (-) - 6-p- [Exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

74.6- p-[exo-6-fenyl-3-azabícyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5H-tiazolo[3,2-a]pyrimidin-5-ón74.6- p- [Exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

75. 6-p-[exo-6,7-difenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl7-metyl-5H-t!azolo[3,2a]-pyrimidin-5-ón75. 6-p- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2a] pyrimidin-5-one

76.6- p-[exo-6,7-bis-(p-fluórfenyl)-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin-5-ón76.6- p- [exo-6,7-bis- (p-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

77.6- p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón77.6- p- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

78. 6-p-[exo-6-m-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo-[3,2-a]pyrimidin-5-ón78. 6-p- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

79.6- p-[exo-6-m-hydroxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo-p^-aJpyrimidin-S-ón79.6- p- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo-β-α-pyrimidin-5-one

80. 6-p-(2-[exo-6-p-aminofenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo-[3,2-a]pyrimidin-5-ón80. 6-p- (2- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

81.6- p-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón81.6- p- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

82. 6-p-[exo-6-p-metoxyfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin-5-ón82. 6-p- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

• ···· • · • · • ···· • · • · ·· · · ·· • · ·· · · • · · · ·· · · • • • • • • • • • • • • • • • • • · • · • • • • • · • · • • • • • · · • · · ·· · · ·· · · ·· · ·

83. 6-p-[exo-6-p-nitrofenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón83. 6-p- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

84. 6-p-[exo-6-m-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón84. 6-p- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5-thiazolo [3,2-a] pyrimidin-5-one

85. 6-P-[exo-6-p-hydroxyfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5H-tiazolo[3,2-a]pyrimidin-5-ón85. 6-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

86. 6-p-[exo-6-p-trifluórmetylfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin-5-ón86. 6-p- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

87. 6-p-[exo-6-(p-t-butylfenyl)73-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo-[3,2-a]pyrimidin-5-ón87. 6-p- [exo-6- (p-t-butylphenyl) 73-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

88. 6-p-[endo-6-(p-t-butylfenyl)-3-azabicyklo[3.2.0]heptan3-yl]etyl-7-metyl-5Htiazolo-[3,2-a]pyrímidin-5-ón88. 6-p- [endo-6- (p-t-butylphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

89. 6-p-[exo-6-(3,4-dichlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin-5-ón89. 6-p- [exo-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5-thiazolo [3,2-a] pyrimidin-5 -one

90. 6-p-[exo-6-(3,4-dimetoxyfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimídin5-ón90. 6-p- [exo-6- (3,4-dimethoxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

91. 6-p-[exo-6-p-kyanofenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón91. 6-p- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5-thiazolo [3,2-a] pyrimidin-5-one

92. 6-p-[exo-6-(3,4-dihydroxyfenyl)-3-azabicyklo[3.2.0]-heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin5-ón92. 6-p- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- one

93. 6-p-[exo-6-(o-fluórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]-pyrimidin-5-ón93. 6-p- [exo-6- (o-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5-thiazolo [3,2-a] pyrimidine-5- one

94. 6-p-[exo-6-tien-3-yl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5H-tiazolo[312a]-pyrimidin-5-ón94. 6-p [exo-6-thien-3-yl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl-7-methyl-5H-thiazolo [3 2 1] pyrimidine-5 one

95. 6-p-[exo-6-.(5-chlórtien-2-yl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-5Htiazolo-[3,2-a]pyrimidin-5-ón95. 6-β- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a ] pyrimidin-5-one

96. 6-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-213-dihydro5H-tiazolo[3,2-a]pyrimidin-5-ón96. 6-p [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl-7-methyl-1 2 3-dihydro-5H-thiazolo [3,2-a] pyrimidine 5-one

• ···· • ···· ·· · · ·· · · ·· · · • · • · • · • · • • • • • • • • • · • · • t • t • · • · ·· · · • • 9 9 • · • · • · • · • • • • • • • • • · · • · · ·· · · ·· · · ·· · · • · • ·

97. 6-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-2,3-dihydro5H-tiazolo[3,2-a]pyrimidin-5-ón97. 6-p- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [3,2-a] pyrimidine 5-one

98. 6-p-[exo-6-p-fIuórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,3,7-trimetyl-5Htiazolo-[3,2-a]pyrimidin-5-ón98. 6-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,3,7-trimethyl-5H-thiazolo [3,2-a] pyrimidine- 5-one

99. 6-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-5H-tiazolo[3,2-a]pyrimidin-5-ón99. 6-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5H-thiazolo [3,2-a] pyrimidin-5-one

100. 6-p-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-5H-tiazolo[3,2-a]pyrimidin-100. 6-p- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5H-thiazolo [3,2-a] pyrimidine-

5-ón5-one

101.7-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-8-metyl-2H,6Hpyrimido-[2,1 -b][ 1,3]tiazin-6-ón101.7-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrido [2,1-b] [1,3] thiazin-6-one

102. 7-p-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-8-metyl-2H,6H- pyrimidop, 1 -b][1,3]tiazin-6-ón102. 7-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrimidop, 1-b] [1,3] thiazine- 6-one

103. 7-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-8-metyl-2H,6Hpyrimido[2,1 -b][ 1,31 tiazin-6-ón103. 7-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,31 thiazin-6-one

104. 7-p-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-8-metyl-2H,6Hpyrimido[2,1 -b][1,3]tiazin-6-ón104. 7-p- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] ] thiazin-6-one

105. 7-p-[exo-6-p-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-8-metyl-2H,6Hpyrimido[2,1-bl[l.3]tiazin-6-ón105. 7-β- [exo-6-β-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b1 [1,3] thiazin-6-one

106. 7-p-[exo-6-m-hydroxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-8-metyl-2H,6Hpyrimido[2,1 -b][ 1,3]tiazin-6-ón106. 7-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrido [2,1-b] [1,3 ] thiazin-6-one

107. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-2,4- (1 H,3H)chinazolin-dión107. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

108. (+)-3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1H,3H)chinazolindión108. (+) - 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

109. (-)-3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1H,3H)chinazolindión109. (-) - 3-p- [Exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

110. 3-p-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1 H,3H)chinazolindión110. 3-p- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

111. 3-p-[exo-6-m-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-etyl-2,4- (1 H,3H)chinazolin-dión111. 3-p- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

-12···· ·· ·· ·· ·· · · · · · · • · · · ·· · · • · β······· ·· · · · · ·· ··· · ·· ·· ··-12 ································· ·· ·· ··

112. 3-p-[exo-6-p-kyanofenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1 H.3H)- chinazolindión112. 3-p- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

113. 3-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión113. 3-p- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

114. 3-3-[exo-6-p-hydroxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1 H.3H)- chinazolindión114. 3-3- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

115. 3-p-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión115. 3-p- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

116. 3-p-[exo-6-m-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1 H,3H)- chinazolindión116. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

117. 3-p-[exo-6-p-nitrofenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión117. 3-p- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

118. 3-p-[endo-6-p-nitrofenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1 H,3H)- chinazolindión118. 3-p- [endo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

119. 3-p-[exo-6-m-hydroxyfenyl-3-azabicyklo(3.2.0]heptan-3-yl]etyl-2,4-(1 H,3H)- chinazolindión119. 3-β- [exo-6-m-hydroxyphenyl-3-azabicyclo (3.2.0) heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

120. 3-p-[exo-6-p-aminofenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2l4-(1H,3H)- chinazolindión120. 3-p- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl- 21- 4- (1H, 3H) -quinazinedione

121. 3-p-[exo-6-p-jódfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión121. 3-p- [exo-6-p-iodophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

122. 3-P-[exo-6-p-trifluórmetylfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1H,3H)- chinazolindión122. 3-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

123. 3-p-[exo-6-(3,4-dichlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1Hl3H)- chinazolindión123. 3-p- [exo-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] heptane-3-yl] ethyl-2,4 (1 H l 3H) - quinazolinedione

124. 3-p-[exo-6-(3,4-dihydroxyfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)-chinazolindión124. 3-p- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione

125. 3-p-[exo-6-(3,5-dichlórfenyl)-3-azabicyklo[3.2.0]heptan3-yl]etyl-2,4-(1H,3H)- chinazolindión125. 3-p- [exo-6- (3,5-dichlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

···· ···· ·· · · ·· · · ·· · · »· »· • • • • • • • • • • • · • · • · • · • • • • • • ·· · · f F • • • • • • • • • • • • • • • • »·· »· · • • ·· · · ·· · · ·· · · • •4 • • 4

126. 3-p-[exo-6-o-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión126. 3-p- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

127. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-8-metyl-2,4- (1 H,3H)-chinazolindión127. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2,4- (1H, 3H) -quinazolinedione

128. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-chlór-2,4-(1 H,3H)chinazolindión128. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-chloro-2,4- (1H, 3H) quinazolinedione

129. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-fluór-2,4-(1H,3H)chinazolindión129. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-fluoro-2,4- (1H, 3H) quinazolinedione

130. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-5-chlór-2,4-(1H,3H)chinazolindión130. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5-chloro-2,4- (1H, 3H) quinazolinedione

131.3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6-fluór-2,4-(1 H.3H)chinazolindión131.3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-fluoro-2,4- (1H, 3H) -quinazinedione

132. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6-metyl-2,4- (1 H,3H)-chinazolindión132. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-methyl-2,4- (1H, 3H) -quinazolinedione

133. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]ľieptan-3-yl]etyl-8-metoxy-2,4- (1 H,3H)-chinazolindión133. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] epteptan-3-yl] ethyl-8-methoxy-2,4- (1H, 3H) -quinazolinedione

134. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6-trifluórmetyl-2,4- (1 H,3H)chinazolindión134. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-trifluoromethyl-2,4- (1H, 3H) quinazolinedione

135. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-nitro-2,4-(1 H.3H)chinazolindión135. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-nitro-2,4- (1H, 3H) -quinazinedione

136. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6-nitro-2,4-(1H,3H)chinazolindión136. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-nitro-2,4- (1H, 3H) quinazolinedione

137. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-amino-2,4- (1 H,3H)-chinazolíndión137. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-amino-2,4- (1H, 3H) -quinazolinedione

138. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6-amino-2,4- (1 H,3H)-chinazolindión138. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-amino-2,4- (1H, 3H) -quinazolinedione

139. 3-p-[exo-6’P-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6-hydroxy-2,4- (1 H,3H)-chinazolindión139. 3-p- [exo-6'P-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-hydroxy-2,4- (1H, 3H) -quinazolinedione

• · • · ···· • • ···· • • • 9 • 9 99 99 9 • 9 • ·· • · ·· · · • · ·· ·· · · ·· · · • • • • • • • • • • 9 9 • • • · • · • • • • ··· · · · • • 99 99 ·· · · ·· · · • · • ·

140. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-5-chlór-2,4-(1H,3H)chinazolindión140. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5-chloro-2,4- (1H, 3H) quinazolinedione

141. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6,7-dimetoxy-2,4- (1 H,3H)chinazolindión141. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,7-dimethoxy-2,4- (1H, 3H) quinazolinedione

142. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6,8-dichlór-2,4- (1 H,3H)-chinazolindión142. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,8-dichloro-2,4- (1H, 3H) -quinazolinedione

143. S-p-íexo-e-p-fluórfenyl-S-azabicyklop^.OJheptan-S-ylJetyl-ej.e-trimetoxy^^(1 H,3H)chinazolindión143. S-p -exo-ε-p-fluorophenyl-S-azabicyclo [eta] &lt; 5 &gt; -heptan-S-yl-ethyl-η-trimethoxy-4- (1H, 3H) quinazolinedione

144. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1-metyl-2,4(1H,3H)-chinazolindión144. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-methyl-2,4 (1H, 3H) -quinazolinedione

145. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1-etyl-2,4-(1 H,3H)chinazolindión145. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-ethyl-2,4- (1H, 3H) quinazolinedione

146. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1-alyl-2,4-(1H,3H)chinazolindión146. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-allyl-2,4- (1H, 3H) quinazolinedione

147. 3-p-[exo-6-p-fluórfeny!-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1-benzyl-2,4- (1 H,3H)-chinazolindión147. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-benzyl-2,4- (1H, 3H) -quinazolinedione

148. 3-Y-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]propyl-2,4-(1H,3H)chinazolindión148. 3-Y- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl-2,4- (1H, 3H) quinazolinedione

149. 3-ô-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]butyl-2,4(1H,3H)chinazolin-dión149. 3-δ- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butyl-2,4 (1H, 3H) quinazoline-dione

150. 3-p-[exo-6-(2-tienyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolindión150. 3-β- [exo-6- (2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

151. 3-p-[exo-6-(5-chlór-2-tienyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4-(1H,3H)chinazolindión151. 3-β- [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

152. 3-p-[exo-6-(3-tienyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,4- (1 H,3H)chinazolindíón152. 3-β- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

153. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1 H-tieno[3,2-d]pyrimidin-2,4-dión153. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1H-thieno [3,2-d] pyrimidine-2,4-dione

• • ···· ···· ·· · · ·· · · ·· · · ·· · · • • • • • • • • • • • • • • • · • · • • • • • • • • • e • e • • • • • • • • • • • • • • • • • • • • ··· · · · • • ·· · · ·· · · ·· · · • •4 • • 4

154. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1 H-tieno[2,3-d]pyrimidin-2,4-dión154. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1H-thieno [2,3-d] pyrimidine-2,4-dione

155. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1 H-tieno[3,4-d]pyrimidin-2,4-dión155. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1H-thieno [3,4-d] pyrimidine-2,4-dione

156. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1 -metyl-1 H.3Hpyrido-[2,3-d]pyrimidin-2,4-dión156. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-methyl-1H-3H-pyrido [2,3-d] pyrimidin-2 , 4-dione

157. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-3Hchinazolin-4-ón157. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-3-quinazolin-4-one

158. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metoxy-3Hchinazolin-4-ón158. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methoxy-3H-quinazolin-4-one

159. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-4Hpy rido[1,2-a]-pyrimidín-4-ón dihydrochlorid159. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one dihydrochloride

160. 3-p-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-4H-pyrido[1,2-a]pyrimidin-4-ón160. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one

161. 3-p-[exo-6-m-chlórfenyi-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-4Hpyrido[1,2-a]-pyrimidin-4-ón161. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one

162. 3-p-[exo-6-m-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-4Hpyrido-[1,2-a]pyrimidin-4-ón162. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one

163. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,6-dimetyl-4Hpyrido-[1,2-a]pyrimidin-4-ón163. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,6-dimethyl-4H-pyrido [1,2-a] pyrimidin-4- one

164. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,7-dimetyl-4Hpyrido-[1,2-a]pyrimidin-4-ón164. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4- one

165. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,8-dimetyl-4Hpyrido-[1,2-a]pyrimidin-4-ón165. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,8-dimethyl-4H-pyrido [1,2-a] pyrimidin-4- one

166. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,9-dimetyl-4Hpyrido-[1,2-a]pyrimidin-4-ón166. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] pyrimidin-4- one

167. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2I6I8-trimetyl-4Hpyrido[1,2-a]pyrimidin-4-ón • ···· ·· · ···· · · ·· • · · · ·· · · · • · ········ · ·· «··· ··· ··· · ·· ·· ·· ···167. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl-2 I 6 I 8-trimethyl-4H-pyrido [1,2-a] pyrimidin-4 -on · ······································· · ·· ·· ·· ···

168. 3-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,7-dimetyl-4H- pyrido-[1,2-a]pyrimidin-4-ón168. 3-p- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidine- 4-one

169. 3-p-[exo-6-o-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,7-dimetyl-4H- py rido-[1,2-a)pyrimidin-4-ón169. 3-p- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidine 4-one

170. 3-p-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,8-dimetyl-4H-pyrido[1,2-170. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,8-dimethyl-4H-pyrido [1,2-

a]-pyrimidin-4-óna] pyrimidin-4-one

171. 3-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,9-dimetyl-4H- pyrido-[1,2-a]pyrimídin-4-ón171. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] pyrimidine- 4-one

172. 3-p-[exo-6-(5-chlórtien-2-yl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-4H- pyrido[1,2-a]pyrimidin-4-ón172. 3-β- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] ] pyrimidin-4-one

173. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6,7,8,9-tetrahydro-173. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,7,8,9-tetrahydro-

2-metyl-4H-pyrido[1,2-a]pyrimidin-4-ón2-methyl-4 H -pyrido [1,2-a] pyrimidin-4-one

174. S-p-fexo-e-p-chlórfenyl-S-azabicyklop^.Olheptan-S-ylletyl-ej.e.g-tetrahydro-174. S-p-fexo-e-p-chlorophenyl-S-azabicyclo [4.1.1] heptan-5-yl-ethyl-e-g-tetrahydro-

2-metyl-4H-pyrido[1I2-a]pyrimidin-4-ón2-methyl-4H-pyrido [I, 1 2-a] pyrimidin-4-one

175. 3-p-[exo-6-p-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-6,7,8,9- tetrahydro-2-metyl-4H-pyrido[1,2-a]pyrimidin-4-ón175. 3-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1] , 2-a] pyrimidin-4-one

176. 3-p-[exo-6-p-fiuórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-4H- pyrimido-[1,2-a]pyrimidin-4-ón176. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrimido [1,2-a] pyrimidin-4- one

177. 3-p-[exo-6-p-fiuórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-7-chlór-4H- pyrimido-[1,2-a]pyrimidin-4-ón177. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-7-chloro-4H-pyrimido [1,2-a] pyrimidin-4-one

178. 6-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-7-metyl-1 H.5H- imidazo-[1,2-a]pyrimidin-5-ón178. 6-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-1H-1H-imidazo [1,2-a] pyrimidine 5-one

179. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metyl-7,8-dihydro-179. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-7,8-dihydro-

4H,6H-pyrrolo[1,2-a]pyrimidin-4-ón4H, 6H-pyrrolo [1,2-a] pyrimidin-4-one

180. 2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metylbenzimidazol180. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methylbenzimidazole

181. 1-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etylbenzimidazol181. 1- p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylbenzimidazole

182. 2-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2,3-dihydrobenz- imidazol-2-όη182. 2-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,3-dihydrobenzimidazol-2-one

-17···· ·· · ···· · 9 ·· • · · 9 ·· · ·· • · ··«····· · ·· · · · · 9 99-17 9 9 9 9 9 99 99 99

999 9 99 99 99999999 9 99 99 99999

183. 2-[exo-6-m-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metylbenzimidazol183. 2- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] methylbenzimidazole

184. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etylindol, t.t. 193 až 195 °C (hydrochlorid)184. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole, m.p. 193-195 ° C (hydrochloride)

185. 3-3-(2-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etylindol185. 3-3- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole

186.3-p-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etylindol, t.t.. 104 až 105 eC (hydrochlorid)186.3-p- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole, m.p. 104 to 105 e C (hydrochloride)

187. 3-p-[exo-6-m-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etylindol187. 3-p- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole

188. 2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-3,4- dihydrochinazolin-4-ón188. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

189. 2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-3,4- dihydrochinazolin-4-tión189. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazoline-4-thione

190. 2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-3,4-dihydrochinazolin-4-ón190. 2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

191. 2-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-3,4- dihydrochinazolin-4-ón191. 2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

192. 2-[exo-6-o-metoxyfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-3,4-dihydrochinazolin-4-ón192. 2- [exo-6-o-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

193. 2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-4-hydroxy-6-metyl- pyrimidín193. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-4-hydroxy-6-methylpyrimidine

194. 6-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyl-2-metyl-4-hydroxy- pyrimidín194. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-2-methyl-4-hydroxy-pyrimidine

195. 6-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyluracil195. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyluracil

196. 6-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]metyluracil196. 6- [Exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyluracil

197. 6-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1,2,3,4-tetrahydro-1,3- dimetyl-214-dioxopyrimidín igS.S-p-íexo-e-p-fluórfenyl-S-azabicykloR.Z.OJheptan-S-ylJetyl-I^.S^-tetrahydro-emetyl-2,4-dioxopyrímidín197. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] -1,2,3,4-tetrahydro-1,3-dimethyl-2 1 4-dioxopyrimidin IGS .Sp-IEXO-EP-S-phenyl-S-azabicykloR.Z.OJheptan ylJetyl-I ^ .S ^ -tetrahydro-emetyl-2,4-dioxopyrimidin

199. 5-8-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1,2,3,4-tetrahydro-199. 5-8- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-

1,6-dimetyl-2,4-dioxopyrimidín • ···· ·· · • · • · • · ··· ·1,6-Dimethyl-2,4-dioxopyrimidine

·· · · ·· · · ·· · · • · • · • · • · • · • · • · • · • · • · ·· · · • · • · • · • · • · • · • · • · ·· · · ·· · · ·· · · ·· · ·

200. S-p-Iexo-e-p-fliióľfenyl-S-azabicyklofS^.OJheptan-S-ylJetyl-I^.SAtetrahydro-200. S-p-Iexo-e-p-Phenyl-phenyl-S-azabicyclo [S, 5] heptan-S-yl-ethyl-1, 6-tetrahydro-

3,6-dimetyl-2,4-dioxopyrimidín3,6-dimethyl-2,4-dioxopyrimidin

201.5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1,2,3,4-tetrahydroS.ô-dimetyl^Aditiopyrimidín201.5 p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl-1,2,3,4-tetrahydroS.ô-dimethyl ^ Aditiopyrimidín

202. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1,2,3l4-tetrahydro- .S.e-trimetyl^^ioxopyrimidín202. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl- 1,2,3,4 -tetrahydro-5-trimethyl-4-dioxopyrimidine

203. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-1,2,3,4-tetrahydro-203. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-

6-amino-1-metyl-2,4-dioxo-pyrimidín6-amino-1-methyl-2,4-dioxo-pyrimidine

204. 5-8-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-amino-6-metyl4(3H)-pyrimidinón204. 5-8- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-6-methyl-4 (3H) -pyrimidinone

205. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-amino-3,6dimetyl-4(3H)pyrimidinón205. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-3,6-dimethyl-4 (3H) pyrimidinone

206. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón206. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

207. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3-etyl-207. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3-ethyl-

6-metyl-4(3H)pyrimidinón6-methyl-4 (3H) pyrimidinone

208. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-amino-3-etyl-6metyl-4(3H)pyrimidinón208. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-3-ethyl-6-methyl-4 (3H) pyrimidinone

209. 5-p-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón209. 5-p- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

210. 5-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón210. 5-p- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

211. 5-p-[exo-6-o-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón211. 5-p- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

212. 5-p-[exo-6-p-trifluórmetylfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2metylamino-3,6-dimetyI-4(3H)pyrimidinón212. 5-p- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

213. 5-p-[exo-6-p-kyanofenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón213. 5-p- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

-19···· ·· · ···· ·· • · · · ·· · · • · ········ • · ···· ·· ··· · ·· ·· ·♦ ·· ···-19 ························································ ♦ ·· ···

214. 5-p-[exo-6-m-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón214. 5-p- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

215. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan3-yl]etyl-2-metylamino-4metoxy-6-metylpyrimidín215. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-4-methoxy-6-methylpyrimidine

216. 3-p-[exo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2,4- (1 H,3H)-chinazolindión216. 3-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) ) -quinazolinedione

217. 3-p-[endo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-214- (1 H,3H)-chinazolindión217. 3-p- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl 2-one 4- (1 H, 3 H ) -quinazolinedione

218. 3-p-[exo-6-p-fluórfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-218. 3-p- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-

2,4-(1 H,3H)chinazolindión2,4- (1H, 3H) quinazolinedione

219. 3-p-[exo-6-p-trifluórmetylfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3yl]-etyl-6-fluór-2.4-(1 H,3H)chinazolindión219. 3-p- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-6-fluoro-2,4- (1) H, 3H) quinazolinedione

220. 3-p-[exo-6-m-chlórfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-220. 3-β- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-

2,4-(1 H,3H)chinazolindión2,4- (1H, 3H) quinazolinedione

221.3-p-[exo-6-p-metoxyfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3yl]etyl-6-metyl-2,4-(1H,3H)chinazolindión221.3 p- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octane-3-yl] ethyl-6-methyl-2,4 (1 H, 3H) quinazolinedione

222. 5-p-[exo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2-metylamino-3,6-dimetyl-4(3H)pyrimidinón222. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl 4 (3H) pyrimidinone

223. 5-p-[exo-6-p-fluórfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2metylamino-3,6-dimetyl-4(3H)pyrimidinón223. 5-p- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl 4 (3H) pyrimidinone

224.1-p-[exo-6-p-fluórfenyl-7-metyl-1l5-cis-3I7-diazabicyklo[3.3.0]oktan-3-yl]etyl2(3H)benzimidazolón224.1 p- [exo-6-p-fluorophenyl-7-methyl-1 l-cis-5 3 I, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl 2 (3 H) benzimidazolone

225.5-p-[exo-6-p-nitrofenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2metylamino-3,6-dimetyl-4(3H)pyrimidinón225.5 p- [exo-6-p-nitrophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl 2metylamino-3,6-dimethyl-4 (3H) pyrimidinone

226. 5-p-[exo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2-metylamino-3,6-dimetyl-4(3H)pyrimidinón226. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl 4 (3H) pyrimidinone

227. 5-p-[endo-6-feRyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2metyl-amino-3,6-dimetyl-4(3H)-pyrimidinón227. 5-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) -pyrimidinone

-20····-20 ····

228. S-p-Iexo-e-p-fluórfenyl-ľ-metyl-I.S-cis-S.ľ-diazabicyklop.S.OJoktan-S-yljetyl^metyI-4H-pyrido[1.2-a]pyrimidin-4-ón228. S-p-Iexo-e-p-fluorophenyl-1'-methyl-1S-cis-2'-diazabicyclop.S.Itoctan-S-yl-ethyl-methyl-4H-pyrido [1,2-a] pyrimidin-4-one

229. 1 -p-[exo-6-p-fluórfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-y I] ety Iindolin-2-ón229. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

230. e-p-Iexo-e-p-fluórfenyl-ľ-metyl-I.S-cis-S.ľ-diazabicyklop.S.Oloktan-S-ylJetyl-ľmetyl-5H-tiazolo[3.2-a]pyrimidin-5-ón230. e-p-Iexo-e-p-fluorophenyl-1'-methyl-1S-cis-2'-diazabicyclop.S.Octo-5-yl-ethyl-1'-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

231. 1 -p-[exo-6-p-fluórfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl2(1 H)chinolón231. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl2 (1H) quinolone

232. 3-p-[7-fenyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión232. 3-β- [7-phenyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

233. 3-p-[7-p-fluórfenyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2,4-(1 H.3H)chinazolindión233. 3-p- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

234. 5-p-[7-p-fluórfenyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl-2-metylamino-234. 5-p- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-

3,6-dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

235. 3-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión235. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

236. 3-p-[exo-6-fenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl-2,4-(1 H,3H)chinazolindión236. 3-β- [exo-6-phenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

237. 3-p-[6,6-difenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl-2,4-(1H,3H)chinazolindión237. 3-p- [6,6-Diphenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

238. 5-p-[exo-6-p-fluórfenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl-2-metylamino-3,6dimetyl-4(3H)pyrimidinón238. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

239. 6-p-[exo-6-m-chlórfenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl-7-metyl-5HtiazoloíS^-aJ-pyrimidin-S-ón239. 6-p- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-7-methyl-5H-thiazolo [3,4-a] pyrimidin-5-one

240. 3-p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl-2,4-(1 H,3H)chinazolindión240. 3-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

241. 5-p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl-2-metylamino-241. 5-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2-methylamino-

3,6-dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

242. 6-p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl-7-metyl-5Htiazolo-ÍS^-alpyrimidin-S-ón242. 6-p- [6-p-Fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-7-methyl-5H-thiazolo-5H-alpyrimidine- S-one

-21 ···· • · ·· · · · · · • · · ·· · · · • · · · · · · ·· ·· ·· ···-21 ···· · ··· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

243. 1-p-[6-fenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl-2(3H)benzimidazolón243. 1- p- [6-Phenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 (3H) benzimidazolone

244.1- p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etylindolin-2-ón244.1-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethylindolin-2-one

245.1- p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl-2(1 H)chinolón245.1-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 (1H) quinolone

246. 3-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan3-yl]etyl-2,4-(1 H,3H)- chinazolindión246. 3-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

II

247. 5-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2-metylamino- , 3,6-dimetyl-4(3H)pyrimidinón247. 5-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-, 3,6-dimethyl-4 ( 3H) pyrimidinone

248. 6-p-[exo-6-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-7-metyl-5H- tiazolo[3.2-a]-pyrimidin-5-ón248. 6-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-one

249.1- p-[exo-6-p-fluórŤenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etylindolin-2-ón249.1-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

250. 1-P-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2(1 H)chinolón250. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2 (1H) quinolone

251. 3-p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2,4-(1 H,3H)- chinazolindión251. 3-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

252. 5-p-[endo-6-p-fiuórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2- metylamino-3,6-dimetyl-4(3H)pyrimidinón252. 5-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) ) pyrimidinone

253. 6-p-[endofenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-7-metyl-5H- tiazolo[3.2-a]-pyrimidin-5-ón253. 6-p- [endophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

254.1- p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etylindolin-2-ón254.1- p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

255.1 -p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-255.1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-

2(1H)chinolón t2 (1H) quinolone m.p.

256. 3-p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2,4-(1 H,3H)- chinazolindión256. 3-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

257. 5-p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2-metylamino-257. 5-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-

3,6-dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

258. 6-p-[exo-7-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-7-metyl-5H- tiazolo[3.2-a]-pyrimidin-5-ón258. 6-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-one

259.1- p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etylindolin-2-ón259.1-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

-22···· ·· · ···· · · ·· • · · · ·· ··· ·· ······ ·Α ··· · ·· ·· ·· ···-22 ···· ···· · · · · · · • · · · · · · · · · · · ······ Α · · · · · · · · · · · · ·

260.1 -p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl-2( 1 H)chinolón260.1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2 (1H) quinolone

261. 3-p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklof4.3.0]non-3-yl]etyl-2,4-(1 H,3H)- chinazolindión261. 3-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

262. 5-p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2-metylamino-262. 5-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-

S.e-dimetyMÍSHJpyrimidinónBs-dimetyMÍSHJpyrimidinón

263. 3-p-[endo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión263. 3-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

264. 5-P-[endo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2-metylamino-3,6- dimetyl-4(3H)pyrimidinón264. 5-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

265. S-p-íendo-e-p-trifluórmetylfenyl-I.S-cis-S-azabicyklo^.S.Olnon-S-ylJetyl-Z^- (1 H,3H)chinazolindión265. S-p-endo-e-p-trifluoromethylphenyl-1S-cis-S-azabicyclo-S.Onon-S-yl-ethyl-Z - (1 H, 3H) quinazolinedione

266. 5-p-[endo-6-p-trifluórmetylfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2- metyl-amino-3,6-dimetyl-4(3H)-pyrimidinón266. 5-p- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methyl-amino-3,6-dimethyl-4 (3 H) -pyrimidinone

267. 3-p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0Inon-7-en-3-yl]etyl-2,4- (1 H,3H)-chinazolindión267. 3-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0-in-7-en-3-yl] ethyl-2,4- (1H, 3H) - quinazolinedione

268. 5-p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2-metyl- am!no-3,6-dimetyl-4(3H)pyrimidinón268. 5-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methyl-amino-3 , 6-dimethyl-4 (3H) pyrimidinone

269. 1 -p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2(3H)benzimidazolón269. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2 (3H) benzimidazolone

270.1-p-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etylindolin-2- ón270.1-p- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethylindolin-2-one

271. 3-p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl-2,4-(1 H,3H)- chinazolindión271. 3-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H) - quinazolinedione

272. 5-p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en3-yl]etyl-2-metylamino-272. 5-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-

3,6-dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

273. 3-p-[6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl-2,4- (1 H,3H)chinazolin-dión273. 3-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

274. 5-p-[6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl-2-metylamino-3,6- dimetyl-4(3H)pyrimidinón274. 5-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) ) pyrimidinone

-23···· · ···· · · · • · · ♦ ·· · · • * ······· ··· · ·· ·· ·· ···-23 ·············································

275. 3-3-[6-p-trifluórmetylfenyl-1,5-cis-3-azabicyklo-[4.3.0]non-6-en-3-yl]etyl-2,4- (1 H,3H)chinazolindión275. 3-3- [6-p-Trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

276. 5-p-[6-p-trifluórmetylfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl-2-metyl- amino-3,6-dimetyl-4(3H)pyrimidinón276. 5-p- [6-p-Trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-3,6-dimethyl 4 (3H) pyrimidinone

277. 1 -p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl-2(3H)benz- imidazolón277. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2 (3H) benzimidazolone

278. 1-p-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etylindolin-2-ón278. 1- p- [6-p-Fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethylindolin-2-one

279. 1 -p-[6-p-flĽiórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl-2(1 HJchinolón279. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2 (1 H) -quinolone

280. 3^-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2,4- (1 H,3H)-chinazolidón280. 3- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2,4- (1H, 3H) -chinazolidón

281. 5-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2- metylamino-3,6-dimetyl-4(3H)pyrimidinón281. 5-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methylamino-3,6-dimethyl 4 (3H) pyrimidinone

282. 3-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2-metyl-282. 3-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methyl-

4H-pyrido[1.2-a]pyrimidin-4-ón4H-pyrido [1,2-a] pyrimidin-4-one

283.1- p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-283.1- p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-

2(1H)chinolón2 (1H) -quinolone

284. 1-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl2(3H)benz-imidazolón284. 1-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2 (3H) -benzimidazolone

285.1- p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etylindolin-2- ón285.1-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethylindolin-2-one

286. 3-p-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2,4-(1 H,3H)chinazolindión286. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

287. 5-p-[exo-6-fenyl-1I5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl-2-metylamino-287. 5-p- [exo-6-phenyl-1-I, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methylamino

3,6-dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

288. 3-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2,4-(1 H,3H)- chinazolindión288. 3-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

289. 5-p-[exo-6-p-fluórfehyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2-metylamino-289. 5-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-

3,6-dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

-24···· ·· ·· ·· · • · ·· · · · · · • · · ·· · · · • · · · · · · ·· ·· ·· ···-24 ···································

290. 3-p-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2,4-(1 H,3H)chinazolin- dión290. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quinazoline-dione

291.5- p-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2-metylamino-3,6- dimetyl-4(3H)pyrimidinón291,5-p- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

292.6- p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-7-metyl-5H- tiazolo-[3.2-a]pyrimidin-5-ón292.6- p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-one

293.1 -p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non3-yl]etyl-2(3H)benzimidazolón293.1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (3H) benzimidazolone

294.1-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non5 3-yl]etylindolin-2-ón294.1-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-5-yl] ethylindolin-2-one

295. 1-p-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non3-yl]etyl-2(1 H)chínolón295. 1-p- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (1H) quinolone

296. 3-p-[exo-7-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl-2,4-(1 H,3H)- chinazolindión296. 3-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2,4- (1H, 3H) - quinazolinedione

297. 5-p-[exo-7-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl-2-metylamino-297. 5-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2-methylamino-

3.6- dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

298. 3-p-[exo-7-p-fluórfenyl-1,5-cis-3'-azabicyklo[4.3.0]non-8-en-3-yl]etyl-2,4- (1 H,3H)-chinazolindión298. 3-p- [exo-7-p-fluorophenyl-1,5-cis-3'-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione

299. 5-p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl-2- metylamino-S.e-dimetyMÍSHJpyrimidinón299. 5-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2-methylamino-5-dimethyl-5H-pyrimidinone

300. 3-p-[7-p-fluórfenyl-3-azabicyklo[4.3.OJnon-1 -eη-3-yI]etyI-2,4- (1 H,3H)chinazolindión300. 3-p- [7-p-fluorophenyl-3-azabicyclo [4.3.1] non-1-ene-3-yl] ethyl-2,4- (1H, 3H) quinazolinedione

301.5-p~[7-fenyl-3-azabicyklo[4.3.0]non-1 -en-3-yl]etyl-2-metylamino-3,6-dirnetyl4(3H)-pyrimidinón301.5-p- [7-phenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) -pyrimidinone

302. 5-p-[7-p-fluórfenyl-3-azabicyklo[4.3.0]non-1-en-3-yl]etyl-2-metylamino-3,6- dimetyl-4(3H)pyrimidinón302. 5-p- [7-p-fluorophenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

303. 3-p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non3-yl]etyl-2,4-(1 H,3H)- chinazolindión303. 3-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) -quinazinedione

304. 5-p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2-metylamino-304. 5-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-

3.6- dimetyl-4(3H)pyrimidinón3,6-dimethyl-4 (3H) pyrimidinone

-25···· »· ·· ·· • ···· · · · • · · ·· · ·-25 ···· · ···· · ···· · · ·

305.1- p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2(3H)benzimidazolón305.1-p- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (3H) benzimidazolone

306.1 -p-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etylindolin-2-ón306.1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethylindolin-2-one

307.1- p-[exo-7-p-fluórfenyl-ltq-cis-3-azabicyklo[4.3.0]non-3-yl]etyl-2(1H)chinolónP 307.1- [exo-7-p-fluorophenyl-r q-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (1H) -quinolone

308. 3-p-[6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3-yl]etyl-2,4(1 H,3H)chinazolindión308. 3-p- [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2,4 (1) H, 3H) quinazolinedione

309. 5-p-[6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3-yl]etyl-2metyl-amino-S.e-dimetyMÍSHJpyrimidinón309. 5-p- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2-methyl-amino-Se -dimetyMÍSHJpyrimidinón

310. 3-p-[exo/endo-6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diaza-bicyklo[3.3.0]oktan-3yl]etyl-2,4-(1H,3H)chinazolindión310. 3-p- [exo-endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diaza-bicyclo [3.3.0] octan-3-yl] ethyl-2,4- ( 1H, 3H) quinazolinedione

311. 5-p-[exo/endo-6-p-fluórfenyl-1 .S-cis-S-oxa-SJ-diaza-bicyklop.S.OJoktan-Syl]etyl-2-metylamino-3,6-dimetyl4(3H)pyrimidinón311. 5-β- [exo-endo-6-p-fluorophenyl-1 S-cis-S-oxa-β-diaza-bicyclo S.Joctan-Syl] ethyl-2-methylamino-3,6-dimethyl4 (3H) pyrimidinone

312. 1-p-[6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diazabicykla[3.3.0]okt-6-en-3ylJetylindoIin-2-ón312. 1-p- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl-ethylindolin-2-one

313. 6-p-[6-fenyl-115-cis-8-oxa-3,7-diazabieyclo[3.3.0]okt-6-en-3-yl]etyl-7-metyl-5Htiazolo[3,2-a]pyrimidin- 5-ón313. 6-p [6-phenyl-1 1 5-cis-8-oxa-3,7-diazabieyclo [3.3.0] oct-6-en-3-yl] ethyl-7-methyl-5Htiazolo [3 , 2-a] pyrimidin-5-one

314. N-(2-[exo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl)-4-fluórbenzamid314. N- (2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -4-fluorobenzamide

315. N-(2-[endo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3-yl]etyl)-4fluór-benzamid315. N- (2- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -4-fluorobenzamide

316. N-(2-[exo-6-p-fluórfenyl-7-metyl-1l5-cis-3I7-diazabicyklo-[3.3.0]oktan-3-yl]etyl)4-fluórbenzamid316. N- (2- [exo-6-p-fluorophenyl-7-methyl-1 l-cis-5 3 I, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -4-fluorobenzamide

317. N-(2-[exo-6-p-trifluórmetylfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3yl]-etyl)benzamid317. N- (2- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

318. N-(2-[exo-6-m-chlórfenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3yl]etyl)-benzamid318. N- (2- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -benzamide

319. N-(2-[exo-6-p-metoxyfenyl-7-metyl-1,5-cis-3,7-diaza-bicyklo[3.3.0]oktan-3yl]etyl)-4-chlórbenzamid ···· ·· ·· ·· • · · · · · • · ·· · · ·· ·· · · · · • · · · · · ·· ·· ··319. N- (2- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diaza-bicyclo [3.3.0] octan-3-yl] ethyl) -4-chlorobenzamide ·································

320. N-(2-[exo-6-fenyl-7-metyl-1,5-cis-3,7-diazabicyklo[3.3.0]oktan-3- yl]etyl)naftalén-1 -karboxamid320. N- (2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

321. 1-(4-fluórfenyl)-4-[exo-6-p-fluórfenyl-7-metyl-1,5-cis-3,7- diazabicyklo[3.3.0]oktan-3-yl]butan-1-ón321. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] butan-1 -one

322. 1-(4-fluórfenyl)-4-[exo-6-p-fluórfenyl-7-metyl-1,5-cis-3,7- diazabicyklo[3.3.0]oktan-3-yl]butan-1-ol322. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] butane-1 ol

323. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl) benzam id323. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) benzamide

324. 1-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)naftalén324. 1- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene

325.1 -(4-fluórfenyl)-4-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]butan-325.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butane-

1-ón1-one

326. 1-(4-fluórfenyl)-4-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]butan-326. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butane-

1-ol1-ol

327. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)-2-(N-metyl)- aminobenzamid327. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -2- (N-methyl) aminobenzamide

328. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)-5-chlórtien-2- yl-karboxamid328. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -5-chlorothien-2-ylcarboxamide

329. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)indén-3- karbox-amid329. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) indene-3-carboxamide

330. N-(2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)-4-fluórbenzamid330. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -4-fluorobenzamide

331. N-(2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]-etyl)naftalén-1 - karboxamid331. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene-1-carboxamide

332.1-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)naftalén332.1- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene

333. 1-(4-fluórfenyl)-4-[exo-6-p-fluórfenyl-1,5-cis-3-aza-bicyklo[4.3.0]non-7-en-3-yl]- butan-1-ón333. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-aza-bicyclo [4.3.0] non-7-en-3-yl] butane- 1-one

334. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)benzamid334. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) benzamide

335. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)indene-3- karboxamid335. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) indene-3-carboxamide

336. N-(2-[exo-6-p-fiuórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)naftalén-336. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene-

1-karboxamid1-carboxamide

-27···· • · · · ·· · · · * · · ········ * ·· · · · · ··· ··· · ·· ·· ·· ·· ·-27 ···· · · · · ···································

337. N-(2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)-4- fluórbenzamid337. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -4-fluorobenzamide

338. N-(2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)-3-chlór-1 - benzo-tien-2-ylkarboxamid338. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -3-chloro-1-benzothiene 2-yl carboxamide

339. 1 -(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)naftalén339. 1- (2- [6-p-Fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) naphthalene

340. 1 -(4-fluórfenyl)-4-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3- yl]butan-1-ón340. 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] butan-1-one

341. 1 -(4-fluórfenyl)-4-[6-p-fluórfenyl-1,5-cis-3-azabicyklo-[4.3.0]non-6-en-3- yl]butan-1-ol341. 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] butan-1-ol

342. N-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)-2-(N-metyl)- aminobenzamid342. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) -2- (N-methyl) aminobenzamide

343. N-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)-5-chlórtien-2- yl-karboxamid343. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) -5-chlorothien-2-ylcarboxamide

344. N-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)benzamid344. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) benzamide

345. N-(2-[6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)-3-chlór-1 - benzotien-2-yl-karboxamid345. N- (2- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) -3-chloro-1-benzothien-2-yl amide

346. N-(2-[6-p-trifluórmetylfenyl-1l5-cis-3-azabicyklo[4.3.0]non-6-en-3- y IJetyl) naftalén-1 -karboxamid346. N- (2- [6-p-trifluoromethylphenyl-1 l 5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl IJetyl) naphthalen-1-carboxamide

347. N-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)inden-3- karbon-imid347. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) indene-3-carbonimide

348. N-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-6-en-3-yl]etyl)naftalén-1 - karboxamid348. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) naphthalene-1-carboxamide

349. 1-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non3-yl]etyl)naftalén349. 1- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene

350.1 -(4-fluórfenyl)-4-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3- yl]butan-1-ón350.1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1-one

351.1 -(4-fluórfenyl)-4-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3- yl]butan-1-ol351.1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1-ol

352. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]-2-(N- metyl)amino-benzamid352. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] -2- (N-methyl) aminobenzamide

-28···· • · · · · ···· • ····'·} · • · · · · · · • · ·· ·· ·· ·-28 ···· · · · ···· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

353. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)benzamid353. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) benzamide

354. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyI)-5-ch lórtien-354. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -5-chlorothiene-

2-yl-karboxamid2-yl-carboxamide

355. N-(2-[endo-6-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)-4-fluórbenzamid355. N- (2- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -4-fluorobenzamide

356. N-(2-[endo-6-p-trifluórmetylfenyl-1,5-cis-3-azabicyklo-[4.3.0]non-3- yl]etyl)indén-3-karboxamid356. N- (2- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) indene-3-carboxamide

357. 2-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)naftalén357. 2- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene

358. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3- yl]etyl)benzamid358. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) benzamide

359. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3-yl]etyl)-2-(N- metyl)aminobenzamid359. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -2- (N-methyl) aminobenzamide

360. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-7-en-3- yljetyl) naftalén-1 -karboxamid360. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl-ethyl) -naphthalene-1-carboxamide

361.1 -(2-[exo-7-p-fluórfenyl-1 .S-cis-S-azabicyklo^.S.OJnon-S-en-S-ylJetylJnaftalén361.1- (2- [exo-7-p-fluorophenyl-1S-cis-S-azabicyclo-5'-non-S-en-S-yl-ethyl) -naphthalene

362.1 -(4-fluórfenyl)-4-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]butan-1-ón362.1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] butan-1-one

363. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl)benzamid363. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) benzamide

364. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl)-5- chlórtien-2-yl-karboxamid364. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -5-chlorothien-2-yl amide

365. N-(2-[exo-7-p-fluórfenyl-1I5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl)-3-chlór-365. N- (2- [exo-7-p-fluorophenyl-1-I, 5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -3-chloro-

-benzotien-2-yl-karboxamidbenzothien-2-yl-carboxamide

366. N-(2-[exo-7-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl)indén-3-karbox- amid366. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) indene-3-carboxamide

367. N-(2-[exo-7-fenyl-1,5-cis-3-azabicyklo[4.3.0]non-8-en-3-yl]etyl)naftalén-1 - karbox-amid367. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) naphthalene-1-carboxamide

368.1- (2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)naftalén368.1- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene

369.1- (4-fluórfenyl)-4-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]biitan-369.1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl]

1-ón1-one

-29···· • · · · · · · ·· • · · ·· · · · • · · · · · · · ·· ·· ···-29 ···· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

370. 1 -(4-fluórfenyl)-4-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]butan-370. 1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butane-

1-ol1-ol

371. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)-2-(N-metyl)- aminobenzamid371. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -2- (N-methyl) aminobenzamide

372. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)benzamid372. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) benzamide

373. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)-5-chlórtien-2- yl-karboxamid373. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -5-chlorothien-2-ylcarboxamide

374. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)naftalén-1 - karbox-amid374. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene-1-carboxamide

375. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[4.3.0]non-3-yl]etyl)indén-3- karbox-amid375. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) indene-3-carboxamide

376. 1-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl)naftalén376. 1- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene

377.1 -(4-fluórfenyl)-4-[6-p-fl uó rfe nyl-1,5-cis-3-azabicyklo-[3.3.0]okt-6-en-3- yl]butan-1-ón377.1- (4-fluorophenyl) -4- [6-p-fluoro-phenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] butan-1-one

378. N-(2-[6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]okt-6-en-3-yl]etyl)benzamid378. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) benzamide

379. N-(2-[6-p-fluórfenyl-1 .S-cis-S-azabicyklolB.S.OJokt-e-en-S-ylletyOnaftalén-l - karbox-amid379. N- (2- [6-p-fluorophenyl-1S-cis-S-azabicyclolB.S.OJO-e-en-S-yl-ethyl) naphthalene-1-carboxamide

380.1- (2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan3-yl]etyl)naftalén380.1- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

381.1- (4-fluórfenyl)-4-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo-[3.3.0]oktan-3- yl]butan-1-ol381.1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butan-1-ol

382. N-(2-[exo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)benzamid382. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

383. N-(2-[exo-6-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)naftalén-1 - karboxamid383. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

384. N-(2-[exo-6-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)indén-3- karboxamid384. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) indene-3-carboxamide

385.1- (2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan3-yl]etyl)naftalén385.1- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

386.1- (4-fluórfenyl)-4-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3- yl]butan-1-ón386.1- (4-Fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butan-1-one

-30···· • ···· · · · • · · ·· · · • ·· ·· ··· · • · · · · · · • ·· ·♦ ·· *-30 ····························

387. N-(2-[endo-6-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan3-yl]etyl)benzamid387. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

388. N-(2-[endo-6-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)naftalén-1 -karbox- amid388. N- (2- [endo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

389.1- (2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan3-yl]etyl)naftalén389.1- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

390.1- (4-f!uórfenyl)-4-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3- yl]butan-1-ón390.1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butan-1-one

391. N-(2-[exo-7-p-fluórfenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)benzamid391. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

392. N-(2-[exo-7-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)naftalén-1 - karboxamid392. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

393. N-(2-[exo-7-fenyl-1,5-cis-3-azabicyklo[3.3.0]oktan-3-yl]etyl)indén-3- karboxamid393. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) indene-3-carboxamide

394. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl)-4-fluórbenzamid394. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) -4-fluorobenzamide

395. N-(2-[exo-6-fenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl)5-chlórtien-2-ylkarboxamid395. N- (2- [exo-6-phenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) 5-chlorothien-2-ylcarboxamide

396. N-(2-[6,6-difenyl-3-azabicyklo[3.1,0]hexan-3-yl]etyl)-naft-1 -yl-karboxamid396. N- (2- [6,6-diphenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) naphth-1-ylcarboxamide

397. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.1.0] hexa n-3-yl]ety!)-3-ch I ó r-1 - benzotien-2-yl-karboxamid397. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) -3-chloro-1-benzothien-2-yl- carboxamide

398. N-(2-[exo-6-m-chlórfenyl-3-azabicyklo[3.1.0]hexan-3-yl]etyl)-4-chlórbenzamid398. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) -4-chlorobenzamide

399. 1-(2-[6-p-fluórfenyl-1,5-cis-8-oxa-3I7-diazabicyklo[3.3.0]okt-6-en-3- yl]etyl)naftalén399. 1- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3 I, 7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene

400. N-(2-[6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3- yl]etyl)benz-amid400. N- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) benzamide

401. N-(2-[6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3-yl]etyl)naftalén-1-karboxamid401. N- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene-1- carboxamide

402. N-(2-[6-p-fluórfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3- yl]etyl)indén-3-karboxamid402. N- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) indene-3- carboxamide

403. 1-(2-[exo/endo-6-p-fluórfenyl-1I5-cis-8-oxa-3l7-diazabicyklo[3.3.0]oktan-3yl]etyl)-naftalén403. 1- (2- [exo / endo-6-p-fluorophenyl-1-I, 5-cis-8-oxa-3 l 7-diazabicyclo [3.3.0] octane-3-yl] ethyl) naphthalene

404. N-(2-[exo/endo-6-p-fluórfenyl-1l5-cis-8-oxa-3,7-diazabicyklo[3.3.0]oktan-3- yl]etyl)-benzamid404. N- (2- [exo-endo-6-p-fluorophenyl- 11,5 -cis-8-oxa-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -benzamide

-31 ···· ·· ·· ·· · • ···· · · · · • · · ·· · · · •J··· · ♦ · ·· ·· ·· ···-31 ······························· · · ·

405.1 -(2-[6-fenyl-1 -5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3-yl]etyl)naftalén405.1- (2- [6-phenyl-1-5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene

406. N-(2-[6-fenyl-1-5-cis-8-oxa-3,7-diazabicyklo[3.3.0]okt-6-en-3-yl]etyl)benzamid406. N- (2- [6-phenyl-1-5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) benzamide

407. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzosulfónamid407. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzosulfonamide

408. N-(2-[exo-6-fenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzosulfónamid408. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzosulfonamide

409. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-N- metylbenzosulfón-amid409. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methylbenzosulfonamide

410. N-(2-[exo-6-(5-chlórtien-2-yl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4-fluórbenzosulfónamid410. N- (2- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorobenzosulfonamide

411.3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1-fenoxypropán411.3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] -1-phenoxypropan

412.2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1-p-fluórfenoxyetán412.2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] -1-p-fluórfenoxyetán

413. 3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1-(1-naftyloxy)propán413. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1- (1-naphthyloxy) propane

414. 3-[exo-6-p-fluórfenyl-3-azabicykÍo[3.2.0]heptan-3-yl]-1-p-t-butylfenoxypropán414. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-t-butylphenoxypropane

415. 3-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1 -p-fluórfenoxypropán415. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-fluorophenoxypropane

416. N-(2-[exo-6-p-fluórŤenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)tiobenzamid416. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiobenzamide

417. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4-fluórtiobenzamid417. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorothiobenzamide

418. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4- chlórtiobenzamid418. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorothiobenzamide

419. O-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzoát419. O- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzoate

420. O-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl-4-fluórbenzoat420. O- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-4-fluorobenzoate

421. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-1 H- benzo[cd]indol-2-ón421. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

422. N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-1H- benzo[cd]indol-2-ón422. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

423. N-(2-[exo-6-m-fluórfenyl-3-azabicyk!o[3.2.0]heptan-3-yl]etyl)-1H- benzo[cd]indol-2-ón423. N- (2- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

424. N-(2-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-1H- benzo[cd]indol-2-ón424. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

-32···· ·· ·· ·· • · · · · · · · • · · · ·· · · ·· ···· · · ··· · ·· ·· ·· 4 -32 ··························· 4 ·

425. 3,3-dimetyl-1-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indolin-425. 3,3-Dimethyl-1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indoline-

2-ón2-one

426. 3,3-dimetyl-1-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indolin-426. 3,3-Dimethyl-1- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indoline-

2-cLne2-boat

427. 3,3-dimetyl-l-(2-[exo-6-m-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indolin-427. 3,3-Dimethyl-1- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indoline-

2-ón2-one

428. 1-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-3,3,5- trimetylindolin-2-ón428. 1- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -3,3,5-trimethylindolin-2-one

429. 3,4-dichlór-N-(2-[exo-6-p-nitrofenyl-3-azabicyklo[3.2.0]heptan-3- yl]etyl)benzamid429. 3,4-Dichloro-N- (2- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

430. 2,5-difluór-N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3- yl]etyl)benzamid430. 2,5-Difluoro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

431. 2-amino-N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzamid431. 2-Amino-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

432. 2-amino-N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzamid432. 2-Amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

433. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-2- metylaminobenz-amid433. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -2-methylaminobenzamide

434. N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-2- metylaminobenz-amid434. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -2-methylaminobenzamide

435. 3-amino-N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzamid435. 3-Amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

436.4-amino-N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzamid436.4-amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl) -benzamide

437. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)tiofén-2- karboxamid437. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

438. 5-chlór-N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)tiofén-2- karboxamid438. 5-chloro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

439. 5-chlór-N-(2-[exo-6-p-chlórfenyl-3-azabícyklo[3.2.0]heptan-3-yl]etyl)tiofén-2- karboxamid439. 5-chloro-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

440. 5-chlór-N-(2-[exo-6-(5-chlór-2-tienyl)-3-azabicyklo-[3.2.0]heptan-3- yl]etyl)tiofén-2-karboxamid440. 5-chloro-N- (2- [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

-33···· ·· · · · · · ··· • · · · ·· · · • · · · · · · · ··· · ·· ·· ·· ·-33 ································ · · · · · · ·

441. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzo[b]furán-2- karboxamid441. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] furan-2-carboxamide

442. 3-chlór-N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzo[b)- tiofén-2-karboxamid442. 3-Chloro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] thiophene-2-carboxamide

443. 3-chlór-N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3- yl]etyl)benzo[b]tiofén-2-karboxamid443. 3-Chloro-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] thiophene-2-carboxamide

444. 3-chlór-N-(2-[exo-6-p-nitrofenyl-3-azabicyklo[3.2.0]heptan-3- yl]etyl)benzo[b]tiofén-2-karboxamid444. 3-chloro-N- (2- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] thiophene-2-carboxamide

445. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indén-3- karboxamid445. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indene-3-carboxamide

446. N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indén-3- karboxamid446. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indene-3-carboxamide

447. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]- etyl)cyklopropánkarbox-amid447. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclopropanecarboxamide

448. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3- yl]etyl)cyklopentánkarbox-amid448. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclopentanecarboxamide

449. N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3- yl]etyl)cyklopentánkarbox-amid449. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclopentanecarboxamide

450. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]- etyl)cyklohexánkarbox-amid450. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclohexanecarboxamide

451. N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]- etyl)cyklohexánkarbox-amid451. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclohexanecarboxamide

452. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)naftalén-1karboxamid452. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) naphthalene-1-carboxamide

453. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indol-2-karboxamid453. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indole-2-carboxamide

454. N-(2-[exo-6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indol-3- karboxamid454. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indole-3-carboxamide

455. exo-6-p-fluórfenyl-3-[2-(1-naftyl)etyl]-3-azabicyklo[3.2.0]heptán455. exo-6-p-fluorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

456. exo-6-p-chlórfenyl-3-[2-(1-naftyl)etyl]-3-azabicyklo[3.2.0]heptán456. exo-6-p-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

• ···· • ···· ·· · · ·· · · ·· · · ·· · ·· · • · • · • · • · • · • · • · • · • · • · ·· · · • e • e • · • · • · · • · · • · · • · · • · • · ·  · • · • · • · • · • · • · ··· · ··· · ·· · · ·· · · ·· · ·

457. exo-6-m-chlórfenyl-3-[2-(1-naftyl)etyl]-3-azabicyklo[3.2.0]heptán457. exo-6-m-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

458. exo-6-(5-chlór-2-tienyl)-3-[2-(1-naftyl)etyl]-3-azabicyklo[3.2.0]heptán458. exo-6- (5-chloro-2-thienyl) -3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

459. exo-6-p-fluórfenyl-3-[2-(2-naftyl)etyl]-3-azabicyklo[3.2.0]heptán459. exo-6-p-fluorophenyl-3- [2- (2-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

460. exo-6-p-fluórfenyl-3-[1-naftylmetyl]-3-azabicyklo-[3.2.0]heptán460. exo-6-p-fluorophenyl-3- [1-naphthylmethyl] -3-azabicyclo [3.2.0] heptane

461. exo-6-p-fluórfenyl-3-[2-naftylmetyl]-3-azabicyklo-[3.2.0]heptán461. exo-6-p-fluorophenyl-3- [2-naphthylmethyl] -3-azabicyclo [3.2.0] heptane

462. 4-(6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1 -(tiofen-2-yl)butan-1 -ón462. 4- (6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1- (thiophen-2-yl) butan-1-one

463. 4-(6-p-chlórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]-1 -(tiofen-2-yl)butan-1 -ón463. 4- (6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1- (thiophen-2-yl) butan-1-one

464. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-4-fenylpyrolidin-2ón464. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-phenylpyrrolidin-2-one

465. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)benzoxazolin-2-ón465. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzoxazolin-2-one

466. N-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)izoindolinón466. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) isoindolinone

467. 1-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indazol467. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indazole

468.1- (2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-1I8-naftalénsultam468.1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-3-yl] ethyl) -1 I-8 naftalénsultam

469. 4-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-1,4-benzoxazin-3ón469. 4- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1,4-benzoxazin-3-one

470. 1-(2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)chinoxalin-2(1H)-ón470. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) quinoxalin-2 (1H) -one

471.1- (2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-yl]etyl)indolin-2-ón471.1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolin-2-one

472.1- (2-[exo-6-p-fluórfenyl-3-azabicyklo[3.2.0]heptan-3-ylletyl)spiro[cyklopropán- ',3-indolin-2-ón]472.1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl-ethyl) spiro [cyclopropan-3-indolin-2-one]

473. 3,6-dimetyl-2-metylamino-5-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3yl)-etyl]-3H-pyrimidin-4-ón473. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3H-pyrimidin-4- one

474. 3,6-dimetyl-2-metylamino-5-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3yl)-etyl]-3H-pyrimidin-4-ón474. 3,6-dimethyl-2-methylamino-5- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3H-pyrimidin-4- one

475. 3,6-dimetyl-2-metylamino-5-[2-(exo-6-(5-chlór-1 -naftyl)-3azabicyklo[3.2.0]heptan-3-yl)etyl]-3H-pyrimidin-4-ón475. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3H-pyrimidine 4-one

476. 3,6-dimetyl-2-metylamino-5-[2-(exo-6-(6-chlór-2-naftyl)-3- azabicyklo[3.2.0] heptan-3-yl)etyl]-3H-pyrimidin-4-ón476. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3H pyrimidin-4-one

-35···· ·· ·· ·· • · · · · · · • ♦ · ·· * · • · · · · · · ·· ·· ··-35 ································

477. 3,6-dimetyl-2-metylamino-5-[2-(exo-6-(9-fenantryl)-3-azabicyklo[3.2.0]heptan-477. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptane-

3-yl)etyl]-3H-pyrimidin-4-ón3-yl) ethyl] -3H-pyrimidin-4-one

478. 7-metyl-6-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-5H- tiazolo[3,2-a]-pyrimidin-5-ón478. 7-Methyl-6- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -5H-thiazolo [3,2-a] - pyrimidin-5-one

479. 3-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1H,3H-chinazolin-479. 3- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazoline-

2,4-dión2,4-dione

480. 3-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1H,3H-chinazolin-480. 3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazoline-

2,4-dión2,4-dione

481. 6-fluór-3-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1H,3H- chinazolin-2,4-dión481. 6-Fluoro-3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazoline-2,4-dione

482. 3-[2-(exo-6-(5-chlór-2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1H,3H- chinazolin-2,4-dión482. 3- [2- (exo-6- (5-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazoline-2,4-dione

483. 3-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-2-metyl-4H- pyrido[1.2-a]-pyrimidin-4-ón483. 3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-one

484.1- [2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-2(1H)chinolón484.1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2 (1H) quinolone

485.1- [2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)-etyl]indolin-2-ón485.1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] indolin-2-one

486.1 -(2-(exo-6-(1 -naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-2(3H)benzimidazolón486.1- (2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl) -2 (3H) benzimidazolone

487.1- [2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-3-metyl-2(3H)benz- imidazolón487.1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3-methyl-2 (3H) benzimidazolone

488. N-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]benzamid488. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

489. N-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]benzamid489. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

490. N-[2-(exo-6-(5-chlór-1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]benzamid490. N- [2- (exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

491. 3-[2-(1-naftyl)etyl]-exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptán491. 3- [2- (1-naphthyl) ethyl] -exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptane

492. 3-[2-(1-naftyl)etyl]-exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptán492. 3- [2- (1-naphthyl) ethyl] -exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptane

493.1- [2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1H-benzo[cd]indol-2- ón493.1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H-benzo [cd] indol-2-one

494.1- [2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1H-benzo[cd]indol-2- ón494.1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H-benzo [cd] indol-2-one

-36- -36- • ···· ·· · • · • ···· ·· · • · ·· • · • · ·· • · • · ·· • · ·· · · • · ·· ·· • · • · ·· • · • · • · • · • · • · • · • · • · • · • · • · • · • · ··· ♦ ··· ♦ ·· · · ·· · · ·· · · • · • ·

495. 3,3-dimetyl-l-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1,3dihydro-indol-2-ón495. 3,3-Dimethyl-1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1,3-dihydro-indol-2-one

496. 3,3-dimetyl-1 -[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1,3dihydro-indol-2-ón496. 3,3-Dimethyl-1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1,3-dihydro-indol-2-one

497. 3,3-dimetyl-1-[2-(exo-6-(6-chlór-2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-497. 3,3-Dimethyl-1- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -

1,3-dihydroindol-2-ón1,3-dihydro-indol-2-one

498. 5-chlór-N-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-2tiofénkarbox-amid498. 5-chloro-N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2-thiophenecarboxamide

499. 5-chlór-N-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-2tiofénkarbox-amid499. 5-chloro-N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2-thiophenecarboxamide

500. N-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-4-fluórbenzamid500. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-fluorobenzamide

501. N-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-4-nitrobenzamid501. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-nitrobenzamide

502. N-[2-(exo-6-(6-chlór-2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]benzamid502. N- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

503. N-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-4-metoxybenzamid503. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-methoxybenzamide

504. N-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-4-hydroxybenzamid504. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-hydroxybenzamide

505. N-p-Cexo-e-íl-naftyO-S-azabicyklotS^.OJheptan-S-yOetylJ-S^-dichlórbenzamid505. N-p-Cexo-e-η-naphthyl-S-azabicyclot-5'-heptan-5-ylethyl-5'-dichlorobenzamide

506. N-[2-(exo-6-(1 -naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]naftalén-1 karboxamid506. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] naphthalene-1 carboxamide

507. N-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]naftalén-1karboxamid507. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] naphthalene-1-carboxamide

508. N-[2-(exo-6-(9-fenantryl).-3-azabicyklo[3.2.0]heptan-3-yl)etyl]benzamid508. N- [2- (exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

509. 1-[2-(exo-6-(6-chlór-2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1Hbenzo[cd]-indol-2-ón509. 1- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1Hbenzo [cd] indol-2-one

510.1-[2-(exo-6-(9-fenantryl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]-1Hbenzo[cd]indol-2-ón510.1- [2- (exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptane-3-yl) ethyl] -1Hbenzo [cd] indol-2-one

511. N-[2-(exo-6-(1-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]izoindolinón511. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] isoindolinone

512. N-[2-(exo-6-(2-naftyl)-3-azabicyklo[3.2.0]heptan-3-yl)etyl]izoindolinón512. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] isoindolinone

513. (+)-(1 S,5R,6S)exo-1-[2-[6-(4-chlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl]-3metyl-2H-1,3-dihydrobenzimidazol-2-ón513. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] heptan-3-yl] -ethyl] -3-methyl-2H -1,3-dihydro-benzoimidazol-2-one

514. (+)-(1 S,5R,6S)exo-1-[2-[6-(4-chlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl)-3etyl-2H-1,3-dihydrobenzimidazol-2-ón514. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] heptan-3-yl] -ethyl] -3-ethyl-2H -1,3-dihydro-benzoimidazol-2-one

515. (+)-(1 S,5R,6S)exo-1-[2-[6-(4-chlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl]-3n-propyl-2H-1,3-dihydro-benzimidazol-2-ón515. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] heptan-3-yl] -ethyl] -3n-propyl 2H-1,3-dihydro-benzoimidazol-2-one

516. (+)-(1 S,5R,6S)exo-2-[2-[6-(4-chlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl]-516. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] heptan-3-yl] -ethyl] -

3.3- dimetyl-2,3-dihydro-1,2-benzizotiazol 1,1 -dioxid3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

517. (+)-(1 S,5R,6S)exo-2-[2-[6-(4-chlórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl]-517. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] heptan-3-yl] -ethyl] -

2.3- dihydro-1,2-benzizotiazol 1,1 -dioxid2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

518. (+)-(1 S,5R,6S)exo-2-[2-[6-(4-fluórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl]-518. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -

3.3- dimetyl-2,3-dihydro-1,2-benzizotiazol 1,1-dioxid3,3-Dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

519. (+)-(1 S,5R,6S)exo-2-[2-[6-(4-fluórfenyl)-3-azabicyklo[3.2.0]heptan-3-yl]etyl]-519. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -

3.3- dietyl-2,3-dihydro-1,2-benzizotiazol 1,1-dioxid3,3-Diethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

520. (+)-(1 S,5R,6S)exo-2-[2-[6-(4-fliiórfenyl)-3-azabicyklo-[3.2.0]heptan-3-yl]etyl]-520. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -

2,3-dihydro-1,2-benzizotiazol 1,1 -dioxid2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

1. Použitie N-substituovaných 3-azabicykloalkánových derivátov všeobecného vzorca IUse of N-substituted 3-azabicycloalkane derivatives of the general formula I

Claims (4)

PATENTOVÉ NÁROKY v ktorom n—R2 PATENT CLAIMS in which n —R 2 W, znamená 4-, 5- alebo 6-členný kruh, ktorý môže obsahovať dvojitú väzbu, W 1 represents a 4-, 5- or 6-membered ring which may contain a double bond, R1 predstavuje fenylovú, naftylovú, fenantrylovú alebo tienylovú skupinu, z ktorých každá môže byť nesubstituovaná alebo mono- alebo disubstituovaná substituentami, ako je atóm halogénu, Ci.4-alkylová skupina, trifluórmetylová skupina, hydroxylová skupina, Ci^alkoxylová skupina, aminoskupina, monometylaminoskupina, dimetylaminoskupina, kyanoskupina alebo nitroskupina, znamená číslo 0,1,2,3 alebo 4, aR 1 represents a phenyl, naphthyl, phenanthryl or thienyl group, each of which may be unsubstituted or mono- or disubstituted with substituents such as a halogen atom, C 1-6. 4- alkyl, trifluoromethyl, hydroxyl, C 1-4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro is 0, 1, 2, 3, or 4, and R2 predstavuje naftylovú skupinu, ktorá je nesubstituovaná substituovaná jedným alebo dvoma atómami halogénu, znamená jeden z nasledujúcich zvyškov:R 2 is naphthyl which is unsubstituted or substituted by two halogen atoms, represents one of the following radicals: alebo alebo <4 oor or <4 o -39····-39 ···· LOJ-r® v ktoromLOJ-r® in which R3 znamená atóm vodíka, hydroxylovú skupinu alebo fenylový zvyšok, ktorý je nesubstituovaný alebo substituovaný atómom fluóru, chlóru alebo brómu,R 3 represents a hydrogen atom, a hydroxyl group or a phenyl radical which is unsubstituted or substituted by a fluorine, chlorine or bromine atom, R4 predstavuje atóm vodíka aleboR 4 represents a hydrogen atom; R3 a R4 spoločne znamenajú atóm kyslíka,R 3 and R 4 together represent an oxygen atom, R5 predstavuje fenylovú, naftylovú alebo tíenylovú skupinu, z ktorých každá môže byť nesubstituovaná alebo mono- alebo disubstituovaná substítuentom, ako je atóm fluóru, chlóru alebo brómu alebo hydroxylová skupina, nitroskupina, aminoskupina, CAalkänoylamínoskupina, Ci-4-alkylaminoskupina, C^-alkylová skupina alebo metoxyskupina,R 5 represents a phenyl, naphthyl or thienyl group, each of which may be unsubstituted or mono- or disubstituted with a substituent such as a fluorine, chlorine or bromine atom or a hydroxyl group, nitro, amino, CAalkanoylamino, C 1-4 -alkylamino, C 1-4 -alkylamino, an alkyl or methoxy group, R6 znamená atóm vodíka alebo metylovú skupinu,R 6 represents a hydrogen atom or a methyl group, -40···· ·· ·· ·· · ·· · ···· · · ·· • · ···· · · · • · e»······ · • · « · · · ··· ··· · ·· ·· ·· ···-40 ······················· ··· ··· · ·· ·· ·· ··· R7 predstavuje fenylovú, naftylovú, benzofurylovú, benzotienylovú, tienylovú, indolylovú, N-metylindolylovú alebo indenylovú skupinu, z ktorých každá môže byť nesubstituovaná alebo mono- alebo disubstituovaná substituentom, ako je atóm fluóru, chlóru alebo brómu alebo C^-alkylová skupina, hydroxylová skupina, metoxyskupina, nitroskupina, kyanoskupina, trifluórmetylová skupina, aminoskupina alebo di-C-M-alkylaminoskupina, alebo znamená C3.7cykloalkylovú skupinu,R 7 represents a phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group, each of which may be unsubstituted or mono- or disubstituted with a substituent such as a fluorine, chlorine or bromine atom or a C 1-4 -alkyl group, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C 1-4 -alkylamino or C 3-7 cycloalkyl, R8 znamená atóm vodíka alebo atóm fluóru alebo chlóru alebo C^alkylovú skupinu, metoxyskupinu alebo aminoskupinu,R 8 represents a hydrogen atom or a fluorine or chlorine atom or a C 1-6 alkyl, methoxy or amino group, R9 predstavuje atóm vodíka alebo metylovú skupinu aR 9 represents a hydrogen atom or a methyl group; R10 znamená atóm vodíka alebo metylovú skupinu aleboR 10 represents a hydrogen atom or a methyl group; R9 a R10 spoločne s atómom uhlíka kruhu predstavujú spirocyklopropánový kruh,R 9 and R 10 together with the ring carbon atom represent a spirocyclopropane ring, R11 znamená atóm vodíka, hydroxylovú skupinu, C^-alkylovú skupinu alebo Cm-alkoxylovú skupinu, alebo spolu s priľahlým atómom uhlíka predstavuje skupinu C=O- alebo skupinu C=S,R 11 represents a hydrogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-4 alkoxy group, or together with an adjacent carbon atom it represents a C = O- group or a C = S group, XaY znamenajú atóm uhlíka, CH, CH2, NH skupinu alebo skupinu C^alkyl-N alebo atóm dusíka,X and Y are carbon, CH, CH 2, NH radical or a C ^ alkyl-N or N, Z predstavuje priamu väzbu, skupinu CO, skupinu CS alebo skupinu CH alebo skupinu CH2, v ktorých atóm vodíka môže byť nahradený hydroxylovou skupinou, aminoskupinou alebo Ci_4-alkoxyskupinou alebo atómom halogénu, aZ represents a direct bond, a CO group, a CS group or a CH group or a CH 2 group in which the hydrogen atom can be replaced by a hydroxyl group, an amino group or a C 1-4 alkoxy group or a halogen atom, and A znamená atóm vodíka, hydroxylovú skupinu, aminoskupinu, merkapto-skupinu, C-M-alkylaminoskupinu, di-Ci^-alkylaminoskupinu, Ci^-alkyltio-skupinu alebo C^-alkoxylovú skupinu alebo spolu s priľahlým atómom uhlíka predstavuje skupinu C=O, aleboA represents a hydrogen atom, a hydroxyl group, an amino group, a mercapto group, a C 1-6 -alkylamino group, a di-C 1-6 -alkylamino group, a C 1-6 -alkylthio group or a C 1-6 -alkoxy group or together with an adjacent carbon atom represents C = O, or • ···· • ···· ·· · · ·· · · ·· · ·· · ·· · ·· · • • • • • · • · • • • • • · • · • · • · • • • • ·· · · • • • • • · • · • · • · • · • · • • • • ··· · ··· · ·· · · ·· · · • e • e • · • ·
A predstavuje Y-viazanú C3-C4-alkylénovú skupinu, ktorá môže obsahovať jednu alebo dve nekumulované dvojité väzby a v ktorej jedna CH alebo CH2 skupina môže byť nahradená atómom dusíka alebo síry alebo NH alebo N-CH3 skupinou a kde kruh je buď monosubstituovaný atómom fluóru alebo atómom chlóru alebo metylovou skupinou, metoxyskupinou, nitroskupinou alebo aminoskupinou, alebo, v prípade benzénového kruhu, tento môže byť mono-, di- alebo trisubstituovaný atómami fluóru alebo chlóru alebo skupinami, ako je metylová skupina, trifluórmetylová skupina, nitroskupina, hydroxylová skupina, metoxyskupina, aminoskupina, monometyl- alebo dimetylaminoskupina, a v ktorom X-, Y- and Z-obsahujúci kruh môže na atóme dusíka č. 1 niesť CrC4alkylovú skupinu, alylovú skupinu alebo benzylovú skupinu a môže obsahovať 1 až 3 nekumulované dvojité väzby, a ich soli s fyziologicky prijateľnými kyselinami na prípravu liečiv na liečenie ochorení centrálnej nervovej sústavy.A represents a Y-linked C 3 -C 4 -alkylene group which may contain one or two non-accumulated double bonds and in which one CH or CH 2 group may be replaced by a nitrogen or sulfur atom or an NH or N-CH 3 group and wherein the ring is either monosubstituted by fluorine or chlorine, or by methyl, methoxy, nitro or amino, or, in the case of a benzene ring, may be mono-, di- or trisubstituted by fluorine or chlorine atoms or by groups such as methyl, trifluoromethyl, nitro, a hydroxyl group, a methoxy group, an amino group, a monomethyl- or dimethylamino group, and in which the X-, Y- and Z-containing ring can, at the nitrogen atom no. 1 may carry C 1 -C 4 alkyl, allyl or benzyl, and may contain 1 to 3 non-accumulated double bonds, and salts thereof with physiologically acceptable acids for the preparation of medicaments for the treatment of diseases of the central nervous system. 2. Použitie podľa nároku 1, na prípravu liečiv na liečenie návykových ochorení.Use according to claim 1, for the preparation of medicaments for the treatment of addictive diseases. 3. Použitie podľa nároku 1 alebo 2, na prípravu liečiv na liečenie závislosti na kokaíne.Use according to claim 1 or 2, for the preparation of medicaments for the treatment of cocaine dependence. 4. Použitie podľa nároku 1 alebo 2, na prípravu liečiv na liečenie návyku na amfetamíny a návyku na látky podobné amfetamínom.Use according to claim 1 or 2, for the preparation of medicaments for the treatment of amphetamine and amphetamine-like substances.
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