HRP20010472A2 - Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system - Google Patents
Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system Download PDFInfo
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- HRP20010472A2 HRP20010472A2 HR20010472A HRP20010472A HRP20010472A2 HR P20010472 A2 HRP20010472 A2 HR P20010472A2 HR 20010472 A HR20010472 A HR 20010472A HR P20010472 A HRP20010472 A HR P20010472A HR P20010472 A2 HRP20010472 A2 HR P20010472A2
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- HR
- Croatia
- Prior art keywords
- azabicyclo
- exo
- ethyl
- fluorophenyl
- heptan
- Prior art date
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 8
- 210000003169 central nervous system Anatomy 0.000 title claims description 3
- 201000010099 disease Diseases 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
- -1 amino, monomethylamino, dimethylamino Chemical group 0.000 claims description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 229910052801 chlorine Inorganic materials 0.000 claims description 12
- 229910052731 fluorine Inorganic materials 0.000 claims description 12
- 239000011737 fluorine Substances 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 10
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 239000000460 chlorine Substances 0.000 claims description 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 125000001544 thienyl group Chemical group 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 4
- 125000003277 amino group Chemical group 0.000 claims description 4
- 230000001186 cumulative effect Effects 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 206010012335 Dependence Diseases 0.000 claims description 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 125000001041 indolyl group Chemical group 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 125000005561 phenanthryl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 125000004434 sulfur atom Chemical group 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 201000006145 cocaine dependence Diseases 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 104
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 56
- KWNQIIMVPSMYEM-UHFFFAOYSA-N 6,7-dimethoxy-1h-quinazoline-2,4-dione Chemical compound N1C(=O)NC(=O)C2=C1C=C(OC)C(OC)=C2 KWNQIIMVPSMYEM-UHFFFAOYSA-N 0.000 description 32
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 28
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 26
- BDTRIDKONHOQQN-UHFFFAOYSA-N 4h-pyrimidin-5-one Chemical compound O=C1CN=CN=C1 BDTRIDKONHOQQN-UHFFFAOYSA-N 0.000 description 20
- MNYCZTMXYXZNIJ-UHFFFAOYSA-N naphthalene-1-carboxamide Chemical compound C1=CC=C[C]2C(C(=O)N)=C=CC=C21 MNYCZTMXYXZNIJ-UHFFFAOYSA-N 0.000 description 14
- PCDHSSHKDZYLLI-UHFFFAOYSA-N butan-1-one Chemical compound CCC[C]=O PCDHSSHKDZYLLI-UHFFFAOYSA-N 0.000 description 10
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 description 10
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical compound NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 description 5
- 239000001273 butane Substances 0.000 description 5
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 5
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- DENPQNAWGQXKCU-UHFFFAOYSA-N thiophene-2-carboxamide Chemical compound NC(=O)C1=CC=CS1 DENPQNAWGQXKCU-UHFFFAOYSA-N 0.000 description 4
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 description 3
- LSGKMZLPZFPAIN-UHFFFAOYSA-N 1h-indole-3-carboxamide Chemical compound C1=CC=C2C(C(=O)N)=CNC2=C1 LSGKMZLPZFPAIN-UHFFFAOYSA-N 0.000 description 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 2
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Natural products O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- RHJVIGLEIFVHIJ-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1[CH]CCCC1 RHJVIGLEIFVHIJ-UHFFFAOYSA-N 0.000 description 2
- OJEYDZBIAYMFFD-UHFFFAOYSA-N cyclopentanecarboxamide Chemical compound NC(=O)C1C[CH]CC1 OJEYDZBIAYMFFD-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- QHKJIJXBJCOABP-UHFFFAOYSA-N 1-benzofuran-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)N)=CC2=C1 QHKJIJXBJCOABP-UHFFFAOYSA-N 0.000 description 1
- VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical compound C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 description 1
- DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical compound O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 description 1
- 125000003163 2-(2-naphthyl)ethyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- ASSKVPFEZFQQNQ-UHFFFAOYSA-N 2-benzoxazolinone Chemical compound C1=CC=C2OC(O)=NC2=C1 ASSKVPFEZFQQNQ-UHFFFAOYSA-N 0.000 description 1
- UGCKJZOTEJEOMX-UHFFFAOYSA-N 4-[6-(4-chlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-1-thiophen-2-ylbutan-1-one Chemical compound C1=CC(Cl)=CC=C1C1C2CN(CCCC(=O)C=3SC=CC=3)CC2C1 UGCKJZOTEJEOMX-UHFFFAOYSA-N 0.000 description 1
- IEWMSXRYDTXBRF-UHFFFAOYSA-N 4-[6-(4-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-1-thiophen-2-ylbutan-1-one Chemical compound C1=CC(F)=CC=C1C1C2CN(CCCC(=O)C=3SC=CC=3)CC2C1 IEWMSXRYDTXBRF-UHFFFAOYSA-N 0.000 description 1
- AHXKIXFHMCYARF-UHFFFAOYSA-N 6h-pyrrolo[1,2-a]pyrimidin-4-one Chemical compound O=C1C=CN=C2C=CCN12 AHXKIXFHMCYARF-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000004300 GABA-A Receptors Human genes 0.000 description 1
- 108090000839 GABA-A Receptors Proteins 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 206010034158 Pathological gambling Diseases 0.000 description 1
- QIOZLISABUUKJY-UHFFFAOYSA-N Thiobenzamide Chemical compound NC(=S)C1=CC=CC=C1 QIOZLISABUUKJY-UHFFFAOYSA-N 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 125000001891 dimethoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- WRSXUNSJGJUKHE-UHFFFAOYSA-N indazole Chemical compound C1=CC=C[C]2C=NN=C21 WRSXUNSJGJUKHE-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- FUZRJXVIEFEITA-UHFFFAOYSA-N n-[2-(6,6-diphenyl-3-azabicyclo[3.1.0]hexan-3-yl)ethyl]naphthalene-1-carboxamide Chemical compound C=1C=CC2=CC=CC=C2C=1C(=O)NCCN(C1)CC2C1C2(C=1C=CC=CC=1)C1=CC=CC=C1 FUZRJXVIEFEITA-UHFFFAOYSA-N 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical compound CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical compound C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229960000581 salicylamide Drugs 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Description
N-supstituirani azabicikloalkanski derivati su već otprije poznati kao neuroleptici (WO 95/13279, WO 95/15327, WO 96/04272, US 5.475.105, US 5.521.209, US 5.616.705, US 5.753.690). Otkriveno je da su ove supstance također pogodne za kontroliranje adiktivnih poremećaja i drugih poremećaja centralnog živčanog sustava. N-substituted azabicycloalkane derivatives are already known as neuroleptics (WO 95/13279, WO 95/15327, WO 96/04272, US 5,475,105, US 5,521,209, US 5,616,705, US 5,753,690). These substances have also been found to be suitable for controlling addictive disorders and other disorders of the central nervous system.
Ovaj izum omogućuje korištenje N-supstituiranih azabicikloalkanskih derivata formule I This invention enables the use of N-substituted azabicycloalkane derivatives of formula I
[image] [image]
gdje su slijedeći parametri naznačeni kako slijedi where the following parameters are indicated as follows
B je 4-, 5- ili 6-članski prsten, koji može sadržavati dvostruku vezu, B is a 4-, 5- or 6-membered ring, which may contain a double bond,
R1 je fenilna, naftilna, fenantrilna ili tienilna grupa, u svakom pojedinačnom slučaju nesupstituiran ili mono- ili disupstituiran s atomima halogena, C1-4-alkil, trifluorometil, hidroksil, C1-4-alkoksi, amino, monometilamino, dimetilamino, cijano ili nitro grupe, R1 is a phenyl, naphthyl, phenanthryl or thienyl group, in each individual case unsubstituted or mono- or disubstituted with halogen, C1-4-alkyl, trifluoromethyl, hydroxyl, C1-4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro atoms groups,
n je broj 0, 1, 2, 3 ili 4, i n is the number 0, 1, 2, 3 or 4, and
R2 je naftilna grupa koja je nesupstituirana ili supstituirana s jednim ili dva atoma halogena, ili s jednim od slijedećih radikala: R2 is a naphthyl group which is unsubstituted or substituted with one or two halogen atoms, or with one of the following radicals:
[image] [image]
u kojima je in which it is
R3 je atom vodika, hidroksilna grupa ili fenilni radikal koji je nesupstituiran ili supstituiran s atomom fluora, klora ili broma, R3 is a hydrogen atom, a hydroxyl group or a phenyl radical which is unsubstituted or substituted with a fluorine, chlorine or bromine atom,
R4 je atom vodika ili R4 is a hydrogen atom or
R3 i R4 su zajedno atom kisika, R3 and R4 together are an oxygen atom,
R5 je fenilna, naftilna ili tienilna grupa, u svakom pojedinačnom slučaju nesupstituiran ili mono- ili disupstituiran s atomima fluora, klora ili broma ili sa hidroksil, nitro, amino, C1-4-alkanilamino, C1-4-alkilamino, C1-4-alkil ili metoksi grupama, R5 is a phenyl, naphthyl or thienyl group, in each individual case unsubstituted or mono- or disubstituted with fluorine, chlorine or bromine atoms or with hydroxyl, nitro, amino, C1-4-alkanylamino, C1-4-alkylamino, C1-4- alkyl or methoxy groups,
R6 je atom vodika ili metilna grupa, R6 is a hydrogen atom or a methyl group,
R7 je fenil, naftil, benzofuril, benzotienil, tienil, indolil, N-metilindolil ili indenilna grupa, u svakom pojedinačnom slučaju nesupstitiran ili mono- ili disupstitruiran s atomom fluora, klora ili broma ili sa C1-4-alkil, hidroksil, metoksi, nitro, cijano, trifluorometil, amino ili di-C1-4-alkilamino grupama, ili je C3-7-cikloalkilna grupa, R7 is a phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group, in each individual case unsubstituted or mono- or disubstituted with a fluorine, chlorine or bromine atom or with C1-4-alkyl, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C1-4-alkylamino groups, or is a C3-7-cycloalkyl group,
R8 je atom vodika, atom fluora ili klora, ili C1-4-alkil, metoksi ili amino grupa, R8 is a hydrogen atom, a fluorine or chlorine atom, or a C1-4-alkyl, methoxy or amino group,
R9 je atom vodika ili metilna grupa, i R9 is a hydrogen atom or a methyl group, and
R10 je atom vodika ili metilna grupa, ili R 10 is a hydrogen atom or a methyl group, or
R9 i R10 zajedno sa prstenom ugljikovih atoma su spirociklopropanski prsten, R9 and R10 together with the ring of carbon atoms are a spirocyclopropane ring,
R11 je atom vodika, hidroksil, C1-4-alkil ili C1-4-alkoksi grupa, ili zajedno sa susjednim atomom ugljika je C=O- ili C=S grupa, R11 is a hydrogen atom, a hydroxyl, a C1-4-alkyl or a C1-4-alkoxy group, or together with an adjacent carbon atom is a C=O- or C=S group,
X i Y su atomi ugljika, CH, CH2, NH, ili C1-4-alkil-N grupe ili atomi dušika X and Y are carbon atoms, CH, CH2, NH, or C1-4-alkyl-N groups or nitrogen atoms
Z je direktna veza, CO grupa, CS grupa ili CH ili CH2 grupa u kojoj atom vodika može biti zamijenjen sa hidroksil, amino ili C1-4-alkoksi grupom ili s atomom vodika, i Z is a direct bond, a CO group, a CS group, or a CH or CH2 group in which the hydrogen atom may be replaced by a hydroxyl, amino or C1-4-alkoxy group or by a hydrogen atom, and
A je atom vodika, hidroksil, amino, merkapto, C1-4-alkilamino, di-C1-4-alkilamino, C1-4-alkiltio, ili C1-4-alkoksi grupa ili pak zajedno sa slijedećim atomom ugljika čini C=O grupu, ili A is a hydrogen atom, hydroxyl, amino, mercapto, C1-4-alkylamino, di-C1-4-alkylamino, C1-4-alkylthio, or C1-4-alkoxy group or together with the next carbon atom forms a C=O group , or
A je na Y vezana C3-C4-alkilenska grupa koja može sadržavati jednu ili dvije nekumulirajuće dvostruke veze, te u kojima jedna CH ili CH2 grupa može biti zamijenjena atomom dušika ili sumpora, sa NH ili N-CH3 grupom, te gdje je prsten ili monosupstituiran atomom fluora ili klora, ili metoksi, metilom, nitro ili amino grupom; ili pak u slučaju benzenskog prstena on može biti mono-, di- ili trisupstituiran s atomom fluora ili klora ili sa metil, trifluorometil, nitro, hidroksil, metoski, amino, monometil ili dimetilamino grupama, A is attached to Y a C3-C4-alkylene group which may contain one or two non-cumulative double bonds, and in which one CH or CH2 group may be replaced by a nitrogen or sulfur atom, with an NH or N-CH3 group, and where the ring or monosubstituted by a fluorine or chlorine atom, or a methoxy, methyl, nitro or amino group; or in the case of a benzene ring, it can be mono-, di- or tri-substituted with a fluorine or chlorine atom or with methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl or dimethylamino groups,
te u kojima X-, Y- i Z-sadržavajući prsten na atomu dušika broj 1 može nositi C1-4-alkil, alil ili benzilnu grupu i može sadržavati 1 do 3 nekumulirajuće dvostruke veze, and wherein the X-, Y- and Z-containing ring on nitrogen atom number 1 may carry a C 1-4 -alkyl, allyl or benzyl group and may contain 1 to 3 non-cumulative double bonds,
i njihove soli sa fiziološki prihvatljivim kislinama za pripravu medikamenata za kontroliranje adikcije, za tretman poremećaja koncentracije (poremećaji pomanjkanja pažnje), hiperaktivnost kod djece (poremećaji hiperaktivnosti i pomanjkanja pažnje), slabljenje mogućnosti učenja i pamćenja (smanjena kognitivna funkcija). and their salts with physiologically acceptable acids for the preparation of drugs to control addiction, for the treatment of concentration disorders (attention deficit disorders), hyperactivity in children (hyperactivity and attention deficit disorders), weakening of the ability to learn and remember (reduced cognitive function).
Ovakvo korištenje u kontekstu ovog izuma odnosi se na sve poremećaje ovisnosti, bilo da su oni uzrokovani zlouporabom supstanci ili drugim adiktivnim poremećajima kao što je primjerice ovisnost o kockanju. Supstance koje formiraju navike mogu biti: Such use in the context of this invention refers to all addictive disorders, whether caused by substance abuse or other addictive disorders such as gambling addiction. Substances that form habits can be:
opioidi kao što su primjerice morfin ili heroin, nikotin, alkohol, opioids such as morphine or heroin, nicotine, alcohol,
supstance koje stupaju u interakciju sa benzodiazepinskim receptorskim kompleksom, sedativi ili trenkvilajzeri kao što su primjerice benzodiazepini. substances that interact with the benzodiazepine receptor complex, sedatives or tranquilizers such as benzodiazepines.
Moguće supstance koje formiraju navike u kontekstu ovog izuma su posebice kokain ili amfetamin i amfetaminu slične supstance. Possible habit-forming substances in the context of this invention are in particular cocaine or amphetamine and amphetamine-like substances.
Supstance formule I mogu biti korištene, kako u obliku njihovih racemata, tako i u obliku njihovih optičkih izomera. Substances of formula I can be used both in the form of their racemates and in the form of their optical isomers.
Kao novitet, supstance se mogu aplicirati na uobičajeni način oralno ili parenteralno, intravenski ili intramuskularno. As a novelty, the substances can be applied in the usual way orally or parenterally, intravenously or intramuscularly.
Doziranje će ovisiti o starosti, kondiciji i tjelesnoj težini pacijenta, te o načinu aplikacije. Općenito uzevši, dnevna doza aktivne supstance se kreće između oko 1 i 100 mg/kg tjelesne težine u slučaju oralne aplikacije, te između 0.1 i 10 mg/kg tjelesne težine u slučaju parenteralne aplikacije. The dosage will depend on the age, condition and body weight of the patient, as well as on the method of application. Generally speaking, the daily dose of the active substance ranges between about 1 and 100 mg/kg of body weight in the case of oral application, and between 0.1 and 10 mg/kg of body weight in the case of parenteral application.
Supstance mogu biti korištene u uobičajenim farmaceutskim oblicima aplikacije, u čvrstom i tekućem obliku, primjerice u obliku tableta, filmom presvučenih tableta, kapsula, prašaka, granula, tableta umočenih u šećer, supozitorija, otopina, masti, krema ili raspršivača. Svi se ti oblici pripravljaju na uobičajeni način. U tu svrhu, aktivne supstance mogu biti procesirane s uobičajenim farmaceutskim dodacima kao što su vezne tvari u tabletama, punjači, prezervativi, razlagači tableta, regulatori protoka, plastifikatori, ovlaživači, disperzanti, emulzifikatori, otapala, agensi koji odlažu otpuštanje aktivne supstance, antioksidansi i/ili propelanti (cf. H. Sucker et al.: Pharmazeutische Technologie (Pharmaceutical Technology), Thieme-Verlag, Stuttgart, 1978). Dobiveni oblici aplikacije obično podrazumijevaju aktivnu susptancu u količini od 1 do 99% težinskog udjela. The substances can be used in the usual pharmaceutical forms of application, in solid and liquid form, for example in the form of tablets, film-coated tablets, capsules, powders, granules, tablets dipped in sugar, suppositories, solutions, ointments, creams or sprays. All these forms are prepared in the usual way. For this purpose, active substances can be processed with common pharmaceutical additives such as binders in tablets, fillers, condoms, tablet disintegrators, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, agents that delay the release of the active substance, antioxidants and /or propellants (cf. H. Sucker et al.: Pharmazeutische Technologie (Pharmaceutical Technology), Thieme-Verlag, Stuttgart, 1978). The resulting forms of application usually include an active substance in the amount of 1 to 99% by weight.
Slijedeće supstance mogu biti navedene kao primjeri supstanci formule I: The following substances may be cited as examples of substances of formula I:
1. 1-(4-fluorofenil)-4-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 1. 1-(4-fluorophenyl)-4-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
2. 1-fenil)-4-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 2. 1-phenyl)-4-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
3. 1-(4-fluorofenil)-4-[egzo-6,7-difenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 3. 1-(4-fluorophenyl)-4-[exo-6,7-diphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
4. 1-(4-fluorofenil)-4-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]butan 4. 1-(4-fluorophenyl)-4-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]butane
5. 1-fenil)-2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etan-1-on 5. 1-phenyl)-2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethan-1-one
6. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan 6. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butane
7. 1-(4-fluorofenil)-4-[egzo-6-m-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 7. 1-(4-fluorophenyl)-4-[exo-6-m-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
8. 1-(4-fluorofenil)-4-[egzo-6-o-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 8. 1-(4-fluorophenyl)-4-[exo-6-o-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
9. 1-(4-fluorofenil)-4-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 9. 1-(4-fluorophenyl)-4-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
10. 1-(4-fluorofenil)-4-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 10. 1-(4-fluorophenyl)-4-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
11. 1-(4-fluorofenil)-4-[egzo-6-p-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 11. 1-(4-fluorophenyl)-4-[exo-6-p-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
12. 1-(4-fluorofenil)-4-[egzo-6-m,p-diklorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 12. 1-(4-fluorophenyl)-4-[exo-6-m,p-dichlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
13. 1-(4-fluorofenil)-4-[egzo-6-m,p-dimetoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 13. 1-(4-fluorophenyl)-4-[exo-6-m,p-dimethoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
14. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 14. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
15. 1-fenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 15. 1-phenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
16. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan 16. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butane
17. 1-(4-fluorofenil)-4-[egzo-6-p-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 17. 1-(4-fluorophenyl)-4-[exo-6-p-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
18. 1-(4-fluorofenil)-4-[egzo-6-m-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 18. 1-(4-fluorophenyl)-4-[exo-6-m-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
19. 1-(4-fluorofenil)-4-[egzo-6-p-trifluorometilfenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 19. 1-(4-fluorophenyl)-4-[exo-6-p-trifluoromethylphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
20. 1-(4-fluorofenil)-4-[egzo-6-p-cijanofenil-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 20. 1-(4-fluorophenyl)-4-[exo-6-p-cyanophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
21. 1-(4-fluorofenil)-4-[egzo-6-tien-3-il-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 21. 1-(4-fluorophenyl)-4-[exo-6-thien-3-yl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
22. 1-(4-fluorofenil)-4-[egzo-6-pirid-3-il-3-azabiciklo[3.2.0]heptan-3-il]-butan-1-on 22. 1-(4-fluorophenyl)-4-[exo-6-pyrid-3-yl-3-azabicyclo[3.2.0]heptan-3-yl]-butan-1-one
23. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]propan-1-on 23. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]propan-1-one
24. 1-(bis-4-fluorofenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan 24. 1-(bis-4-fluorophenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butane
25. 1-(bis-4-fluorofenil)-4-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]butan 25. 1-(bis-4-fluorophenyl)-4-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]butane
26. 1-(4-fluorofenil)-4-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 26. 1-(4-fluorophenyl)-4-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
27. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 27. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
28. 1-(4-fluorofenil)-4-[egzo-6,7-difenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 28. 1-(4-fluorophenyl)-4-[exo-6,7-diphenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
29. 1-fenil)-4-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 29. 1-phenyl)-4-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
30. 1-fenil)-4-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 30. 1-phenyl)-4-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
31. 1-(4-fluorofenil)-4-[egzo-6-o-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 31. 1-(4-fluorophenyl)-4-[exo-6-o-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
32. 1-(4-fluorofenil)-4-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 32. 1-(4-fluorophenyl)-4-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
33. 1-(4-fluorofenil)-4-[egzo-6-p-trifluorometilfenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-ol 33. 1-(4-fluorophenyl)-4-[exo-6-p-trifluoromethylphenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-ol
34. 1-(4-fluorofenil)-4-[egzo-6-p-aminofenil-3-azabiciklo[3.2.0]heptan-3-il]butan-1-on 34. 1-(4-fluorophenyl)-4-[exo-6-p-aminophenyl-3-azabicyclo[3.2.0]heptan-3-yl]butan-1-one
35. N-(3-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-4-fluorobenzamid 35. N-(3-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-4-fluorobenzamide
36. N-(3-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]propil)benzamid 36. N-(3-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)benzamide
37. N-(2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-fluorobenzamid 37. N-(2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-fluorobenzamide
38. N-(2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 38. N-(2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
39. N-(2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metil-4-fluorobenzamid 39. N-(2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methyl-4-fluorobenzamide
40. N-(2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metilbenzamid 40. N-(2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methylbenzamide
41. N-(2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metil-4-izopropilbenzamid 41. N-(2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methyl-4-isopropylbenzamide
42. N-(3-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-4-klorobenzamid 42. N-(3-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-4-chlorobenzamide
43. N-(2-[egzo-6-p-trifluormetilfenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-klorobenzamid 43. N-(2-[exo-6-p-trifluoromethylphenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-chlorobenzamide
44. N-(3-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-3-metoksibenzamid 44. N-(3-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-3-methoxybenzamide
45. N-(3-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-3-nitrobenzamid 45. N-(3-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-3-nitrobenzamide
46. N-(3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-4-fluorobenzamid 46. N-(3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-4-fluorobenzamide
47. N-(3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]propil)benzamid 47. N-(3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)benzamide
48. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-fluorobenzamid 48. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-fluorobenzamide
49. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 49. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
50. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metil-4-fluorobenzamid 50. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methyl-4-fluorobenzamide
51. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metilbenzamid 51. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methylbenzamide
52. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metil-4-izopropilobenzamid 52. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methyl-4-isopropylbenzamide
53. N-(3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-4-klorobenzamid 53. N-(3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-4-chlorobenzamide
54. N-(3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-3-metoksibenzamid 54. N-(3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-3-methoxybenzamide
55. N-(3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]propil)-3-nitrobenzamid 55. N-(3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]propyl)-3-nitrobenzamide
56. N-(2-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-klorobenzamid 56. N-(2-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-chlorobenzamide
57. N-(2-[egzo-6-o-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-klorobenzamid 57. N-(2-[exo-6-o-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-chlorobenzamide
58. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-2-hidroksibenzamid 58. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-2-hydroxybenzamide
59. N-(2-[egzo-6-m-hidroksifenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-klorobenzamid 59. N-(2-[exo-6-m-hydroxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-chlorobenzamide
60. egzo-3-n-butil-6-fenil-3-azabiciklo[3.2.0]heptan 60. exo-3-n-butyl-6-phenyl-3-azabicyclo[3.2.0]heptane
61. egzo-3-metil-6-fenil-3-azabiciklo[3.2.0]heptan 61. exo-3-methyl-6-phenyl-3-azabicyclo[3.2.0]heptane
62. egzo-3-metil-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan 62. exo-3-methyl-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptane
63. egzo-3-n-propil-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan 63. exo-3-n-propyl-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptane
64. egzo-3-metil-6,7-difenil-3-azabiciklo[3.2.0]heptan 64. exo-3-methyl-6,7-diphenyl-3-azabicyclo[3.2.0]heptane
65. egzo-3-n-propil-6-m-hidroksifenil-3-azabiciklo[3.2.0]heptan 65. exo-3-n-propyl-6-m-hydroxyphenyl-3-azabicyclo[3.2.0]heptane
66. egzo-3-alil-6-m-metoksifenil-3-azabiciklo[3.2.0]heptan 66. exo-3-allyl-6-m-methoxyphenyl-3-azabicyclo[3.2.0]heptane
67. egzo-3-(3,4-dimetoksi)fenetil-6-fenil-3-azabiciklo[3.2.0]heptan 67. exo-3-(3,4-dimethoxy)phenethyl-6-phenyl-3-azabicyclo[3.2.0]heptane
68. egzo-3-(3,4.dimetoksi)fenetil-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan 68. exo-3-(3,4.dimethoxy)phenethyl-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptane
69. egzo-3-(3,4-dihidriksi)fenetil-3-azabiciklo[3.2.0]heptan 69. exo-3-(3,4-dihydroxy)phenethyl-3-azabicyclo[3.2.0]heptane
70. egzo-3-fenetil-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan 70. exo-3-phenethyl-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptane
71. 6-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 71. 6-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
72. (+)6-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 72. (+)6-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine-5 -he
73. (-)6-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 73. (-)6-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine-5 -he
74. 6-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 74. 6-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
75. 6-β-[egzo-6,7-difenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 75. 6-β-[exo-6,7-diphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
76. 6-β-[egzo-6,7-bis-(p-fluorofenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 76. 6-β-[exo-6,7-bis-(p-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a] pyrimidine-5-one
77. 6-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 77. 6-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
78. 6-β-[egzo-6-m-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 78. 6-β-[exo-6-m-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
79. 6-β-[egzo-6-m-hidroksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 79. 6-β-[exo-6-m-hydroxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
80. 6-β-(2-[egzo-6-p-aminofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 80. 6-β-(2-[exo-6-p-aminophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine-5 -he
81. 6-β-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 81. 6-β-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
82. 6-β-[egzo-6-p-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 82. 6-β-[exo-6-p-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
83. 6-β-[egzo-6-p-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 83. 6-β-[exo-6-p-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
84. 6-β-[egzo-6-m-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 84. 6-β-[exo-6-m-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
85. 6-β-[egzo-6-p-hidroksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 85. 6-β-[exo-6-p-hydroxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
86. 6-β-[egzo-6-p-trifluorometilfenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 86. 6-β-[exo-6-p-trifluoromethylphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
87. 6-β-[endo-6-(p-t-butilfenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 87. 6-β-[endo-6-(p-t-butylphenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine-5- he
88. 6-β-[egzo-6-(p-t-butilfenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 88. 6-β-[exo-6-(p-t-butylphenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine-5- he
89. 6-β-[egzo-6-(3,4-diklorofenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 89. 6-β-[exo-6-(3,4-dichlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine- 5-he
90. 6-β-[egzo-6-(3,4-dimetoksifenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 90. 6-β-[exo-6-(3,4-dimethoxyphenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine- 5-he
91. 6-β-[egzo-6-p-cijanofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 91. 6-β-[exo-6-p-cyanophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5-one
92. 6-β-[egzo-6-(3,4-dihidroksifenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 92. 6-β-[exo-6-(3,4-dihydroxyphenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine- 5-he
93. 6-β-[egzo-6-(p-fluorofenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 93. 6-β-[exo-6-(p-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidine-5- he
94. 6-β-[egzo-6-tien-3-il-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 94. 6-β-[exo-6-thien-3-yl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a]pyrimidin-5- he
95. 6-β-[egzo-6-(5-klorotien-2-il)-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 95. 6-β-[exo-6-(5-chlorothien-2-yl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a] pyrimidine-5-one
96. 6-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-2,3-dihidro-5H-tiazolo[3.2-a]pirimidin-5-on 96. 6-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-2,3-dihydro-5H-thiazolo[3.2-a] pyrimidine-5-one
97. 6-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-2,3-dihidro-5H-tiazolo[3.2-a]pirimidin-5-on 97. 6-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-2,3-dihydro-5H-thiazolo[3.2-a] pyrimidine-5-one
98. 6-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,3,7-trimetil-5H-tiazolo[3.2-a]pirimidin-5-on 98. 6-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,3,7-trimethyl-5H-thiazolo[3.2-a]pyrimidine- 5-he
99. 6-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-5H-tiazolo[3.2-a]pirimidin-5-on 99. 6-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-5H-thiazolo[3.2-a]pyrimidin-5-one
100. 6-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-5H-tiazolo[3.2-a]pirimidin-5-on 100. 6-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-5H-thiazolo[3.2-a]pyrimidin-5-one
101. 7-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2H,6H-pirimido[2,1-b][1,3]tiazin-6-on 101. 7-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1 ,3]thiazin-6-one
102. 7-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2H,6H-pirimido[2,1-b][1,3]tiazin-6-on 102. 7-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3 ]thiazin-6-one
103. 7-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2H,6H-pirimido[2,1-b][1,3]tiazin-6-on 103. 7-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1 ,3]thiazin-6-one
104. 7-β-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2H,6H-pirimido[2,1-b][1,3]tiazin-6-on 104. 7-β-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1 ,3]thiazin-6-one
105. 7-β-[egzo-6-p-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2H,6H-pirimido[2,1-b][1,3]tiazin-6-on 105. 7-β-[exo-6-p-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1 ,3]thiazin-6-one
106. 7-β-[egzo-6-m-hidroksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2H,6H-pirimido[2,1-b][1,3]tiazin-6-on 106. 7-β-[exo-6-m-hydroxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1 ,3]thiazin-6-one
107. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 107. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
108. (+)3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 108. (+)3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
109. (-)3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 109. (-)3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
110. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 110. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
111. 3-β-[egzo-6-m-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 111. 3-β-[exo-6-m-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
112. 3-β-[egzo-6-p-cijanofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 112. 3-β-[exo-6-p-cyanophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
113. 3-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 113. 3-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
114. 3-β-[egzo-6-p-hidroksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 114. 3-β-[exo-6-p-hydroxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
115. 3-β-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 115. 3-β-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
116. 3-β-[egzo-6-m-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 116. 3-β-[exo-6-m-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
117. 3-β-[egzo-6-p-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 117. 3-β-[exo-6-p-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
118. 3-β-[endo-6-p-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 118. 3-β-[endo-6-p-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
119. 3-β-[egzo-6-m-hidroksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 119. 3-β-[exo-6-m-hydroxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
120. 3-β-[egzo-6-p-aminofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 120. 3-β-[exo-6-p-aminophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
121. 3-β-[egzo-6-p-jodofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 121. 3-β-[exo-6-p-iodophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
122. 3-β-[egzo-6-p-trifluorometilfenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 122. 3-β-[exo-6-p-trifluoromethylphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
123. 3-β-[egzo-6-(3,4-diklorofenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 123. 3-β-[exo-6-(3,4-dichlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
124. 3-β-[egzo-6-(3,4-dihidroksifenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 124. 3-β-[exo-6-(3,4-dihydroxyphenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
125. 3-β-[egzo-6-(3,5-diklorofenil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 125. 3-β-[exo-6-(3,5-dichlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
126. 3-β-[egzo-6-o-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 126. 3-β-[exo-6-o-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
127. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metil-2,4-(1H,3H)kvinazolindion 127. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methyl-2,4-(1H,3H)quinazolinedione
128. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-kloro-2,4-(1H,3H)kvinazolindion 128. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-chloro-2,4-(1H,3H)quinazolinedione
129. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-fluoro-2,4-(1H,3H)kvinazolindion 129. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-fluoro-2,4-(1H,3H)quinazolinedione
130. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-5-kloro-2,4-(1H,3H)kvinazolindion 130. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-5-chloro-2,4-(1H,3H)quinazolindione
131. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6-fluoro-2,4-(1H,3H)kvinazolindion 131. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6-fluoro-2,4-(1H,3H)quinazolinedione
132. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6-metil-2,4-(1H,3H)kvinazolindion 132. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6-methyl-2,4-(1H,3H)quinazolindione
133. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-8-metoksi-2,4-(1H,3H)kvinazolindion 133. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-8-methoxy-2,4-(1H,3H)quinazolinedione
134. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-3-trifluorometil-2,4-(1H,3H)kvinazolindion 134. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-3-trifluoromethyl-2,4-(1H,3H)quinazolinedione
135. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-nitro-2,4-(1H,3H)kvinazolindion 135. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-nitro-2,4-(1H,3H)quinazolinedione
136. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6-nitro-2,4-(1H,3H)kvinazolindion 136. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6-nitro-2,4-(1H,3H)quinazolindione
137. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-amino-2,4-(1H,3H)kvinazolindion 137. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-amino-2,4-(1H,3H)quinazolindione
138. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6-amino-2,4-(1H,3H)kvinazolindion 138. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6-amino-2,4-(1H,3H)quinazolindione
139. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6-hidroksi-2,4-(1H,3H)kvinazolindion 139. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6-hydroxy-2,4-(1H,3H)quinazolinedione
140. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-5-kloro-2,4-(1H,3H)kvinazolindion 140. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-5-chloro-2,4-(1H,3H)quinazolinedione
141. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6,7-dimetoksi-2,4-(1H,3H)kvinazolindion 141. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6,7-dimethoxy-2,4-(1H,3H)quinazolindione
142. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6,8-dikloro-2,4-(1H,3H)kvinazolindion 142. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6,8-dichloro-2,4-(1H,3H)quinazolinedione
143. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6,7,8-trimetoksi-2,4-(1H,3H)kvinazolindion 143. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6,7,8-trimethoxy-2,4-(1H,3H)quinazolinedione
144. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1-metil-2,4-(1H,3H)kvinazolindion 144. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1-methyl-2,4-(1H,3H)quinazolinedione
145. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1-etil-2,4-(1H,3H)kvinazolindion 145. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1-ethyl-2,4-(1H,3H)quinazolinedione
146. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1-alil-2,4-(1H,3H)kvinazolindion 146. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1-allyl-2,4-(1H,3H)quinazolinedione
147. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1-benzil-2,4-(1H,3H)kvinazolindion 147. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1-benzyl-2,4-(1H,3H)quinazolinedione
148. 3-γ-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-propil-2,4-(1H,3H)kvinazolindion 148. 3-γ-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-propyl-2,4-(1H,3H)quinazolindione
149. 3-δ-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-butil-2,4-(1H,3H)kvinazolindion 149. 3-δ-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-butyl-2,4-(1H,3H)quinazolindione
150. 3-β-[egzo-6-(2-tienil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 150. 3-β-[exo-6-(2-thienyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
151. 3-β-[egzo-6-(5-kloro-2-tienil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 151. 3-β-[exo-6-(5-chloro-2-thienyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
152. 3-β-[egzo-6-(3-tienil)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,4-(1H,3H)kvinazolindion 152. 3-β-[exo-6-(3-thienyl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
153. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1H-tieno[3,2-d]pirimidin-2,4-dion 153. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1H-thieno[3,2-d]pyrimidine-2,4-dione
154. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1H-tieno[2,3-d]pirimidin-2,4-dion 154. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1H-thieno[2,3-d]pyrimidine-2,4-dione
155. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1H-tieno[3,4-d]pirimidin-2,4-dion 155. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1H-thieno[3,4-d]pyrimidine-2,4-dione
156. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1-metil-1H,3H-pirido[2,3-d]pirimidin-2,4-dion 156. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1-methyl-1H,3H-pyrido[2,3-d]pyrimidine- 2,4-dione
157. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-3H-kvinazolin-4-on 157. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-3H-quinazolin-4-one
158. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metoksi-3H-kvinazolin-4-on 158. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methoxy-3H-quinazolin-4-one
159. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-4H-pirido[1,2-a]pirimidin-4-on dihidroklorid 159. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4- he dihydrochloride
160. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-4H-pirido[1,2-a]pirimidin-4-on 160. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
161. 3-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-4H-pirido[1,2-a]pirimidin-4-on 161. 3-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4- he
162. 3-β-[egzo-6-m-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-4H-pirido[1,2-a]pirimidin-4-on 162. 3-β-[exo-6-m-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4- he
163. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,6-dimetil-4H-pirido[1,2-a]pirimidin-4-on 163. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidine- 4-he
164. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,7-dimetil-4H-pirido[1,2-a]pirimidin-4-on 164. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidine- 4-he
165. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,8-dimetil-4H-pirido[1,2-a]pirimidin-4-on 165. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4- he
166. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,9-dimetil-4H-pirido[1,2-a]pirimidin-4-on 166. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4- he
167. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,6,8-trimetil-4H-pirido[1,2-a]pirimidin-4-on 167. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidine- 4-he
168. 3-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,7-dimetil-4H-pirido[1,2-a]pirimidin-4-on 168. 3-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidine- 4-he
169. 3-β-[egzo-6-o-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,7-dimetil-4H-pirido[1,2-a]pirimidin-4-on 169. 3-β-[exo-6-o-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidine- 4-he
170. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,8-dimetil-4H-pirido[1,2-a]pirimidin-4-on 170. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4- he
171. 3-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,9-dimetil-4H-pirido[1,2-a]pirimidin-4-on 171. 3-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidine- 4-he
172. 3-β-[egzo-6-(5-klorotien-2-il)-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-4H-pirido[1,2-a]pirimidin-4-on 172. 3-β-[exo-6-(5-chlorothien-2-yl)-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one
173. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6,7,8,9-tetrahidro-2-metil-4H-pirido[1,2-a]pirimidin-4-on 173. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1, 2-a]pyrimidin-4-one
174. 3-β-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6,7,8,9-tetrahidro-2-metil-4H-pirido[1,2-a]pirimidin-4-on 174. 3-β-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[ 1,2-a]pyrimidin-4-one
175. 3-β-[egzo-6-p-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-6,7,8,9-tetrahidro-2-metil-4H-pirido[1,2-a]pirimidin-4-on 175. 3-β-[exo-6-p-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[ 1,2-a]pyrimidin-4-one
176. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-4H-pirido[1,2-a]pirimidin-4-on 176. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4- he
177. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-7-kloro-4H-pirido[1,2-a]pirimidin-4-on 177. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-7-chloro-4H-pyrido[1,2-a] pyrimidine-4-one
178. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-7-metil-1H,5H-imidazo[1,2-a]pirimidin-5-on 178. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-7-methyl-1H,5H-imidazo[1,2-a]pyrimidine- 5-he
179. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metil-7,8-dihidro-4H,6H-pirolo[1,2-a]pirimidin-4-on 179. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methyl-7,8-dihydro-4H,6H-pyrrolo[1, 2-a]pyrimidin-4-one
180. 2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metilbenzimidazol 180. 2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methylbenzimidazole
181. 1-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etilbenzimidazol 181. 1-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethylbenzimidazole
182. 1-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2,3-dihidrobenzimidazol-2-on 182. 1-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2,3-dihydrobenzimidazol-2-one
183. 2-[egzo-6-m-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-metilbenzimidazol 183. 2-[exo-6-m-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methylbenzimidazole
184. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etilindol, m.p. 193-195°C (hidroklorid) 184. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethylindole, m.p. 193-195°C (hydrochloride)
185. 3-β-(2-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etilindol 185. 3-β-(2-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethylindole
186. 3-β-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-etilindol, m.p. 104-105°C (hidroklorid) 186. 3-β-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethylindole, m.p. 104-105°C (hydrochloride)
187. 3-β-[egzo-6-m-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-etilindol 187. 3-β-[exo-6-m-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethylindole
188. 2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-3,4-dihidrokvinazolin-4-on 188. 2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-3,4-dihydroquinazolin-4-one
189. 2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-3,4-dihidrokvinazolin-4-tion 189. 2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-3,4-dihydroquinazolin-4-thione
190. 2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-3,4-dihidrokvinazolin-4-on 190. 2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-3,4-dihydroquinazolin-4-one
191. 2-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-3,4-dihidrokvinazolin-4-on 191. 2-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-3,4-dihydroquinazolin-4-one
192. 2-[egzo-6-o-metoksifenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-3,4-dihidrokvinazolin-4-on 192. 2-[exo-6-o-methoxyphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-3,4-dihydroquinazolin-4-one
193. 2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-4-hidroksi-6-metilpirimidin 193. 2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-4-hydroxy-6-methylpyrimidine
194. 6-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-2-metil-4-hidroksipirimidin 194. 6-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-2-methyl-4-hydroxypyrimidine
195. 6-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-metiluracil 195. 6-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyluracil
196. 6-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]-metil-uracil 196. 6-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]-methyl-uracil
197. 6-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-1,2,3,4-tetrahidro-1,3-dimetil-2,4-dioksopirimidin 197. 6-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxopyrimidine
198. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1,2,3,4-tetrahidro-6-metil-2,4-dioksopirimidin 198. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1,2,3,4-tetrahydro-6-methyl-2,4- dioxopyrimidine
199. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1,2,3,4-tetrahidro-1,6-dimetil-2,4-dioksopirimidin 199. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1,2,3,4-tetrahydro-1,6-dimethyl-2, 4-dioxopyrimidine
200. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1,2,3,4-tetrahidro-3,6-dimetil-2,4-dioksopirimidin 200. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1,2,3,4-tetrahydro-3,6-dimethyl-2, 4-dioxopyrimidine
201. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1,2,3,4-tetrahidro-3,6-dimetil-2,4-ditiopirimidin 201. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1,2,3,4-tetrahydro-3,6-dimethyl-2, 4-dithiopyrimidine
202. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1,2,3,4-tetrahidro-1,3,6-trimetil-2,4-dioksopirimidin 202. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1,2,3,4-tetrahydro-1,3,6-trimethyl- 2,4-dioxopyrimidine
203. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-1,2,3,4-tetrahidro-6-amino-1-metil-2,4-dioksopirimidin 203. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-1,2,3,4-tetrahydro-6-amino-1-methyl- 2,4-dioxopyrimidine
204. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-amino-6-metil-4(3H)pirimidinon 204. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-amino-6-methyl-4(3H)pyrimidinone
205. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-amino-3,6-dimetil-4(3H)pirimidinon 205. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-amino-3,6-dimethyl-4(3H)pyrimidinone
206. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 206. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
207. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3-etil-6-metil-4(3H)pirimidinon 207. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3-ethyl-6-methyl-4(3H)pyrimidinone
208. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-amino-3-etil-6-metil-4(3H)pirimidinon 208. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-amino-3-ethyl-6-methyl-4(3H)pyrimidinone
209. 5-β-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 209. 5-β-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
210. 5-β-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 210. 5-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
211. 5-β-[egzo-6-o-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 211. 5-β-[exo-6-o-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
212. 5-β-[egzo-6-p-trifluorometilfenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 212. 5-β-[exo-6-p-trifluoromethylphenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
213. 5-β-[egzo-6-p-cijanofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 213. 5-β-[exo-6-p-cyanophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
214. 5-β-[egzo-6-m-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 214. 5-β-[exo-6-m-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
215. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-2-metilamino-4-metoksi-6-metilpirimidin 215. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-2-methylamino-4-methoxy-6-methylpyrimidine
216. 3-β-[egzo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 216. 3-β-[exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H )quinazolinedione
217. 3-β-[endo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 217. 3-β-[endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H )quinazolinedione
218. 3-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 218. 3-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H ,3H) quinazolinedione
219. 3-β-[egzo-6-p-trifluorometilfenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-6-fluoro-2,4-(1H,3H)kvinazolindion 219. 3-β-[exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-6-fluoro-2, 4-(1H,3H)quinazolinedione
220. 3-β-[egzo-6-m-klorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 220. 3-β-[exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H ,3H) quinazolinedione
221. 3-β-[egzo-6-p-metoksifenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-6-metil-2,4-(1H,3H)kvinazolindion 221. 3-β-[exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-6-methyl-2, 4-(1H,3H)quinazolinedione
222. 5-β-[egzo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)-pirimidinon 222. 5-β-[exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6- dimethyl-4(3H)-pyrimidinone
223. 5-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 223. 5-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3, 6-dimethyl-4(3H)pyrimidinone
224. 1-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2(3H)benyimidazolon 224. 1-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2(3H)benyimidazolone
225. 5-β-[egzo-6-p-nitrofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 225. 5-β-[exo-6-p-nitrophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3, 6-dimethyl-4(3H)pyrimidinone
226. 5-β-[egzo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 226. 5-β-[exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6- dimethyl-4(3H)pyrimidinone
227. 5-β-[endo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 227. 5-β-[endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6- dimethyl-4(3H)pyrimidinone
228. 5-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metil-4H-pirido[1.2-a]-pirimidin-4-on 228. 5-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methyl-4H- pyrido[1.2-a]-pyrimidin-4-one
229. 1-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etilindolin-2-on 229. 1-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethylindolin-2-one
230. 6-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-7-metil-5H-tiazolo[3.2-a]-pirimidin-5-on 230. 6-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-7-methyl-5H- thiazolo[3.2-a]-pyrimidin-5-one
231. 1-β-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2(1H)kvinolon 231. 1-β-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2(1H)quinolone
232. 3-β-[7-fenil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 232. 3-β-[7-phenyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
233. 3-β-[7-p-fluorofenil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 233. 3-β-[7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
234. 5-β-[7-p-fluorofenil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 234. 5-β-[7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
235. 3-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.1.0]heksan-3-il]-etil-2,4-(1H,3H)kvinazolindion 235. 3-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.1.0]hexan-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
236. 3-β-[egzo-6-fenil-3-azabiciklo[3.1.0]heksan-3-il]-etil-2,4-(1H,3H)kvinazolindion 236. 3-β-[exo-6-phenyl-3-azabicyclo[3.1.0]hexan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
237. 3-β-[6,6-difenil-3-azabiciklo[3.1.0]heksan-3-il]-etil-2,4-(1H,3H)kvinazolindion 237. 3-β-[6,6-diphenyl-3-azabicyclo[3.1.0]hexan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
238. 5-β-[egzo-6-p-fluorofenil-3-azabiciklo[3.1.0]heksan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 238. 5-β-[exo-6-p-fluorophenyl-3-azabicyclo[3.1.0]hexan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
239. 6-β-[egzo-6-m-klorofenil-3-azabiciklo[3.1.0]heksan-3-il]-etil-7-metil-5H-tiazolo[3,2-a]pirimidin-5-on 239. 6-β-[exo-6-m-chlorophenyl-3-azabicyclo[3.1.0]hexan-3-yl]-ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidine-5- he
240. 3-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 240. 3-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2-methylamino-3,6- dimethyl-4(3H)pyrimidinone
241. 5-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 241. 5-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl- 4(3H)pyrimidinone
242. 6-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]-etil-7-metil-5H-tiazolo[3,2-a]pirimidin-5-on 242. 6-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-7-methyl-5H-thiazolo[3, 2-a]pyrimidin-5-one
243. 1-β-[6-fenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]-etil-2(3H)benzimidazolon 243. 1-β-[6-phenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2(3H)benzimidazolone
244. 1-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]-etil-2(3H)etilindolin-2-on 244. 1-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2(3H)ethylindolin-2-one
245. 1-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]-etil-2(1H)kvinolon 245. 1-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2(1H)quinolone
246. 3-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 246. 3-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
247. 5-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 247. 5-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
248. 6-β-[egzo-6-fenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-7-metil-5H-tiazolo[3,2-a]pirimidin-5-on 248. 6-β-[exo-6-phenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-7-methyl-5H-thiazolo[3,2-a] pyrimidine-5-one
249. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etilindolin-2-on 249. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethylindolin-2-one
250. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2(1H)kvinolon 250. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2(1H)quinolone
251. 3-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 251. 3-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
252. 5-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 252. 5-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
253. 6-β-[endofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-7-metil-5H-tiazolo[3,2-a]pirimidin-5-on 253. 6-β-[endophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidine-5- he
254. 1-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etilindolin-2-on 254. 1-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethylindolin-2-one
255. 1-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2(1H)kvinolon 255. 1-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2(1H)quinolone
256. 3-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2,4-(1H,3H)kvinazolindion 256. 3-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
257. 5-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 257. 5-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
258. 6-β-[egzo-7-fenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-7-metil-5H-tiazolo[3,2-a]pirimidin-5-on 258. 6-β-[exo-7-phenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-7-methyl-5H-thiazolo[3,2-a] pyrimidine-5-one
259. 1-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etilindolin-2-on 259. 1-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethylindolin-2-one
260. 1-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]-etil-2(1H)kvinolon 260. 1-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]-ethyl-2(1H)quinolone
261. 3-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2,4-(1H,3H)kvinazolindion 261. 3-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
262. 5-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 262. 5-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
263. 3-β-[endo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2,4-(1H,3H)kvinazolindion 263. 3-β-[endo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
264. 5-β-[endo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 264. 5-β-[endo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinone
265. 3-β-[endo-6-p-trifluormetilfenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2,4-(1H,3H)kvinazolindion 265. 3-β-[endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
266. 5-β-[endo-6—p-trifluormetilfenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)-pirimidinon 266. 5-β-[endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)-pyrimidinone
267. 3-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 267. 3-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2,4-(1H,3H )quinazolinedione
268. 5-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 268. 5-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2-methylamino-3,6- dimethyl-4(3H)pyrimidinone
269. 1-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2(3H)benzimidazolon 269. 1-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2(3H)benzimidazolone
270. 1-β-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etilindolin-2-on 270. 1-β-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethylindolin-2-one
271. 3-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 271. 3-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
272. 5-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 272. 5-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl- 4(3H)pyrimidinone
273. 3-β-[6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 273. 3-β-[6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
274. 5-β-[6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 274. 5-β-[6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
275. 3-β-[6-p-trifluormetilfenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 275. 3-β-[6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
276. 5-β-[6-p-trifluormetilfenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 276. 5-β-[6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl- 4(3H)pyrimidinone
277. 1-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2(3H)benzimidazolon 277. 1-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2(3H)benzimidazolone
278. 1-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etilindolin-2-on 278. 1-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethylindolin-2-one
279. 1-β-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]-etil-2(1H)kvinolon 279. 1-β-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]-ethyl-2(1H)quinolone
280. 3-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2,4-(1H,3H)kvinazolidon 280. 3-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2,4-(1H,3H )quinazolidone
281. 5-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2-metilamino-3,6-dimetil-,4(3H)pirimidinon 281. 5-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2-methylamino-3,6- dimethyl-,4(3H)pyrimidinone
282. 3-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2-metil-(4H)-pirido[1.2-a]pirimidin-4-on 282. 3-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2-methyl-(4H)- pyrido[1.2-a]pyrimidin-4-one
283. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2(1H)kvinolon 283. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2(1H)quinolone
284. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2(3H)benzimidazolon 284. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2(3H)benzimidazolone
285. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etilindolin-2-on 285. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethylindolin-2-one
286. 3-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2,4-(1H,3H)-kvinazolindion 286. 3-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2,4-(1H,3H )-quinazolinedione
287. 5-β-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 287. 5-β-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl- 4(3H)pyrimidinone
288. 3-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2,4-(1H,3H)kvinazolindion 288. 3-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
289. 5-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 289. 5-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
290. 3-β-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2,4-(1H,3H)kvinazolindion 290. 3-β-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
291. 5-β-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 291. 5-β-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinone
292. 6-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-7-metil-5H-tiazolo[3.2-a]pirimidin-5-on 292. 6-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-7-methyl-5H-thiazolo[3.2-a] pyrimidine-5-one
293. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2(3H)benzimidazolon 293. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2(3H)benzimidazolone
294. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etilindolin-2-on 294. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethylindolin-2-one
295. 1-β-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2(1H)kvinolon 295. 1-β-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2(1H)quinolone
296. 3-β-[egzo-7-fenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 296. 3-β-[exo-7-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
297. 5-β-[egzo-7-fenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 297. 5-β-[exo-7-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl- 4(3H)pyrimidinone
298. 3-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 298. 3-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]-ethyl-2,4-(1H,3H )quinazolinedione
299. 5-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)-pirimidinon 299. 5-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]-ethyl-2-methylamino-3,6- dimethyl-4(3H)-pyrimidinone
300. 3-β-[egzo-7-p-fluorofenil-3-azabiciklo[4.3.0]non-1-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 300. 3-β-[exo-7-p-fluorophenyl-3-azabicyclo[4.3.0]non-1-en-3-yl]-ethyl-2,4-(1H,3H)quinazolindione
301. 5-β-[7-fenil-3-azabiciklo[4.3.0]non-1-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 301. 5-β-[7-phenyl-3-azabicyclo[4.3.0]non-1-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
302. 5-β-[7-p-fluorofenil-3-azabiciklo[4.3.0]non-1-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 302. 5-β-[7-p-fluorophenyl-3-azabicyclo[4.3.0]non-1-en-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinone
303. 3-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2,4-(1H,3H)kvinazolindion 303. 3-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2,4-(1H,3H)quinazolinedione
304. 5-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 304. 5-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2-methylamino-3,6-dimethyl-4( 3H)pyrimidinone
305. 1-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2(3H)benzimidazolon 305. 1-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2(3H)benzimidazolone
306. 1-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etilindolin-2-on 306. 1-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethylindolin-2-one
307. 1-β-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-etil-2(1H)kvinolon 307. 1-β-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-ethyl-2(1H)quinolone
308. 3-β-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]-etil-2,4-(1H,3H)kvinazolindion 308. 3-β-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2,4- (1H,3H)quinazolinedione
309. 5-β-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 309. 5-β-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-2-methylamino- 3,6-dimethyl-4(3H)pyrimidinone
310. 3-β-[egzo/endo-6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-3-il]-etil-2,4-(1H,3H)kvinazolindion 310. 3-β-[exo/endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-3-yl]-ethyl-2,4- (1H,3H)quinazolinedione
311. 5-β-[egzo/endo-6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-3-il]-etil-2-metilamino-3,6-dimetil-4(3H)pirimidinon 311. 5-β-[exo/endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-3-yl]-ethyl-2-methylamino- 3,6-dimethyl-4(3H)pyrimidinone
312. 1-β-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]-etilindolin-2-on 312. 1-β-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]-ethylindolin-2-one
313. 6-β-[6-fenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]-etil-7-metil-5H-tiazolo[3,2-a]pirimidin-5-on 313. 6-β-[6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]-ethyl-7-methyl-5H- thiazolo[3,2-a]pyrimidin-5-one
314. N-(2-[egzo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil)-4-fluorbenzamid 314. N-(2-[exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl)-4-fluorobenzamide
315. N-(2-[endo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil)-4-fluorbenzamid 315. N-(2-[endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl)-4-fluorobenzamide
316. N-(2-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil)-4-fluorbenzamid 316. N-(2-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl)-4-fluorobenzamide
317. N-(2-[egzo-6-p-trifluormetilfenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etilbenzamid 317. N-(2-[exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethylbenzamide
318. N-(2-[egzo-6-m-klorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil)benzamid 318. N-(2-[exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl)benzamide
319. N-(2-[egzo-6-p-metoksifenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil)-4-klorobenzamid 319. N-(2-[exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl)-4-chlorobenzamide
320. N-(2-[egzo-6-fenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-etil)naftalen-1-karboksamid 320. N-(2-[exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-ethyl)naphthalene-1-carboxamide
321. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-butan-1-on 321. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-butan- 1-he
322. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3,7-diazabiciklo[3.3.0]oktan-3-il]-butan-1-ol 322. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo[3.3.0]octan-3-yl]-butan- 1-ol
323. N-(2-[egzo-6-p-fluorofenil-7-metil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)benzamid 323. N-(2-[exo-6-p-fluorophenyl-7-methyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)benzamide
324. 1-(2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)naftalen 324. 1-(2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)naphthalene
325. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]butan-1-on 325. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]butan-1-one
326. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]butan-1-ol 326. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]butan-1-ol
327. N-(2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-2-(N-metil)aminobenzamid 327. N-(2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-2-(N-methyl)aminobenzamide
328. N-2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-5-klorotien-2-ilkarboksamid 328. N-2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-5-chlorothien-2-ylcarboxamide
329. N-2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)inden-3-karboksamid 329. N-2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)inden-3-carboxamide
330. N-2-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-4-fluorbenzamid 330. N-2-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-4-fluorobenzamide
331. N-2-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)naftalen-1-karboksamid 331. N-2-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)naphthalene-1-carboxamide
332. 1-(2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)naftalen 332. 1-(2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)naphthalene
333. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]butan-1-on 333. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]butan-1-one
334. N-2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)benzamid 334. N-2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)benzamide
335. N-2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)inden-3-karboksamid 335. N-2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)inden-3-carboxamide
336. N-2-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)-4-fluorbenzamid 336. N-2-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)-4-fluorobenzamide
337. N-2-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-7-en-il]etil)-3-kloro-1-benzotien-2-ilkarboksamid 337. N-2-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-7-en-yl]ethyl)-3-chloro-1-benzothien-2- ylcarboxamide
338. N-2-[egzo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-7-en-il]etil)-3-kloro-1-benzotien-2-ilkarboksamid 338. N-2-[exo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-7-en-yl]ethyl)-3-chloro-1-benzothien-2- ylcarboxamide
339. 1-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-6-en-il]etil)naftalen 339. 1-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-6-en-yl]ethyl)naphthalene
340. 1-(4-fluorofenil)-4-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]butan-1-on 340. 1-(4-fluorophenyl)-4-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]butan-1-one
341. 1-(4-fluorofenil)-4-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]butan-1-ol 341. 1-(4-fluorophenyl)-4-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]butan-1-ol
342. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etil)-2-(N-metil)aminobenzamid 342. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethyl)-2-(N-methyl)aminobenzamide
343. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etil)-5-klorotien-2-ilkarboksamid 343. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethyl)-5-chlorothien-2-ylcarboxamide
344. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etilbenzamid 344. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethylbenzamide
345. N-(2-[6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etil)-3-kloro-1-benzotien-2-ilkarboksamid 345. N-(2-[6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethyl)-3-chloro-1-benzothien-2-ylcarboxamide
346. N-(2-[6-p-trifluorometilfenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etil)naftalen-1-karboksamid 346. N-(2-[6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethyl)naphthalene-1-carboxamide
347. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etil)inden-3-karbonimid 347. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethyl)inden-3-carbonimid
348. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-6-en-3-il]etil)naftalen-1-karboksamid 348. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-6-en-3-yl]ethyl)naphthalene-1-carboxamide
349. 1-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)naftalen 349. 1-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)naphthalene
350. 1-(4-fluorofenil)-4-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]butan-1-on 350. 1-(4-fluorophenyl)-4-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]butan-1-one
351. 1-(4-fluorofenil)-4-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]butan-1-ol 351. 1-(4-fluorophenyl)-4-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]butan-1-ol
352. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]-2-(N-metil)aminobenzamid 352. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]-2-(N-methyl)aminobenzamide
353. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)benzamid 353. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)benzamide
354. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-5-klorotien-2-ilkarboksamid 354. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-5-chlorothien-2-ylcarboxamide
355. N-(2-[endo-6-fenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-4-fluorbenzamid 355. N-(2-[endo-6-phenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-4-fluorobenzamide
356. N-(2-[endo-6-p-trifluorometilfenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)inden-3-karboksamid 356. N-(2-[endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)inden-3-carboxamide
357. 2-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)naftalen 357. 2-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)naphthalene
358. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)benzamid 358. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)benzamide
359. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)-2-(N-metil)aminobenzamid 359. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)-2-(N-methyl) aminobenzamide
360. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-7-en-3-il]etil)naftalen-1-karboksamid 360. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-7-en-3-yl]ethyl)naphthalene-1-carboxamide
361. 1-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]etil)naftalen 361. 1-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]ethyl)naphthalene
362. 1-(4-fluorofenil)-4-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]butan-1-on 362. 1-(4-fluorophenyl)-4-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]butan-1-one
363. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]benzamid 363. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]benzamide
364. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]etil)-5-klorotien-2-ilkarboksamid 364. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]ethyl)-5-chlorothien-2-ylcarboxamide
365. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]etil)-3-kloro-1-benzotien-2-ilkarboksamid 365. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]ethyl)-3-chloro-1-benzothien -2-ylcarboxamide
366. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]etil)inden-3-karboksamid 366. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]ethyl)inden-3-carboxamide
367. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]etil)naftalen-1-karboksamid 367. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]ethyl)naphthalene-1-carboxamide
368. 1-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-8-en-3-il]etil)naftalen 368. 1-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-8-en-3-yl]ethyl)naphthalene
369. 1-(4-fluorofenil)-4-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]butan-1-on 369. 1-(4-fluorophenyl)-4-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]butan-1-one
370. 1-(4-fluorofenil)-4-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]butan-1-ol 370. 1-(4-fluorophenyl)-4-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]butan-1-ol
371. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-2-(N-metil)aminobenzamid 371. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-2-(N-methyl)aminobenzamide
372. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)benzamid 372. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)benzamide
373. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)-5-klorotien-2-ilkarboksamid 373. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)-5-chlorothien-2-ylcarboxamide
374. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)naftalen-1-karboksamid 374. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)naphthalene-1-carboxamide
375. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[4.3.0]non-3-il]etil)inden-3-karboksamid 375. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[4.3.0]non-3-yl]ethyl)inden-3-carboxamide
376. 1-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen 376. 1-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]ethyl)naphthalene
377. 1-(4-fluorofenil)-4-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]butan-1-on 377. 1-(4-fluorophenyl)-4-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]butan-1-one
378. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]etil)benzamid 378. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]ethyl)benzamide
379. N-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen-1-karboksamid 379. N-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]ethyl)naphthalene-1-carboxamide
380. 1-(2-[6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen 380. 1-(2-[6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]ethyl)naphthalene
381. 1-(4-fluorofenil)-4-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]okt-6-en-3-il]butan-1-ol 381. 1-(4-fluorophenyl)-4-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]oct-6-en-3-yl]butan-1-ol
382. N-(2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)benzamid 382. N-(2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)benzamide
383. N-(2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)naftalen-1-karboksamid 383. N-(2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)naphthalene-1-carboxamide
384. N-(2-[egzo-6-fenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)inden-3-karboksamid 384. N-(2-[exo-6-phenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)inden-3-carboxamide
385. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)naftalen 385. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)naphthalene
386. 1-(4-fluorofenil)-4-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]butan-1-on 386. 1-(4-fluorophenyl)-4-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]butan-1-one
387. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)benzamid 387. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)benzamide
388. N-(2-[endo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)naftalen-1-karboksamid 388. N-(2-[endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)naphthalene-1-carboxamide
389. 1-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)naftalen 389. 1-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)naphthalene
390. 1-(4-fluorofenil)-4-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]butan-1-on 390. 1-(4-fluorophenyl)-4-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]butan-1-one
391. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)benzamid 391. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)benzamide
392. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)naftalen-1-karboksamid 392. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)naphthalene-1-carboxamide
393. N-(2-[egzo-7-p-fluorofenil-1,5-cis-3-azabiciklo[3.3.0]oktan-3-il]etil)inden-3-karboksamid 393. N-(2-[exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo[3.3.0]octan-3-yl]ethyl)inden-3-carboxamide
394. N-(2-[egzo-6-p-fluorofenil-1,5-cis-3-azabiciklo[3.1.0]heksan-3-il]etil)-4-fluorbenzamid 394. N-(2-[exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo[3.1.0]hexan-3-yl]ethyl)-4-fluorobenzamide
395. N-(2-[egzo-6-fenil-1,5-cis-3-azabiciklo[3.1.0]heksan-3-il]etil)-5-klorotien-2-ilkarboksamid 395. N-(2-[exo-6-phenyl-1,5-cis-3-azabicyclo[3.1.0]hexan-3-yl]ethyl)-5-chlorothien-2-ylcarboxamide
396. N-(2-[6,6-difenil-3-azabiciklo[3.1.0]heksan-3-il]etil)-naft-1-ilkarboksamid 396. N-(2-[6,6-diphenyl-3-azabicyclo[3.1.0]hexan-3-yl]ethyl)-naphth-1-ylcarboxamide
397. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.1.0]heksan-3-il]etil)-3-kloro-1-benzotien-2-ilkarboksamid 397. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.1.0]hexan-3-yl]ethyl)-3-chloro-1-benzothien-2-ylcarboxamide
398. N-(2-[egzo-6-m-klorofenil-3-azabiciklo[3.1.0]heksan-3-il]etil)-4-klorobenzamid 398. N-(2-[exo-6-m-chlorophenyl-3-azabicyclo[3.1.0]hexan-3-yl]ethyl)-4-chlorobenzamide
399. 1-(2-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen 399. 1-(2-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl)naphthalene
400. N-(2-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)benzamid 400. N-(2-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl)benzamide
401. N-(2-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen-1-karboksamid 401. N-(2-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl)naphthalen-1- carboxamide
402. N-(2-[6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)inden-3-karboksamid 402. N-(2-[6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl)inden-3- carboxamide
403. 1-(2-[egzo/endo-6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen 403. 1-(2-[exo/endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl) naphthalene
404. N-(2-[egzo/endo-6-p-fluorofenil-1,5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)benzamid 404. N-(2-[exo/endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl) benzamide
405. 1-(2-[6-fenil-1-5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)naftalen 405. 1-(2-[6-phenyl-1-5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl)naphthalene
406. N-(2-[6-fenil-1-5-cis-8-oksa-3,7-diazabiciklo[3.3.0]okt-6-en-3-il]etil)benzamid 406. N-(2-[6-phenyl-1-5-cis-8-oxa-3,7-diazabicyclo[3.3.0]oct-6-en-3-yl]ethyl)benzamide
407. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzosulfonamid 407. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzosulfonamide
408. N-(2-[egzo-6-fenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzosulfonamid 408. N-(2-[exo-6-phenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzosulfonamide
409. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-N-metilbenzosulfonamid 409. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-N-methylbenzosulfonamide
410. N-(2-[egzo-6-(5-klorotien-2-il)-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-fluorbenzosulfonamid 410. N-(2-[exo-6-(5-chlorothien-2-yl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-fluorobenzosulfonamide
411. 3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-1-fenoksipropan 411. 3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-1-phenoxypropane
412. 2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-1-p-fluorofenoksietan 412. 2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-1-p-fluorophenoxyethane
413. 3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-1-(1-naftiloksi)propan 413. 3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-1-(1-naphthyloxy)propane
414. 3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-1-p-t-butilfenoksipropan 414. 3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-1-p-t-butylphenoxypropane
415. 3-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-1-p-fluorfenoksipropan 415. 3-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-1-p-fluorophenoxypropane
416. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)tiobenzamid 416. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)thiobenzamide
417. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-fluorotiobenzamid 417. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-fluorothiobenzamide
418. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-klorotiobenzamid 418. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-chlorothiobenzamide
419. O-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzoat 419. O-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzoate
420. O-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]-etil-4-fluorbenzoat 420. O-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]-ethyl-4-fluorobenzoate
421. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H-benzo[cd]indol-2-on 421. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H-benzo[cd]indol-2-one
422. N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H-benzo[cd]indol-2-on 422. N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H-benzo[cd]indol-2-one
423. N-(2-[egzo-6-m-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H-benzo[cd]indol-2-on 423. N-(2-[exo-6-m-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H-benzo[cd]indol-2-one
424. N-(2-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H-benzo[cd]indol-2-on 424. N-(2-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H-benzo[cd]indol-2-one
425. 3,3-dimetil-1-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indolin-2-on 425. 3,3-dimethyl-1-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indolin-2-one
426. 3,3-dimetil-1-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indolin-2-on 426. 3,3-dimethyl-1-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indolin-2-one
427. 3,3-dimetil-1-(2-[egzo-6-m-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indolin-2-on 427. 3,3-dimethyl-1-(2-[exo-6-m-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indolin-2-one
428. 1-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-3,3,5-trimetilindolin-2-on 428. 1-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-3,3,5-trimethylindolin-2-one
429. 3,4-dikloro-N-(2-[egzo-6-p-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 429. 3,4-dichloro-N-(2-[exo-6-p-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
430. 2,5-difluoro-N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 430. 2,5-difluoro-N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
431. 2-amino-N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 431. 2-amino-N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
432. 2-amino-N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 432. 2-amino-N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
433. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-2-metilaminobenzamid 433. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-2-methylaminobenzamide
434. N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-2-metilaminobenzamid 434. N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-2-methylaminobenzamide
435. 3-amino-N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 435. 3-amino-N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
436. 4-amino-N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzamid 436. 4-amino-N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzamide
437. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)tiofen-2-karboksamid 437. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)thiophene-2-carboxamide
438. 5-kloro-N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)tiofen-2-karboksamid 438. 5-chloro-N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)thiophene-2-carboxamide
439. 5-kloro-N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)tiofen-2-karboksamid 439. 5-chloro-N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)thiophene-2-carboxamide
440. 5-kloro-N-(2-[egzo-6-(5-kloro-2-tienil)-3-azabiciklo[3.2.0]heptan-3-il]etil)tiofen-2-karboksamid 440. 5-chloro-N-(2-[exo-6-(5-chloro-2-thienyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)thiophene-2-carboxamide
441. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzo[b]furan-2-karboksamid 441. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzo[b]furan-2-carboxamide
442. 3-kloro-N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzo[b]tiofen-2-karboksamid 442. 3-chloro-N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzo[b]thiophene-2-carboxamide
443. 3-kloro-N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzo[b]tiofen-2-karboksamid 443. 3-chloro-N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzo[b]thiophene-2-carboxamide
444. 3-kloro-N-(2-[egzo-6-p-nitrofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzo[b]tiofen-2-karboksamid 444. 3-chloro-N-(2-[exo-6-p-nitrophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzo[b]thiophene-2-carboxamide
445. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)inden-3-karboksamid 445. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)inden-3-carboxamide
446. N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)inden-3-karboksamid 446. N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)inden-3-carboxamide
447. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)ciklopropankarboksamid 447. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)cyclopropanecarboxamide
448. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)ciklopentankarboksamid 448. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)cyclopentanecarboxamide
449. N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)ciklopentankarboksamid 449. N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)cyclopentanecarboxamide
450. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)cikloheksankarboksamid 450. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)cyclohexanecarboxamide
451. N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)cikloheksankarboksamid 451. N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)cyclohexanecarboxamide
452. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)naftalen-1-karboksamid 452. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)naphthalene-1-carboxamide
453. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indol-2-karboksamid 453. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indole-2-carboxamide
454. N-(2-[egzo-6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indol-3-karboksamid 454. N-(2-[exo-6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indole-3-carboxamide
455. egzo-6-p-fluorofenil-3-[2-(1-naftil)etil]-3-azabiciklo[3.2.0]heptan 455. exo-6-p-fluorophenyl-3-[2-(1-naphthyl)ethyl]-3-azabicyclo[3.2.0]heptane
456. egzo-6-p-klorofenil-3-[2-(1-naftil)etil]-3-azabiciklo[3.2.0]heptan 456. exo-6-p-chlorophenyl-3-[2-(1-naphthyl)ethyl]-3-azabicyclo[3.2.0]heptane
457. egzo-6-m-klorofenil-3-[2-(1-naftil)etil]-3-azabiciklo[3.2.0]heptan 457. exo-6-m-chlorophenyl-3-[2-(1-naphthyl)ethyl]-3-azabicyclo[3.2.0]heptane
458. egzo-6-(5-kloro-2-tienil)-3-[2-(1-naftil)etil]-3-azabiciklo[3.2.0]heptan 458. exo-6-(5-chloro-2-thienyl)-3-[2-(1-naphthyl)ethyl]-3-azabicyclo[3.2.0]heptane
459. egzo-6-p-fluorofenil-3-[2-(2-naftil)etil]-3-azabiciklo[3.2.0]heptan 459. exo-6-p-fluorophenyl-3-[2-(2-naphthyl)ethyl]-3-azabicyclo[3.2.0]heptane
460. egzo-6-p-fluorofenil-3-(1-naftilmetil)-3-azabiciklo[3.2.0]heptan 460. exo-6-p-fluorophenyl-3-(1-naphthylmethyl)-3-azabicyclo[3.2.0]heptane
461. egzo-6-p-fluorofenil-3-[2-naftilmetil]-3-azabiciklo[3.2.0]heptan 461. exo-6-p-fluorophenyl-3-[2-naphthylmethyl]-3-azabicyclo[3.2.0]heptane
462. 4-(6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il)-1-(tiofen-2-il)butan-1-on 462. 4-(6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl)-1-(thiophen-2-yl)butan-1-one
463. 4-(6-p-klorofenil-3-azabiciklo[3.2.0]heptan-3-il)-1-(tiofen-2-il)butan-1-on 463. 4-(6-p-chlorophenyl-3-azabicyclo[3.2.0]heptan-3-yl)-1-(thiophen-2-yl)butan-1-one
464. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-4-fenilpirolidin-2-on 464. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-4-phenylpyrrolidin-2-one
465. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)benzoksazolin-2-on 465. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)benzoxazolin-2-one
466. N-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)izoindolinon 466. N-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)isoindolinone
467. 1-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indazol 467. 1-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indazole
468. 1-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-1,8-naftalensultam 468. 1-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1,8-naphthalenesultam
469. 4-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)-1,4-benzoksazin-3-on 469. 4-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1,4-benzoxazin-3-one
470. 1-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)kvinoksalin-2(1H)-on 470. 1-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)quinoxalin-2(1H)-one
471. 1-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)indolin-2-on 471. 1-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indolin-2-one
472. 1-(2-[egzo-6-p-fluorofenil-3-azabiciklo[3.2.0]heptan-3-il]etil)spiro[ciklopropan-1',3-indolin-2-on] 472. 1-(2-[exo-6-p-fluorophenyl-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)spiro[cyclopropan-1',3-indolin-2-one]
473. 3,6-dimetil-2-metilamino-5-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-3H-pirimidin-4-on 473. 3,6-dimethyl-2-methylamino-5-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-3H-pyrimidin-4 -he
474. 3,6-dimetil-2-metilamino-5-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-3H-pirimidin-4-on 474. 3,6-dimethyl-2-methylamino-5-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-3H-pyrimidin-4 -he
475. 3,6-dimetil-2-metilamino-5-[2-(egzo-6-(5-kloro-1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-3H-pirimidin-4-on 475. 3,6-dimethyl-2-methylamino-5-[2-(exo-6-(5-chloro-1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-3H -pyrimidin-4-one
476. 3,6-dimetil-2-metilamino-5-[2-(egzo-6-(6-kloro-2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-3H-pirimidin-4-on 476. 3,6-dimethyl-2-methylamino-5-[2-(exo-6-(6-chloro-2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-3H -pyrimidin-4-one
477. 3,6-dimetil-2-metilamino-5-[2-(egzo-6-(9-fenantril)-3-azabiciklo[3.2.0]heptan-3-il]etil)-3H-pirimidin-4-on 477. 3,6-dimethyl-2-methylamino-5-[2-(exo-6-(9-phenanthryl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-3H-pyrimidin-4 -he
478. 7-metil-6-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-5H-tiazolo[3,2-a]pirimidin-5-on 478. 7-methyl-6-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-5H-thiazolo[3,2-a]pyrimidine -5-he
479. 3-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H,3H-kvinazolin-2,4-dion 479. 3-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H,3H-quinazoline-2,4-dione
480. 3-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H,3H-kvinazolin-2,4-dion 480. 3-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H,3H-quinazoline-2,4-dione
481. 6-fluoro-3-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H,3H-kvinazolin-2,4-dion 481. 6-fluoro-3-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H,3H-quinazolin-2,4-dione
482. 3-[2-(egzo-6-(5-kloro-2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-1H,3H-kvinazolin-2,4-dion 482. 3-[2-(exo-6-(5-chloro-2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-1H,3H-quinazoline-2,4-dione
483. 3-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-2-metil-4H-pirido[1.2-a]pirimidin-4-on 483. 3-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-2-methyl-4H-pyrido[1.2-a]pyrimidine-4 -he
484. 1-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)-2(1H)kvinolon 484. 1-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)-2(1H)quinolone
485. 1-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)indolin-2-on 485. 1-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)indolin-2-one
486. 1-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil)]-2(3H)benzimidazolon 486. 1-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl)]-2(3H)benzimidazolone
487. 1-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil]-3-metil-2(3H)benzimidazolon 487. 1-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl]-3-methyl-2(3H)benzimidazolone
488. N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil]benzamid 488. N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl]benzamide
489. N-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil]benzamid 489. N-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl]benzamide
490. N-[2-(egzo-6-(5-kloro-1-naftil)-3-azabiciklo[3.2.0]heptan-3-il]etil]benzamid 490. N-[2-(exo-6-(5-chloro-1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl]ethyl]benzamide
491. 3-[2-(1-naftil)etil]-egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan 491. 3-[2-(1-naphthyl)ethyl]-exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptane
492. 3-[2-(1-naftil)etil]-egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan 492. 3-[2-(1-naphthyl)ethyl]-exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptane
493. 1-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1H-benzo[cd]indol-2-on 493. 1-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1H-benzo[cd]indol-2-one
494. 1-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1H-benzo[cd]indol-2-on 494. 1-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1H-benzo[cd]indol-2-one
495. 3,3-dimetil-1-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1,3-dihidroindol-2-on 495. 3,3-dimethyl-1-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1,3-dihydroindol-2- he
496. 3,3-dimetil-1-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1,3-dihidroindol-2-on 496. 3,3-dimethyl-1-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1,3-dihydroindol-2- he
497. 3,3-dimetil-1-[2-(egzo-6-(6-kloro-2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1,3-dihidroindol-2-on 497. 3,3-dimethyl-1-[2-(exo-6-(6-chloro-2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1,3- dihydroindol-2-one
498. 5-kloro-N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-2-tiofenkarboksamid 498. 5-chloro-N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-2-thiophenecarboxamide
499. 5-kloro-N-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-2-tiofenkarboksamid 499. 5-chloro-N-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-2-thiophenecarboxamide
500. N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-4-fluorobenzamid 500. N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-4-fluorobenzamide
501. N-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-4-nitrobenzamid 501. N-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-4-nitrobenzamide
502. N-[2-(egzo-6-(6-kloro-2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]benzamid 502. N-[2-(exo-6-(6-chloro-2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]benzamide
503. N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-4-metoksibenzamid 503. N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-4-methoxybenzamide
504. N-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-4-hidroksibenzamid 504. N-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-4-hydroxybenzamide
505. N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3,4-diklorobenzamid 505. N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3,4-dichlorobenzamide
506. N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]naftalen-1-karboksamid 506. N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]naphthalene-1-carboxamide
507. N-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]naftalen-1-karboksamid 507. N-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]naphthalene-1-carboxamide
508. N-[2-(egzo-6-(9-fenantril)-3-azabiciklo[3.2.0]heptan-3-il)-etil]benzamid 508. N-[2-(exo-6-(9-phenanthryl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]benzamide
509. 1-[2-(egzo-6-(6-kloro-2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1H-benzo[cd]indol-2-on 509. 1-[2-(exo-6-(6-chloro-2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1H-benzo[cd]indol-2- he
510. 1-[2-(egzo-6-(9-fenantril)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-1H-benzo[cd]indol-2-on 510. 1-[2-(exo-6-(9-phenanthryl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-1H-benzo[cd]indol-2-one
511. N-[2-(egzo-6-(1-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]izoindolinon 511. N-[2-(exo-6-(1-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]isoindolinone
512. N-[2-(egzo-6-(2-naftil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]izoindolinon 512. N-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]isoindolinone
513. (+)-(1S,5R,6S)egzo-1-[2-[6-(4-klorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3-metil-2H-1,3-dihidro-benzimidazol-2-on 513. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3-methyl -2H-1,3-dihydro-benzimidazol-2-one
514. (+)-(1S,5R,6S)egzo-1-[2-[6-(4-klorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3-etil-2H-1,3-dihidro-benzimidazol-2-on 514. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3-ethyl -2H-1,3-dihydro-benzimidazol-2-one
515. (+)-(1S,5R,6S)egzo-1-[2-[6-(4-klorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3-n-propil-2H-1,3-dihidro-benzimidazol-2-on 515. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3-n -propyl-2H-1,3-dihydro-benzimidazol-2-one
516. (+)-(1S,5R,6S)egzo-2-[2-[6-(4-klorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3,3-dimetil-2,3-dihidro-1,2-benzizotiazol 1,1-dioksid 516. (+)-(1S,5R,6S)exo-2-[2-[6-(4-chlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3,3 -dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
517. (+)-(1S,5R,6S)egzo-2-[2-[6-(4-klorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-2,3-dihidro-1,2-benzizotiazol 1,1-dioksid 517. (+)-(1S,5R,6S)exo-2-[2-[6-(4-chlorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-2,3 -dihydro-1,2-benzisothiazole 1,1-dioxide
518. (+)-(1S,5R,6S)egzo-2-[2-[6-(4-fluorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3,3-dimetil-2,3-dihidro-1,2-benzizotiazol 1,1-dioksid 518. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3,3 -dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
519. (+)-(1S,5R,6S)egzo-2-[2-[6-(4-fluorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-3,3-dietil-2,3-dihidro-1,2-benzizotiazol 1,1-dioksid 519. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-3,3 -diethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
520. (+)-(1S,5R,6S)egzo-2-[2-[6-(4-fluorofenil)-3-azabiciklo[3.2.0]heptan-3-il)-etil]-2,3-dihidro-1,2-benzizotiazol 1,1-dioksid 520. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorophenyl)-3-azabicyclo[3.2.0]heptan-3-yl)-ethyl]-2,3 -dihydro-1,2-benzisothiazole 1,1-dioxide
Claims (4)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19854147A DE19854147A1 (en) | 1998-11-24 | 1998-11-24 | Control of cocaine addiction comprises administration of N-substituted azabicycloalkane derivative |
| PCT/EP1999/008734 WO2000030639A1 (en) | 1998-11-24 | 1999-11-12 | Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010472A2 true HRP20010472A2 (en) | 2003-04-30 |
Family
ID=7888824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010472A HRP20010472A2 (en) | 1998-11-24 | 2001-06-21 | Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1133293A1 (en) |
| JP (1) | JP2002530333A (en) |
| KR (1) | KR20010080535A (en) |
| CN (1) | CN1328455A (en) |
| AR (1) | AR021502A1 (en) |
| AU (1) | AU1775300A (en) |
| BG (1) | BG105549A (en) |
| BR (1) | BR9915589A (en) |
| CA (1) | CA2352526A1 (en) |
| CZ (1) | CZ20011796A3 (en) |
| DE (1) | DE19854147A1 (en) |
| HK (1) | HK1040933A1 (en) |
| HR (1) | HRP20010472A2 (en) |
| HU (1) | HUP0104416A3 (en) |
| IL (1) | IL143181A0 (en) |
| NO (1) | NO20012538L (en) |
| PL (1) | PL348758A1 (en) |
| SK (1) | SK7112001A3 (en) |
| TR (1) | TR200101476T2 (en) |
| WO (1) | WO2000030639A1 (en) |
| ZA (1) | ZA200103976B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1836183A2 (en) | 2004-12-13 | 2007-09-26 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
| GB0812310D0 (en) | 2008-07-03 | 2008-08-13 | Syngenta Ltd | Novel herbicides |
| WO2014111837A1 (en) * | 2013-01-15 | 2014-07-24 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004311A1 (en) * | 1987-11-12 | 1989-05-18 | American Home Products Corporation | Polycyclicamines with psychotropic activity |
| DE4427648A1 (en) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituted 3-azabicyclo [3,2,0,] heptane derivatives, their preparation and use |
| DE4341403A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted 3-azabicycloalkane derivatives, their preparation and use |
| DE4427647A1 (en) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
-
1998
- 1998-11-24 DE DE19854147A patent/DE19854147A1/en not_active Withdrawn
-
1999
- 1999-11-12 TR TR2001/01476T patent/TR200101476T2/en unknown
- 1999-11-12 JP JP2000583522A patent/JP2002530333A/en active Pending
- 1999-11-12 PL PL99348758A patent/PL348758A1/en not_active Application Discontinuation
- 1999-11-12 EP EP99960974A patent/EP1133293A1/en not_active Withdrawn
- 1999-11-12 BR BR9915589-3A patent/BR9915589A/en not_active IP Right Cessation
- 1999-11-12 AU AU17753/00A patent/AU1775300A/en not_active Abandoned
- 1999-11-12 SK SK711-2001A patent/SK7112001A3/en unknown
- 1999-11-12 CA CA002352526A patent/CA2352526A1/en not_active Abandoned
- 1999-11-12 HU HU0104416A patent/HUP0104416A3/en unknown
- 1999-11-12 WO PCT/EP1999/008734 patent/WO2000030639A1/en not_active Application Discontinuation
- 1999-11-12 KR KR1020017006445A patent/KR20010080535A/en not_active Application Discontinuation
- 1999-11-12 CN CN99813559A patent/CN1328455A/en active Pending
- 1999-11-12 CZ CZ20011796A patent/CZ20011796A3/en unknown
- 1999-11-12 IL IL14318199A patent/IL143181A0/en unknown
- 1999-11-24 AR ARP990105979A patent/AR021502A1/en unknown
-
2001
- 2001-05-16 ZA ZA200103976A patent/ZA200103976B/en unknown
- 2001-05-23 NO NO20012538A patent/NO20012538L/en not_active Application Discontinuation
- 2001-05-30 BG BG105549A patent/BG105549A/en unknown
- 2001-06-21 HR HR20010472A patent/HRP20010472A2/en not_active Application Discontinuation
-
2002
- 2002-04-12 HK HK02102768.4A patent/HK1040933A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE19854147A1 (en) | 2000-05-25 |
| BG105549A (en) | 2001-12-29 |
| HUP0104416A2 (en) | 2002-04-29 |
| PL348758A1 (en) | 2002-06-03 |
| HUP0104416A3 (en) | 2002-11-28 |
| EP1133293A1 (en) | 2001-09-19 |
| IL143181A0 (en) | 2002-04-21 |
| ZA200103976B (en) | 2002-05-16 |
| CN1328455A (en) | 2001-12-26 |
| NO20012538L (en) | 2001-07-04 |
| AR021502A1 (en) | 2002-07-24 |
| SK7112001A3 (en) | 2001-12-03 |
| NO20012538D0 (en) | 2001-05-23 |
| HK1040933A1 (en) | 2002-06-28 |
| BR9915589A (en) | 2001-08-07 |
| CA2352526A1 (en) | 2000-06-02 |
| TR200101476T2 (en) | 2001-10-22 |
| WO2000030639A1 (en) | 2000-06-02 |
| AU1775300A (en) | 2000-06-13 |
| CZ20011796A3 (en) | 2002-05-15 |
| KR20010080535A (en) | 2001-08-22 |
| JP2002530333A (en) | 2002-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| OBST | Application withdrawn |