EP1133293A1 - Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system - Google Patents

Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system

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Publication number
EP1133293A1
EP1133293A1 EP99960974A EP99960974A EP1133293A1 EP 1133293 A1 EP1133293 A1 EP 1133293A1 EP 99960974 A EP99960974 A EP 99960974A EP 99960974 A EP99960974 A EP 99960974A EP 1133293 A1 EP1133293 A1 EP 1133293A1
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EP
European Patent Office
Prior art keywords
azabicyclo
exo
ethyl
fluorophenyl
heptan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP99960974A
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German (de)
French (fr)
Inventor
Gerd Steiner
Rainer Munschauer
Gerhard Gross
Martin Traut
Liliane Unger
Hans-Jürgen Teschendorf
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Abbott GmbH and Co KG
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BASF SE
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Publication of EP1133293A1 publication Critical patent/EP1133293A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Definitions

  • N-substituted azabicycloalkane derivatives for the treatment of diseases of the central nervous system
  • N-substituted azabicycloalkane derivatives are already known as neuroleptics (WO 95/13279, WO 95/15327, WO 96/04272, US 5,475,105, US 5,521,209, US 5,616,705, US 5,753,690). It has now been found that these substances are also suitable for combating addiction disorders and other disorders of the central nervous system.
  • the invention relates to the use of N-substituted 3-azabicycloalkane derivatives of the formula I.
  • B is a 4-, 5- or 6-ring which can contain a double bond
  • R 1 is a mono- or disubstituted phenyl, naphthyl or optionally substituted by halogen atoms, C 4 alkyl, trifluoromethyl, hydroxy, C 4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups Phenanthryl or thienyl group,
  • n the number 0, 1, 2, 3 or 4 and
  • R 2 denotes a naphthyl group which is optionally substituted by one or two halogen atoms or one of the following radicals: R3 0 R8 C R5 NR 6 CR 7 NR 6 - so 2 - (CJS
  • R 3 represents a hydrogen atom, a hydroxyl group or a phenyl radical optionally substituted by a fluorine, chlorine or bromine atom,
  • R 4 represents a hydrogen atom
  • R 3 and R 4 together represent an oxygen atom
  • R 5 is optionally mono- or disubstituted phenyl by fluorine, chlorine or bromine atoms or hydroxyl, nitro, amino, C ⁇ _ 4 -alkanoylamino, C ⁇ - 4 alkyl, amino, C ⁇ _ 4 alkyl or methoxy groups , Naphthyl or thienyl group means
  • R 6 represents a hydrogen atom or a methyl group
  • R 7 is a phenyl mono- or disubstituted by fluorine, chlorine or bromine atoms or by C 4 alkyl, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C 4 alkylamino groups -, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group or a C 3 _ 7 -cycloalkyl group,
  • R 8 is a hydrogen atom or a fluorine or chlorine atom or a C 4 alkyl, methoxy or amino group
  • R 9 represents a hydrogen atom or a methyl group
  • R 10 represents a hydrogen atom or a methyl group
  • R 9 and R 10 together with the ring carbon atom represent a spirocyclopropane ring
  • R 11 is a hydrogen atom, a hydroxy, -CC 4 alkyl or
  • X and Y are carbon atoms, CH, CH 2 , NH or -CC alkyl-N groups or nitrogen atoms,
  • Z is a direct bond, a CO group, CS group or one
  • A is a hydrogen tom, a hydroxy, amino, mercapto,
  • A denotes a C 3 -C 4 -alkylene group linked to Y, which may contain one or two non-cumulative double bonds and in which a CH or CH 2 group is replaced by a nitrogen or sulfur atom or an NH or N-CH 3 - Group can be replaced and the ring either by a fluorine or chlorine atom or a methyl, methoxy, nitro or amino group monosubstituted or in the case of a benzene ring this by fluorine or chlorine atoms or methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl or dimethylamino groups can be mono-, di- or tri-substituted,
  • ring containing X, Y and Z on nitrogen atom No. 1 has a C ⁇ -C 4 -alkyl, allyl or benzyl group and can contain 1 to 3 non-cumulative double bonds,
  • Addictive substances can be:
  • Opioids such as morphine or heroin, nicotine, alcohol,
  • Substances that interact with the benzodiazepine-receptor complex sedatives or tranquilizers, such as the benzodiazepines.
  • cocaine or amphetamine and amphetamine-like substances are particularly suitable as addictive substances.
  • the compounds of formula I can be used both in the form of their racemates and their optical isomers.
  • the compounds can be administered orally or parenterally, intravenously or intramuscularly in the usual way.
  • the dosage depends on the age, condition and weight of the patient and on the type of application.
  • the daily dose of active substance is between approximately 1 and 100 mg / kg body weight when administered orally and between 0.1 and 10 mg / kg body weight when administered parenterally.
  • the compounds can be used in common galenical application forms in solid or liquid form, for example as tablets, film tablets, capsules, powders, granules, dragees, suppositories, solutions, ointments, creams or sprays. These are produced in the usual way.
  • the active ingredients can be processed with the usual pharmaceutical auxiliaries such as tablet binders, fillers, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, retardants, antioxidants 10 and / or propellants (see H. Sucker et al:
  • the administration forms obtained in this way normally contain the active ingredient in an amount of 1 to 99% by weight.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula (I), wherein B, R<1>, R<2> and n have the meanings given in the description, for combating diseases of addiction and other diseases of the central nervous system.

Description

Verwendung von N-substituierten Azabicycloalkan-Derivaten zur Behandlung von Erkrankungen des zentralen NervensystemsUse of N-substituted azabicycloalkane derivatives for the treatment of diseases of the central nervous system
Beschreibungdescription
N-substituierte Azabicycloalkan-Derivate sind bereits als Neuroleptika bekannt (WO 95/13279, WO 95/15327, WO 96/04272, US 5.475.105, US 5.521.209, US 5.616.705, US 5.753.690). Es wurde nun gefunden, daß sich diese Substanzen auch zur Bekämpfung von Suchterkrankungen und anderen Erkrankungen des zentralen Nervensystems eignen.N-substituted azabicycloalkane derivatives are already known as neuroleptics (WO 95/13279, WO 95/15327, WO 96/04272, US 5,475,105, US 5,521,209, US 5,616,705, US 5,753,690). It has now been found that these substances are also suitable for combating addiction disorders and other disorders of the central nervous system.
Gegenstand der Erfindung ist die Verwendung von N-substituierten 3-Azabicycloalkan-Derivaten der Formel IThe invention relates to the use of N-substituted 3-azabicycloalkane derivatives of the formula I.
worinwherein
B ein 4-, 5- oder 6-Ring ist, der eine Doppelbindung enthalten kann, ist,B is a 4-, 5- or 6-ring which can contain a double bond,
R1 eine gegebenenfalls durch Halogenatome, Cι_4-Alkyl, Trifluor- methyl-, Hydroxy-, Cι-4-Alkoxy-, Amino-, Monomethylamino-, Dimethylamino- , Cyano- oder Nitrogruppen mono- oder disubstituierte Phenyl-, Naphthyl-, Phenanthryl-, oder Thienylgruppe bedeutet,R 1 is a mono- or disubstituted phenyl, naphthyl or optionally substituted by halogen atoms, C 4 alkyl, trifluoromethyl, hydroxy, C 4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups Phenanthryl or thienyl group,
n die Zahl 0, 1, 2, 3 oder 4 bedeutet undn represents the number 0, 1, 2, 3 or 4 and
R2 eine gegebenenfalls durch ein oder zwei Halogenatome substituierte Naphthylgruppe oder einen der folgenden Reste bedeutet : R3 0 R8 C R5 NR6 C R7 NR6 — so2 — ( CJSR 2 denotes a naphthyl group which is optionally substituted by one or two halogen atoms or one of the following radicals: R3 0 R8 C R5 NR 6 CR 7 NR 6 - so 2 - (CJS
R4 R 4
worin wherein
R3 ein Wasserstof fatom, eine Hydroxygruppe oder einen gegebenenfalls durch ein Fluor- , Chlor- oder Bromatom substituierten Phenylrest darstellt ,R 3 represents a hydrogen atom, a hydroxyl group or a phenyl radical optionally substituted by a fluorine, chlorine or bromine atom,
R4 ein Wasserstoffatom bedeutet oderR 4 represents a hydrogen atom or
R3 und R4 zusammen ein Sauerstoffato darstellen, R5 eine gegebenenfalls durch Fluor-, Chlor- oder Bromatome oder Hydroxy- , Nitro-, Amino-, Cι_4-Alkanoylamino-, Cι-4-Alkyl- amino-, Cι_4-Alkyl- oder Methoxygruppen mono- oder disubstituierte Phenyl-, Naphthyl- oder Thienylgruppe bedeu- tet,R 3 and R 4 together represent an oxygen atom, R 5 is optionally mono- or disubstituted phenyl by fluorine, chlorine or bromine atoms or hydroxyl, nitro, amino, Cι_ 4 -alkanoylamino, Cι- 4 alkyl, amino, Cι_ 4 alkyl or methoxy groups , Naphthyl or thienyl group means
R6 ein Wasserstoffatom oder eine Methylgruppe darstellt,R 6 represents a hydrogen atom or a methyl group,
R7 eine durch Fluor-, Chlor- oder Bromatome oder durch Cι_4-Alkyl-, Hydroxy-, Methoxy-, Nitro-, Cyano-, Trifluor- methyl-, Amino- oder Di-Cι_4-Alkylaminogruppen mono- oder disubstituierte Phenyl-, Naphthyl-, Benzofuryl-, Benzo- thienyl-, Thienyl-, Indolyl-, N-Methylindolyl- oder Indenyl- gruppe oder eine C3_7-Cycloalkylgruppe bedeutet,R 7 is a phenyl mono- or disubstituted by fluorine, chlorine or bromine atoms or by C 4 alkyl, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C 4 alkylamino groups -, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group or a C 3 _ 7 -cycloalkyl group,
R8 ein Wasserstoffatom oder ein Fluor- oder Chloratom oder eine Cι_4-Alkyl-, Methoxy- oder Aminogruppe ist,R 8 is a hydrogen atom or a fluorine or chlorine atom or a C 4 alkyl, methoxy or amino group,
R9 ein Wasserstoffatom oder eine Methylgruppe darstellt undR 9 represents a hydrogen atom or a methyl group and
R10 ein Wasserstoffatom oder eine Methylgruppe oderR 10 represents a hydrogen atom or a methyl group or
R9 und R10 zusammen mit dem Ring-Kohlenstoffatom einen Spirocyclo- propanring darstellen,R 9 and R 10 together with the ring carbon atom represent a spirocyclopropane ring,
R11 ein Wasserstoffatom, eine Hydroxy-, Cι-C4-Alkyl- oderR 11 is a hydrogen atom, a hydroxy, -CC 4 alkyl or
Cι-C4-Alkoxygruppe ist, oder zusammen mit dem benachbarten Kohlenstoffatom eine C=0- oder C=S-Gruppe bedeutet,C 1 -C 4 alkoxy group, or together with the adjacent carbon atom means a C = 0 or C = S group,
X und Y Kohlenstoffatome, CH-, CH2-, NH- oder Cι-C-Alkyl-N- Gruppen oder Stickstoffatome bedeuten,X and Y are carbon atoms, CH, CH 2 , NH or -CC alkyl-N groups or nitrogen atoms,
Z eine direkte Bindung, eine CO-Gruppe, CS-Gruppe oder eineZ is a direct bond, a CO group, CS group or one
CH- bzw. CH2-Gruppe, in denen ein Wasserstoffatom gegen eine Hydroxy-, Amino- oder Cι-C4~Alkoxygruppe oder ein Halogenatom ausgetauscht sein kann, darstellt, undCH or CH 2 group, in which a hydrogen atom can be replaced by a hydroxy, amino or -CC 4 ~ alkoxy group or a halogen atom, and
A ein Wasserstoff tom, eine Hydroxy-, Amino-, Mercapto-,A is a hydrogen tom, a hydroxy, amino, mercapto,
C1-C4-Alkylamino-, Di-Cι-C4-alkylamino-, Cι~C4-Alkylthio- oder C-C4-Alkoxygruppe oder zusammen mit dem benachbarten Kohlenstoffatom eine C=0-Gruppe bedeutet, oderC 1 -C 4 alkylamino, di-C 4 -C 4 alkylamino, C ~ C 4 alkylthio or CC 4 alkoxy group or together with the adjacent carbon atom means a C = 0 group, or
A eine mit Y verknüpfte C3-C4~Alkylengruppe bedeutet, die eine oder zwei nicht kumulierte Doppelbindungen enthalten kann und in der eine CH- oder CH2-Gruppe durch ein Stickstoff- oder Schwefelatom oder eine NH- oder N-CH3-Gruppe ersetzt sein kann und wobei der Ring entweder durch ein Fluor- oder Chlor- atom oder eine Methyl-, Methoxy-, Nitro- oder Aminogruppe monosubstituiert oder im Fall eines Benzolrings dieser durch Fluor- oder Chloratome oder Methyl-, Trifluormethyl-, Nitro-, Hydroxy-, Methoxy-, Amino-, Monomethyl- oder Dimethylamino- gruppen mono-, di- oder trisubstituiert sein kann,A denotes a C 3 -C 4 -alkylene group linked to Y, which may contain one or two non-cumulative double bonds and in which a CH or CH 2 group is replaced by a nitrogen or sulfur atom or an NH or N-CH 3 - Group can be replaced and the ring either by a fluorine or chlorine atom or a methyl, methoxy, nitro or amino group monosubstituted or in the case of a benzene ring this by fluorine or chlorine atoms or methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl or dimethylamino groups can be mono-, di- or tri-substituted,
und worin der X, Y und Z enthaltende Ring am Stickstoffatom Nr. 1 eine Cχ-C4-Alkyl-, Allyl- oder Benzylgruppe tragen und 1 bis 3 nicht kumulierte Doppelbindungen enthalten kann,and in which the ring containing X, Y and Z on nitrogen atom No. 1 has a Cχ-C 4 -alkyl, allyl or benzyl group and can contain 1 to 3 non-cumulative double bonds,
und deren Salze mit physiologisch verträglichen Säuren zur Herstellung von Arzneimitteln zur Sucht-Bekämpfung, zur Behandlung von Konzentrationsstörungen (attention deficit disorders) , Hyperaktivität bei Kindern (attention deficit hyperactivity disorders), Lern- und Gedächtnisschwäche (impaired cognitive function) .and their salts with physiologically acceptable acids for the manufacture of medicaments for combating addiction, for the treatment of concentration disorders (attention deficit disorders), hyperactivity in children (attention deficit hyperactivity disorders), learning and memory impairment (impaired cognitive function).
Die erfindungsgemäße Verwendung betrifft alle Suchterkrankungen, seien sie durch Abusus von Substanzen verursacht oder andere Suchterkrankungen wie beispielsweise die Spielsucht. Suchterzeugende Substanzen können sein:The use according to the invention relates to all addictions, be they caused by abuse of substances or other addictions such as gambling addiction. Addictive substances can be:
Opioide wie beispielsweise Morphin oder Heroin, Nikotin, Alkohol,Opioids such as morphine or heroin, nicotine, alcohol,
Substanzen, die mit dem Benzodiazepin-Rezeptor-Komplex inter- agieren, Sedativa oder Tranquilizer, wie beispielsweise die Benzodiazepine .Substances that interact with the benzodiazepine-receptor complex, sedatives or tranquilizers, such as the benzodiazepines.
Als suchterzeugende Substanzen kommen erfindungsgemäß insbesondere Cocain oder Amphetamin sowie amphetaminartige Substanzen in Betracht.According to the invention, cocaine or amphetamine and amphetamine-like substances are particularly suitable as addictive substances.
Die Verbindungen der Formel I können sowohl in Form ihrer Racemate als auch ihrer optischen Isomeren verwendet werden.The compounds of formula I can be used both in the form of their racemates and their optical isomers.
Die Verbindungen können für die neue Indikation in üblicher Weise oral oder parenteral, intravenös oder intramuskulär verabfolgt werden.For the new indication, the compounds can be administered orally or parenterally, intravenously or intramuscularly in the usual way.
Die Dosierung hängt vom Alter, Zustand und Gewicht des Patienten sowie von der Applikationsart ab. In der Regel beträgt die tägliche Wirkstoffdosis zwischen etwa 1 und 100 mg/kg Körpergewicht bei oraler Gabe und zwischen 0,1 und 10 mg/kg Körpergewicht bei parenteraler Gabe. Die Verbindungen können in gebräuchlichen galenischen Applikationsformen fest oder flüssig angewendet werden, z.B. als Tabletten, Filmtabletten, Kapseln, Pulver, Granulate, Dragees, Supposi- torien, Lösungen, Salben, Cremes oder Sprays. Diese werden in 5 üblicher Weise hergestellt. Die Wirkstoffe können dabei mit den üblichen galenischen Hilfsmitteln wie Tablettenbindern, Füllstoffen, Konservierungsmitteln, Tablettensprengmitteln, Fließreguliermitteln, Weichmachern, Netzmitteln, Dispergiermitteln, Emulgatoren, Lösungsmitteln, Retardierungsmitteln, Antioxidantien 10 und/oder Treibgasen verarbeitet werden (vgl. H. Sucker et al :The dosage depends on the age, condition and weight of the patient and on the type of application. As a rule, the daily dose of active substance is between approximately 1 and 100 mg / kg body weight when administered orally and between 0.1 and 10 mg / kg body weight when administered parenterally. The compounds can be used in common galenical application forms in solid or liquid form, for example as tablets, film tablets, capsules, powders, granules, dragees, suppositories, solutions, ointments, creams or sprays. These are produced in the usual way. The active ingredients can be processed with the usual pharmaceutical auxiliaries such as tablet binders, fillers, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, retardants, antioxidants 10 and / or propellants (see H. Sucker et al:
Pharmazeutische Technologie, Thieme-Verlag, Stuttgart, 1978) . Die so erhaltenen Applikationsformen enthalten den Wirkstoff normalerweise in einer Menge von 1 bis 99 Gew.-%.Pharmaceutical Technology, Thieme-Verlag, Stuttgart, 1978). The administration forms obtained in this way normally contain the active ingredient in an amount of 1 to 99% by weight.
15 Folgende Substanzen seien als Beispiele für Verbindungen der Formel I genannt :15 The following substances may be mentioned as examples of compounds of the formula I:
1. 1- (4-Fluor-phenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl]butan-l-on 201. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - heptan-3-yl] butan-l-one 20
2. l-Phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - butan-1-on2. l-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - butan-1-one
3. 1- (4-Fluor-phenyl) -4- [exo-6 , 7-diphenyl-3-azabicyclo- 25 [3.2.0] -heptan-3-yl] -butan-1-on3. 1- (4-fluoro-phenyl) -4- [exo-6, 7-diphenyl-3-azabicyclo-25 [3.2.0] -heptan-3-yl] butan-1-one
4. 1- (4-Fluor-phenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl] -butan4. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane
30 5. l-Phenyl-2- [exo-6-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethan-1-on30 5. l-phenyl-2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethan-1-one
6. 1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-3-azabicyclo-6. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo-
[3.2.0]heptan-3-yl] -butan 35[3.2.0] heptan-3-yl] butane 35
7. 1- (4-Fluor-phenyl) -4- [exo-6-m-fluor-phenyl-3-azabicyclo-7. 1- (4-fluorophenyl) -4- [exo-6-m-fluorophenyl-3-azabicyclo-
[3.2.0]heptan-3-yl] -butan-1-on[3.2.0] heptan-3-yl] butan-1-one
8. 1- (4-Fluor-phenyl) -4- [exo-6-o-fluor-phenyl-3-azabicyclo- 40 [3.2.0]heptan-3-yl] -butan-1-on8. 1- (4-fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo-40 [3.2.0] heptan-3-yl] butan-1-one
9. 1- (4-Fluor-phenyl) -4- [exo-6-p-chlor-phenyl-3-azabicyclo- [3.2.0]heptan-3-yl] -butan-1-on9. 1- (4-fluorophenyl) -4- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one
45 10. 1- (4-Fluor-phenyl) -4- [exo-6-m-chlor-phenyl-3-azabicyclo- [3.2.0]heptan-3-yl] -butan-1-on 11. 1- (4-Fluor-phenyl) -4- [exo-6-p-methoxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -butan-1-on45 10. 1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo- [3.2.0] heptan-3-yl] butan-1-one 11. 1- (4-fluorophenyl) -4- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one
12. 1- (4-Fluor-phenyl) -4- [exo-6-m,p-dichlor-phenyl-3-aza- 5 bicyclo [3.2.0]heptan-3-yl] -butan-1-on12. 1- (4-fluorophenyl) -4- [exo-6-m, p-dichlorophenyl-3-aza-5 bicyclo [3.2.0] heptan-3-yl] butan-1-one
13. 1- (4-Fluor-phenyl) -4- [exo-6-m,p-dimethoxy-phenyl-3-aza- bicyclo [3.2.0]heptan-3-yl] -bu an-1-on13. 1- (4-fluoro-phenyl) -4- [exo-6-m, p-dimethoxy-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -bu an-1-one
10 14. 1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-3-azabicy- clo- [3.2.0]heptan-3-yl] -butan-1-on10 14. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one
15. l-Phenyl-4- [exo-6-p-fluor-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl] -butan-1-on 1515. l-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - heptan-3-yl] butan-1-one 15
16. 1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-3-azabicyclo-16. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo-
[3.2.0]heptan-3-yl] -butan[3.2.0] heptan-3-yl] butane
17. 1- (4-Fluor-phenyl) -4- [exo-6-p-nitro-phenyl-3-azabicyclo- 20 [3.2.0]heptan-3-yl]-butan-l-on17. 1- (4-fluoro-phenyl) -4- [exo-6-p-nitro-phenyl-3-azabicyclo-20 [3.2.0] heptan-3-yl] butan-1-one
18. 1- (4-Fluor-phenyl) -4- [exo-6-m-nitro-phenyl-3-azabicyclo-18. 1- (4-fluoro-phenyl) -4- [exo-6-m-nitro-phenyl-3-azabicyclo-
[3.2.0]heptan-3-yl]-butan-l-on[3.2.0] heptan-3-yl] butan-l-one
25 19. 1- (4-Fluor-phenyl)-4- [exo-6-p-trifluormethyl-phenyl-3- azabicyclo [3.2.0]heptan-3-yl] -butan-1-on25 19. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one
20. 1- (4-Fluor-phenyl) -4- [exo-6-p-cyano-phenyl-3-azabicyclo-20. 1- (4-fluorophenyl) -4- [exo-6-p-cyano-phenyl-3-azabicyclo-
[3.2.0]heptan-3-yl] -butan-1-on 30[3.2.0] heptan-3-yl] butan-1-one 30
21. 1- (4-Fluor-phenyl) -4- [exo-6-thien-3-yl-3-azabicyclo-21. 1- (4-fluoro-phenyl) -4- [exo-6-thien-3-yl-3-azabicyclo-
[3 .2 . 0 ] heptan-3-yl ] -butan-l-on[3 .2. 0] heptan-3-yl] butan-l-one
22 . 1- (4-Fluor-phenyl ) -4- [exo-6-pyrid-3-yl-3-azabicyclo- 35 [3 .2 . 0 ] heptan-3-yl] -butan-l-on22. 1- (4-fluoro-phenyl) -4- [exo-6-pyrid-3-yl-3-azabicyclo- 35 [3 .2. 0] heptan-3-yl] butan-l-one
23. 1- (4-Fluor-phenyl) -3- [exo-6-p-fluor-phenyl-3-azabicyclo-23. 1- (4-fluorophenyl) -3- [exo-6-p-fluorophenyl-3-azabicyclo-
[3.2.0]heptan-3-yl]-propan-l-on[3.2.0] heptan-3-yl] propane-l-one
40 24. 1- (Bis-4-fluor-phenyl) -4- [exo-6-p-fluor-phenyl-3-azabicyclo- [3.2.0]heptan-3-yl] -butan40 24. 1- (bis-4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo- [3.2.0] heptan-3-yl] butane
25. 1- (Bis-4-fluor-phenyl) -4- [exo-6-phenyl-3-azabicyclo- [3.2.0]heptan-3-yl]butan 45 26. 1- (4-Fluor-phenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl] -butan-1-ol25. 1- (bis-4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane 45 26. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol
27. 1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-3-azabicyclo- 5 [3.2.0]heptan-3-yl] -butan-l-ol27. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo- 5 [3.2.0] heptan-3-yl] butan-1-ol
28. 1- (4-Fluor-phenyl) -4- [exo-6, 7-diphenyl-3-azabicyclo- [3.2.0] heptan-3-yl] -butan-1-ol28. 1- (4-Fluorophenyl) -4- [exo-6, 7-diphenyl-3-azabicyclo- [3.2.0] heptan-3-yl] butan-1-ol
10 29. l-Phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - butan-l-ol10 29. l-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-l-ol
30. l-Phenyl-4- [exo-6-p-fluor-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl] -butan-1-ol 1530. l-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol 15
31. 1- (4-Fluor-phenyl) -4- [exo-6-o-fluor-phenyl-3 -azabicyclo- [3.2.0]heptan-3-yl] -butan-1-ol31. 1- (4-fluoro-phenyl) -4- [exo-6-o-fluoro-phenyl-3-azabicyclo- [3.2.0] heptan-3-yl] butan-1-ol
32. 1- (4-Fluor-phenyl)-4- [exo-6-m-chlor-phenyl-3-azabicyclo- 20 [3.2.0]heptan-3-yl]-butan-l-ol32. 1- (4-fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo-20 [3.2.0] heptan-3-yl] butan-1-ol
33. 1- ( 4-Fluor-phenyl) -4- [exo-6-p-trifluormethyl-phenyl-3- azabicyclo [3.2.0]heptan-3-yl] -butan-l-ol33. 1- (4-fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol
25 34. 1- (4-Fluor-phenyl) -4- [exo-6-p~amino-phenyl-3-azabicyclo- [3.2.0] -heptan-3-yl] -butan-1-on25 34. 1- (4-Fluoro-phenyl) -4- [exo-6-p ~ aminophenyl-3-azabicyclo- [3.2.0] -heptan-3-yl] butan-1-one
35. N- (3- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -propyl) -35. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -
4-fluor-benzamid 304-fluoro-benzamide 30
36. N- (3- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - propyl ) -benzamid36. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) benzamide
37. N- (2-[exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - 35 ethyl) -4-fluor-benzamid37. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl) -4-fluoro-benzamide
38. N- (2- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl ) -benzamid38. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide
40 39. N-(2-[exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl]- ethyl) -N-methyl-4-fluorbenzamid40 39. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-fluorobenzamide
40. N- (2- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl) -N-methyl-benzamid 45 41. N- (2- [exo-6~Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl) -N-methyl-4-isopropylbenzamid40. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-benzamide 45 41. N- (2- [exo-6 ~ phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-isopropylbenzamide
42. N- (3-[exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - 5 propyl) -4-chlor-benzamid42. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5-propyl) -4-chloro-benzamide
43. N- (2- [exo-6-p-Trifluormethyl-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl] -ethyl) -4-chlor-benzamid43. N- (2- [exo-6-p-trifluoromethyl-phenyl-3-azabicyclo [3.2.0] - heptan-3-yl] -ethyl) -4-chloro-benzamide
10 44. N- (3-[exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - propyl) -3-methoxy-benzamid10 44. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-methoxy-benzamide
45. N- (3- [exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - propyl ) -3-nitro-benzamid 1545. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-nitro-benzamide 15
46. N- (3- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-46. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -propyl) -4-fluor-benzamid3-yl] propyl) -4-fluoro-benzamide
47. N- (3- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 20 3-yl] -propyl) -benzamid47. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-20 3-yl] propyl) benzamide
48. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-48. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl) -4-fluor-benzamid3-yl] ethyl) -4-fluoro-benzamide
25 49. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo[3.2.0]heptan- 3-yl] -ethyl) -benzamid25 49. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl) benzamide
50. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-50. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl ] -ethyl ) -N-methyl-4-fluor-benzamid 303-yl] -ethyl) -N-methyl-4-fluoro-benzamide 30
51. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-51. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl) -N-methyl-benzamid3-yl] -ethyl) -N-methyl-benzamide
52. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 35 3-yl] -ethyl) -N-methyl-4-isopropylbenzamid52. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-35 3-yl] ethyl) -N-methyl-4-isopropylbenzamide
53. N- (3- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-53. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -propyl )-4-chlor-benzamid3-yl] propyl) -4-chloro-benzamide
40 54. N- (3- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -propyl) -3-methoxy-benzamid40 54. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-methoxy-benzamide
55. N- (3- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -propyl) -3-nitro-benzamid 45 56. N- (2- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-55. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-nitro-benzamide 45 56. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl) -4-chlor-benzamid3-yl] ethyl) -4-chloro-benzamide
57. N- (2- [exo-6-o-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 5 3-yl] -ethyl) -4-chlor-benzamid57. N- (2- [exo-6-o-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-5 3-yl] ethyl) -4-chloro-benzamide
58. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-58. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl) -2-hydroxy-benzamid3-yl] ethyl) -2-hydroxy-benzamide
10 59. N- (2- [exo-6-m-Hydroxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl) -4-chlor-benzamid10 59. N- (2- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chloro-benzamide
60. exo-3-n-Butyl-6-phenyl-3-azabicyclp [3.2.0]heptan60. exo-3-n-butyl-6-phenyl-3-azabicyclp [3.2.0] heptane
15 61. exo-3-Methyl-6-phenyl-3-azabicyclo [3.2.0]heptan15 61. exo-3-methyl-6-phenyl-3-azabicyclo [3.2.0] heptane
62. exo-3-Methyl-6-p-fluor-phenyl-3-azabicyclo [3.2.0]heptan62. exo-3-methyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
63. exo-3-n-Propyl-6-p-fluor-phenyl-3-azabicyclo [3.2.0]- 20 heptan63. exo-3-n-propyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] - 20 heptane
64. exo-3-Methyl-6, 7-diphenyl-3-azabicyclo [3.2.0] heptan64. exo-3-methyl-6, 7-diphenyl-3-azabicyclo [3.2.0] heptane
65. exo-3-n-Propyl-6-m-hydroxy-phenyl-3-azabicyclo [3.2.0]- 25 heptan65. exo-3-n-propyl-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - 25 heptane
66. exo-3-Allyl-6-m-methoxy-phenyl-3-azabicyclo [3.2.0]- heptan66. exo-3-allyl-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptane
30 67. exo-3- (3 , 4-Dimethoxy) -phenethyl-6-phenyl-3-azabicyclo- [3.2.0] heptan30 67. exo-3- (3, 4-dimethoxy) phenethyl-6-phenyl-3-azabicyclo- [3.2.0] heptane
68. exo-3- (3 , 4-Dimethoxy) -phenethyl-6-p-fluor-phenyl-3- azabicyclo [3.2.0] -heptan 3568. exo-3- (3,4-dimethoxy) phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane 35
69. exo-3- (3 , 4-Dihydroxy) -phenethyl-3-azabicyclo [3.2.0]- heptan69. exo-3- (3, 4-dihydroxy) phenethyl-3-azabicyclo [3.2.0] heptane
70. exo-3-Phenethyl-6-p-fluor-phenyl-3-azabicyclo [3.2.0]- 40 heptan70. exo-3-phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] - 40 heptane
71. 6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on71. 6-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine- 5-one
45 72. (+)-6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on 73. (-) -6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on45 72. (+) - 6-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2 -a] pyrimidin-5-one 73. (-) -6-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2- a] pyrimidin-5-one
74. 6-ß- [exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] -ethyl-7- 5 methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on74. 6-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7- 5 methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
75. 6-ß- [exo-6 , 7-Diphenyl-3-azabicyclo [3.2.0]heptan-3-yl] -ethyl- 7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on75. 6-ß- [exo-6, 7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine-5- on
10 76. 6-ß- [exo-6 , 7-bis- (p-Fluor-phenyl) -3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on10 76. 6-ß- [exo-6, 7-bis (p-fluorophenyl) -3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-7-methyl-5H-thiazolo [3 , 2-a] pyrimidin-5-one
77. 6-ß- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on 1577. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine 5-on 15
78. 6-ß- [exo-6-m-Methoxy-phenyl-3-azabicyclo [3.2.0] -heptan-3-yl] - ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on78. 6-β- [exo-6-m-methoxy-phenyl-3-azabicyclo [3.2.0] -heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine -5-on
79. 6-ß- [exo-6-m-Hydroxy-phenyl-3-azabicyclo [3.2.0]heptan- 20 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on79. 6-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-20 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine -5-on
80. 6-ß- (2- [exo-6-p-Amino-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on80. 6-ß- (2- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a ] pyrimidin-5-one
25 81. 6-ß- [exo-6-p-Chlor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on25 81. 6-ß- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine -5-on
82. 6-ß- [exo-6-p-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-82. 6-ß- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on 303-yl] -ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one 30
83. 6-ß- [exo-6-p-Nitro-phenyl-3-azabicyclo [3.2.0]heptan-83. 6-ß- [exo-6-p-nitro-phenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on3-yl] -ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
84. 6-ß- [exo-6-m-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 35 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on84. 6-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-35 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine -5-on
85. 6-ß- [exo-6-p-Hydroxy-phenyl-3-azabicyclo [3.2.0]heptan-85. 6-ß- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on3-yl] -ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
40 86. 6-ß- [exo-6-p-Trifluormethyl-phenyl-3-azabicyclo [3.2.0] - heptan-3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin- 5-on40 86. 6-ß- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] - heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
87. 6-ß- [exo-6- (p-t-Butyl-phenyl) -3-azabicyclo [3.2.0]heptan- 45 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on 88. 6-ß- [endo-6- (p-t-Butyl-phenyl) -3-azabicyclo [3.2.0]heptan-87. 6-ß- [exo-6- (pt-butylphenyl) -3-azabicyclo [3.2.0] heptan-45 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a ] pyrimidin-5-one 88. 6-ß- [endo-6- (pt-butylphenyl) -3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on3-yl] -ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
89. 6-ß- [exo-6- (3, 4-Dichlor-phenyl)-3-azabicyclo [3.2.0]heptan- 5 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on89. 6-β- [exo-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] heptan-5 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2 -a] pyrimidin-5-one
90. 6-ß- [exo-6- (3, 4-Dimethoxy-phenyl) -3-azabicyclo [3.2.0]- heptan-3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin- 5-on 1090. 6-ß- [exo-6- (3,4-dimethoxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2 -a] pyrimidin-5-one 10
91. 6-ß- [exo-6-p-Cyano-penyl-3-azabicyclo [3.2.0] heptan- 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on91. 6-β- [exo-6-p-cyano-penyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine- 5-one
92. 6-ß- [exo-6-(3, 4-Dihydroxy-phenyl ) -3-azabicyclo [3.2.0]- 15 heptan-3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-92. 6-ß- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] - 15 heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine
5-on5-one
93. 6-ß- [exo-6- (o-Fluor-phenyl-) -3-azabicyclo [3.2.0] heptan-93. 6-ß- [exo-6- (o-fluoro-phenyl-) -3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on 203-yl] -ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one 20
94. 6-ß- [exo-6-Thien-3-yl-3-azabicyclo[3.2.0]heptan-3-yl] - ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on94. 6-ß- [exo-6-thien-3-yl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidine- 5-one
95. 6-ß- [exo-6-(5-Chlor-thien-2-yl)-3-azabicyclo[3.2.0]heptan- 25 3-yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on95. 6-ß- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan- 25 3-yl] ethyl-7-methyl-5H-thiazolo [3 , 2-a] pyrimidin-5-one
96. 6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-7-methyl-2 , 3-dihydro-5H-thiazolo [3 , 2-a]pyrimidin- 5-on 3096. 6-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-2, 3-dihydro-5H-thiazolo [3, 2-a] pyrimidin-5-one 30
97. 6-ß- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-7-methyl-2 , 3-dihydro-5H-thiazolo [3 , 2-a]pyrimidin- 5-on97. 6-ß- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-2, 3-dihydro-5H-thiazolo [3, 2-a] pyrimidin-5-one
35 98. 6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - ethyl-2 , 3 , 7-trimethyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on35 98. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 3, 7-trimethyl-5H-thiazolo [3, 2 -a] pyrimidin-5-one
99. 6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on 4099. 6-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5H-thiazolo [3, 2-a] pyrimidin-5-one 40
100.6-ß- [exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] -ethyl-5H- thiazolo [3 , 2-a]pyrimidin-5-on100.6-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
101.7-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 45 ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [1, 3] thiazin-6-on 102.7-ß- [exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] -ethyl-101.7-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 45 ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [ 1, 3] thiazin-6-one 102.7-ß- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-
8-methyl-2H, 6H-pyrimido [2 , 1-b] [1,3] thiazin-6-on8-methyl-2H, 6H-pyrimido [2, 1-b] [1,3] thiazin-6-one
103.7-ß- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 5 ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [1, 3 ] thiazin-6-on103.7-ß- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5-ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [ 1, 3] thiazin-6-one
104.7-ß- [exo-6-p-Chlor-phenyl-3-azabicyclo [3.2.0]he tan-3-yl] - ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [1,3] thiazin-6-on104.7-ß- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] he tan-3-yl] - ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [ 1,3] thiazin-6-one
10 105.7-ß- [exo-6-p-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [1.3] thiazin-6-on10 105.7-β- [exo-6-p-methoxy-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [ 1.3] thiazin-6-one
106.7-ß- [exo-6-m-Hydroxy-phenyl-3-azabicyclo [3.2.0]heptan-106.7-ß- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptane
3-yl]-ethyl-8-methyl-2H, 6H-pyrimido [2 , 1-b] [1,3] thiazin-6-on 153-yl] -ethyl-8-methyl-2H, 6H-pyrimido [2, 1-b] [1,3] thiazin-6-one 15
107.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion107.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
108. (+) -3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 20 3-yl] -ethyl-2, 4-(lH, 3H) -chinazolindion108. (+) -3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-20 3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
109. (-) -3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-2, 4-(lH, 3H) -chinazolindion109. (-) -3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
25 110.3-ß- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -ethyl-2 , - (1H, 3H) -chinazolindion25 110.3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, - (1H, 3H) -quinazolinedione
111.3-ß- [exo-6-m-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion 30111.3-ß- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione 30
112.3-ß- [exo-6-p-Cyano-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion112.3-β- [exo-6-p-cyano-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
113.3-ß- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl-2, 4-(lH, 3H) -chinazolindion113.3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl-2, 4- (1H, 3H) -quinazolinedione
114.3-ß- [exo-6-p-Hydroxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion114.3-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
40 115.3-ß- [exo-6-p-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion40 115.3-ß- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
116.3-ß- [exo-6-m-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion 45 117.3-ß- [exo-6-p-Nitro-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2 , 4- (1H, 3H) -chinazolindion116.3-β- [exo-6-m-methoxy-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione 45 117.3-β- [exo-6-p-nitro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
118.3-ß- [endo-6-p-Nitro-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 5 ethyl-2, 4-(lH, 3H) -chinazolindion118.3-β- [endo-6-p-nitro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5-ethyl-2, 4- (1H, 3H) -quinazolinedione
119.3-ß- [exo-6-m-Hydroxy-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - ethyl-2 , 4- (1H, 3H) -chinazolindion119.3-ß- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
10 120.3-ß- [exo-6-p-Amino-phenyl-3-azabicyclo [3.2.0]heptan-3-yl) - ethyl-2 , 4- (1H, 3H) -chinazolindion10 120.3-β- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl) ethyl-2, 4- (1H, 3H) -quinazolinedione
121.3-ß- [exo-6-p-Jod-phenyl-3-azabicyclo [3.2.0]heptan-3-yl ) - ethyl-2 , 4- (1H, 3H) -chinazolindion 15121.3-ß- [exo-6-p-iodophenyl-3-azabicyclo [3.2.0] heptan-3-yl) ethyl-2, 4- (1H, 3H) -quinazolinedione 15
122.3-ß- [exo-6-p-Trifluormethyl-phenyl-3-azabicyclo [3.2.0]- heptan-3-yl] -ethyl-2 , 4- ( 1H, 3H) -chinazolindion122.3-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
123.3-ß- [exo-6- (3 , 4-Dichlor-phenyl ) -3-azabicyclo [3.2.0]- 20 heptan-3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion123.3-β- [exo-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] - 20 heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
124.3-ß- [exo-6- (3 , 4-Dihydroxy-phenyl) -3-azabicyclo [3.2.0]- heptan-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion124.3-ß- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
25 125.3-ß- [exo-6-(3, 5-Dichlor-phenyl ) -3-azabicyclo [3.2.0]heptan- 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion25 125.3-β- [exo-6- (3,5-dichlorophenyl) -3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
126.3-ß- [exo-6-o-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yi] - ethyl-2 , 4- ( 1H, 3H) -chinazolindion 30126.3-ß- [exo-6-o-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yi] ethyl-2, 4- (1H, 3H) -quinazolinedione 30
127.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-8-methyl-2 , 4- ( 1H, 3H) -chinazolindion127.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2,4- (1H, 3H) -quinazolinedione
128.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl-7-chlor-2, - (1H, 3H) -chinazolindion128.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl-7-chloro-2, - (1H, 3H) -quinazolinedione
129.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - ethyl-7-fluor-2 , 4- (1H, 3H) -chinazolindion129.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-fluoro-2,4- (1H, 3H) -quinazolinedione
40 130.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-5-chlor-2, 4- (1H, 3H) -chinazolindion40 130.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5-chloro-2,4- (1H, 3H) -quinazolinedione
131.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6-fluor-2, 4- (1H, 3H) -chinazolindion 45 132.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6-methyl-2 , 4- ( 1H, 3H) -chinazolindion131.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-fluoro-2,4- (1H, 3H) -quinazolinedione 45 132.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-methyl-2, 4- (1H, 3H) -quinazolinedione
133.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 5 ethyl-8-methoxy-2 , 4- (1H, 3H) -chinazolindion133.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5-ethyl-8-methoxy-2, 4- (1H, 3H) -quinazolinedione
134.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6-trifluormethyl-2 , 4- (1H, 3H) -chinazolindion134.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-trifluoromethyl-2, 4- (1H, 3H) -quinazolinedione
10 135.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-7-nitro-2, 4- (1H, 3H) -chinazolindion10 135.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-nitro-2, 4- (1H, 3H) -quinazolinedione
136.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6-nitro-2, 4- (1H, 3H) -chinazolindion 15136.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-nitro-2, 4- (1H, 3H) -quinazolinedione 15
137.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-7-amino-2, 4- (1H, 3H) -chinazolindion137.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-amino-2, 4- (1H, 3H) -quinazolinedione
138.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 20 ethyl-6-amino-2 , 4- (1H, 3H) -chinazolindion138.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 20 ethyl-6-amino-2, 4- (1H, 3H) -quinazolinedione
139.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6-hydroxy-2 , 4- (1H, 3H) -chinazolindion139.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-hydroxy-2, 4- (1H, 3H) -quinazolinedione
25 140.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-5-chlor-2, 4- (1H, 3H) -chinazolindion25 140.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5-chloro-2,4- (1H, 3H) -quinazolinedione
141.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6, 7-dimethoxy-2 , 4- (1H, 3H) -chinazolindion 30141.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6, 7-dimethoxy-2, 4- (1H, 3H) -quinazolinedione 30
142.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6, 8-dichlor-2 , 4- (1H, 3H) -chinazolindion142.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6, 8-dichloro-2, 4- (1H, 3H) -quinazolinedione
143.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl-6, 7, 8-trimethoxy-2 , 4- (1H, 3H) -chinazolindion143.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl-6, 7, 8-trimethoxy-2, 4- (1H, 3H) -chinazolinedione
144.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-l-methyl-2 , 4- (1H, 3H) -chinazolindion144.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-l-methyl-2,4- (1H, 3H) -quinazolinedione
40 145.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-l-ethyl-2, 4- (1H, 3H) -chinazolindion40 145.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-ethyl-2,4- (1H, 3H) -quinazolinedione
146.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-l-allyl-2, 4- (1H, 3H) -chinazolindion 45 147.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - ethyl-l-benzyl-2 , 4- (1H, 3H) -chinazolindion146.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-l-allyl-2,4- (1H, 3H) -quinazolinedione 45 147.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-l-benzyl-2,4- (1H, 3H) -quinazolinedione
148.3-γ- [exo-6-p-Fluor-pheny1-3-azabicyclo [3.2.0]heptan-3-yl] - 5 propyl-2 , 4- (1H, 3H) -chinazolindion148.3-γ- [exo-6-p-fluoro-pheny1-3-azabicyclo [3.2.0] heptan-3-yl] -5-propyl-2, 4- (1H, 3H) -quinazolinedione
149.3-δ- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - butyl-2, 4- (1H, 3H) -chinazolindion149.3-δ- [exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butyl-2, 4- (1H, 3H) -quinazolinedione
10 150.3-ß-[exo-6-(2-Thienyl)-3-azabicyclo[3.2.0]heptan-3-yl]- ethyl-2, 4- (1H, 3H) -chinazolindion10 150.3-ß- [exo-6- (2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
151.3-ß- [exo-6-(5-Chlor-2-thienyl)-3-azabicyclo[3.2.0]heptan- 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion 15151.3-β- [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] heptan- 3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione 15
152.3-ß- [exo-6- ( 3-Thienyl ) -3 -azabicyclo [3.2.0] heptan-3-yl] - ethyl-2 , 4- (1H, 3K) -chinazolindion152.3-ß- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 4- (1H, 3K) -quinazolinedione
153.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 20 ethyl-lH-thieno [3 , 2-d]pyrimidin-2 , 4-dion153.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 20 ethyl-1H-thieno [3, 2-d] pyrimidin-2, 4-dione
154.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-lH-thieno [2 , 3-d]pyrimidin-2 , 4-dion154.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-lH-thieno [2, 3-d] pyrimidin-2, 4-dione
25 155.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - ethyl-lH-thieno [3 , 4-d]pyrimidin-2 , 4-dion25 155.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-lH-thieno [3, 4-d] pyrimidin-2, 4-dione
156.3-ß- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0] heptan-3-yl] - ethyl-1-methyl-lH, 3H-pyrido [2 , 3-d] pyrimidin-2 , 4-dion 30156.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-methyl-1H, 3H-pyrido [2, 3-d] pyrimidine- 2, 4-dione 30
157.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methyl-3H-chinazolin-4-on157.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-3H-quinazolin-4-one
158.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl-2-methoxy-3H-chinazolin-4-on158.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl-2-methoxy-3H-quinazolin-4-one
159.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methyl-4H-pyrido [1, 2-a]pyrimidin-4-on Dihydrochlorid159.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1, 2-a] pyrimidine-4- on dihydrochloride
40 160.3-ß- [exo-6-Phenyl-3-azabicyclo[3.2.0]heptan-3-yl] -ethyl- 2-methyl-4H-pyrido [1, 2-a]pyrimidin-4-on40 160.3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1, 2-a] pyrimidin-4-one
161.3-ß- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methyl-4H-pyrido [1 , 2-a]pyrimidin-4-on 45 162.3-ß- [exo-6-m-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-161.3-ß- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1, 2-a] pyrimidine-4- on 45 162.3-ß- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2-methyl-4H-pyrido [1, 2-a]pyrimidin-4-on3-yl] -ethyl-2-methyl-4H-pyrido [1, 2-a] pyrimidin-4-one
163.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-163.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
5 3-yl] -ethyl-2, 6-dimethyl-4H-pyrido [1, 2-a]pyrimidin-4-on5 3-yl] -ethyl-2, 6-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one
164.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-164.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2 , 7-dimethyl-4H-pyrido [1, 2-a]pyrimidin-4-on3-yl] ethyl-2, 7-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one
10 165.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-10 165.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2 , 8-dimethyl-4H-pyrido [1 , 2-a]pyrimidin-4-on3-yl] ethyl-2, 8-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one
166.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-166.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2 , 9-dimethyl-4H-pyrido [1 , 2-a]pyrimidin-4-on 153-yl] -ethyl-2, 9-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one 15
167.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-167.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2 , 6, 8-trimethyl-4H-pyrido [1, 2-a]pyrimidin-4-on3-yl] ethyl-2, 6, 8-trimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one
168.3-ß- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan- 20 3-yl] -ethyl-2, 7-dimethyl-4H-pyrido [1, 2-a]pyrimidin-4-on168.3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan- 20 3-yl] ethyl-2, 7-dimethyl-4H-pyrido [1, 2-a] pyrimidine -4-on
169.3-ß- [exo-6-o-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-169.3-ß- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2, 7-dimethyl-4H-pyrido [1, 2-a]pyrimidin-4-on3-yl] ethyl-2, 7-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one
25 170.3-ß- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -ethyl- 2 , 8-dimethyl-4H-pyrido [1, 2-a]pyrimidin-4-on25 170.3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 8-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one
171.3-ß- [exo-6-m-Chlor-pheny1-3-azabicyclo [3.2.0]heptan-171.3-ß- [exo-6-m-chloropheny1-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2 , 9-dimethyl-4H-pyrido [1 , 2-a]pyrimidin-4-on 303-yl] -ethyl-2, 9-dimethyl-4H-pyrido [1, 2-a] pyrimidin-4-one 30
172.3-ß- [exo-6-(5-Chlor-thien-2-yl)-3-azabicyclo [3.2.0]heptan-172.3-ß- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2-methyl-4H-pyrido [1, 2-a]pyrimidin-4-on3-yl] -ethyl-2-methyl-4H-pyrido [1, 2-a] pyrimidin-4-one
173.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl-6, 7,8, 9-tetrahydro-2-methyl-4H-pyrido [1, 2-a]pyrimidin-173.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl-6, 7,8, 9-tetrahydro-2-methyl-4H-pyrido [1, 2-a] pyrimidine
4-on4-on
174.3-ß- [exo-6-p-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6, 7,8, 9-tetrahydro-2-methyl-4H-pyrido [1, 2-a]pyrimidin- 40 4-on174.3-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6, 7,8, 9-tetrahydro-2-methyl-4H-pyrido [ 1, 2-a] pyrimidin-40 4-one
175.3-ß- [exo-6-p-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-6, 7, 8, 9-tetrahydro-2-methyl-4H-pyrido [1, 2-a]pyrimidin- 4-on 45 176.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methyl-4H-pyrimido [1 , 2-a]pyrimidin-4-on175.3-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6, 7, 8, 9-tetrahydro-2-methyl-4H-pyrido [ 1, 2-a] pyrimidin-4-one 45 176.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrimido [1, 2-a] pyrimidin-4- on
177.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 5 ethyl-2-methyl-7-chlor-4H-pyrimido [1, 2-a]pyrimidin-4-on177.3-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5-ethyl-2-methyl-7-chloro-4H-pyrimido [1, 2-a ] pyrimidin-4-one
178.6-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-7-methyl-1H, 5H-imidazo [1, 2-a]pyrimidin-5-on178.6-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-1H, 5H-imidazo [1, 2-a] pyrimidine 5-one
10 179.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methyl-7 , 8-dihydro-4H, 6H-pyrrolo [1 , 2-a]pyrimidin- 4-on10 179.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-7, 8-dihydro-4H, 6H-pyrrolo [1 , 2-a] pyrimidin-4-one
180.2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]hept n-3-yl] - 15 methyl-benzimidazol180.2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] hept n-3-yl] - 15 methyl-benzimidazole
181.1-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-benzimidazol181.1-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl benzimidazole
20 182.1-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2, 3-dihydro-benzimidazol-2-on20 182.1-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2, 3-dihydro-benzimidazol-2-one
183.2- [exo-6-m-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - methyl-benzimidazol 25183.2- [exo-6-m-methoxy-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-benzimidazole 25
184.3-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-indol, Schmp. 193-195°C (Hydrochlorid)184.3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl indole, mp. 193-195 ° C. (hydrochloride)
185.3-ß- (2- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.2.0]heptan- 30 3-yl] -ethyl-indol185.3-ß- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptane-30 3-yl] ethyl indole
186.3-ß- [exo-6-Pheny1-3-azabicyclo [3.2.0]heptan-3-yl] -ethyl- indol, Schmp. 104-105°C (Hydrochlorid)186.3-β- [exo-6-Pheny1-3-azabicyclo [3.2.0] heptan-3-yl] ethyl indole, mp. 104-105 ° C (hydrochloride)
35 187.3-ß- [exo-6-m-Methoxy-phenyl-3-azabicyclo [3.2.0] eptan-3-yl] - ethyl-indol35 187.3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] eptan-3-yl] ethyl indole
188.2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - methyl-3 , 4-dihydro-chinazolin-4-on 40188.2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydro-quinazolin-4-one 40
189.2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - methyl-3 , 4-dihydro-chinazolin-4-thion189.2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydro-quinazolin-4-thione
190.2- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -methyl- 45 3 , 4-dihydro-chinazolin-4-on 191.2- [exo-6-m-Chlor-pheny1-3-azabicyclo [3.2.0]heptan-3-yl] - methyl-3 , 4-dihydro-chinazolin-4-on190.2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-45 3, 4-dihydro-quinazolin-4-one 191.2- [exo-6-m-chloropheny1-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydro-quinazolin-4-one
192.2- [exo-6-o-Methoxy-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 5 methyl-3 , 4-dihydro-chinazolin-4-on192.2- [exo-6-o-methoxy-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5 methyl-3, 4-dihydro-quinazolin-4-one
193.2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - methy1-4-hydroxy-6-methyl-pyrimidin193.2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl 1-4-hydroxy-6-methyl-pyrimidine
10 194.6- [exo-6-p-Fluor-pheny1-3-azabicyclo [3.2.0]heptan-3-yl] - methy1-2-methy1-4-hydroxy-pyrimidin10 194.6- [exo-6-p-fluoro-pheny1-3-azabicyclo [3.2.0] heptan-3-yl] - methy1-2-methy1-4-hydroxy-pyrimidine
195.6- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - methyl-uracil 15195.6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl uracil 15
196.6- [exo-6-Phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -methyl- uracil196.6- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl uracil
197.6- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 20 1,2,3, 4-tetrahydro-1 , 3-dimethyl-2 , 4-dioxo-pyrimidin197.6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 20 1,2,3, 4-tetrahydro-1, 3-dimethyl-2, 4-dioxo -pyrimidine
198.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-198.5-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane
3-yl]-ethyl-l, 2,3, 4-tetrahydro-6-methyl-2 , 4-dioxo-pyrimidin3-yl] -ethyl-l, 2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidine
25 199.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-1 , 2,3, 4-tetrahydro-l , 6-dimethyl-2 , 4-dioxo-pyrimidin25 199.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1, 2,3, 4-tetrahydro-l, 6-dimethyl-2 , 4-dioxopyrimidine
200.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-1 , 2,3, 4-tetrahydro-3 , 6-dimethyl-2 , 4-dioxo-pyrimidin 30200.5-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1, 2,3, 4-tetrahydro-3,6-dimethyl-2, 4-dioxopyrimidine 30
201.5-ß- [exo-6-p-Fluor-pheny1-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-1 , 2,3, 4-tetrahydro-3 , 6-dimethyl-2 , 4-dithio-pyrimidin201.5-β- [exo-6-p-fluoro-pheny1-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1, 2,3, 4-tetrahydro-3,6-dimethyl-2, 4-dithio-pyrimidine
202.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl-1 , 2,3, 4-tetrahydro-l , 3 , 6-trimethyl-2 , 4-dioxo-pyrimidin202.5-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl-1, 2,3, 4-tetrahydro-l, 3,6-trimethyl -2, 4-dioxopyrimidine
203.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-1, 2,3, 4-tetrahydro-6-amino-l-methyl-2 , 4-dioxo- pyrimidin 40203.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1, 2,3,4-tetrahydro-6-amino-l-methyl- 2,4-dioxopyrimidine 40
204.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-amino-6-methyl-4 (3H) -pyrimidinon204.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-6-methyl-4 (3H) pyrimidinone
205.5-ß- [exo-6-p-Fluor-pheny1-3-azabicyclo [3.2.0]heptan-3-yl] - 45 ethyl-2-amino-3 , 6-dimethyl-4 (3H) -pyrimidinon 206.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon205.5-β- [exo-6-p-fluoro-pheny1-3-azabicyclo [3.2.0] heptan-3-yl] - 45 ethyl-2-amino-3,6-dimethyl-4 (3H) -pyrimidinone 206.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
207.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - 5 ethyl-2-methylamino-3-ethyl-6-methyl-4 (3H) -pyrimidinon207.5-ß- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -5-ethyl-2-methylamino-3-ethyl-6-methyl-4 (3H) - pyrimidinone
208.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-amino-3-ethyl-6-methyl-4 (3H) -pyrimidinon208.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-3-ethyl-6-methyl-4 (3H) pyrimidinone
10 209.5-ß- [exo-6-p-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon10 209.5-ß- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
210.5-ß- [exo-6-m-Chlor-pheny1-3-azabicyclo [3.2.0] heptan-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon210.5-β- [exo-6-m-chloropheny1-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) -pyrimidinone
1515
211.5-ß- [exo-6-o-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon211.5-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
212.5-ß- [exo-6-p-Trifluormethyl-phenyl-3-azabicyclo [3.2.0]- 20 heptan-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H)- pyrimidinon212.5-ß- [exo-6-p-trifluoromethyl-phenyl-3-azabicyclo [3.2.0] - 20 heptan-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) -pyrimidinone
213.5-ß- [exo-6-p-Cyano-phenyl-3-azabicyclo [3.2.0]heptan-213.5-ß- [exo-6-p-cyano-phenyl-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon 253-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone 25
214.5-ß- [exo-6-m-Fluor-pheny1-3-azabicyclo [3.2.0]heptan-214.5-ß- [exo-6-m-fluoro-pheny1-3-azabicyclo [3.2.0] heptane
3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
215.5-ß- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan- 30 3-yl] -ethyl-2-methylamino-4-methoxy-6-methyl-pyrimidin215.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-30 3-yl] ethyl-2-methylamino-4-methoxy-6-methylpyrimidine
216.3-ß- [exo-6-Phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion216.3-ß- [exo-6-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2, 4- (1H, 3H ) -quinazolinedione
217.3-ß- [endo-6-Phenyl-7-methyl-l, 5-cis-3 , 7-diazabicyclo [3.3.0]- 35 octan-3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion217.3-β- [endo-6-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] - 35 octan-3-yl] ethyl-2, 4- (1H, 3H ) -quinazolinedione
218.3-ß- [exo-6-p-Fluor-phenyl-7-methyl-1, 5-cis-3, 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion218.3-ß- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
40 219.3-ß-[exo-6-p-Trifluormethyl-phenyl-7-methyl-l, 5-cis-3,7- diazabicyclo [3.3.0] octan-3-yl] -ethyl-6-fluor-2 , 4- ( 1H, 3H) - chinazolindion40 219.3-ß- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-6-fluoro-2 , 4- (1H, 3H) - quinazoline indione
220.3-ß- [exo-6-m-Chlor-phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- 45 cyclo[3.3.0] octan-3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion 221.3-ß- [exo-6-p-Methoxy-phenyl-7 -methyl-1, 5-cis-3 , 7-diazabi- cyclo[3.3.0]octan-3-yl] -ethyl-6-methyl-2 , 4- (1H,3H) -chinazolindion220.3-ß- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3, 7-diazabi-45 cyclo [3.3.0] octan-3-yl] ethyl-2,4 - (1H, 3H) -quinazolinedione 221.3-ß- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-6-methyl- 2,4- (1H, 3H) -quinazolinedione
5 222.5-ß- [exo-6-Phenyl-7-methyl-1, 5-cis-3 , 7-diazabicyclo [3.3.0] oc- tan-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon5 222.5-β- [exo-6-phenyl-7-methyl-1, 5-cis-3, 7-diazabicyclo [3.3.0] oc-tan-3-yl] ethyl-2-methylamino-3, 6 -dimethyl-4 (3H) pyrimidinone
223.5-ß- [exo-6-p-Fluor-phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl ] -ethyl-2-methylamino-3 , 6-dimethyl- 10 4 (3H) -pyrimidinon223.5-ß- [exo-6-p-fluorophenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino- 3, 6-dimethyl-10 4 (3H) pyrimidinone
224.1-ß- [exo-6-p-Fluor-phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl-2 (3H) -benzimidazolon224.1-ß- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2 (3H) -benzimidazolone
15 225.5-ß- [exo-6-p-Nitro-phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl- 4 (3H) -pyrimidinon15 225.5-β- [exo-6-p-nitro-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino -3, 6-dimethyl-4 (3H) pyrimidinone
226.5-ß- [exo-6-Phenyl-7-methyl-l, 5-cis-3 , 7-diazabicyclo- 20 [3.3.0] -octan-3-yl]-ethyl-2-methylamino-3, 6-dimethyl-4 (3H)- pyrimidinon226.5-β- [exo-6-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo-20 [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6 -dimethyl-4 (3H) pyrimidinone
227.5-ß- [endo-6-Phenyl-7-methyl-l, 5-cis-3 , 7-diazabicyclo-227.5-ß- [endo-6-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo-
[3.3.0] -octan-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) - 25 pyrimidinon[3.3.0] octan-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) - 25 pyrimidinone
228.3-ß- [exo-6-p-Fluor-phenyl-7 -methyl-1, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl-2-methyl-4H-pyrido [1.2-a] - pyrimidin-4-on 30228.3-ß- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methyl- 4H-pyrido [1.2-a] pyrimidin-4-one 30
229.1-ß- [exo-6-p-Fluor-phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl-indolin-2-on229.1-ß- [exo-6-p-fluorophenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-indolin-2- on
230.6-ß- [exo-δ-p-Fluor-phenyl-7-methyl-l, 5-cis-3 , 7-diazabicyclo- 35 [3.3.0]octan-3-yl] -ethyl-7-methyl-5H-thiazolo [3.2-a] - pyrimidin-5-on230.6-ß- [exo-δ-p-fluorophenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo-35 [3.3.0] octan-3-yl] ethyl-7-methyl- 5H-thiazolo [3.2-a] pyrimidin-5-one
231.1-ß- [exo-6-p-Fluor-phenyl-7-methyl-1, 5-eis-3 , 7-diazabicyclo- [3.3.0] octan-3-yl] -ethyl-2 (1H) -chinolon 40231.1-ß- [exo-6-p-fluorophenyl-7-methyl-1,5-ice-3,7-diazabicyclo- [3.3.0] octan-3-yl] ethyl-2 (1H) - quinolone 40
232.3-ß- [7-Phenyl-l, 5-cis-3 , 7-diazabicyclo [3.3.0] octan-3-yl] - ethyl-2 , 4- (1H, 3H) -chinazolindion232.3-β- [7-phenyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
233.3-ß- [7-p-Fluor-phenyl-l, 5-cis-3 , 7-diazabicyclo [3.3.0] oetan- 45 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion 234.5-ß- 7-p-Fluor-phenyl-l , 5-cis-3 , 7-diazabicyclo [3.3.0] octan- 3-yl -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon233.3-β- [7-p-fluorophenyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] oetan-45 3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione 234.5-ß-7-p-fluorophenyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan- 3-yl-ethyl-2-methylamino-3, 6-dimethyl-4 (3H) -pyrimidinone
235.3-ß- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.1.0]hexan-3-yl] - 5 ethyl 2, 4- (1H, 3H) -chinazolindion235.3-β-exo-6-p-fluoro-phenyl-3-azabicyclo [3.1.0] hexan-3-yl] - 5 ethyl 2,4- (1H, 3H) -quinazolinedione
236.3-ß- exo-6-Phenyl-3-azabicyclo [3.1.0]hexan-3-yl] -ethyl- 2,4- 1H, 3H) -chinazolindion236.3-β-exo-6-phenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-2,4-1H, 3H) -quinazolinedione
10 237.3-ß- 6, 6-Diphenyl-3 -azabicyclo [3.1.0]hexan-3-yl] -ethyl- 2,4- 1H, 3H) -chinazolindion10 237.3-ß-6, 6-diphenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-2,4-1H, 3H) -quinazolinedione
238.5-ß- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.1.0]hexan-3-yl] - ethyl 2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon238.5-β-exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl 2-methylamino-3, 6-dimethyl-4 (3H) -pyrimidinone
1515
239.6-ß exo-6-m-Chlor-phenyl-3 -azabicyclo [3.1.0]hexan-3-yl] - ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on239.6-β exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one
240.3-ß- 6-p-Fluor-phenyl-l , 5-cis-3 -azabicyclo [3.3.0] oct-6-en- 20 3-yl -ethyl-2 , 4- (1H, 3H) -chinazolindion240.3-β-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oct-6-en-20 3-yl-ethyl-2,4- (1H, 3H) -quinazolinedione
241.5-ß- 6-p-Fluor-phenyl-l , 5-cis-3 -azabicyclo [3.3.0] oct-6-en- 3-yl -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon241.5-ß-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl-ethyl-2-methylamino-3, 6-dimethyl-4 ( 3H) pyrimidinone
25 242.6-ß- 6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [3.3.0] oct-6-en- 3-yl -ethyl-7-methyl-5H-thiazolo [3 , 2-a]pyrimidin-5-on25 242.6-ß-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl-ethyl-7-methyl-5H-thiazolo [3, 2 -a] pyrimidin-5-one
243.1-ß- 6-Phenyl-1, 5-eis-3 -azabicyclo [3.3.0] oct-6-en-3-yl] - ethyl-2 (3H) -benzimidazolon 30243.1-β-6-phenyl-1,5-eis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 (3H) -benzimidazolone 30
244.1-ß- 6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [3.3.0] oct-6-en- 3-yl -ethyl-indolin-2-on244.1-β-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [3.3.0] oct-6-en-3-yl-ethyl-indolin-2-one
245.1-ß- 6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [3.3.0] oct-6-en- 35 3-yl -ethyl-2 (1H) -chinolon245.1-ß-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [3.3.0] oct-6-en-35 3-yl-ethyl-2 (1H) -quinolone
246.3-ß- exo-6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [3.3.0] oetan- 3-yl -ethyl-2, 4- (1H, 3H) -chinazolindion246.3-β-exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oetan-3-yl-ethyl-2,4- (1H, 3H) -quinazolinedione
40 247.5-ß- exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [3.3.0] oetan- 3-yl -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon40 247.5-ß-exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [3.3.0] oetan-3-yl-ethyl-2-methylamino-3, 6-dimethyl-4 (3H ) -pyrimidinone
248.6-ß- [exo-6-Phenyl-l, 5-cis-3 -azabicyclo [3.3.0] octan-3-yi ethyl-7-methyl-5H-thiazolo [3.2-a]pyrimidin-5-on248.6-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yi ethyl-7-methyl-5H-thiazolo [3.2-a] pyrimidin-5-one
45 249. ι-ß-[exo-6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [3.3.0] octan-45 249. ι-ß- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] octane
3-yl] -ethyl-indolin-2-on3-yl] ethyl indolin-2-one
250. ι-ß-[exo-6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [3.3.0] octan-250. ι-ß- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] octane
5 3-yl] -ethyl-2 ( 1H) -chinolon5 3-yl] ethyl-2 (1H) -quinolone
251. 3-ß-[endo-6-p-Fluor-phenyl-1, 5-eis-3-azabicyclo [3.3.0] octan- 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion251. 3-ß- [endo-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2, 4- (1H, 3H) - quinazolinedione
10 252. 5-ß-[endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [3.3.0] oetan-10 252. 5-ß- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oetane
3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
253 6-ß-[endo-Phenyl-1, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] - ethyl 7-methyl-5H-thiazolo [3.2-a]pyrimidin-5-on253 6-ß- [endo-phenyl-1,5-eis-3-azabicyclo [3.3.0] octan-3-yl] ethyl 7-methyl-5H-thiazolo [3.2-a] pyrimidin-5-one
1515
254 ι-ß-[endo-6-p-Fluor-phenyl-l, 5-cis-3 -azabicyclo [3.3.0] oetan-254 ι-ß- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oetane
3-yl] -ethyl-indolin-2-on3-yl] ethyl indolin-2-one
255 ι-ß-[endo-6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [3.3.0] oetan-255 ι-ß- [endo-6-p-fluorophenyl-1, 5-eis-3 -azabicyclo [3.3.0] oetane
20 3-yl] -ethyl-2 ( 1H) -chinolon20 3-yl] ethyl-2 (1H) -quinolone
256 3-ß-[exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [3.3.0] oetan-256 3-ß- [exo-7-p-fluorophenyl-1,5-ice-3-azabicyclo [3.3.0] oetane
3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
25 257 5-ß-[exo-7-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [3.3.0] oetan-25 257 5-ß- [exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oetane
3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
258.6-ß exo-7-Phenyl-1 , 5-cis-3-azabicyclo [3.3.0] octan-3-yl] - ethyl-7-methyl-5H-thiazolo [3.2-a]pyrimidin-5-on258.6-β exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3.2-a] pyrimidin-5-one
3030
259. 1-ß- exo-7-p-Fluor-phenyl-i, 5-cis-3 -azabicyclo [3.3.0] oetan-259. 1-ß-exo-7-p-fluorophenyl-i, 5-cis-3-azabicyclo [3.3.0] oetane
3-yl -ethyl-indolin-2-on3-yl-ethyl-indolin-2-one
260.1-ß- exo-7-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [3.3.0] oetan- 35 3-yl -ethyl-2 (1H) -chinolon260.1-β-exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oetan-35 3-yl-ethyl-2 (1H) -quinolone
261.3-ß- endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 3-yl -ethyl-2, 4- (1H, 3H) -chinazolindion261.3-β-endo-6-p-fluoro-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl-ethyl-2,4- (1H, 3H) -quinazolinedione
40 262 5-ß- endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-40 262 5-ß-endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-
3-yl -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon3-yl-ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
263.3-ß- [endo-6-Phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-3-yl] ethyl-2 , 4- (1H, 3H) -chinazolindion263.3-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
45 264.5-ß- [endo-6-Phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon45 264.5-β- [endo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
265.3-ß- [endo-6-p-Trifluormethyl-phenyl-1, 5-cis-3-azabicyclo- 5 [4.3.0]non-3-yl] -ethyl-2 , 4- ( 1H, 3H) -chinazolindion,265.3-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo- 5 [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) - quinazolinedione,
266.5-ß- [endo-6-p-Trifluormethyl-phenyl-1 , 5-cis-3-azabicyclo- [4.3.0]non-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) - pyrimidinon 10266.5-ß- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo- [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) - pyrimidinone 10
267.3-ß- [endo-6-p-Fluor-phenyl-1, 5-cis-3-azabicyclo [4.3.0]non- 7-en-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion267.3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2,4- (1H, 3H ) -quinazolinedione
268.5-ß- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 15 7-en-3-yl] -ethyl-2 -methylamino-3 , 6-dimethyl-4 (3H) - pyrimidinon268.5-ß- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-15 7-en-3-yl] ethyl-2-methylamino-3, 6 -dimethyl-4 (3H) pyrimidinone
269.1-ß- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-269.1-ß- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-
7-en-3-yl] -ethyl-2 (3H) -benzimidazolon 207-en-3-yl] ethyl-2 (3H) -benzimidazolone 20
270.1-ß- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-270.1-ß- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-
7-en-3-yl] -ethyl-indolin-2-on7-en-3-yl] ethyl indolin-2-one
271.3-ß- [6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-6-en- 25 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion271.3-ß- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-ene-25 3-yl] ethyl-2, 4- (1H, 3H) -chinazolinedione
272.5-ß- [6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-6-en- 3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon272.5-ß- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-3, 6-dimethyl- 4 (3H) pyrimidinone
30 273.3-ß-[6-Phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-6-en-3-yl] - ethyl-2 , 4- (1H, 3H) -chinazolindion30 273.3-ß- [6-phenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
274.5-ß- [6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0] non-6-en-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon 35274.5-ß- [6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] - ethyl-2-methylamino-3, 6-dimethyl-4 (3H) -pyrimidinone 35
275.3-ß- [6-p-Trifluormethyl-phenyl-1, 5-cis-3-azabicyclo-275.3-ß- [6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo-
[4.3.0]non-6-en-3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion[4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
276.5-ß- [6-p-Trifluormethyl-phenyl-1, 5-cis-3-azabicyclo [4.3.0]- 40 non-6-en-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) - pyrimidinon276.5-β- [6-p-trifluoromethyl-phenyl-1,5-cis-3-azabicyclo [4.3.0] - 40 non-6-en-3-yl] ethyl-2-methylamino-3, 6- dimethyl-4 (3H) pyrimidinone
277.1-ß- [6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-6-en- 3-yl] -ethyl-2 (3H) -benzimidazolon 45 278.1-ß- [6-p-Fluor-phenyl-l, 5-eis-3-azabicyclo [4.3.0]non-6-en- 3-yl] -ethyl-indoiin-2-on277.1-ß- [6-p-fluorophenyl-1,5-eis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2 (3H) -benzimidazolone 45 278.1-ß- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-indoiin-2-one
279.1-ß- [6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-6-en- 5 3-yl] -ethyl-2 (1H) -chinolon279.1-ß- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-en-5 3-yl] ethyl-2 (1H) -quinolone
280.3-ß- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-7- en-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolidon280.3-ß- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-7- en-3-yl] ethyl-2, 4- (1H, 3H ) -quinazolidone
10 281.5-ß- [exo-6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non-7- en-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon10 281.5-ß- [exo-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-7- en-3-yl] ethyl-2-methylamino-3, 6 -dimethyl-4 (3H) pyrimidinone
282.3-ß- [exo-6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non-7- en-3-yl] -ethyl-2 -methyl-4H-pyrido [1.2-a]pyrimidin-4-on 15282.3-ß- [exo-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-7- en-3-yl] ethyl-2-methyl-4H-pyrido [ 1.2-a] pyrimidin-4-one 15
283.1-ß- [exo-6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [4.3.0] non-7- en-3-yl] -ethyl-2 (1H) -chinolon283.1-β- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7- en-3-yl] ethyl-2 (1H) -quinolone
284.1-ß- [exo-6-p-Fluor-phenyl-1 , 5-eis-3 -azabicyclo [4.3.0]non-7- 20 en-3-yl] -ethyl-2 (3H) -benzimidazolon284.1-ß- [exo-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-7- 20 en-3-yl] ethyl-2 (3H) -benzimidazolone
285.1-ß- [exo-6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [4.3.0] non-7- en-3-yl] -ethyl-indolin-2-on285.1-ß- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7- en-3-yl] ethyl-indolin-2-one
25 286.3-ß-[exo-6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0]non-7-en-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion25 286.3-β- [exo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
287.5-ß- [exo-6-Phenyl-1, 5-cis-3 -azabicyclo [4.3.0]non-7-en-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon 30287.5-β- [exo-6-phenyl-1, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] - ethyl-2-methylamino-3, 6-dimethyl-4 ( 3H) pyrimidinone 30
288.3-ß- [exo-6-p-Fluor-phenyl-1, 5-eis-3-azabicyclo [4.3.0]non- 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion288.3-ß- [exo-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
289.5-ß- [exo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 35 3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H)pyrimidinon289.5-ß- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-35 3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
290.3 -ß-[exo-6-Phenyl-l,5-cis-3 -azabicyclo [4.3.0]non-3-yl] -ethyl- 2 , 4- (1H, 3H) -chinazolindion290.3 -ß- [exo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
40 291.5-ß- [exo-6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0] non-3-yl] -ethyl- 2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon40 291.5-ß- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) - pyrimidinone
292.6-ß- [exo-6-p-Fluor-phenyl-1, 5-cis-3 -azabicyclo [4.3.0]non- 3-yl] -ethy1-7-methyl-5H-thiazolo [3.2-a] -pyrimidin-5-on 45 293.1-ß- [exo-6-p-Fluor-phenyl-l , 5-cis-3 -azabicyclo [4.3.0] non- 3-yl] -ethyl-2 (3H) -benzimidazolon292.6-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl 1-7-methyl-5H-thiazolo [3.2-a] -pyrimidin-5-one 45 293.1-β- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (3H) -benzimidazolone
294.1-ß- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non- 5 3-yl] -ethyl-indolin-2-on294.1-β- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-5 3-yl] ethyl-indolin-2-one
295.1-ß- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0] non- 3-yl] -ethyl-2 (1H) -chinolon295.1-ß- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (1H) -quinolone
10 296.3 -ß-[exo-7-Phenyl-l,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] - ethyl-2 , 4- (1H, 3H) -chinazolindion10 296.3 -ß- [exo-7-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione
297.5-ß- [exo-7-Phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] - ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon 15297.5-ß- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 ( 3H) pyrimidinone 15
298.3-ß- [exo-7-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-298.3-ß- [exo-7-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-
8-en-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion8-en-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
299.5-ß- [exo-7-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0] non- 20 8-en-3-yl] -ethyl-2 -methylamino-3 , 6-dimethyl-4 (3H) - pyrimidinon299.5-β- [exo-7-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-20 8-en-3-yl] ethyl-2-methylamino-3, 6 -dimethyl-4 (3H) pyrimidinone
300.3-ß- [7-p-Fluor-phenyl-3 -azabicyclo [4.3.0]non-l-en-3-yl] - ethyl-2, 4- (1H, 3H) -chinazolindion 25300.3-ß- [7-p-fluorophenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] ethyl-2, 4- (1H, 3H) -quinazolinedione 25
301.5-ß- [7-Phenyl-3-azabicyclo[4.3.0] non-l-en-3-yl] -ethyl- 2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon301.5-ß- [7-phenyl-3-azabicyclo [4.3.0] non-l-en-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
302.5-ß- [7-p-Fluor-phenyl-3 -azabicyclo [4.3.0]non-l-en-3-yl] - 30 ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon302.5-ß- [7-p-fluorophenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] - 30 ethyl-2-methylamino-3, 6-dimethyl-4 (3H) - pyrimidinone
303.3-ß- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non- 3-yl] -ethyl-2, 4- (1H, 3H) -chinazolindion303.3-β- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) -quinazolinedione
35 304.5-ß- [exo-7-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) -pyrimidinon35 304.5-ß- [exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
305.1-ß- [exo-7-p-Fluor-phenyl-1, 5-eis-3-azabicyclo [4.3.0]non- 3-yl] -ethyl-2 (3H) -benzimidazolon 40305.1-ß- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (3H) -benzimidazolone 40
306.1-ß- [exo-7-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-306.1-ß- [exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-
3-yl] -ethyl-indolin-2-on3-yl] ethyl indolin-2-one
307.1-ß- [exo-7-p-Fluor-phenyl-l , 5-cis-3 -azabicyclo [4.3.0] on- 45 3-yl] -ethyl-2 (1H) -chinolon 308.3-ß- [6-p-Fluor-phenyl-l , 5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0]- occ-6-en-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion307.1-β- [exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] on- 45 3-yl] ethyl-2 (1H) -quinolone 308.3-ß- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - occ-6-en-3-yl] ethyl-2,4 - (1H, 3H) -quinazolinedione
309.5-ß- [6-p-Fluor-phenyl-l, 5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0]- 5 oct-6-en-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) - pyrimidinon309.5-ß- [6-p-fluorophenyl-l, 5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] - 5 oct-6-en-3-yl] ethyl-2- methylamino-3, 6-dimethyl-4 (3H) pyrimidinone
310.3-ß- [exo/endo-6-p-Fluor-phenyl-l, 5~cis-8-oxa-3 , 7-diazabi- cyclo[3.3.0] -octan-3-yl] -ethyl-2 , 4- (1H, 3H) -chinazolindion 10310.3-ß- [exo / endo-6-p-fluorophenyl-l, 5 ~ cis-8-oxa-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2 , 4- (1H, 3H) -quinazolinedione 10
311.5-ß- [exo/endo-6-p-Fluor-phenyl-l, 5-cis-8-oxa-3 , 7-diazabi- cyclo [3.3.0] -octan-3-yl] -ethyl-2-methylamino-3 , 6-dimethyl- 4 (3H) -pyrimidinon311.5-ß- [exo / endo-6-p-fluorophenyl-l, 5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2 -methylamino-3, 6-dimethyl-4 (3H) -pyrimidinone
15 312.1-ß- [6-p-Fluor-phenyl-l, 5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0]- oct-6-en-3-yl] -ethyl-indolin-2-on15 312.1-ß- [6-p-fluorophenyl-l, 5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] - oct-6-en-3-yl] ethyl indoline - 2-one
313.6-ß-[6-Phenyl-l, 5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0] - oct-6-en-3 -yl] -ethyl-7-methyl-5H-thiazolo [3 , 2-a] pyrimidin- 20 5-on313.6-β- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-20 5-one
314. N- (2-[exo-6-Phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] -ethyl) -4-fluor-benzamid314. N- (2- [exo-6-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -4-fluoro-benzamide
25 315. N- (2- [endo-6-Phenyl-7-methyl-l, 5-cis-3 , 7-diazabicyclo [3.3.0]- octan-3-yl] -ethyl) -4-fluor-benzamid25 315. N- (2- [endo-6-phenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] - octan-3-yl] ethyl) -4-fluoro- benzamide
316. N- (2- [exo-6-p-Fluor-phenyl-7-methyl-l, 5-cis-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl) -4-fluor-benzamid 30316. N- (2- [exo-6-p-fluorophenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl) - 4-fluoro-benzamide 30
317. N- (2- [exo-6-p-Trifluormethyl-phenyl-7-methyl-l, 5-cis-3 , 7- diazabicyclo [3.3.0] octan-3-yl] -ethyl) -benzamid317. N- (2- [exo-6-p-trifluoromethylphenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl) benzamide
318. N- (2- [exo-6-m-Chlor-phenyl-7-methyl-l, 5-cis-3, 7-diazabi- 35 cyclo [3.3.0] octan-3-yl] -ethyl) -benzamid318. N- (2- [exo-6-m-chlorophenyl-7-methyl-l, 5-cis-3, 7-diazabi-35 cyclo [3.3.0] octan-3-yl] ethyl) -benzamide
319. N- (2- [exo-6-p-Methoxy-phenyl-7-methyl-l, 5-cis-3, 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl) -4-chlor-benzamid319. N- (2- [exo-6-p-methoxyphenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl) - 4-chloro-benzamide
40 320. N- (2- [exo-6-Phenyl-7-methyl-1, 5-cis-3, 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl) -naphthalin-1-carbonamid40,320. N- (2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -naphthalene-1 -carbonamide
321.1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-7-methyl-l, 5- cis-3 , 7-diazabicyclo [3.3.0] octan-3-yl] -butan-1-on 45 322.1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-7-methyl-1, 5- cis-3 , 7-diazabicyclo [3.3.0] octan-3-yl] -butan-l-ol321.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-l, 5-cis-3, 7-diazabicyclo [3.3.0] octan-3-yl] - butan-1-one 45 322.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] - butan-l-ol
323. N- (2- [exo-6-p-Fluor-phenyl-l, 5-cis-3 -azabicyclo [4.3.0] 5 non-3-yl] -ethyl) -benzamid323. N- (2- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] 5 non-3-yl] ethyl) benzamide
324.1- (2-[exo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] -ethyl) -naphthalin324.1- (2- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene
10 325.1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-1, 5-cis-3- azabicyclo [4.3.0]non-3-yl] -butan-1-on10 325.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1, 5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1-one
326.1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-1, 5-cis-3- azabicyclo [4.3.0]non-3-yl] -butan-1-ol 15326.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1, 5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1-ol 15
327. N- (2- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-327. N- (2- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-
3-yl] -ethyl) -2- (N-methyl ) -amino-benzamid3-yl] ethyl) -2- (N-methyl) amino benzamide
328. N- (2- [exo-6-p-Fluor-phenyl-1 , 5-eis-3 -azabicyclo [4.3.0]non- 20 3-yl] -ethyl) -5-chlor-thien-2-yl-carbonamid328. N- (2- [exo-6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-20 3-yl] ethyl) -5-chlorothien-2 -yl-carbonamide
329. N- (2- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-329. N- (2- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-
3-yl] -ethyl) -inden-3-carbonamid3-yl] -ethyl) -inden-3-carbonamide
25 330. N- (2- [exo-6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0]non-3-yl] - ethyl) -4-fluor-benzamid25 330. N- (2- [exo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -4-fluoro-benzamide
331. N- (2-[exo-6-Phenyl-l, 5-cis-3-azabicyclo [4.3.0]non-3-yl] - ethyl) -naphthalin-1-carbonamid 30331. N- (2- [exo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -naphthalene-1-carbonamide 30
332.1- (2- [exo-6-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [4.3.0]non-332.1- (2- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-
7-en-3-yl] -ethyl) -naphthalin7-en-3-yl] ethyl) naphthalene
333.1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-1, 5-cis-3-aza- 35 bicyclo [4.3.0]non-7-en-3-yl] -butan-1-on333.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1, 5-cis-3-aza-35 bicyclo [4.3.0] non-7-en-3-yl] -butan-1-one
334. N- (2- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-334. N- (2- [exo-6-p-fluorophenyl-l, 5-eis-3 -azabicyclo [4.3.0] non-
7-en-3-y1] -ethyl) -benzamid7-en-3-y1] ethyl) benzamide
40 335. N- (2- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non- 7-en-3-yl] -ethyl) -inden-3-carbonamid40 335. N- (2- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -inden-3 -carbonamide
336. N- (2- [exo-6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non- 7-en-3-yl] -ethyl) -naphthalin-1-carbonamid 45 337. N- (2- [exo-6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0]non-7-en-3-yl] - ethyl) -4-fluor-benzamid336. N- (2- [exo-6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene-1- carbonamide 45 337. N- (2- [exo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -4-fluoro-benzamide
338. N- (2- [exo-6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0] non-7-en-3-yl] - 5 ethyl) -3-chlor-l-benzothien-2-yl-carbonamid338. N- (2- [exo-6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] -5-ethyl) -3-chloro-l-benzothiene -2-yl-carbonamide
339.1- (2- [6-p-Fluor-phenyl-l , 5-eis-3 -azabicyclo [4.3.0] non-6-en- 3-yl] -ethyl) -naphthalin339.1- (2- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) naphthalene
10 340.1- (4-Fluor-phenyl) -4- [6-p-fluor-phenyl-1 , 5-cis-3-azabicyclo- [4.3.0]non-6-en-3-yl] -butan-1-on10 340.1- (4-fluorophenyl) -4- [6-p-fluorophenyl-1, 5-cis-3-azabicyclo- [4.3.0] non-6-en-3-yl] butane 1-on
341.1- (4-Fluor-phenyl) -4- [ 6-p-fluor-phenyl-1, 5-cis-3-azabicyclo- [4.3.0]non-6-en-3-yl] -butan-l-ol 15341.1- (4-fluorophenyl) -4- [6-p-fluorophenyl-1, 5-cis-3-azabicyclo- [4.3.0] non-6-en-3-yl] butane-l -ol 15
342. N- (2- [6-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non-6-en-342. N- (2- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-6-en-
3-yl] -ethyl) -2- (N-methyl) -amino-benzamid3-yl] ethyl) -2- (N-methyl) amino benzamide
343. N- (2- [6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non-6-en- 20 3-yl] -ethyl) -5-chlor-thien-2-yl-carbonamid343. N- (2- [6-p-Fluoro-phenyl-1,5-ice-3-azabicyclo [4.3.0] non-6-en-20 3-yl] ethyl) -5-chlorothiene -2-yl-carbonamide
344. N- (2- [6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non-6-en-344. N- (2- [6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-6-en-
3-yl ] -ethyl ) -benzamid3-yl] ethyl) benzamide
25 345. N- (2- [6-Phenyl-l, 5-cis-3 -azabicyclo [4.3.0]non-6-en-3-yl] - ethyl) -3-chlor-l-benzothien-2-yl-carbonamid25,345. N- (2- [6-phenyl-l, 5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) -3-chloro-l-benzothien-2 -yl-carbonamide
346. N- (2- [6-p-Trifluormethyl-phenyl-1, 5-cis-3-azabicyclo [4.3.0]- non-6-en-3-yl] -ethyl) -naphthalin-1-carbonamid 30346. N- (2- [6-p-Trifluoromethylphenyl-1, 5-cis-3-azabicyclo [4.3.0] - non-6-en-3-yl] ethyl) -naphthalene-1-carbonamide 30th
347. N- (2- [6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0] non-6-en-347. N- (2- [6-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-6-en-
3-yl] -ethyl) -inden-3-carbonimid3-yl] -ethyl) -inden-3-carbonimide
348. N- (2- [6-p-Fluor-phenyl-1, 5-eis-3-azabicyclo [4.3.0]non-6-en- 35 3-yl] -ethyl) -napthalin-1-carbonamid348. N- (2- [6-p-Fluoro-phenyl-1,5-ice-3-azabicyclo [4.3.0] non-6-ene-35 3-yl] ethyl) napthalene-1-carbonamide
349.1- (2- [endo-6-p-Fluor-phenyl-1, 5-cis-3-azabicyclo [4.3.0]non- 3-yl] -ethyl) -naphthalin349.1- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene
40 350.1- (4-Fluor-phenyl) -4- [endo-6-p-Fluor-phenyl-l, 5-cis-3- azabicyclo [4.3.0]non-3-yl] -butan-1-on40 350.1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1-one
351.1- (4-Fluor-phenyl) -4- [endo-6-p-Fluor-phenyl-l, 5-cis-3- azabicyclo [4.3.0]non-3-yl] -butan-l-ol 45 352. N- (2- [endo-6-p-Fluor-phenyl-1, 5-cis-3 -azabicyclo [4.3.0]non- 3-yl] -2- (N-methyl) -amino-benzamid351.1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-l-ol 45 352. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] -2- (N-methyl) amino-benzamide
353. N- (2- [endo-6-p-Fluor-phenyl-1, 5-eis-3-azabicyclo [4.3.0]non- 5 3 -yl ] -ethyl ) -benzamid353. N- (2- [endo-6-p-fluorophenyl-1,5-ice-3-azabicyclo [4.3.0] non-5 3 -yl] ethyl) benzamide
354. N- (2- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 3-yl] -ethyl) -5-chlor-thien-2-yl-carbonamid354. N- (2- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -5-chlorothien-2- yl carbonamide
10 355. N- (2- [endo-6-Phenyl-1, 5-cis-3-azabicyclo [4.3.0]non-3-yl] - ethyl) -4-fluor-benzamid10,355. N- (2- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -4-fluoro-benzamide
356. N- (2- [endo-6-p-Trifluormethyl-phenyl-1, 5-cis-3-azabicyclo- [4.3.0]non-3-yl] -ethyl) -inden-3-carbonamid 15356. N- (2- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo- [4.3.0] non-3-yl] ethyl) -inden-3-carbonamide 15
357.2- (2- [endo-6-p-Fluor-phenyl-1, 5-cis-3-azabicyclo [4.3.0]non- 7-en-3-yl] -ethyl ) -naphthalin357.2- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene
358. N- (2- [endo-6-p-Fluor-phenyl-1, 5-cis-3-azabicyclo [4.3.0]non- 20 7-en-3-yl] -ethyl) -benzamid358. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-20 7-en-3-yl] ethyl) benzamide
359. N- (2- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 7-en-3-yl] -ethyl) -2- (N-methyl) amino-benzamid359. N- (2- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -2- (N -methyl) amino-benzamide
25 360. N- (2- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [4.3.0]non- 7-en-3-yl] -ethyl) -naphthalin-1-carbonamid25 360. N- (2- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -naphthalene-1 -carbonamide
361.1- (2- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0] non-361.1- (2- [exo-7-p-fluorophenyl-1, 5-eis-3 -azabicyclo [4.3.0] non-
8-en-3-yl] -ethyl) -naphthalin 308-en-3-yl] ethyl) naphthalene 30
362.1- (4-Fluor-phenyl) -4- [exo-7-p-fluor-phenyl-1, 5-eis-3- azabicyclo [4.3.0]non-8-en-3-yl] -butan-1-on362.1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-8-en-3-yl] butane 1-on
363. N- (2- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0] non- 35 8-en-3-yl] -ethyl) -benzamid363. N- (2- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-35 8-en-3-yl] ethyl) benzamide
364. N- (2- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non- 8-en-3-yl] -ethyl) -5-chlor-thien-2-yl-carbonamid364. N- (2- [exo-7-p-fluorophenyl-1, 5-eis-3 -azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -5-chloro thien-2-yl carbonamide
40 365. N- (2- [exo-7-p-Fluor-phenyl-l, 5-eis-3 -azabicyclo [4.3.0]non- 8-en-3-yl] -ethyl ) -3-chlor-l-benzothien-2-yl-carbonamid40 365. N- (2- [exo-7-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -3-chlorine -l-benzothien-2-yl-carbonamide
366. N- (2- [exo-7-Phenyl-1, 5-cis-3-azabicyclo [4.3.0]non-8-en- 3-yl] -ethyl) -inden-3-carbonamid 45 367. N- (2- [exo-7-Phenyl-1, 5-cis-3 -azabicyclo [4.3.0] non-8-en- 3-yl] -ethyl) -naphthalin-1-carbonamid366. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -inden-3-carbonamide 45 367. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -naphthalene-1-carbonamide
368.1- (2- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [4.3.0]non- 5 3-yl] -ethyl) -naphthalin368.1- (2- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-5 3-yl] ethyl) naphthalene
369.1- (4-Fluor-phenyl) -4- [exo-7-p-fluor-phenyl-1, 5-eis-3- azabicyclo [4.3.0]non-3-yl] -butan-1-on369.1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [4.3.0] non-3-yl] butan-1-one
10 370.1- (4-Fluor-phenyl) -4- [exo-7-p-fluor-phenyl-1, 5-cis-3- azabicyclo [4.3.0]non-3-yl] -butan-l-ol10 370.1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1, 5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1-ol
371. N- (2- [exo-7-p-Fluor-phenyl-1 , 5-eis-3 -azabicyclo [4.3.0]non- 3-yl ] -ethyl) -2 - (N-methyl ) -amino-benzamid 15371. N- (2- [exo-7-p-fluorophenyl-1, 5-eis-3 -azabicyclo [4.3.0] non-3-yl] ethyl) -2 - (N-methyl) - amino-benzamide 15
372. N- (2- [exo-7-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [4.3.0] non-372. N- (2- [exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-
3-yl] -ethyl) -benzamid3-yl] ethyl) benzamide
373. N- (2- [exo-7-p-Fluor-phenyl-l , 5-eis-3 -azabicyclo [4.3.0] non- 20 3-yl] -ethyl) -5-chlor-thien-2-yl-carbonamid373. N- (2- [exo-7-p-fluorophenyl-l, 5-eis-3-azabicyclo [4.3.0] non-20 3-yl] ethyl) -5-chlorothien-2 -yl-carbonamide
374. N- (2- [exo-7-p-Fluor-phenyl-1, 5-cis-3 -azabicyclo [4.3.0]non- 3-yl] -ethyl) -naphthalin-1-carbonamid374. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene-1-carbonamide
25 375. N- (2- [exo-7-p-Fluor-phenyl-l , 5-cis-3-azabicyclo [4.3.0] non- 3-yl] -ethyl) -inden-3-carbonamid25,375. N- (2- [exo-7-p-fluorophenyl-l, 5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -inden-3-carbonamide
376.1- (2- [6-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [3.3.0]oct-6-en- 3-yl] -ethyl) -naphthalin 30376.1- (2- [6-p-fluorophenyl-1, 5-eis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene 30
377.1- (4-Fluor-phenyl) -4- [ 6-p-fluor-phenyl-1, 5-cis-3-azabicycio- [3.3.0] oct-6-en-3-yl] -butan-1-on377.1- (4-fluorophenyl) -4- [6-p-fluorophenyl-1, 5-cis-3-azabicycio- [3.3.0] oct-6-en-3-yl] butan-1 -on
378. N- (2- [6-p-Fluor-phenyl-1, 5-eis-3-azabicyclo [3.3.0] oct-6-en- 35 3-yl] -ethyl) -benzamid,378. N- (2- [6-p-fluorophenyl-1, 5-eis-3-azabicyclo [3.3.0] oct-6-ene-35 3-yl] ethyl) benzamide,
379. N- (2- [6-p-Fluor-phenyl-l, 5-eis-3-azabicyclo [3.3.0] oct-6-en- 3-yl] -ethyl) -naphthalin-1-carbonamid379. N- (2- [6-p-fluorophenyl-l, 5-eis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) -naphthalene-1-carbonamide
40 380.1- (2- [exo-6-p-Fluor-phenyl-l, 5-cis-3 -azabicyclo [3.3.0] octan- 3-yl] -ethyl) -naphthalin40 380.1- (2- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene
381.1- (4-Fluor-phenyl) -4- [exo-6-p-fluor-phenyl-1, 5-cis-3- azabicyclo- [3.3.0] octan-3-yl] -butan-1-ol 45 382. N- (2- [exo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [3.3.0] octan- 3-yl ] -ethyl ) -benzamid381.1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1, 5-cis-3-azabicyclo- [3.3.0] octan-3-yl] butan-1-ol 45 382. N- (2- [exo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide
383. N- (2- [exo-6-Phenyl-l, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] - 5 ethyl) -naphthalin-1-carbonamid383. N- (2- [exo-6-phenyl-l, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] -5-ethyl) -naphthalene-1-carbonamide
384. N- (2- [exo-6-Phenyl-I, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] - ethyl) -inden-3-carbonamid384. N- (2- [exo-6-phenyl-I, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) -inden-3-carbonamide
10 385.1- (2- [endo-6-p-Fluor-phenyl-1, 5-cis-3-azabicyclo [3.3.0] octan- 3 -yl ] -ethyl ) -naphthalin10 385.1- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene
386.1- (4-Fluor-phenyl) -4- [endo-6-p-fluor-phenyl-1, 5-cis-3- azabicyclo- [3.3.0] octan-3-yl] -butan-1-on 15386.1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1, 5-cis-3-azabicyclo- [3.3.0] octan-3-yl] butan-1-one 15
387. N- (2- [endo-6-p-Fluor-phenyl-l, 5-cis-3-azabicyclo [3.3.0] oetan-387. N- (2- [endo-6-p-fluorophenyl-l, 5-cis-3-azabicyclo [3.3.0] oetane
3-yl] -ethyl) -benzamid3-yl] ethyl) benzamide
388. N- (2- [endo-6-Phenyl-1, 5-cis-3-azabicyclo [3.3.0] octan-3-yl] - 20 ethyl) -naphthalin-1-carbonamid388. N- (2- [endo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] - 20 ethyl) -naphthalene-1-carbonamide
389.1- (2- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [3.3.0] octan- 3-yl] -ethyl) -naphthalin389.1- (2- [exo-7-p-fluorophenyl-1, 5-eis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene
25 390. l-(4-Fluor-phenyl)-4-[exo-7-p-fluor-phenyl-l, 5-cis-3- azabicyclo [3.3.0] octan-3-yl] -butan-1-on25,390. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butane-1 -on
391. N- (2- [exo-7-p-Fluor-phenyl-1, 5-eis-3 -azabicyclo [3.3.0] oetan-391. N- (2- [exo-7-p-fluorophenyl-1, 5-eis-3 -azabicyclo [3.3.0] oetane
3-yl] -ethyl) -benzamid 303-yl] ethyl) benzamide 30
392. N- (2-[exo-7-Phenyl-l, 5-cis-3 -azabicyclo [3.3.0] octan-3-yl] - ethyl) -naphthalin-1-carbonamid392. N- (2- [exo-7-phenyl-l, 5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) -naphthalene-1-carbonamide
393. N- (2- [exo-7-Phenyl-1, 5-cis-3-azabicyclo [3.3.0] octan-3-yl] - 35 ethyl) -inden-3-carbonamid393. N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] - 35 ethyl) -inden-3-carbonamide
394. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.1.0]hexan-3-yl] - ethyl) -4-fluor-benzamid394. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) -4-fluorobenzamide
40 395. N- (2- [exo-6-Phenyl-3-azabicyclo[3.1.0]hexan-3-yl] -ethyl) - 5-chlor-thien-2-yl-carbonamid40 395. N- (2- [exo-6-phenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) - 5-chlorothien-2-yl-carbonamide
396. N- (2- [6, 6-Diphenyl-3 -azabicyclo [3.1.0]hexan-3-yl] -ethyl) - naphth-1-yl-carbonamid 45 397. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.1.0]hexan-3-yl] - ethyl) -3-chlor-l-benzochien-2-yl-carbonamid396. N- (2- [6, 6-Diphenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) - naphth-1-yl-carbonamide 45 397. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] ethyl) -3-chloro-l-benzochien-2-yl-carbonamide
398. N- (2- [exo-6-m-Chlor-phenyl-3-azabicyclo [3.1.0]hexan-3-yl] - 5 ethyl) -4-chlor-benzamid398. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] hexan-3-yl] -5-ethyl) -4-chloro-benzamide
399.1- (2- [6-p-Fluor-phenyl-l-5-cis-8-oxa-3,7-diazabicyclo[3.3.0] - oct-6-en-3-yl] -ethyl) -naphthalin399.1- (2- [6-p-fluorophenyl-l-5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene
10 400. N- (2- [6-p-Fluor-phenyl-l-5-cis-8-oxa-3,7-diazabicyclo[3.3.0]- oct-6-en-3 -yl] -ethyl ) -benzamid10,400. N- (2- [6-p-fluorophenyl-l-5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl ) -benzamide
401. N- (2- [6-p-Fluor-phenyl-l-5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0]- oct-6-en-3-yl] -ethyl) -naphthalin-1-carbonamid 15401. N- (2- [6-p-fluorophenyl-l-5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] - oct-6-en-3-yl] ethyl) -naphthalene-1-carbonamide 15
402. N- (2- [6-p-Fluor-phenyl-l-5-cis-8-oxa-3, 7-diazabicyclo [3.3.0]- oct-6-en-3-yl] -ethyl ) -inden-3-carbonamid402. N- (2- [6-p-fluorophenyl-l-5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] - oct-6-en-3-yl] ethyl) -inden-3-carbonamide
403.1- (2- [exo/endo-6-p-Fluor-phenyl-l-5-cis-8-oxa-3 , 7-diazabi- 20 cyclo [3.3.0] octan-3-yl] -ethyl) -naphthalin403.1- (2- [exo / endo-6-p-fluorophenyl-l-5-cis-8-oxa-3, 7-diazabi-20 cyclo [3.3.0] octan-3-yl] ethyl) -naphthalene
404. N- (2- [exo/endo-6-p-Fluor-phenyl-l-5-cis-8-oxa-3 , 7-diazabi- cyclo [3.3.0] octan-3-yl] -ethyl) -benzamid404. N- (2- [exo / endo-6-p-fluorophenyl-l-5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] octan-3-yl] ethyl ) -benzamide
25 405.1- (2- [6-Phenyl-l-5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0] oct- 6-en-3-yl] -ethyl) -naphthalin25 405.1- (2- [6-phenyl-l-5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene
406. N- (2- [6-Phenyl-l-5-cis-8-oxa-3 , 7-diazabicyclo [3.3.0] oct- 6-en-3-yl] -ethyl) -benzamid 30406. N- (2- [6-Phenyl-l-5-cis-8-oxa-3, 7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) benzamide 30
407. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0] -heptan-3-yl] ethyl) -benzosulfonamid407. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] -heptan-3-yl] ethyl) -benzosulfonamide
408. N- (2- [exo-6-Phenyl-3-azabicyclo [3.2.0] heptan-3-y1] -ethyl ) - 35 benzosulfonamid408. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-y1] ethyl) - 35 benzenesulfonamide
409. N- (2- [exo-6-p-Fluor-phenyl-3-azabicyclo- [3.2.0] -heptan- -3-yl] -ethyl) -N-methyl-benzosulfonamid409. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo- [3.2.0] -heptan- -3-yl] -ethyl) -N-methyl-benzosulfonamide
40 410. N-(2-[exo-6-(5-Chlor-thien-2-yl)-3-azabicyclo[3.2.0] - heptan-3-yl] -ethyl) -4-fluor-benzosulfonamid40 410. N- (2- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] - heptan-3-yl] ethyl) -4-fluoro-benzosulfonamide
411.3- [exo-6-p-Fluor-pheny1-3-azabicyclo [3.2.0]heptan-3-yl] -1- phenoxy-propan 45 412.2- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -1-p- fluor-phenoxy-ethan411.3- [exo-6-p-fluoro-pheny1-3-azabicyclo [3.2.0] heptan-3-yl] -1-phenoxypropane 45 412.2- [exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-fluoro-phenoxy-ethane
413.3- [exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -1- 5 (1-naphthyloxy) -propan413.3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1- 5 (1-naphthyloxy) propane
414.3- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] -1-p- t-buty1-phenoxy-propan414.3- [exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-t-buty1-phenoxypropane
10 415.3- [exo-6-p-Fluor-phenyl-3-azabicyclo- [3.2.0]heptan- -3-yl] -1-p-fluor-phenoxy-propan10 415.3- [exo-6-p-fluorophenyl-3-azabicyclo- [3.2.0] heptan- -3-yl] -1-p-fluorophenoxypropane
416. N- (2- [exo-6-p-Fluor-phenyi-3-azabicyclo- [3.2.0]heptan-416. N- (2- [exo-6-p-fluorophenyi-3-azabicyclo- [3.2.0] heptane
-3-yl] -ethyl) -thiobenzamid 15-3-yl] ethyl) thiobenzamide 15
417. N- (2- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0] hepta -3 -yl] - ethyl) -4-fluor-thiobenzamid417. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] hepta -3 -yl] ethyl) -4-fluorothiobenzamide
418. N- (2- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - 20 ethyl) -4-chlor-thiobenzamid418. N- (2- [exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 20 ethyl) -4-chloro-thiobenzamide
419.0- (2-[exo-6-p-Fluor-phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - ethyl ) -benzoat419.0- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzoate
25 420.0- (2-[exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl-4-fluor-benzoat25 420.0- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl 4-fluoro-benzoate
421. N- (2- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] ethyl) -lH-benzo [cd] indol-2-on421. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -lH-benzo [cd] indol-2-one
3030
422. N- (2- [exo-6-p-Chor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl) -lH-benzo [cd] indol-2-on422. N- (2- [exo-6-p-chloro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -IH-benzo [cd] indol-2-one
423. N- (2- [exo-6-m-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl) -lH-benzo [cd] indol-2-on423. N- (2- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl) -lH-benzo [cd] indol-2-one
424. N- (2 -[exo-6-m-Chlor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl ) -lH-benzo [cd] indol-2 -on424. N- (2 - [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -lH-benzo [cd] indol-2 -one
40 425.3, 3-Dimethyl-l-(2- [exo-6-p-fluor-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl) -indolinon-240 425.3, 3-dimethyl-1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolinone-2
426.3 , 3-Dimethyl-l- (2- [exo-6-p-chlor-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl) -indolinon-2 45 427.3 , 3-Dimethyl-l- (2- [exo-6-m-chlor-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl ) -indolinon-2426.3, 3-dimethyl-1- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolinone-2 45 427.3, 3-dimethyl-1- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolinone-2
428.1- (2- [exo-6-p-Chlor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - 5 ethyl) -3,3, 5-trimethyl-indolinon-2428.1- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 5 ethyl) -3,3, 5-trimethyl-indolinone-2
429.3 , 4-Dichlor-N- (2- [exo-6-p-nitro-phenyl-3 -azabicyclo [3.2.0] heptan-3 -yl] -ethyl ) -benzamid429.3, 4-dichloro-N- (2- [exo-6-p-nitro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide
10 430.2 , 5-Difluor-N- (2- [exo-6-p-fluor-phenyl-3 -azabicyclo [3.2.0] heptan-3-yl] -ethyl ) -benzamid10 430.2, 5-difluoro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide
431.2-Amino-N- (2- [exo-6-p-fluor-phenyl-3 -azabicyclo [3.2.0 ] heptan- 3-yl] -ethyl) -benzamid 15431.2-amino-N- (2- [exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide 15
432.2-Amino-N- (2- [exo-6-p-chlor-phenyl-3 -azabicyclo [3.2.0] heptan-432.2-amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptane
3 -yl ] -ethyl ) -benzamid3 -yl] -ethyl) -benzamide
433. N- (2- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - 20 ethyl) -2-methylamino-benzamid433. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 20 ethyl) -2-methylamino-benzamide
434. N- (2- [exo-6-p-Chlor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl) -2-methylamino-benzamid434. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -2-methylamino-benzamide
25 435.3-Amino-N- (2- [exo-6-p-chlor-phenyl-3 -azabicyclo [3.2.0]heptan- 3-yl] -ethyl) -benzamid25 435.3-Amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl) benzamide
436.4-Amino-N- (2- [exo-6-p-chlor-phenyl-3 -azabicyclo [3.2.0] heptan-436.4-amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptane
3 -yl ] -ethyl ) -benzamid 303 -yl] -ethyl) -benzamide 30
437. N- (2- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl) -thiophen-2-carbonsäureamid437. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide
438.5-Chlor-N- (2- [exo-6-p-fluor-phenyl-3 -azabicyclo [3.2.0] heptan- 35 3-yl] -ethyl) -thiophen-2-carbonsäureamid438.5-chloro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane-35 3-yl] ethyl) thiophene-2-carboxamide
439.5-Chlor-N- (2- [exo-6-p-chlor-phenyl-3 -azabicyclo [3.2.0] heptan- 3-yl] -ethyl) -thiophen-2-carbonsäureamid439.5-chloro-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl) thiophene-2-carboxamide
40 440.5-Chlor-N- (2- [exo-6- (5-chlor-2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] -ethyl) -thiophen-2-carbonsäureamid40 440.5-chloro-N- (2- [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide
441. N- (2-[exo-6-p-Fluor-phenyl-3-azabicyclo[3.2.0]heptan-3-yl] - ethyl) -benzo [b] furan-2-carbonsäureamid 45 442.3-Chlor-N- (2- [exo- 6-p-fluor-phenyl -3 -azabicyclo [3.2.0 ] heptan-441. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] furan-2-carboxamide 45 442.3-chloro-N- (2- [exo-6-p-fluorophenyl -3-azabicyclo [3.2.0] heptane
3-yl] -ethyl) -benzo [b] thiophen-2-carbonsäureamid3-yl] ethyl) benzo [b] thiophene-2-carboxamide
443.3-Chlor-N- (2- [exo-6-p-chlor-phenyl-3-azabicyclo [3.2.0]heptan- 5 3-yl] -ethyl) -benzo [b] thiophen-2-carbonsäureamid443.3-Chloro-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-5 3-yl] ethyl) benzo [b] thiophene-2-carboxamide
444.3-Chlor-N- (2- [exo-6-p-nitro-phenyl-3 -azabicyclo [3.2.0 ] heptan- 3-yl] -ethyl) -benzo [b] thiophen-2-carbonsäureamid444.3-Chloro-N- (2- [exo-6-p-nitro-phenyl-3-azabicyclo [3.2.0] heptan- 3-yl] ethyl) benzo [b] thiophene-2-carboxamide
10 445. N-(2- exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] ethyl -inden-3-carbonsäureamid10,445. N- (2-exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl -inden-3-carboxamide
446. N-(2- exo-6-p-Chlor-phenyl-3 -azabicyclo [3.2.0] heptan-3 -yl] ethyl -inden-3-carbonsäureamid446. N- (2-exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl -inden-3-carboxamide
1515
447. N-(2- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] ethyl -cyclopropan-carbonsäureamid447. N- (2-exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-cyclopropane-carboxamide
448. . N-(2- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl]448.. N- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl]
20 ethyl -cyclopentan-carbonsäureamid20 ethyl cyclopentane carboxamide
449. , N-(2- exo-6-p-Chlor-phenyl-3 -azabicyclo [3.2.0] heptan-3-yl] ethyl -cyclopentan-carbonsäureamid449., N- (2-exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-cyclopentane-carboxamide
25 450. . N- ( 2 - exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] ethyl -cyclohexan-carbonsäureamid25 450. N- (2 - exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-cyclohexane-carboxamide
451. . N-(2- exo- 6-p-Chlor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] ethyl -cyclohexan-carbonsäureamid451.. N- (2-exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-cyclohexane-carboxamide
3030
452. , N- ( 2 - exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] ethyl -naphthalin-1-carbonsäureamid452., N- (2 - exo-6-p-fluoro-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-naphthalene-1-carboxamide
453. . N-(2- exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl]453.. N- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl]
35 ethyl -indol-2-carbonsäureamid35 ethyl indole-2-carboxamide
454. N- (2- [exo-6-p-Chlor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] -e thyl ) -indol-3-carbonsäureamid454. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indole-3-carboxamide
40 455. exo-6-p-Fluorphenyl-3- [2- (1-naphthyl) -ethyl] -3 -azabicyclo [3.2.0] heptan40 455. exo-6-p-fluorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane
456. exo-6-p-Chlor-phenyl-3- [2- (1-naphthyl) -ethyl] -3-azabicyclo [3.2.0] heptan456. exo-6-p-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane
45 457. exo-6-m-Chlor-phenyl-3- [2- (1-naphthyl) -ethyl] -3 -azabicyclo [3.2.0]heptan45 457. exo-6-m-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane
458. exo-6- (5-Chlor-2-thienyl) -3- [2- ( 1-naphthyl ) -ethyl] -3-azabi- 5 cyclo [3.2.0] heptan458. exo-6- (5-chloro-2-thienyl) -3- [2- (1-naphthyl) ethyl] -3-azabi-5 cyclo [3.2.0] heptane
459. exo- 6-p-Fluor-phenyl-3- [2- (2 -naphthyl) -ethyl] -3 -azabicyclo [3.2.0]heptan459. exo-6-p-fluorophenyl-3- [2- (2-naphthyl) ethyl] -3 -azabicyclo [3.2.0] heptane
10 460. exo-6-p-Fluor-phenyl-3- [1-naphthyl-methyl] -3-azabicyclo [3.2.0]heptan10,460. Exo-6-p-fluorophenyl-3- [1-naphthylmethyl] -3-azabicyclo [3.2.0] heptane
461. exo-6-p-Fluor-phenyl-3- [2-naphthyl-methyl] -3 -azabicyclo [3.2.0]heptan 15461. exo-6-p-fluorophenyl-3- [2-naphthyl-methyl] -3-azabicyclo [3.2.0] heptane 15
462.4- ( 6 -p-Fluor-pheny1-3 -azabicyclo [3.2.0]heptan-3-yl) -1- (thio- phen-2-yl) -butan-1-on462.4- (6-p-fluoropheny1-3 azabicyclo [3.2.0] heptan-3-yl) -1- (thiophen-2-yl) butan-1-one
463.4- ( 6-p-Chlor-phenyl-3 -azabicyclo [3.2.0] heptan-3-yl) -1- (thio- 20 phen-2-yl) -butan-1-on463.4- (6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl) -1- (thio-20 phen-2-yl) butan-1-one
464. N-(2- exo-6-p-Fluor-pheny1-3 -azabicyclo- [3.2.0] heptan-3-yl] ethyl -4-phenyl-pyrrolidinon-2464. N- (2-exo-6-p-fluoro-pheny1-3 -azabicyclo- [3.2.0] heptan-3-yl] ethyl -4-phenyl-pyrrolidinon-2
25 465. N-(2- exo-6-p-Fluor-phenyl-3-azabicycio- [3.2.0]heptan-3-yl] ethyl -benzoxazolinon-225,465. N- (2-exo-6-p-fluorophenyl-3-azabicycio- [3.2.0] heptan-3-yl] ethyl-benzoxazolinone-2
466. N-(2- exo-6-p-Fiuor-phenyl-3-azabicyclo- [3.2.0]heptan-3-yl] ethyl -isoindolinon466. N- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl isindolinone
3030
467. l-(2- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl -indazol467. l- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl indazole
468. l-(2- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - 35 ethyl -1, 8-naphthalinsultam468. l- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] - 35 ethyl -1, 8-naphthalenesultam
469.4-(2- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl -1, 4-benzoxazin-3-on469.4- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl -1,4-benzoxazin-3-one
40 470. l-(2- exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl -chinoxalin-2 ( 1H) -on40,470. 1- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-quinoxalin-2 (1H) -one
471. l-(2- exo-6-p-Fluor-phenyl-3-azabicyclo [3.2.0]heptan-3-yl] - ethyl -indolinon-2 45 472.1- (2- [exo-6-p-Fluor-phenyl-3 -azabicyclo [3.2.0]heptan-3-yl] - ethyl) -spiro [cyclopropan-1 ' , 3-indolinon-2]471. l- (2-exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindolinone-2 45 472.1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -spiro [cyclopropan-1 ', 3-indolinone-2]
473.3 , 6-Dimethyl-2-methylamino-5- [2- (exo-6- (2-naphthyl ) -3-aza- 5 bicyclo [3.2.0]heptan-3-yl) -ethyl] -3H-pyrimidin-4-on473.3, 6-Dimethyl-2-methylamino-5- [2- (exo-6- (2-naphthyl) -3-aza-5 bicyclo [3.2.0] heptan-3-yl) ethyl] -3H-pyrimidine -4-on
474.3 , 6-Dimethyl-2-methylamino-5- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0]heptan-3-yl) -ethyl] -3H-pyrimidin-4-on474.3, 6-dimethyl-2-methylamino-5- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3H-pyrimidin-4- on
10 475.3, 6-Dimethyl-2-methylamino-5- [2- (exo-6- (5-chlor- 1-naphthyl )- 3 -azabicyclo [3.2.0] heptan-3-yl) -ethyl] -3H-pyrimidin-4-on10 475.3, 6-dimethyl-2-methylamino-5- [2- (exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3H -pyrimidin-4-one
476.3 , 6-Dimethyl-2-methylamino-5- [2- (exo-6- ( 6-chlor-2-naph- thyl) -3-azabicyclo [3.2.0] eptan-3-yl) -ethyl] -3H-pyrimi- 15 din-4-on476.3, 6-dimethyl-2-methylamino-5- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] eptan-3-yl) ethyl] - 3H-pyrimi- 15 din-4-one
477.3 , 6-Dimethyl-2-me hylamino-5- [2- (exo-6- ( 9-phenanthryl) -3- azabicyclo [3.2.0]heptan-3-yi ) -ethyl] -3H-pyrimidin-4-on477.3, 6-dimethyl-2-methylamino-5- [2- (exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptan-3-yi) ethyl] -3H-pyrimidin-4 -on
20 478.7-Methyl-6-[2-(exo-6-(2-naphthyl)-3-azabicyclo[3.2.0]- heptan-3-yl) -ethyl) -5H-thiazolo [3 , 2-a]pyrimidin-5-on20 478.7-methyl-6- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - heptan-3-yl) -ethyl) -5H-thiazolo [3, 2-a] pyrimidin-5-one
479.3- [2- (exo-6- (2-Napthyl) -3-azabicyclo [3.2.0]heptan-3-yl) - ethyl] -1H, 3H-chinazolin-2 , 4-dion 25479.3- [2- (exo-6- (2-Napthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazolin-2, 4-dione 25
480.3- [2- (exo-6- ( 1-Nap thyl) -3 -azabicyclo [3.2.0] eptan-3-yl) - ethyl] -1H, 3H-chinazolin-2 , 4-dion480.3- [2- (exo-6- (1-Napthyl) -3 -azabicyclo [3.2.0] eptan-3-yl) ethyl] -1H, 3H-quinazolin-2, 4-dione
481.6-Fluor-3- [2- (exo-6- (1-naphthyl) -3 -azabicyclo [3.2.0] heptan- 30 3-yl) -ethyl] -1H, 3H-chinazolin-2 , 4-dion481.6-Fluoro-3- [2- (exo-6- (1-naphthyl) -3 -azabicyclo [3.2.0] heptan- 30 3-yl) -ethyl] -1H, 3H-quinazolin-2, 4-dione
482.3- [2-(exo-6- (5-chlor-2-naphthyl) -3-azabicyclo [3.2.0]heptan- 3-yl) -ethyl] -1H, 3H-chinazolin-2 , 4-dion482.3- [2- (exo-6- (5-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan- 3-yl) ethyl] -1H, 3H-quinazolin-2, 4-dione
35 483.3- [2- (exo-6- (1-Naph hyl) -3-azabicyclo [3.2.0] -heptan-3-yl) - ethyl] -2-methyl-4H-pyrido [1.2-a] -pyrimidin-4-on35 483.3- [2- (exo-6- (1-Naphyl) -3-azabicyclo [3.2.0] -heptan-3-yl) - ethyl] -2-methyl-4H-pyrido [1.2-a] - pyrimidin-4-one
484.1- [2-(exo-6- (2-Naphthyl) -3-azabicyclo [3.2.0]heptan-3-yl) - ethyl] -2 (1H) -chinolon484.1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2 (1H) -quinolone
4040
485.1- [2-(exo-6- (2 -Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - ethyl] -indolin-2-on485.1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] indolin-2-one
486.1- [2 -(exo-6-( 1-Naphthyl) -3 -azabicyclo [3.2.0] -heptan-3-yl) - 45 ethyl] -2 (3H) -benzimidazolon 487.1- [2- (exo-6- (1-Naphthyl) -3-azabicyclo [3.2.0] -heptan-3-yl ) - ethyl] -3-methyl-2 (3H) -benzimidazolon486.1- [2 - (exo-6- (1-naphthyl) -3 -azabicyclo [3.2.0] -heptan-3-yl) - 45 ethyl] -2 (3H) -benzimidazolone 487.1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] -heptan-3-yl) ethyl] -3-methyl-2 (3H) -benzimidazolone
488. N- [2-(exo-6-(l-Naphthyl) -3-azabicyclo [3.2.0]heptan-3-yl) - 5 ethyl] -benzamid488. N- [2- (exo-6- (l-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) -5-ethyl] -benzamide
489. N- [2- (exo-6- (2-Naphthyl) -3-azabicyclo [3.2.0]heptan-3-yl) - ethyl] -benzamid489. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide
10 490. N- [2-(exo-6-(5-Chlor-l-naphthyl)-3-azabicyclo-[3.2.0] heptan-3-yl) ethyl] -benzamid10 490. N- [2- (exo-6- (5-chloro-l-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide
491.3- [2-(l-Naphthyl)ethyl]-exo-6- (1-naphthyl) -3-azabicyclo- [3.2.0]heptan491.3- [2- (l-naphthyl) ethyl] -exo-6- (1-naphthyl) -3-azabicyclo- [3.2.0] heptane
1515
492.3- [2- (1-Naphthyl) ethyl] -exo-6- (2 -naphthyl) -3-azabi- cyclo [3.2.0] heptan492.3- [2- (1-naphthyl) ethyl] -exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptane
493.1- [2- (exo-6- (1-Naphthyl) -3-azabicyclo [3.2.0]heptan- 20 3-yl) ethyl] -lH-benzo [cd] indol-2-on493.1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan- 20 3-yl) ethyl] -lH-benzo [cd] indol-2-one
494.1- [2- (exo-6- (2 -Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - ethyl] -lH-benzo [cd) indol-2-on494.1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -lH-benzo [cd) indol-2-one
25 495.3, 3-Dimethyl-l-[2-(exo-6-(l-naphthyl)-3-azabicyclo- [3.2.0]heptan-3-yl) ethyl] -1, 3-dihydroindol-2-on25 495.3, 3-dimethyl-l- [2- (exo-6- (l-naphthyl) -3-azabicyclo- [3.2.0] heptan-3-yl) ethyl] -1, 3-dihydroindol-2-one
496.3 , 3-Dimethyl-l- [2- (exo-6- (2-naphthyl) -3-azabicyclo- [3.2.0 ]heptan-3-yl) ethyl ]-l, 3-dihydroindol-2-on 30496.3, 3-Dimethyl-l- [2- (exo-6- (2-naphthyl) -3-azabicyclo- [3.2.0] heptan-3-yl) ethyl] -l, 3-dihydroindol-2-one 30
497.3, 3-Dimethyl-l- [2- (exo-6- ( 6-chlor-2-naphthyl ) -3-azabicyclo [3.2.0]heptan-3-yl) ethyl] -1 , 3-dihydroindol-2-on497.3, 3-dimethyl-1- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1, 3-dihydroindol-2 -on
498.5-Chlor-N- [2-(exo-6- (1-naphthyl) -3 -azabicyclo- [3.2.0]- 35 heptan-3-yl) ethyl] -2-thiophencarbonsäureamid498.5-chloro-N- [2- (exo-6- (1-naphthyl) -3 -azabicyclo- [3.2.0] - 35 heptan-3-yl) ethyl] -2-thiophenecarboxamide
499.5-Chlor-N- [2- (exo-6- (2-Naphthyl) -3 -azabicyclo [3.2.0] - heptan-3-yl) ethyl] -2-thiophencarbonsäureamid499.5-chloro-N- [2- (exo-6- (2-naphthyl) -3 -azabicyclo [3.2.0] - heptan-3-yl) ethyl] -2-thiophenecarboxamide
40 500. N- [2 -(exo-6- (1-Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - ethyl] -4-fluor-benzamid40,500. N- [2 - (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-fluoro-benzamide
501. N- [2- (exo-6- (2-Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - ethyl] -4-nitro-benzamid 45 502 . N- [2 - ( exo-6- ( 6 -Chlor-2 -naphthyl ) -3 -azabicyclo [ 3 . 2 . 0] - heptan-3-yl) -ethyl] -benzamid501. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-nitro-benzamide 45 502. N- [2 - (exo-6- (6-Chloro-2-naphthyl) -3 -azabicyclo [3. 2. 0] - heptan-3-yl) ethyl] benzamide
503. N- [2-(exo-6- (1-Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - 5 ethyl] -4-methoxy-benzamid503. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) -5-ethyl] -4-methoxy-benzamide
504. N- [2- (exo-6- (2 -Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - ethyl] -4-hydroxy-benzamid504. N- [2- (exo-6- (2-naphthyl) -3 -azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-hydroxy-benzamide
10 505. N- [2-(exo-6-(l-Naphthyl)-3-azabicyclo[3.2.0]heptan-3-yl) - ethyl] -3 , -dichlor-benzamid10 505. N- [2- (exo-6- (l-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3, -dichlorobenzamide
506. N- [2-(exo-6- (1-Naphthyl) -3-azabicyclo [3.2.0]heptan-3-yl) - ethyl] -naphthalin-1-carbonamid506. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -naphthalene-1-carbonamide
1515
507. N- [2-(exo-6- (2-Naphthyl) -3-azabicyclo [3.2.0]heptan-3-yl) - ethyl] -naphthalin-1-carbonamid507. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -naphthalene-1-carbonamide
508. N- [2- (exo-6- ( 9-Phenanthryl) -3-azabicyclo [3.2.0]heptan- 20 3-yl) -ethyl] -benzamid508. N- [2- (exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptan- 20 3-yl) ethyl] benzamide
509.1- [2-(exo-6- ( 6-Chlor-2 -naphthyl) -3 -azabicyclo-509.1- [2- (exo-6- (6-chloro-2-naphthyl) -3 -azabicyclo-
[3.2.0]heptan-3-yl) -ethyl] -lH-benzo [cd] indol-2-on[3.2.0] heptan-3-yl) ethyl] -IH-benzo [cd] indol-2-one
25 510.1- [2- (exo-6-(9-Phenanthryl)-3-azabicyclo-25 510.1- [2- (exo-6- (9-phenanthryl) -3-azabicyclo-
[3.2.0]heptan-3-yl) -ethyl] -lH-benzo [cd] indol-2-on[3.2.0] heptan-3-yl) ethyl] -IH-benzo [cd] indol-2-one
511. N- [2-(exo-6- (1-Naphthyl) -3-azabicyclo [3. .0]heptan-3-yl) - ethyl] -isoindolinon511. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3. .0] heptan-3-yl) ethyl] isoindolinone
3030
512. N- [2-(exo-6- (2-Naphthyl) -3 -azabicyclo [3.2.0]heptan-3-yl) - ethyl] -isoindolinon512. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] isoindolinone
513. (+ )-(lS, 5R, 6S)-exo-l- [2- [6- (4-Chlor-phenyl) -3-azabicyclo- 35 [3.2.0]heptan-3-yl] -ethyl] -3-methyl-2H-l, 3-dihydro-benz- imidazol-2-on513. (+) - (IS, 5R, 6S) -exo-l- [2- [6- (4-chlorophenyl) -3-azabicyclo-35 [3.2.0] heptan-3-yl] ethyl ] -3-methyl-2H-l, 3-dihydro-benzimidazol-2-one
514. (+)- (IS, 5R, 6S) -exo-l-[2- [6- (4-Chlor-phenyl) -3-azabicyclo- [3.2.0]heptan-3-yl] -ethyl] -3-ethyl-2H-l, 3-dihydro-benz-514. (+) - (IS, 5R, 6S) -exo-l- [2- [6- (4-chlorophenyl) -3-azabicyclo- [3.2.0] heptan-3-yl] ethyl] -3-ethyl-2H-l, 3-dihydro-benz-
40 imidazol-2-on40 imidazol-2-one
515. (+)- (IS, 5R, 6S) -exo-1- [2- [6- (4-Chlor-phenyl) -3-azabicyclo- [3.2.0]heptan-3-yl] -ethyl] -3-n-propyl-2H-l, 3-dihydro-benz- imidazol-2-on515. (+) - (IS, 5R, 6S) -exo-1- [2- [6- (4-chlorophenyl) -3-azabicyclo- [3.2.0] heptan-3-yl] ethyl] -3-n-propyl-2H-1,3-dihydro-benzimidazol-2-one
45 516. (4-)- (IS, 5R, 6S) -exo-2-[2- [6- (4-Chlor-phenyl ) -3-azabicyclo-45 516. (4 -) - (IS, 5R, 6S) -exo-2- [2- [6- (4-chlorophenyl) -3-azabicyclo-
[3.2.0]heptan-3-yl] -ethyl] -3 , 3-dimethyl-2 , 3-dihydro-l, 2-benz- isothiazol-1, 1-dioxid[3.2.0] heptan-3-yl] ethyl] -3, 3-dimethyl-2,3-dihydro-1,2-benzisothiazol-1,1-dioxide
5 517. (4-) -(IS, 5R,6S)-exo-2-[2- [6- ( 4-Chlor-phenyl) -3-azabicyclo- [3.2.0]heptan-3-yl] -ethyl] -2 , 3-dihydro-l, 2-benzisothiazol- 1, 1-dioxid5,517. (4-) - (IS, 5R, 6S) -exo-2- [2- [6- (4-chlorophenyl) -3-azabicyclo- [3.2.0] heptan-3-yl] - ethyl] -2, 3-dihydro-l, 2-benzisothiazole-1, 1-dioxide
518. (4-)- (IS, 5R, 6S) -exo-2- [2- [6- ( 4-Fluor-phenyl ) -3-azabicyclo- 0 [3.2.0]heptan-3-yl] -ethyl] -3 , 3-dimethyl-2 , 3-dihydro-l, 2-benz- isothiazol-1, 1-dioxid518. (4 -) - (IS, 5R, 6S) -exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo- 0 [3.2.0] heptan-3-yl] - ethyl] -3, 3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide
519. (4-) - (IS, 5R, 6S) -exo-2-[2- [6- (4-Fluor-phenyl) -3-azabicyclo-519. (4-) - (IS, 5R, 6S) -exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo-
[3.2.0]heptan-3-yl] -ethyl] -3 , 3-diethyl-2 , 3-dihydro-l, 2-benz- 5 isothiazol-1, 1-dioxid[3.2.0] heptan-3-yl] ethyl] -3, 3-diethyl-2, 3-dihydro-l, 2-benz-5-isothiazol-1, 1-dioxide
520. (4-)- (IS, 5R, 6S) -exo-2-[2- [6- (4-Fluor-phenyl ) -3-azabicycio- [3.2.0]heptan-3-yl] -ethyl] -2 , 3-dihydro-l, 2-benzisothiazol- 1, 1-dioxid 0520. (4 -) - (IS, 5R, 6S) -exo-2- [2- [6- (4-fluorophenyl) -3-azabicycio- [3.2.0] heptan-3-yl] ethyl ] -2, 3-dihydro-1,2-benzisothiazole-1,1-dioxide 0
55
00
55
00
5 5

Claims

Patentansprüche claims
1. Verwendung von N-substituierten 3 -Azabicycloalkan-Derivaten der Formel I1. Use of N-substituted 3-azabicycloalkane derivatives of the formula I.
worinwherein
B ein 4-, 5- oder 6-Ring ist, der eine Doppelbindung enthalten kann, ist,B is a 4-, 5- or 6-ring which can contain a double bond,
R1 eine gegebenenfalls durch Halogenatome, Cι_4-Alkyl,R 1 is optionally a halogen atom, C 4 alkyl,
Trifluormethyl- , Hydroxy-, Cι_ -Alkoxy- , Amino-, Mono- methylamino-, Dimethylamino- , Cyano- oder Nitrogruppen mono- oder disubstituierte Phenyl-, Naphthyl-, Phen- anthryl-, oder Thienylgruppe bedeutet,Trifluoromethyl, hydroxy, C 1 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups means mono- or disubstituted phenyl, naphthyl, phenanthryl or thienyl group,
n die Zahl 0, 1, 2, 3 oder 4 bedeutet undn represents the number 0, 1, 2, 3 or 4 and
R2 eine gegebenenfalls durch ein oder zwei Halogenatome substituierte Naphthylgruppe oder einen der folgenden Reste bedeutet:R 2 denotes a naphthyl group which is optionally substituted by one or two halogen atoms or one of the following radicals:
worin wherein
R3 ein Wasserstoffatom, eine Hydroxygruppe oder einen gegebenenfalls durch ein Fluor-, Chlor- oder Bromatom substituierten Phenylrest darstellt,R 3 represents a hydrogen atom, a hydroxyl group or a phenyl radical optionally substituted by a fluorine, chlorine or bromine atom,
R4 ein Wasserstoffatom bedeutet oderR 4 represents a hydrogen atom or
R3 und R4 zusammen ein Sauerstoffatom darstellen,R 3 and R 4 together represent an oxygen atom,
R5 eine gegebenenfalls durch Fluor-, Chlor- oder Bromatome oder Hydroxy-, Nitro-, Amino-, Cι_4-Alkanoylamino-, Cι-4-Alkylamino-, Cι-4-Alkyl- oder Methoxygruppen mono- oder disubstituierte Phenyl-, Naphthyl- oder Thienyl- gruppe bedeutet,R 5 is a phenyl group which is mono- or disubstituted, optionally by fluorine, chlorine or bromine atoms or hydroxyl, nitro, amino, Cι_ 4 alkanoylamino, Cι- 4 alkylamino, Cι- 4 alkyl or methoxy groups, Naphthyl or thienyl group means
R6 ein Wasserstoffatom oder eine Methylgruppe darstellt,R 6 represents a hydrogen atom or a methyl group,
R7 eine durch Fluor-, Chlor- oder Bromatome oder durch Cι_4-Alkyl-, Hydroxy-, Methoxy-, Nitro-, Cyano-, Tri- fluormethyl-, Amino- oder Di-Cι_4-Alkylaminogruppen mono- oder disubstituierte Phenyl-, Naphthyl-, Benzofuryl-, Benzothienyl- , Thienyl-, Indolyl-, N-Methylindolyl- oder Indenylgruppe oder eine C_ -Cycloalkylgruppe bedeutet, R8 ein Wasserstoffatom oder ein Fluor- oder Chloratom oder eine Cι_4-Alkyl-, Methoxy- oder Aminogruppe ist,R 7 is a phenyl mono- or disubstituted by fluorine, chlorine or bromine atoms or by C 4 alkyl, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C 4 alkylamino groups -, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group or a C_ -cycloalkyl group, R 8 is a hydrogen atom or a fluorine or chlorine atom or a C 4 alkyl, methoxy or amino group,
R9 ein Wasserstoffatom oder eine Methylgruppe darstellt undR 9 represents a hydrogen atom or a methyl group and
R10 ein Wasserstoffatom oder eine Methylgruppe oderR 10 represents a hydrogen atom or a methyl group or
R9 und R10 zusammen mit dem Ring-Kohlenstoffatom einen Spiro- cyclopropanring darstellen,R 9 and R 10 together with the ring carbon atom represent a spirocyclopropane ring,
R11 ein Wasserstoffatom, eine Hydroxy-, Cι-C4~Alkyl- oder Cι~C4-Alkoxygruppe ist, oder zusammen mit dem benachbarten Kohlenstoffatom eine C=0- oder C=S-Gruppe bedeutet,R 11 is a hydrogen atom, a hydroxy, Cι-C ~ 4 alkyl or Cι ~ C 4 alkoxy group, or together with the adjacent carbon atom is a C = 0 or C = S group,
X und Y Kohlenstoffatome, CH-, CH2-, NH- oder Cι-C-Alkyl- N-Gruppen oder Stickstoffatome bedeuten,X and Y represent carbon atoms, CH, CH 2 , NH or -CC alkyl N groups or nitrogen atoms,
Z eine direkte Bindung, eine CO-Gruppe, CS-Gruppe oder eine CH- bzw. CH2-Gruppe, in denen ein Wasserstoffatom gegen eine Hydroxy-, Amino- oder Cι-C4~Alkoxygruppe oder ein Halogenatom ausgetauscht sein kann, darstellt, undZ is a direct bond, a CO group, CS group or a CH or CH 2 group, in which a hydrogen atom can be replaced by a hydroxyl, amino or -CC 4 ~ alkoxy group or a halogen atom , and
A ein Wasserstoffatom, eine Hydroxy-, Amino-, Mercapto-, Cι-C-Alkylamino-, Di-Cι-C-alkylamino-, Cι-C4-Alkylthio- oder Cι_-C4-Alkoxygruppe oder zusammen mit dem benachbarten Kohlenstoffatom eine C=0-Gruppe bedeutet, oderA is a hydrogen atom, a hydroxyl, amino, mercapto, C 1 -C 4 -alkylamino, di-C 1 -C 4 -alkylamino, C 1 -C 4 alkylthio or C 1 -C 4 alkoxy group or together with the adjacent carbon atom means a C = 0 group, or
A eine mit Y verknüpfte C3-C4-Alkylengruppe bedeutet, die eine oder zwei nicht kumulierte Doppelbindungen enthalten kann und in der eine CH- oder CH2-Gruppe durch ein Stickstoff- oder Schwefelatom oder eine NH- oder N-CH-Gruppe ersetzt sein kann und wobei der Ring entweder durch ein Fluor- oder Chloratom oder eine Methyl-, Methoxy-, Nitro- oder Aminogruppe monosubstituiert oder im Fall einesA represents a C 3 -C 4 alkylene group linked to Y which may contain one or two non-cumulative double bonds and in which a CH or CH 2 group is represented by a nitrogen or sulfur atom or an NH or N-CH group can be replaced and wherein the ring is either monosubstituted by a fluorine or chlorine atom or a methyl, methoxy, nitro or amino group or in the case of one
Benzolrings dieser durch Fluor- oder Chloratome oder Methyl-, Trifluormethyl-, Nitro-, Hydroxy-, Methoxy-, Amino-, Monomethyl- oder Dimethylaminogruppen mono-, di- oder trisubstituiert sein kann,Benzene rings which can be mono-, di- or tri-substituted by fluorine or chlorine atoms or methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl or dimethylamino groups,
und worin der X, Y und Z enthaltende Ring am Stickstoffatom Nr. 1 eine Cι-C4-Alkyl-, Allyl- oder Benzylgruppe tragen und 1 bis 3 nicht kumulierte Doppelbindungen enthalten kann, und deren Salze mit physiologisch verträglichen Säurenand in which the ring containing X, Y and Z on nitrogen atom No. 1 has a C 1 -C 4 -alkyl, allyl or benzyl group and can contain 1 to 3 non-cumulative double bonds, and their salts with physiologically acceptable acids
zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen des zentralen Nervensystems..for the manufacture of medicinal products for the treatment of diseases of the central nervous system.
2. Verwendung nach Anspruch 1 zur Herstellung von Arzneimitteln zur Behandlung von Suchterkrankungen.2. Use according to claim 1 for the manufacture of medicaments for the treatment of addictions.
3. Verwendung nach Anspruch 1 oder 2 zur Herstellung von Arznei- mittein zur Bekämpfung der Cocain-Sucht .3. Use according to claim 1 or 2 for the manufacture of medicaments for combating cocaine addiction.
4. Verwendung nach Anspruch 1 oder 2 zur Herstellung con Arzneimitteln zur Bekämpfung der Sucht nach Amphetaminen und amphetaminartigen Substanzen. 4. Use according to claim 1 or 2 for the production of medicaments for combating addiction to amphetamines and amphetamine-like substances.
EP99960974A 1998-11-24 1999-11-12 Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system Withdrawn EP1133293A1 (en)

Applications Claiming Priority (3)

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DE19854147 1998-11-24
DE19854147A DE19854147A1 (en) 1998-11-24 1998-11-24 Control of cocaine addiction comprises administration of N-substituted azabicycloalkane derivative
PCT/EP1999/008734 WO2000030639A1 (en) 1998-11-24 1999-11-12 Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system

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DE4341403A1 (en) * 1993-12-04 1995-06-08 Basf Ag N-substituted 3-azabicycloalkane derivatives, their preparation and use
DE4427647A1 (en) * 1994-08-04 1996-02-08 Basf Ag N-substituted azabicycloheptane derivatives, their preparation and use

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AR021502A1 (en) 2002-07-24
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IL143181A0 (en) 2002-04-21
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HUP0104416A3 (en) 2002-11-28
HRP20010472A2 (en) 2003-04-30
AU1775300A (en) 2000-06-13
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NO20012538D0 (en) 2001-05-23
BR9915589A (en) 2001-08-07
CZ20011796A3 (en) 2002-05-15
WO2000030639A1 (en) 2000-06-02
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