KR20010080535A - Use of N-Substituted Azabicycloalkane Derivatives for Treating Diseases of the Central Nervous System - Google Patents

Use of N-Substituted Azabicycloalkane Derivatives for Treating Diseases of the Central Nervous System Download PDF

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KR20010080535A
KR20010080535A KR1020017006445A KR20017006445A KR20010080535A KR 20010080535 A KR20010080535 A KR 20010080535A KR 1020017006445 A KR1020017006445 A KR 1020017006445A KR 20017006445 A KR20017006445 A KR 20017006445A KR 20010080535 A KR20010080535 A KR 20010080535A
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azabicyclo
exo
ethyl
fluorophenyl
heptan
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게르트 스타이너
라이너 문샤우어
게르하르트 그로쓰
마르틴 트라우트
릴리아네 운거
한스-위르겐 테셴도르프
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스타르크, 카르크
바스프 악티엔게젤샤프트
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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Abstract

본 발명은 중추신경계의 중독성 질환 및 다른 질환을 치료하기 위한, 하기 화학식 Ⅰ의 N-치환 3-아자비시클로알칸 유도체의 용도에 관한 것이다.The present invention relates to the use of N-substituted 3-azabicycloalkane derivatives of the general formula (I) below for the treatment of addictive diseases and other diseases of the central nervous system.

<화학식 Ⅰ><Formula I>

상기 식에서,Where

B, R1, R2및 n은 본 명세서에서 주어진 의미를 갖는다.B, R 1 , R 2 and n have the meanings given herein.

Description

중추신경계 질환의 치료를 위한 Ｎ-치환 아자비시클로알칸 유도체의 용도 {Use of Ｎ-Substituted Azabicycloalkane Derivatives for Treating Diseases of the Central Nervous System}Use of N-substituted Azabicycloalkane Derivatives for Treating Diseases of the Central Nervous System}

N-치환 아자비시클로알칸 유도체는 신경이완제로서 이미 공지되어 있다 (국제 특허 공개 제95/13279호, 국제 특허 공개 제95/15327호, 국제 특허 공개 제96/04272호, 미국 특허 제5,475,105호, 미국 특허 제5,521,209호, 미국 특허 제5,616,705호, 미국 특허 제5,753,690호 참조). 또한 이러한 물질은 중추신경계의 중독성 질환 및 다른 질환 억제에 적합하다는 것이 밝혀져 있다.N-substituted azabicycloalkane derivatives are already known as neuroleptics (International Publication No. 95/13279, International Publication No. 95/15327, International Publication No. 96/04272, US Patent No. 5,475,105, USA Patent 5,521,209, US patent 5,616,705, US patent 5,753,690). It has also been found that these substances are suitable for suppressing toxic and other diseases of the central nervous system.

본 발명은 중독을 억제하고, 집중 장애 (주의 결핍 장애), 아동의 활동항진 상태 (주의 결핍 활동항진 상태 장애), 학습 및 기억력 결함 (인지 능력의 손상)을 치료하는 약제 제조를 위한, 하기 화학식 Ⅰ의 N-치환 3-아자비시클로알칸 유도체 및 이들 유도체와 생리학적으로 허용되는 산과의 염의 용도를 제공한다.The present invention is directed to the manufacture of a medicament for inhibiting addiction and treating concentration disorders (attention deficit disorders), hyperactivity in children (attention deficit hyperactivity disorders), learning and memory deficits (impairment of cognitive ability), N-substituted 3-azabicycloalkane derivatives of I and the use of these derivatives with physiologically acceptable acids are provided.

상기 식에서,Where

B는 이중 결합을 함유할 수 있는 4-, 5- 또는 6-원 고리이며,B is a 4-, 5- or 6-membered ring which may contain double bonds,

R1은 각각 할로겐 원자, C1-4알킬, 트리플루오로메틸, 히드록실, C1-4알콕시, 아미노, 모노메틸아미노, 디메틸아미노, 시아노 또는 니트로기에 의하여 단일치환 또는 이치환되거나, 치환되지 않은 페닐, 나프틸, 페난트릴 또는 티에닐기이고,R 1 is monosubstituted or disubstituted or substituted by a halogen atom, C 1-4 alkyl, trifluoromethyl, hydroxyl, C 1-4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro group, respectively Phenyl, naphthyl, phenanthryl or thienyl groups,

n은 0, 1, 2, 3 또는 4의 수이며,n is a number of 0, 1, 2, 3 or 4,

R2는 1개 또는 2개의 할로겐 원자에 의하여 치환되거나, 치환되지 않은 나프틸기이거나, 또는 하기의 라디칼들 중 하나이다:R 2 is an unsubstituted naphthyl group, substituted by one or two halogen atoms, or one of the following radicals:

(상기 식에서,(Wherein

R3은 수소 원자, 히드록실기이거나, 또는 불소, 염소 또는 브롬 원자에 의하여 치환되거나, 치환되지 않은 페닐 라디칼이고,R 3 is a hydrogen atom, a hydroxyl group, or a phenyl radical substituted or unsubstituted by a fluorine, chlorine or bromine atom,

R4는 수소 원자이거나, 또는R 4 is a hydrogen atom, or

R3및 R4는 함께 산소 원자이고,R 3 and R 4 together are oxygen atom,

R5는 각각 불소, 염소 또는 브롬 원자에 의하여, 또는 히드록실, 니트로, 아미노, C1-4알카노일아미노, C1-4알킬아미노, C1-4알킬 또는 메톡시기에 의하여 단일치환 또는 이치환되거나, 치환되지 않은 페닐, 나프틸 또는 티에닐기이며,R 5 is mono- or di-substituted by fluorine, chlorine or bromine atoms, or by hydroxyl, nitro, amino, C 1-4 alkanoylamino, C 1-4 alkylamino, C 1-4 alkyl or methoxy groups Or an unsubstituted phenyl, naphthyl or thienyl group,

R6은 수소 원자 또는 메틸기이고,R 6 is a hydrogen atom or a methyl group,

R7은 각각 불소, 염소 또는 브롬 원자에 의하여, 또는 C1-4알킬, 히드록실, 메톡시, 니트로, 시아노, 트리플루오로메틸, 아미노 또는 디-C1-4알킬아미노기에 의하여 단일치환 또는 이치환되거나, 치환되지 않은 페닐, 나프틸, 벤조푸릴, 벤조티에닐, 티에닐, 인돌릴, N-메틸인돌릴 또는 인데닐기이거나, 또는 C3-7시클로알킬기이고,R 7 is monosubstituted by fluorine, chlorine or bromine atoms, or by C 1-4 alkyl, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C 1-4 alkylamino groups, respectively Or a di-substituted or unsubstituted phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group, or a C 3-7 cycloalkyl group,

R8은 수소 원자, 또는 불소 또는 염소 원자, 또는 C1-4알킬, 메톡시 또는 아미노기이며,R 8 is a hydrogen atom or a fluorine or chlorine atom or a C 1-4 alkyl, methoxy or amino group,

R9는 수소 원자 또는 메틸기이고,R 9 is a hydrogen atom or a methyl group,

R10은 수소 원자 또는 메틸기이거나, 또는R 10 is a hydrogen atom or a methyl group, or

R9와 R10은 고리 탄소 원자와 함께 스피로시클로프로판 고리를 형성하고,R 9 and R 10 together with the ring carbon atom form a spirocyclopropane ring,

R11은 수소 원자, 히드록실, C1-C4알킬 또는 C1-C4알콕시기이거나, 인접한 탄소 원자와 함께 C=O- 또는 C=S기를 형성하고,R 11 is a hydrogen atom, hydroxyl, a C 1 -C 4 alkyl or a C 1 -C 4 alkoxy group or together with adjacent carbon atoms forms a C═O— or C═S group,

X 및 Y는 탄소 원자, CH, CH2, NH 또는 C1-C4알킬-N기, 또는 질소 원자이고,X and Y are carbon atoms, CH, CH 2 , NH or C 1 -C 4 alkyl-N groups, or nitrogen atoms,

Z는 직접 결합, CO기, CS기이거나, 또는 수소 원자가 히드록실, 아미노 또는 C1-C4알콕시기에 의하여 또는 할로겐 원자에 의하여 치환될 수 있는 CH 또는 CH2기이고,Z is a direct bond, a CO group, a CS group, or a CH or CH 2 group where the hydrogen atom may be substituted by a hydroxyl, amino or C 1 -C 4 alkoxy group or by a halogen atom,

A는 수소 원자, 히드록실, 아미노, 메르캅토, C1-C4알킬아미노, 디-C1-C4알킬아미노, C1-C4알킬티오 또는 C1-C4알콕시기이거나, 인접한 탄소 원자와 함께 C=O기를 형성하거나, 또는A is a hydrogen atom, hydroxyl, amino, mercapto, C 1 -C 4 alkylamino, di-C 1 -C 4 alkylamino, C 1 -C 4 alkylthio or C 1 -C 4 alkoxy group, or an adjacent carbon Form a C═O group with an atom, or

A는 이중 결합을 비연속적으로 1개 또는 2개 함유할 수 있고 CH 또는 CH2기 중 하나가 질소 또는 황 원자에 의하여 또는 NH 또는 N-CH3기에 의하여 대체될 수 있는, Y에 결합된 C3-C4알킬렌기이고, 이와 같은 A 함유 고리는 불소 또는 염소 원자에 의하여, 또는 메틸, 메톡시, 니트로 또는 아미노기에 의하여 단일 치환되고, 상기 고리가 벤젠 고리인 경우, 이 고리는 불소 또는 염소 원자 또는 메틸, 트리플루오로메틸, 니트로, 히드록실, 메톡시, 아미노, 모노메틸 또는 디메틸아미노기에 의하여 단일치환, 이치환, 또는 삼치환될 수 있으며,A is a C bonded to Y, which may contain one or two double bonds discontinuously and one of the CH or CH 2 groups may be replaced by a nitrogen or sulfur atom or by an NH or N-CH 3 group. A 3 -C 4 alkylene group, such an A containing ring is mono-substituted by a fluorine or chlorine atom or by a methyl, methoxy, nitro or amino group, and when the ring is a benzene ring, the ring is fluorine or chlorine Mono-, di-, or tri-substituted by an atom or a methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl or dimethylamino group,

X-, Y- 및 Z-함유 고리는 1번 질소 원자에서 C1-C4알킬, 알릴 또는 벤질기를 가질 수 있으며, 이중 결합을 비연속적으로 1개 내지 3개 함유할 수 있다).X-, Y- and Z-containing rings may have a C 1 -C 4 alkyl, allyl or benzyl group at nitrogen atom 1 and may contain 1 to 3 double bonds discontinuously).

본 발명에 따른 용도는 물질의 남용에 의한 중독성 질환, 또는 예를 들어 도박 중독과 같은 다른 중독성 질환을 불문하고 모든 중독성 질환과 관련이 있다. 습관성 물질로는, 예를 들어 모르핀 또는 헤로인과 같은 오피오이드; 니코틴; 알콜; 및 예를 들어 벤조디아제핀과 같은 벤조디아제핀 수용체 복합체와 상호작용하는 물질, 진정제 또는 신경안정제가 있을 수 있다.The use according to the invention relates to all addictive diseases, whether addictive diseases by substance abuse or other addictive diseases such as, for example, gambling addiction. Additive substances include, for example, opioids such as morphine or heroin; nicotine; Alcohol; And substances that interact with benzodiazepine receptor complexes, such as, for example, benzodiazepine.

본 발명에 따른 습관성 물질로 가능한 것은 특히, 코카인 또는 암페타민 및암페타민계 물질이다.Possible addictive substances according to the invention are in particular cocaine or amphetamines and amphetamine-based substances.

화학식 Ⅰ의 화합물은 이들의 라세미체 및 광학 이성질체 둘다의 형태로 사용될 수 있다.The compounds of formula (I) can be used in the form of both their racemates and optical isomers.

신규한 적용을 위하여, 상기 화합물은 통상적인 방법에 의하여 경구적 또는 비경구적, 정맥내 또는 근육내로 투여될 수 있다.For novel applications, the compounds can be administered orally or parenterally, intravenously or intramuscularly by conventional methods.

투여량은 환자의 연령, 상태 및 체중, 그리고 투여형에 좌우된다. 일반적으로 활성 화합물의 1일 투여량은 경구 투여인 경우에는 체중 1kg 당 약 1 내지 100 mg이며, 비경구 투여인 경우에는 체중 1kg 당 약 0.1 내지 10 mg이다.Dosage depends on the age, condition and weight of the patient and the dosage form. In general, the daily dose of the active compound is about 1 to 100 mg / kg body weight for oral administration and about 0.1 to 10 mg / kg body weight for parenteral administration.

상기 화합물은 통상적인 제약 투여형, 예를 들어, 정제, 필름 제피정 (film-coated tablets), 캡슐, 분말, 과립, 당의정, 좌제, 용액, 연고, 크림 또는 스프레이 같은 고상물 또는 액상물 형태로서 사용될 수 있다. 이들은 통상적인 방법으로 제조된다. 이러한 목적으로, 상기 활성 화합물은 정제 결합제, 충전제, 보존제, 정제 붕해제, 유동 조절제, 가소제, 습윤제, 분산제, 유화제, 용매, 방출-지연제, 산화방지제 및(또는) 추진제와 같은 통상적인 제약 보조제와 함께 가공될 수 있다 (서커 (H. Sucker) 등의 문헌 [Pharmazeutische Technologie (Pharmaceutical Technology), Thieme-Verlag, Stuttgart, 1978] 참조). 이렇게 하여 얻어진 투여 형태는 일반적으로 활성 화합물을 1 내지 99 중량%의 양으로 포함한다.The compound may be in the form of a solid or liquid form as a conventional pharmaceutical dosage form, for example tablets, film-coated tablets, capsules, powders, granules, dragees, suppositories, solutions, ointments, creams or sprays. Can be used. These are prepared by conventional methods. For this purpose, the active compounds are conventional pharmaceutical adjuvants such as tablet binders, fillers, preservatives, tablet disintegrants, flow control agents, plasticizers, wetting agents, dispersants, emulsifiers, solvents, release-delaying agents, antioxidants and / or propellants. (See Pharmazeutische Technologie (Pharmaceutical Technology), Thieme-Verlag, Stuttgart, 1978) by H. Sucker et al.). Dosage forms thus obtained generally comprise the active compound in an amount of 1 to 99% by weight.

하기의 물질들은 화학식 Ⅰ의 화합물의 예로서 언급될 수 있다.The following materials may be mentioned as examples of the compounds of formula (I).

1. 1-(4-플루오로페닐)-4-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온1. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

2. 1-페닐-4-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]-부탄-1-온2. 1-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] -butan-1-one

3. 1-(4-플루오로페닐)-4-[엑소-6,7-디페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온3. 1- (4-fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

4. 1-(4-플루오로페닐)-4-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄4. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

5. 1-페닐-2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에탄-1-온5. 1-phenyl-2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethan-1-one

6. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄6. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

7. 1-(4-플루오로페닐)-4-[엑소-6-m-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온7. 1- (4-Fluorophenyl) -4- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

8. 1-(4-플루오로페닐)-4-[엑소-6-o-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온8. 1- (4-fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

9. 1-(4-플루오로페닐)-4-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온9. 1- (4-fluorophenyl) -4- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

10. 1-(4-플루오로페닐)-4-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온10. 1- (4-fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

11. 1-(4-플루오로페닐)-4-[엑소-6-p-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온11. 1- (4-fluorophenyl) -4- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

12. 1-(4-플루오로페닐)-4-[엑소-6-m,p-디클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온12. 1- (4-fluorophenyl) -4- [exo-6-m, p-dichlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

13. 1-(4-플루오로페닐)-4-[엑소-6-m,p-디메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온13. 1- (4-fluorophenyl) -4- [exo-6-m, p-dimethoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

14. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온14. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

15. 1-페닐-4-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온15. 1-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

16. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄16. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

17. 1-(4-플루오로페닐)-4-[엑소-6-p-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온17. 1- (4-fluorophenyl) -4- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

18. 1-(4-플루오로페닐)-4-[엑소-6-m-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온18. 1- (4-fluorophenyl) -4- [exo-6-m-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

19. 1-(4-플루오로페닐)-4-[엑소-6-p-트리플루오로메틸페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온19. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

20. 1-(4-플루오로페닐)-4-[엑소-6-p-시아노페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온20. 1- (4-Fluorophenyl) -4- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

21. 1-(4-플루오로페닐)-4-[엑소-6-티엔-3-일-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온21. 1- (4-fluorophenyl) -4- [exo-6-thien-3-yl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

22. 1-(4-플루오로페닐)-4-[엑소-6-피리드-3-일-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온22. 1- (4-Fluorophenyl) -4- [exo-6-pyrid-3-yl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

23. 1-(4-플루오로페닐)-3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로판-1-온23. 1- (4-fluorophenyl) -3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propan-1-one

24. 1-(비스-4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-3-아자비시클로24. 1- (bis-4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo

[3.2.0]헵탄-3-일]부탄[3.2.0] heptan-3-yl] butane

25. 1-(비스-4-플루오로페닐)-4-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄25. 1- (bis-4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butane

26. 1-(4-플루오로페닐)-4-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올26. 1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

27. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올27. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

28. 1-(4-플루오로페닐)-4-[엑소-6,7-디페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올28. 1- (4-fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

29. 1-페닐-4-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올29. 1-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

30. 1-페닐-4-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올30. 1-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

31. 1-(4-플루오로페닐)-4-[엑소-6-o-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올31. 1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

32. 1-(4-플루오로페닐)-4-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올32. 1- (4-fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

33. 1-(4-플루오로페닐)-4-[엑소-6-p-트리플루오로메틸페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-올33. 1- (4-fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-ol

34. 1-(4-플루오로페닐)-4-[엑소-6-p-아미노페닐-3-아자비시클로[3.2.0]헵탄-3-일]부탄-1-온34. 1- (4-fluorophenyl) -4- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butan-1-one

35. N-(3-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-4-플루오로벤즈아미드35. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-fluorobenzamide

36. N-(3-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)벤즈아미드36. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) benzamide

37. N-(2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-플루오로벤즈아미드37.N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorobenzamide

38. N-(2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드38. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

39. N-(2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-N-메틸-4-플루오로벤즈아미드39. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-fluorobenzamide

40. N-(2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-N-메틸벤즈아미드40. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methylbenzamide

41. N-(2-[엑소-6-페닐-3-아자비시클로[3-2.0]헵탄-3-일]에틸)-N-메틸-4-이소프로필벤즈아미드41.N- (2- [exo-6-phenyl-3-azabicyclo [3-2.0] heptan-3-yl] ethyl) -N-methyl-4-isopropylbenzamide

42. N-(3-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-4-클로로벤즈아미드42.N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-chlorobenzamide

43. N-(2-[엑소-6-p-트리플루오로메틸페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-4-클로로벤즈아미드43. N- (2- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -4-chlorobenzamide

44. N-(3-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-3-메톡시벤즈아미드44. N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-methoxybenzamide

45. N-(3-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-3-니트로벤즈아미드45.N- (3- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-nitrobenzamide

46. N-(3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-4-플루오로벤즈아미드46. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-fluorobenzamide

47. N-(3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)벤즈아미드47. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) benzamide

48. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-플루오로벤즈아미드48. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorobenzamide

49. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드49.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

50. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-N-메틸-4-플루오로벤즈아미드50.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-fluorobenzamide

51. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-N-메틸벤즈아미드51.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methylbenzamide

52. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-N-메틸-4-이소프로필벤즈아미드52. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methyl-4-isopropylbenzamide

53. N-(3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-4-클로로벤즈아미드53. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -4-chlorobenzamide

54. N-(3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-3-메톡시벤즈아미드54. N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-methoxybenzamide

55. N-(3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필)-3-니트로벤즈아미드55.N- (3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl) -3-nitrobenzamide

56. N-(2-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-클로로벤즈아미드56. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorobenzamide

57. N-(2-[엑소-6-o-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-4-클로로벤즈아미드57. N- (2- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -4-chlorobenzamide

58. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-2-히드록시벤즈아미드58. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -2-hydroxybenzamide

59. N-(2-[엑소-6-m-히드록시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-클로로벤즈아미드59. N- (2- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorobenzamide

60. 엑소-3-n-부틸-6-페닐-3-아자비시클로[3.2.0]헵탄60. Exo-3-n-butyl-6-phenyl-3-azabicyclo [3.2.0] heptane

61. 엑소-3-메틸-6-페닐-3-아자비시클로[3.2.0]헵탄61. Exo-3-methyl-6-phenyl-3-azabicyclo [3.2.0] heptane

62. 엑소-3-메틸-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄62. Exo-3-methyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

63. 엑소-3-n-프로필-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄63. Exo-3-n-propyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

64. 엑소-3-메틸-6,7-디페닐-3-아자비시클로[3.2.0]헵탄64. Exo-3-methyl-6,7-diphenyl-3-azabicyclo [3.2.0] heptane

65. 엑소-3-n-프로필-6-m-히드록시페닐-3-아자비시클로[3.2.0]헵탄65. Exo-3-n-propyl-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptane

66. 엑소-3-알릴-6-m-메톡시페닐-3-아자비시클로[3.2.0]헵탄66. Exo-3-allyl-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptane

67. 엑소-3-(3,4-디메톡시)펜에틸-6-페닐-3-아자비시클로[3.2.0]헵탄67. Exo-3- (3,4-dimethoxy) phenethyl-6-phenyl-3-azabicyclo [3.2.0] heptane

68. 엑소-3-(3,4-디메톡시)펜에틸-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄68. Exo-3- (3,4-dimethoxy) phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

69. 엑소-3-(3,4-디히드록시)펜에틸-3-아자비시클로[3.2.0]헵탄69. Exo-3- (3,4-dihydroxy) phenethyl-3-azabicyclo [3.2.0] heptane

70. 엑소-3-펜에틸-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄70. Exo-3-phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane

71. 6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온71. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyri Midin-5-on

72. (+)-6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온72. (+)-6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2 -a] pyrimidin-5-one

73. (-)-6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온73. (-)-6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2 -a] pyrimidin-5-one

74. 6-β-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온74. 6-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- On

75. 6-β-[엑소-6,7-디페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온75. 6-β- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine -5-on

76. 6-β-[엑소-6,7-비스-(p-플루오로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온76. 6-β- [exo-6,7-bis- (p-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3 , 2-a] pyrimidin-5-one

77. 6-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온77. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine -5-on

78. 6-β-[엑소-6-m-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온78. 6-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyri Midin-5-on

79. 6-β-[엑소-6-m-히드록시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온79. 6-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyri Midin-5-on

80. 6-β-(2-[엑소-6-p-아미노페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온80. 6-β- (2- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a ] Pyrimidin-5-one

81. 6-β-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온81. 6-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine -5-on

82. 6-β-[엑소-6-p-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온82. 6-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrid Midin-5-on

83. 6-β-[엑소-6-p-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온83. 6-β- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine -5-on

84. 6-β-[엑소-6-m-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온84. 6-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrid Midin-5-on

85. 6-β-[엑소-6-p-히드록시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온85. 6-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyri Midin-5-on

86. 6-β-[엑소-6-p-트리플루오로메틸페닐-3-아자비시클로[3.2.0]-헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온86. 6-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] -heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a ] Pyrimidin-5-one

87. 6-β-[엑소-6-(p-t-부틸페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온87. 6-β- [exo-6- (pt-butylphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] Pyrimidin-5-one

88. 6-β-[엔도-6-(p-t-부틸페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온88. 6-β- [endo-6- (pt-butylphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] Pyrimidin-5-one

89. 6-β-[엑소-6-(3,4-디클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온89. 6-β- [exo-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2- a] pyrimidin-5-one

90. 6-β-[엑소-6-(3,4-디메톡시페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온90. 6-β- [exo-6- (3,4-dimethoxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2 -a] pyrimidin-5-one

91. 6-β-[엑소-6-p-시아노페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온91. 6-β- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyridine Midin-5-on

92. 6-β-[엑소-6-(3,4-디히드록시페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온92. 6-β- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one

93. 6-β-[엑소-6-(o-플루오로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온93. 6-β- [exo-6- (o-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a ] Pyrimidin-5-one

94. 6-β-[엑소-6-티엔-3-일-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온94. 6-β- [exo-6-thien-3-yl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyridine Midin-5-on

95. 6-β-[엑소-6-(5-클로로티엔-2-일)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온95. 6-β- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-5H-thiazolo [3, 2-a] pyrimidin-5-one

96. 6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-7-메틸-2,3-디히드로-5H-티아졸로[3,2-a]피리미딘-5-온96. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [ 3,2-a] pyrimidin-5-one

97. 6-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-7-메틸-2,3-디히드로-5H-티아졸로[3,2-a]피리미딘-5-온97. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [3 , 2-a] pyrimidin-5-one

98. 6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,3,7-트리메틸-5H-티아졸로[3,2-a]피리미딘-5-온98. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,3,7-trimethyl-5H-thiazolo [3,2 -a] pyrimidin-5-one

99. 6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-5H-티아졸로[3,2-a]피리미딘-5-온99. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5H-thiazolo [3,2-a] pyrimidine-5- On

100. 6-β-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-5H-티아졸로100. 6-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5H-thiazolo

[3,2-a]피리미딘-5-온[3,2-a] pyrimidin-5-one

101. 7-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-8-메틸-2H,6H-피리미도[2,1-b][1,3]티아진-6-온101. 7-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b ] [1,3] thiazine-6-one

102. 7-β-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-8-메틸-2H,6H-피리미도[2,1-b][1,3]티아진-6-온102. 7-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1, 3] thiazine-6-one

103. 7-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.O]헵탄-3-일]-에틸-8-메틸-2H,6H-피리미도[2,1-b][1,3]티아진-6-온103. 7-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] -ethyl-8-methyl-2H, 6H-pyrimido [2,1-b ] [1,3] thiazine-6-one

104. 7-β-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.O]헵탄-3-일]-에틸-8-메틸-2H,6H-피리미도[2,1-b][1,3]티아진-6-온104. 7-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] -ethyl-8-methyl-2H, 6H-pyrimido [2,1-b ] [1,3] thiazine-6-one

105. 7-β-[엑소-6-p-메톡시페닐-3-아자비시클로[3.2.O]헵탄-3-일]-에틸-8-메틸-2H,6H-피리미도[2,1-b][1.3]티아진-6-온105. 7-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.O] heptan-3-yl] -ethyl-8-methyl-2H, 6H-pyrimido [2,1- b] [1.3] thiazine-6-one

106. 7-β-[엑소-6-m-히드록시페닐-3-아자비시클로[3.2.O]헵탄-3-일]-에틸-8-메틸-2H,6H-피리미도[2,1-b][1,3]티아진-6-온106. 7-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.O] heptan-3-yl] -ethyl-8-methyl-2H, 6H-pyrimido [2,1- b] [1,3] thiazine-6-one

107. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온107. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

108. (+)-3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온108. (+)-3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

109. (-)-3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온109. (-)-3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

110. 3-β-[엑소-6-페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온110. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

111. 3-β-[엑소-6-m-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온111. 3-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

112. 3-β-[엑소-6-p-시아노페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온112. 3-β- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

113. 3-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온113. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

114. 3-β-[엑소-6-p-히드록시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온114. 3-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

115. 3-β-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온115. 3-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

116. 3-β-[엑소-6-m-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온116. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

117. 3-β-[엑소-6-p-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온117. 3-β- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

118. 3-β-[엔도-6-p-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온118. 3-β- [endo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

119. 3-β-[엑소-6-m-히드록시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온119. 3-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

120. 3-β-[엑소-6-p-아미노페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온120. 3-β- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

121. 3-β-[엑소-6-p-요오도페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온121. 3-β- [exo-6-p-iodophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

122. 3-β-[엑소-6-p-트리플루오로메틸페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온122. 3-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

123. 3-β-[엑소-6-(3,4-디클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온123. 3-β- [exo-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

124. 3-β-[엑소-6-(3,4-디히드록시페닐)-3-아자비시클로[3.2.O]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온124. 3-β- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.O] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline Dion

125. 3-β-[엑소-6-(3,5-디클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온125. 3-β- [exo-6- (3,5-dichlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

126. 3-β-[엑소-6-o-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온126. 3-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

127. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-8-메틸-2,4-(1H,3H)퀴나졸린디온127. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-8-methyl-2,4- (1H, 3H) quinazolindione

128. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-7-클로로-2,4-(1H,3H)퀴나졸린디온128. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-7-chloro-2,4- (1H, 3H) quinazolindione

129. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-7-플루오로-2,4-(1H,3H)퀴나졸린디온129. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-7-fluoro-2,4- (1H, 3H) quinazoline Dion

130. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-5-클로로-2,4-(1H,3H)퀴나졸린디온130. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-5-chloro-2,4- (1H, 3H) quinazolindione

131. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6-플루오로-2,4-(1H,3H)퀴나졸린디온131. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-fluoro-2,4- (1H, 3H) quinazoline Dion

132. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6-메틸-2,4-(1H,3H)퀴나졸린디온132. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-methyl-2,4- (1H, 3H) quinazolindione

133. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-8-메톡시-2,4-(1H,3H)퀴나졸린디온133. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-8-methoxy-2,4- (1H, 3H) quinazoline Dion

134. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6-트리플루오로메틸-2,4-(1H,3H)퀴나졸린디온134. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-trifluoromethyl-2,4- (1H, 3H) Quinazolindione

135. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-니트로-2,4-(1H,3H)퀴나졸린디온135. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-nitro-2,4- (1H, 3H) quinazolindione

136. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6-니트로-2,4-(1H,3H)퀴나졸린디온136. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-nitro-2,4- (1H, 3H) quinazolindione

137. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-아미노-2,4-(1H,3H)퀴나졸린디온137. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-amino-2,4- (1H, 3H) quinazolindione

138. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6-아미노-2,4-(1H,3H)퀴나졸린디온138. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-amino-2,4- (1H, 3H) quinazolindione

139. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6-히드록시-2,4-(1H,3H)퀴나졸린디온139. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6-hydroxy-2,4- (1H, 3H) quinazoline Dion

140. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-5-클로로-2,4-(1H,3H)퀴나졸린디온140. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-5-chloro-2,4- (1H, 3H) quinazolindione

141. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6,7-디메톡시-2,4-(1H,3H)퀴나졸린디온141. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,7-dimethoxy-2,4- (1H, 3H) Quinazolindione

142. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6,8-디클로로-2,4-(1H,3H)퀴나졸린디온142. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,8-dichloro-2,4- (1H, 3H) quina Sleepy dione

143. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-6,7,8-트리메톡시-2,4-(1H,3H)퀴나졸린디온143. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-6,7,8-trimethoxy-2,4- (1H , 3H) quinazolindione

144. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1-메틸-2,4-(1H,3H)퀴나졸린디온144. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-methyl-2,4- (1H, 3H) quinazolindione

145. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1-에틸-2,4-(1H,3H)퀴나졸린디온145. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-ethyl-2,4- (1H, 3H) quinazolindione

146. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1-알릴-2,4-(1H,3H)퀴나졸린디온146. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-allyl-2,4- (1H, 3H) quinazolindione

147. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1-벤질-2,4-(1H,3H)퀴나졸린디온147. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1-benzyl-2,4- (1H, 3H) quinazolindione

148. 3-γ-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]프로필-2,4-(1H,3H)퀴나졸린디온148. 3-γ- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] propyl-2,4- (1H, 3H) quinazolindione

149. 3-δ-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]부틸-2,4-(1H,3H)퀴나졸린디온149. 3-δ- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] butyl-2,4- (1H, 3H) quinazolindione

150. 3-β-[엑소-6-(2-티에닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온150. 3-β- [exo-6- (2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

151. 3-β-[엑소-6-(5-클로로-2-티에닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온151. 3-β- [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazoline Dion

152. 3-β-[엑소-6-(3-티에닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온152. 3-β- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

153. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1H-티에노[3,2-d]피리미딘-2,4-디온153. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1H-thieno [3,2-d] pyrimidine-2, 4-dion

154. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1H-티에노[2,3-d]피리미딘-2,4-디온154. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1H-thieno [2,3-d] pyrimidine-2, 4-dion

155. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1H-티에노[3,4-d]피리미딘-2,4-디온155. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1H-thieno [3,4-d] pyrimidine-2, 4-dion

156. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-1-메틸-1H,3H-피리도[2,3-d]피리미딘-2,4-디온156. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-1-methyl-1H, 3H-pyrido [2,3- d] pyrimidine-2,4-dione

157. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-3H-퀴나졸린-4-온157. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-3H-quinazolin-4-one

158. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메톡시-3H-퀴나졸린-4-온158. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methoxy-3H-quinazolin-4-one

159. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-2-메틸-4H-피리도[1,2-a]피리미딘-4-온 디히드로클로라이드159. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-2-methyl-4H-pyrido [1,2-a] Pyrimidin-4-one dihydrochloride

160. 3-β-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-4H-피리도[1,2-a]피리미딘-4-온160. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine-4- On

161. 3-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-4H-피리도[1,2-a]피리미딘-4-온161. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine -4-on

162. 3-β-[엑소-6-m-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-4H-피리도[1,2-a]피리미딘-4-온162. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1,2-a] pyri Midin-4-one

163. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-2,6-디메틸-4H-피리도[1,2-a]피리미딘-4-온163. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-2,6-dimethyl-4H-pyrido [1,2-a ] Pyrimidin-4-one

164. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,7-디메틸-4H-피리도[1,2-a]피리미딘-4-온164. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,7-dimethyl-4H-pyrido [1,2-a ] Pyrimidin-4-one

165. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,8-디메틸-4H-피리도[1,2-a]피리미딘-4-온165. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,8-dimethyl-4H-pyrido [1,2-a ] Pyrimidin-4-one

166. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,9-디메틸-4H-피리도[1,2-a]피리미딘-4-온166. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,9-dimethyl-4H-pyrido [1,2-a ] Pyrimidin-4-one

167. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,6,8-트리메틸-4H-피리도[1,2-a]피리미딘-4-온167. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,6,8-trimethyl-4H-pyrido [1,2 -a] pyrimidin-4-one

168. 3-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,7-디메틸-4H-피리도[1,2-a]피리미딘-4-온168. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] Pyrimidin-4-one

169. 3-β-[엑소-6-o-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,7-디메틸-4H-피리도[1,2-a]피리미딘-4-온169. 3-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,7-dimethyl-4H-pyrido [1,2-a ] Pyrimidin-4-one

170. 3-β-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,8-디메틸-4H-피리도[1,2-a]피리미딘-4-온170. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,8-dimethyl-4H-pyrido [1,2-a] pyrimidine- 4-on

171. 3-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,9-디메틸-4H-피리도[1,2-a]피리미딘-4-온171. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] Pyrimidin-4-one

172. 3-β-[엑소-6-(5-클로로티엔-2-일)-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-4H-피리도[1,2-a]피리미딘-4-온172. 3-β- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrido [1, 2-a] pyrimidin-4-one

173. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-6,7,8,9-테트라히드로-2-메틸-4H-피리도[l,2-a]피리미딘-4-온173. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-6,7,8,9-tetrahydro-2-methyl- 4H-pyrido [l, 2-a] pyrimidin-4-one

174. 3-β-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-6,7,8,9-테트라히드로-2-메틸-4H-피리도[1,2-a]피리미딘-4-온174. 3-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-6,7,8,9-tetrahydro-2-methyl-4H -Pyrido [1,2-a] pyrimidin-4-one

175. 3-β-[엑소-6-p-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-6,7,8,9-테트라히드로-2-메틸-4H-피리도[1,2-a]피리미딘-4-온175. 3-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-6,7,8,9-tetrahydro-2-methyl- 4H-pyrido [1,2-a] pyrimidin-4-one

176. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-4H-피리미도[1,2-a]피리미딘-4-온176. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-4H-pyrimido [1,2-a] pyri Midin-4-one

177. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸-2-메틸-7-클로로-4H-피리미도[1,2-a]피리미딘-4-온177. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl-2-methyl-7-chloro-4H-pyrimido [1,2 -a] pyrimidin-4-one

178. 6-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-7-메틸-1H,5H-이미다조[l,2-a]피리미딘-5-온178. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-7-methyl-1H, 5H-imidazo [l, 2-a ] Pyrimidin-5-one

179. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸-7,8-디히드로-4H,6H-피롤로[1,2-a]피리미딘-4-온179. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methyl-7,8-dihydro-4H, 6H-pi Rolo [1,2-a] pyrimidin-4-one

180. 2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸벤즈이미다졸180. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methylbenzimidazole

181. 1-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸벤즈이미다졸181. 1-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylbenzimidazole

182. 1-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2,3-디히드로벤즈이미다졸-2-온182. 1-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2,3-dihydrobenzimidazol-2-one

183. 2-[엑소-6-m-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸벤즈이미다졸183. 2- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] methylbenzimidazole

184. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸인돌, m.p. 193-195℃ (히드로클로라이드)184. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole, m.p. 193-195 ° C (hydrochloride)

185. 3-β-(2-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸인돌185. 3-β- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole

186. 3-β-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸인돌,186. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole,

m.p. 104-105℃ (히드로클로라이드)m.p. 104-105 ° C (hydrochloride)

187. 3-β-[엑소-6-m-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸인돌187. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethylindole

188. 2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-3,4-디히드로퀴나졸린-4-온188. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

189. 2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-3,4-디히드로퀴나졸린-4-티온189. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-thione

190. 2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-3,4-디히드로퀴나졸린-4-온190. 2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

191. 2-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-3,4-디히드로퀴나졸린-4-온191. 2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

192. 2-[엑소-6-o-메톡시페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-3,4-디히드로퀴나졸린-4-온192. 2- [exo-6-o-methoxyphenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-3,4-dihydroquinazolin-4-one

193. 2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-4-히드록시-6-메틸피리미딘193. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-4-hydroxy-6-methylpyrimidine

194. 6-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸-2-메틸-4-히드록시피리미딘194. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyl-2-methyl-4-hydroxypyrimidine

195. 6-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸우라실195. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyluracil

196. 6-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]메틸우라실196. 6- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] methyluracil

197. 6-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-1,2,3,4-테트라히드로-1,3-디메틸-2,4-디옥소피리미딘197. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1,2,3,4-tetrahydro-1,3-dimethyl-2, 4-dioxopyrimidine

198. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1,2,3,4-테트라히드로-6-메틸-2,4-디옥소피리미딘198. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-6-methyl-2 , 4-dioxopyrimidine

199. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1,2,3,4-테트라히드로-1,6-디메틸-2,4-디옥소피리미딘199. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-1,6-dimethyl -2,4-dioxopyrimidine

200. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1,2,3,4-테트라히드로-3,6-디메틸-2,4-디옥소피리미딘200. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-3,6-dimethyl -2,4-dioxopyrimidine

201. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1,2,3,4-테트라히드로-3,6-디메틸-2,4-디티오피리미딘201.5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-3,6-dimethyl -2,4-dithiopyrimidine

202. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1,2,3,4-테트라히드로-1,3,6-트리메틸-2,4-디옥소피리미딘202. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-1,3,6 -Trimethyl-2,4-dioxopyrimidine

203. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-1,2,3,4-테트라히드로-6-아미노-1-메틸-2,4-디옥소피리미딘203. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-1,2,3,4-tetrahydro-6-amino-1 -Methyl-2,4-dioxopyrimidine

204. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-아미노-6-메틸-4(3H)피리미디논204. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-6-methyl-4 (3H) pyrimidinone

205. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-아미노-3,6-디메틸-4(3H)피리미디논205. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-3,6-dimethyl-4 (3H) pyrimidy Paddy field

206. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논206. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

207. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-3-에틸-6-메틸-4(3H)피리미디논207. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3-ethyl-6-methyl-4 (3H Pyrimidinone

208. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-아미노-3-에틸-6-메틸-4(3H)피리미디논208. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-amino-3-ethyl-6-methyl-4 (3H) Pyrimidinone

209. 5-β-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논209. 5-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

210. 5-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논210. 5-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

211. 5-β-[엑소-6-o-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논211. 5-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

212. 5-β-[엑소-6-p-트리플루오로메틸페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논212. 5-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) Pyrimidinone

213. 5-β-[엑소-6-p-시아노페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논213. 5-β- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

214. 5-β-[엑소-6-m-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논214. 5-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

215. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-2-메틸아미노-4-메톡시-6-메틸피리미딘215. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-2-methylamino-4-methoxy-6-methylpyrimidine

216. 3-β-[엑소-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온216. 3-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

217. 3-β-[엔도-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온217. 3-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

218. 3-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로218. 3-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온[3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

219. 3-β-[엑소-6-p-트리플루오로메틸페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-6-플루오로-2,4-(1H,3H)퀴나졸린디온219. 3-β- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-6- Fluoro-2,4- (1H, 3H) quinazolindione

220. 3-β-[엑소-6-m-클로로페닐-7-메틸-1,5-시스-3,7-디아자비시클로220. 3-β- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온[3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

221. 3-β-[엑소-6-p-메톡시페닐-7-메틸-1,5-시스-3,7-디아자비시클로221. 3-β- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-6-메틸-2,4-(1H,3H)퀴나졸린디온[3.3.0] octan-3-yl] ethyl-6-methyl-2,4- (1H, 3H) quinazolindione

222. 5-β-[엑소-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]-옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논222. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] -octan-3-yl] ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) pyrimidinone

223. 5-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로223. 5-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논[3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

224. 1-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로224. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2(3H)벤즈이미다졸론[3.3.0] octan-3-yl] ethyl-2 (3H) benzimidazolone

225. 5-β-[엑소-6-p-니트로페닐-7-메틸-1,5-시스-3,7-디아자비시클로225. 5-β- [exo-6-p-nitrophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논[3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

226. 5-β-[엑소-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]-옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논226. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] -octan-3-yl] ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) pyrimidinone

227. 5-β-[엔도-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]-옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논227. 5-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] -octan-3-yl] ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) pyrimidinone

228. 3-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로228. 3-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2-메틸-4H-피리도[l.2-a]피리미딘-4-온[3.3.0] octan-3-yl] ethyl-2-methyl-4H-pyrido [l.2-a] pyrimidin-4-one

229. 1-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로229. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸인돌린-2-온[3.3.0] octan-3-yl] ethylindolin-2-one

230. 6-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로230. 6-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-7-메틸-5H-티아졸로[3.2-a]피리미딘-5-온[3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3.2-a] pyrimidin-5-one

231. 1-β-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로231. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸-2(1H)퀴놀론[3.3.0] octan-3-yl] ethyl-2 (1H) quinolone

232. 3-β-[7-페닐-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온232. 3-β- [7-phenyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

233. 3-β-[7-p-플루오로페닐-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온233. 3-β- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) Quinazolindione

234. 5-β-[7-p-플루오로페닐-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논234. 5-β- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6- Dimethyl-4 (3H) pyrimidinone

235. 3-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸-2,4-(1H,3H)퀴나졸린디온235. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

236. 3-β-[엑소-6-페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸-2,4-(1H,3H)퀴나졸린디온236. 3-β- [exo-6-phenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

237. 3-β-[6,6-디페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸-2,4-(1H,3H)퀴나졸린디온237. 3-β- [6,6-diphenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

238. 5-β-[엑소-6-p-플루오로페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논238. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrid Midinon

239. 6-β-[엑소-6-m-클로로페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온239. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine -5-on

240. 3-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온240. 3-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2,4- (1H, 3H Quinazolindione

241. 5-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논241. 5-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone

242. 6-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온242. 6-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one

243. 1-β-[6-페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-2(3H)벤즈이미다졸론243. 1-β- [6-phenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 (3H) benzimidazolone

244. 1-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸인돌린-2-온244. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethylindolin-2-one

245. 1-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-2(1H)퀴놀론245. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 (1H) quinolone

246. 3-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온246. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

247. 5-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논247. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

248. 6-β-[엑소-6-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온248. 6-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3,2-a ] Pyrimidin-5-one

249. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸인돌린-2-온249. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

250. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.O]옥탄-3-일]에틸-2(1H)퀴놀론250. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.O] octan-3-yl] ethyl-2 (1H) quinolone

251. 3-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온251. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

252. 5-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논252. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

253. 6-β-[엔도페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-7-메틸-5H-티아졸로[3.2-a]피리미딘-5-온253. 6-β- [endophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3.2-a] pyrimidine-5 -On

254. 1-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸인돌린-2-온254. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

255. 1-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2(1H)퀴놀론255. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2 (1H) quinolone

256. 3-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온256. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

257. 5-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논257. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

258. 6-β-[엑소-7-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸-7-메틸-5H-티아졸로[3.2-a]피리미딘-5-온258. 6-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl-7-methyl-5H-thiazolo [3.2-a] pyrid Midin-5-on

259. 1-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸인돌린-2-온259. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethylindolin-2-one

260. 1-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.O]옥탄-3-일]에틸-2(1H)퀴놀론260. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.O] octan-3-yl] ethyl-2 (1H) quinolone

261. 3-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2,4-(1H,3H)퀴나졸린디온261. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

262. 5-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논262. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

263. 3-β-[엔도-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2,4-(1H,3H)퀴나졸린디온263. 3-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

264. 5-β-[엔도-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논264. 5-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H Pyrimidinone

265. 3-β-[엔도-6-p-트리플루오로메틸페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2,4-(1H,3H)퀴나졸린디온265. 3-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) Quinazolindione

266. 5-β-[엔도-6-p-트리플루오로메틸페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논266. 5-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6- Dimethyl-4 (3H) pyrimidinone

267. 3-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온267. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2,4- (1H , 3H) quinazolindione

268. 5-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논268. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) pyrimidinone

269. 1-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2(3H)벤즈이미다졸론269. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2 (3H) benzimi Dazolon

270. 1-β-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-7-엔-3-일]에틸인돌린-2-온270. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-7-en-3-yl] ethylindolin-2-one

271. 3-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온271. 3-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H Quinazolindione

272. 5-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논272. 5-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone

273. 3-β-[6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온273. 3-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

274. 5-β-[6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논274. 5-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

275. 3-β-[6-p-트리플루오로메틸페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온275. 3-β- [6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

276. 5-β-[6-p-트리플루오로메틸페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논276. 5-β- [6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2-methylamino-3, 6-dimethyl-4 (3H) pyrimidinone

277. 1-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2(3H)벤즈이미다졸론277. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2 (3H) benzimidazolone

278. 1-β-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸인돌린-2-온278. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethylindolin-2-one

279. 1-β-[6-p-플루오로페닐-l,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸-2(1H)퀴놀론279. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl-2 (1H) quinolone

280. 3-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2,4-(1H,3H)퀴나졸리돈280. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2,4- (1H , 3H) quinazolidone

281. 5-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논281. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) pyrimidinone

282. 3-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2-메틸-4H-피리도[1.2-a]피리미딘-4-온282. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2-methyl-4H- Pyrido [1.2-a] pyrimidin-4-one

283. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2(1H)퀴놀론283. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2 (1H) quinolone

284. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2(3H)벤즈이미다졸론284. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2 (3H) benzimi Dazolon

285. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸인돌린-2-온285. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethylindolin-2-one

286. 3-β-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온286. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

287. 5-β-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]-에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논287. 5-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] -ethyl-2-methylamino-3,6- Dimethyl-4 (3H) pyrimidinone

288. 3-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2,4-(1H,3H)퀴나졸린디온288. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

289. 5-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논289. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

290. 3-β-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2,4-(1H,3H)퀴나졸린디온290. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

291. 5-β-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논291. 5-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H Pyrimidinone

292. 6-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-7-메틸-5H-티아졸로[3.2-a]피리미딘-5-온292. 6-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-7-methyl-5H-thiazolo [3.2 -a] pyrimidin-5-one

293. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2(3H)벤즈이미다졸론293. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (3H) benzimidazolone

294. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸인돌린-2-온294. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethylindolin-2-one

295. 1-β-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2(1H)퀴놀론295. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (1H) quinolone

296. 3-β-[엑소-7-페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온296. 3-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

297. 5-β-[엑소-7-페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논297. 5-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

298. 3-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온298. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2,4- (1H , 3H) quinazolindione

299. 5-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논299. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl-2-methylamino-3 , 6-dimethyl-4 (3H) pyrimidinone

300. 3-β-[7-p-플루오로페닐-3-아자비시클로[4.3.0]논-1-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온300. 3-β- [7-p-fluorophenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] ethyl-2,4- (1H, 3H) quinazolindione

301. 5-β-[7-페닐-3-아자비시클로[4.3.0]논-1-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논301. 5-β- [7-phenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone

302. 5-β-[7-p-플루오로페닐-3-아자비시클로[4.3.0]논-1-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논302. 5-β- [7-p-fluorophenyl-3-azabicyclo [4.3.0] non-1-en-3-yl] ethyl-2-methylamino-3,6-dimethyl-4 (3H Pyrimidinone

303. 3-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2,4-(1H,3H)퀴나졸린디온303. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2,4- (1H, 3H) quina Sleepy dione

304. 5-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논304. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-3-yl] ethyl-2-methylamino-3,6-dimethyl -4 (3H) pyrimidinone

305. 1-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸-2(3H)벤즈이미다졸론305. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl-2 (3H) benzimidazolone

306. 1-β-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸인돌린-2-온306. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethylindolin-2-one

307. 1-β-[엑소-7-p-플루오로페닐-l,5-시스-3-아자비시클로[4.3.O]논-3-일]에틸-2(1H)퀴놀론307. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-3-yl] ethyl-2 (1H) quinolone

308. 3-β-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-2,4-(1H,3H)퀴나졸린디온308. 3-β- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 , 4- (1H, 3H) quinazolindione

309. 5-β-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논309. 5-β- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl-2 -Methylamino-3,6-dimethyl-4 (3H) pyrimidinone

310. 3-β-[엑소/엔도-6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]-옥탄-3-일]에틸-2,4-(1H,3H)퀴나졸린디온310. 3-β- [exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] -octan-3-yl] ethyl- 2,4- (1H, 3H) quinazolindione

311. 5-β-[엑소/엔도-6-p-플루오로페닐-l,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸-2-메틸아미노-3,6-디메틸-4(3H)피리미디논311. 5-β- [exo / endo-6-p-fluorophenyl-l, 5-cis-8-oxa-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl-2 -Methylamino-3,6-dimethyl-4 (3H) pyrimidinone

312. 1-β-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸인돌린-2-온312. 1-β- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethylindolin 2-on

313. 6-β-[6-페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸-7-메틸-5H-티아졸로[3,2-a]피리미딘-5-온313. 6-β- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl-7-methyl-5H -Thiazolo [3,2-a] pyrimidin-5-one

314. N-(2-[엑소-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸)-4-플루오로벤즈아미드314.N- (2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -4-fluorobenz amides

315. N-(2-[엔도-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸)-4-플루오로벤즈아미드315.N- (2- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) -4-fluorobenz amides

316. N-(2-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로316. N- (2- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸)-4-플루오로벤즈아미드[3.3.0] octan-3-yl] ethyl) -4-fluorobenzamide

317. N-(2-[엑소-6-p-트리플루오로메틸페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸)벤즈아미드317. N- (2- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) benz amides

318. N-(2-[엑소-6-m-클로로페닐-7-메틸-1,5-시스-3,7-디아자비시클로318.N- (2- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸)벤즈아미드[3.3.0] octan-3-yl] ethyl) benzamide

319. N-(2-[엑소-6-p-메톡시페닐-7-메틸-1,5-시스-3,7-디아자비시클로319.N- (2- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo

[3.3.0]옥탄-3-일]에틸)-4-클로로벤즈아미드[3.3.0] octan-3-yl] ethyl) -4-chlorobenzamide

320. N-(2-[엑소-6-페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌-1-카르복스아미드320. N- (2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carbox amides

321. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]부탄-1-온321. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octane-3 -Day] butan-1-one

322. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-7-메틸-1,5-시스-3,7-디아자비시클로[3.3.0]옥탄-3-일]부탄-1-올322. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] octane-3 -Yl] butan-1-ol

323. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)벤즈아미드323. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) benzamide

324. 1-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)나프탈렌324. 1- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene

325. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]부탄-1-온325. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1- On

326. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]부탄-1-올326. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1- Come

327. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)-2-(N-메틸)아미노벤즈아미드327. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -2- (N-methyl) amino Benzamide

328. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)-5-클로로티엔-2-일카르복스아미드328. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -5-chlorothien-2-yl Carboxamide

329. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)인덴-3-카르복스아미드329.N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) indene-3-carboxamide

330. N-(2-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)-4-플루오로벤즈아미드330. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -4-fluorobenzamide

331. N-(2-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)나프탈렌-1-카르복스아미드331.N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene-1-carboxamide

332. 1-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)나프탈렌332. 1- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene

333. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]부탄-1-온333. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] Butan-1-one

334. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)벤즈아미드334. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) benzamide

335. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)인덴-3-카르복스아미드335. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) inden-3-car Voxamide

336. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)나프탈렌-1-카르복스아미드336. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene-1-car Voxamide

337. N-(2-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.O]논-7-엔-3-일]에틸)-4-플루오로벤즈아미드337.N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.O] non-7-en-3-yl] ethyl) -4-fluorobenzamide

338. N-(2-[엑소-6-페닐-1,5-시스-3-아자비시클로[4.3.O]논-7-엔-3-일]에틸)-3-클로로-1-벤조티엔-2-일카르복스아미드338. N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.O] non-7-en-3-yl] ethyl) -3-chloro-1-benzothiene 2-ylcarboxamide

339. 1-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸)나프탈렌339. 1- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) naphthalene

340. 1-(4-플루오로페닐)-4-[6-p-플루오로페닐-1,5-시스-3-아자비시클로340. 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo

[4.3.0]논-6-엔-3-일]부탄-1-온[4.3.0] non-6-en-3-yl] butan-1-one

341. 1-(4-플루오로페닐)-4-[6-p-플루오로페닐-1,5-시스-3-아자비시클로341. 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo

[4.3.0]논-6-엔-3-일]부탄-1-올[4.3.0] non-6-en-3-yl] butan-1-ol

342. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-6-엔-3-일]에틸)-2-(N-메틸)아미노벤즈아미드342. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-6-en-3-yl] ethyl) -2- (N-methyl Aminobenzamide

343. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-6-엔-3-일]에틸)-5-클로로티엔-2-일카르복스아미드343.N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-6-en-3-yl] ethyl) -5-chlorothiene-2 Monocarboxamide

344. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-6-엔-3-일]에틸)벤즈아미드344. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-6-en-3-yl] ethyl) benzamide

345. N-(2-[6-페닐-1,5-시스-3-아자비시클로[4.3.O]논-6-엔-3-일]에틸)-3-클로로-1-벤조티엔-2-일카르복스아미드345. N- (2- [6-phenyl-1,5-cis-3-azabicyclo [4.3.O] non-6-en-3-yl] ethyl) -3-chloro-1-benzothiene-2 Monocarboxamide

346. N-(2-[6-p-트리플루오로메틸페닐-1,5-시스-3-아자비시클로[4.3.0]논-6-엔-3-일]에틸)나프탈렌-1-카르복스아미드346. N- (2- [6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-6-en-3-yl] ethyl) naphthalene-1-carbox amides

347. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-6-엔-3-일]에틸)인덴-3-카르본이미드347. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-6-en-3-yl] ethyl) indene-3-carbonyl mid

348. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-6-엔-3-일]에틸)나프탈렌-1-카르복스아미드348. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-6-en-3-yl] ethyl) naphthalene-1-carboxamide

349. 1-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)나프탈렌349. 1- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene

350. 1-(4-플루오로페닐)-4-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]부탄-1-온350. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1- On

351. 1-(4-플루오로페닐)-4-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]부탄-1-올351. 1- (4-Fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1- Come

352. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]-2-(N-메틸)아미노벤즈아미드352.N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] -2- (N-methyl) aminobenzamide

353. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)벤즈아미드353.N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) benzamide

354. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.O]논-3-일]에틸)-5-클로로티엔-2-일카르복스아미드354. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.O] non-3-yl] ethyl) -5-chlorothien-2-yl Carboxamide

355. N-(2-[엔도-6-페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)-4-플루오로벤즈아미드355. N- (2- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -4-fluorobenzamide

356. N-(2-[엔도-6-p-트리플루오로메틸페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)인덴-3-카르복스아미드356. N- (2- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) indene-3-carboxamide

357. 2-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)나프탈렌357. 2- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene

358. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)벤즈아미드358. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) benzamide

359. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)-2-(N-메틸)아미노벤즈아미드359. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) -2- (N -Methyl) aminobenzamide

360. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-7-엔-3-일]에틸)나프탈렌-1-카르복스아미드360. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-7-en-3-yl] ethyl) naphthalene-1-car Voxamide

361. 1-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸)나프탈렌361. 1- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) naphthalene

362. 1-(4-플루오로페닐)-4-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]부탄-1-온362. 1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] Butan-1-one

363. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸)벤즈아미드363. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) benzamide

364. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸)-5-클로로티엔-2-일카르복스아미드364. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -5-chlorothiene 2-ylcarboxamide

365. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸)-3-클로로-1-벤조티엔-2-일카르복스아미드365. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) -3-chloro- 1-benzothien-2-ylcarboxamide

366. N-(2-[엑소-7-페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸)인덴-3-카르복스아미드366.N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) indene-3-carboxamide

367. N-(2-[엑소-7-페닐-1,5-시스-3-아자비시클로[4.3.0]논-8-엔-3-일]에틸)나프탈렌-1-카르복스아미드367.N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] non-8-en-3-yl] ethyl) naphthalene-1-carboxamide

368. 1-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)나프탈렌368. 1- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene

369. 1-(4-플루오로페닐)-4-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]부탄-1-온369. 1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1- On

370. 1-(4-플루오로페닐)-4-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]부탄-1-올370. 1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] butan-1- Come

371. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)-2-(N-메틸)아미노벤즈아미드371. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -2- (N-methyl) amino Benzamide

372. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)벤즈아미드372.N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) benzamide

373. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)-5-클로로티엔-2-일카르복스아미드373. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) -5-chlorothien-2-yl Carboxamide

374. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)나프탈렌-1-카르복스아미드374. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) naphthalene-1-carboxamide

375. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[4.3.0]논-3-일]에틸)인덴-3-카르복스아미드375. N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] non-3-yl] ethyl) indene-3-carboxamide

376. 1-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)나프탈렌376. 1- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene

377. 1-(4-플루오로페닐)-4-[6-p-플루오로페닐-1,5-시스-3-아자비시클로377. 1- (4-fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo

[3.3.0]옥트-6-엔-3-일]부탄-1-온[3.3.0] oct-6-en-3-yl] butan-1-one

378. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)벤즈아미드378.N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) benzamide

379. N-(2-[6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)나프탈렌-1-카르복스아미드379. N- (2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene-1-carboxamide

380. 1-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌380. 1- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

381. 1-(4-플루오로페닐)-4-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]부탄-1-올381. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butan-1- Come

382. N-(2-[엑소-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)벤즈아미드382. N- (2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

383. N-(2-[엑소-6-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌-1-카르복스아미드383.N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

384. N-(2-[엑소-6-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)인덴-3-카르복스아미드384.N- (2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) indene-3-carboxamide

385. 1-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌385. 1- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

386. 1-(4-플루오로페닐)-4-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]부탄-1-온386. 1- (4-Fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butan-1- On

387. N-(2-[엔도-6-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)벤즈아미드387. N- (2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

388. N-(2-[엔도-6-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌-1-카르복스아미드388.N- (2- [endo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

389. 1-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌389. 1- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

390. 1-(4-플루오로페닐)-4-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]부탄-1-온390. 1- (4-Fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] butane-1- On

391. N-(2-[엑소-7-p-플루오로페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)벤즈아미드391.N- (2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) benzamide

392. N-(2-[엑소-7-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌-1-카르복스아미드392.N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene-1-carboxamide

393. N-(2-[엑소-7-페닐-1,5-시스-3-아자비시클로[3.3.0]옥탄-3-일]에틸)인덴-3-카르복스아미드393.N- (2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] octan-3-yl] ethyl) indene-3-carboxamide

394. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸)-4-플루오로벤즈아미드394. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl) -4-fluorobenzamide

395. N-(2-[엑소-6-페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸)-5-클로로티엔-2-일카르복스아미드395.N- (2- [exo-6-phenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl) -5-chlorothien-2-ylcarboxamide

396. N-(2-[6,6-디페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸)나프트-1-일카르복스아미드396. N- (2- [6,6-diphenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl) naphth-1-ylcarboxamide

397. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.1.O]헥산-3-일]에틸)-3-클로로-1-벤조티엔-2-일카르복스아미드397.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.O] hexane-3-yl] ethyl) -3-chloro-1-benzothien-2-ylcarbox amides

398. N-(2-[엑소-6-m-클로로페닐-3-아자비시클로[3.1.0]헥산-3-일]에틸)-4-클로로벤즈아미드398. N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] hexane-3-yl] ethyl) -4-chlorobenzamide

399. 1-(2-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)나프탈렌399. 1- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene

400. N-(2-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.O]옥트-6-엔-3-일]에틸)벤즈아미드400. N- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.O] oct-6-en-3-yl] ethyl) Benzamide

401. N-(2-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)나프탈렌-1-카르복스아미드401. N- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) Naphthalene-1-carboxamide

402. N-(2-[6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)인덴-3-카르복스아미드402.N- (2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) Inden-3-carboxamide

403. 1-(2-[엑소/엔도-6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸)나프탈렌403. 1- (2- [exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) naphthalene

404. N-(2-[엑소/엔도-6-p-플루오로페닐-1,5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥탄-3-일]에틸)벤즈아미드404. N- (2- [exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] octan-3-yl] ethyl) Benzamide

405. 1-(2-[6-페닐-1-5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)나프탈렌405. 1- (2- [6-phenyl-1-5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) naphthalene

406. N-(2-[6-페닐-1-5-시스-8-옥사-3,7-디아자비시클로[3.3.0]옥트-6-엔-3-일]에틸)벤즈아미드406. N- (2- [6-phenyl-1-5-cis-8-oxa-3,7-diazabicyclo [3.3.0] oct-6-en-3-yl] ethyl) benzamide

407. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조술폰아미드407. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzosulfonamide

408. N-(2-[엑소-6-페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조술폰아미드408. N- (2- [exo-6-phenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzosulfonamide

409. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-N-메틸벤조술폰아미드409.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -N-methylbenzosulfonamide

410. N-(2-[엑소-6-(5-클로로티엔-2-일)-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-플루오로벤조술폰아미드410.N- (2- [exo-6- (5-chlorothien-2-yl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorobenzosulfonamide

411. 3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-1-페녹시프로판411. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-phenoxypropane

412. 2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-1-p-플루오로페녹시에탄412. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-fluorophenoxyethane

413. 3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-1-(1-나프틸옥시)프로판413. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1- (1-naphthyloxy) propane

414. 3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-1-p-t-부틸페녹시프로판414. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-t-butylphenoxypropane

415. 3-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]-1-p-플루오로페녹시프로판415. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] -1-p-fluorophenoxypropane

416. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)티오벤즈아미드416. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiobenzamide

417. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-플루오로티오벤즈아미드417. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-fluorothiobenzamide

418. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-클로로티오벤즈아미드418. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-chlorothiobenzamide

419. O-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조에이트419.O- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzoate

420. 0-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸-4-플루오로벤조에이트420. 0- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl-4-fluorobenzoate

421. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-1H-벤조[cd]인돌-2-온421.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

422. N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-1H-벤조[cd]인돌-2-온422.N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

423. N-(2-[엑소-6-m-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-1H-벤조[cd]인돌-2-온423.N- (2- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

424. N-(2-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-1H-벤조[cd]인돌-2-온424.N- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -1H-benzo [cd] indol-2-one

425. 3,3-디메틸-1-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인돌린-2-온425. 3,3-Dimethyl-1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolin-2-one

426. 3,3-디메틸-1-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인돌린-2-온426. 3,3-Dimethyl-1- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolin-2-one

427. 3,3-디메틸-1-(2-[엑소-6-m-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인돌린-2-온427. 3,3-Dimethyl-1- (2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolin-2-one

428. 1-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-3,3,5-트리메틸인돌린-2-온428. 1- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -3,3,5-trimethylindolin-2-one

429. 3,4-디클로로-N-(2-[엑소-6-p-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드429. 3,4-Dichloro-N- (2- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

430. 2,5-디플루오로-N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드430. 2,5-Difluoro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

431. 2-아미노-N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드431. 2-Amino-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

432. 2-아미노-N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드432. 2-amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

433. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-2-메틸아미노벤즈아미드433.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -2-methylaminobenzamide

434. N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)-2-메틸아미노벤즈아미드434. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) -2-methylaminobenzamide

435. 3-아미노-N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드435. 3-Amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

436. 4-아미노-N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈아미드436. 4-Amino-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzamide

437. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)티오펜-2-카르복스아미드437.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

438. 5-클로로-N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)티오펜-2-카르복스아미드438. 5-Chloro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

439. 5-클로로-N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)티오펜-2-카르복스아미드439. 5-Chloro-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) thiophene-2-carboxamide

440. 5-클로로-N-(2-[엑소-6-(5-클로로-2-티에닐)-3-아자비시클로-[3.2.0]헵탄-3-일]에틸)티오펜-2-카르복스아미드440. 5-Chloro-N- (2- [exo-6- (5-chloro-2-thienyl) -3-azabicyclo- [3.2.0] heptan-3-yl] ethyl) thiophen-2- Carboxamide

441. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조[b]푸란-2-카르복스아미드441.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] furan-2-carboxamide

442. 3-클로로-N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조[b]티오펜-2-카르복스아미드442. 3-Chloro-N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] thiophene-2-carbox amides

443. 3-클로로-N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조[b]티오펜-2-카르복스아미드443. 3-Chloro-N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] thiophene-2-carboxamide

444. 3-클로로-N-(2-[엑소-6-p-니트로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤조[b]티오펜-2-카르복스아미드444. 3-Chloro-N- (2- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzo [b] thiophene-2-carboxamide

445. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인덴-3-카르복스아미드445. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indene-3-carboxamide

446. N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인덴-3-카르복스아미드446. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indene-3-carboxamide

447. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)시클로프로판카르복스아미드447. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclopropanecarboxamide

448. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.O]헵탄-3-일]에틸)시클로펜탄카르복스아미드448.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.O] heptan-3-yl] ethyl) cyclopentanecarboxamide

449. N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)시클로펜탄카르복스아미드449. N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclopentanecarboxamide

450. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)시클로헥산카르복스아미드450. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclohexanecarboxamide

451. N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)시클로헥산카르복스아미드451.N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) cyclohexanecarboxamide

452. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)나프탈렌-1-카르복스아미드452. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) naphthalene-1-carboxamide

453. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인돌-2-카르복스아미드453.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indole-2-carboxamide

454. N-(2-[엑소-6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인돌-3-카르복스아미드454.N- (2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indole-3-carboxamide

455. 엑소-6-p-플루오로페닐-3-[2-(1-나프틸)에틸]-3-아자비시클로[3.2.0]헵탄455. Exo-6-p-fluorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

456. 엑소-6-p-클로로페닐-3-[2-(1-나프틸)에틸)-3-아자비시클로[3.2.0]헵탄456. Exo-6-p-chlorophenyl-3- [2- (1-naphthyl) ethyl) -3-azabicyclo [3.2.0] heptane

457. 엑소-6-m-클로로페닐-3-[2-(1-나프틸)에틸]-3-아자비시클로[3.2.0]헵탄457. Exo-6-m-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

458. 엑소-6-(5-클로로-2-티에닐)-3-[2-(1-나프틸)에틸]-3-아자비시클로458. Exo-6- (5-chloro-2-thienyl) -3- [2- (1-naphthyl) ethyl] -3-azabicyclo

[3.2.0]헵탄[3.2.0] heptane

459. 엑소-6-p-플루오로페닐-3-[2-(2-나프틸)에틸]-3-아자비시클로[3.2.0]헵탄459. Exo-6-p-fluorophenyl-3- [2- (2-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane

460. 엑소-6-p-플루오로페닐-3-[1-나프틸메틸]-3-아자비시클로[3.2.0]헵탄460. Exo-6-p-fluorophenyl-3- [1-naphthylmethyl] -3-azabicyclo [3.2.0] heptane

461. 엑소-6-p-플루오로페닐-3-[2-나프틸메틸]-3-아자비시클로[3.2.0]헵탄461.exo-6-p-fluorophenyl-3- [2-naphthylmethyl] -3-azabicyclo [3.2.0] heptane

462. 4-(6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일)-1-(티오펜-2-일)부탄-1-온462. 4- (6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl) -1- (thiophen-2-yl) butan-1-one

463. 4-(6-p-클로로페닐-3-아자비시클로[3.2.0]헵탄-3-일)-1-(티오펜-2-일)부탄-1-온463. 4- (6-p-chlorophenyl-3-azabicyclo [3.2.0] heptan-3-yl) -1- (thiophen-2-yl) butan-1-one

464. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-4-페닐피롤리딘-2-온464. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -4-phenylpyrrolidin-2-one

465. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)벤즈옥사졸린-2-온465. N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) benzoxazolin-2-one

466. N-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)이소인돌리논466.N- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) isoindolinone

467. 1-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인다졸467. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indazole

468. 1-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-1,8-나프탈렌술탐468. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1,8-naphthalenesultam

469. 4-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)-1,4-벤즈옥사진-3-온469. 4- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) -1,4-benzoxazin-3-one

470. 1-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)퀴녹살린-2(1H)-온470. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) quinoxalin-2 (1H) -one

471. 1-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)인돌린-2-온471. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) indolin-2-one

472. 1-(2-[엑소-6-p-플루오로페닐-3-아자비시클로[3.2.0]헵탄-3-일]에틸)스피로[시클로프로판-1',3-인돌린-2-온]472. 1- (2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptan-3-yl] ethyl) spiro [cyclopropane-1 ', 3-indolin-2- On]

473. 3,6-디메틸-2-메틸아미노-5-[2-(엑소-6-(2-나프틸)-3-아자비시클로473. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (2-naphthyl) -3-azabicyclo

[3.2.0]헵탄-3-일)에틸]-3H-피리미딘-4-온[3.2.0] heptan-3-yl) ethyl] -3H-pyrimidin-4-one

474. 3,6-디메틸-2-메틸아미노-5-[2-(엑소-6-(1-나프틸)-3-아자비시클로474. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (1-naphthyl) -3-azabicyclo

[3.2.0]헵탄-3-일)에틸]-3H-피리미딘-4-온[3.2.0] heptan-3-yl) ethyl] -3H-pyrimidin-4-one

475. 3,6-디메틸-2-메틸아미노-5-[2-(엑소-6-(5-클로로-1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-3H-피리미딘-4-온475. 3,6-dimethyl-2-methylamino-5- [2- (exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl ] -3H-pyrimidin-4-one

476. 3,6-디메틸-2-메틸아미노-5-[2-(엑소-6-(6-클로로-2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-3H-피리미딘-4-온476. 3,6-Dimethyl-2-methylamino-5- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl ] -3H-pyrimidin-4-one

477. 3,6-디메틸-2-메틸아미노-5-[2-(엑소-6-(9-페난트릴)-3-아자비시클로477. 3,6-dimethyl-2-methylamino-5- [2- (exo-6- (9-phenanthryl) -3-azabicyclo

[3.2.0]헵탄-3-일)에틸]-3H-피리미딘-4-온[3.2.0] heptan-3-yl) ethyl] -3H-pyrimidin-4-one

478. 7-메틸-6-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-5H-티아졸로[3,2-a]피리미딘-5-온478. 7-Methyl-6- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -5H-thiazolo [3,2- a] pyrimidin-5-one

479. 3-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H,3H-퀴나졸린-2,4-디온479. 3- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazolin-2,4-dione

480. 3-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H,3H-퀴나졸린-2,4-디온480. 3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H, 3H-quinazolin-2,4-dione

481. 6-플루오로-3-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H,3H-퀴나졸린-2,4-디온481. 6-Fluoro-3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1 H, 3H-quinazolin-2 , 4-dione

482. 3-[2-(엑소-6-(5-클로로-2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H,3H-퀴나졸린-2,4-디온482. 3- [2- (exo-6- (5-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1 H, 3H-quinazolin-2, 4-dion

483. 3-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-2-메틸-4H-피리도[1.2-a]피리미딘-4-온483. 3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2-methyl-4H-pyrido [1.2-a] Pyrimidin-4-one

484. 1-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-2(1H)퀴놀론484. 1- [2- (Exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2 (1H) quinolone

485. 1-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]인돌린-2-온485. 1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] indolin-2-one

486. 1-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-2(3H)벤즈이미다졸론486. 1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2 (3H) benzimidazolone

487. 1-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-3-메틸-2(3H)벤즈이미다졸론487. 1- [2- (Exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -3-methyl-2 (3H) benzimidazolone

488. N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]벤즈아미드488. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

489. N-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]벤즈아미드489. N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

490. N-[2-(엑소-6-(5-클로로-1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]벤즈아미드490. N- [2- (exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

491. 3-[2-(1-나프틸)에틸]-엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄491. 3- [2- (1-naphthyl) ethyl] -exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptane

492. 3-[2-(1-나프틸)에틸]-엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄492. 3- [2- (1-naphthyl) ethyl] -exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptane

493. 1-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H-벤조[cd]인돌-2-온493. 1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H-benzo [cd] indol-2-one

494. 1-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H-벤조[cd]인돌-2-온494. 1- [2- (Exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H-benzo [cd] indol-2-one

495. 3,3-디메틸-1-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1,3-디히드로인돌-2-온495. 3,3-Dimethyl-1- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1,3-dihydroindole 2-on

496. 3,3-디메틸-1-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1,3-디히드로인돌-2-온496. 3,3-Dimethyl-1- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1,3-dihydroindole 2-on

497. 3,3-디메틸-1-[2-(엑소-6-(6-클로로-2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1,3-디히드로인돌-2-온497. 3,3-Dimethyl-1- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1,3 -Dihydroindol-2-one

498. 5-클로로-N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-2-티오펜카르복스아미드498. 5-Chloro-N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2-thiophenecarboxamide

499. 5-클로로-N-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-2-티오펜카르복스아미드499. 5-Chloro-N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -2-thiophenecarboxamide

500. N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-4-플루오로벤즈아미드500. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-fluorobenzamide

501. N-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-4-니트로벤즈아미드501.N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -4-nitrobenzamide

502. N-[2-(엑소-6-(6-클로로-2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]벤즈아미드502. N- [2- (exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

503. N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.O]헵탄-3-일)에틸]-4-메톡시벤즈아미드503.N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.O] heptan-3-yl) ethyl] -4-methoxybenzamide

504. N-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.O]헵탄-3-일)에틸]-4-히드록시벤즈아미드504.N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.O] heptan-3-yl) ethyl] -4-hydroxybenzamide

505. N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.O]헵탄-3-일)에틸]-3,4-디클로로벤즈아미드505. N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.O] heptan-3-yl) ethyl] -3,4-dichlorobenzamide

506. N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]나프탈렌-1-카르복스아미드506.N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] naphthalene-1-carboxamide

507. N-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.O]헵탄-3-일)에틸]나프탈렌-1-카르복스아미드507.N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.O] heptan-3-yl) ethyl] naphthalene-1-carboxamide

508. N-[2-(엑소-6-(9-페난트릴)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]벤즈아미드508. N- [2- (exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] benzamide

509. 1-[2-(엑소-6-(6-클로로-2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H-벤조[cd]인돌-2-온509. 1- [2- (Exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H-benzo [cd] indole-2 -On

510. 1-[2-(엑소-6-(9-페난트릴)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]-1H-벤조[cd]인돌-2-온510. 1- [2- (Exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] -1H-benzo [cd] indol-2-one

511. N-[2-(엑소-6-(1-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]이소인돌리논511.N- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] isoindolinone

512. N-[2-(엑소-6-(2-나프틸)-3-아자비시클로[3.2.0]헵탄-3-일)에틸]이소인돌리논512.N- [2- (exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptan-3-yl) ethyl] isoindolinone

513. (+)-(1S,5R,6S)엑소-1-[2-[6-(4-클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-3-메틸-2H-1,3-디히드로벤즈이미다졸-2-온513. (+)-(1S, 5R, 6S) exo-1- [2- [6- (4-chlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -3- Methyl-2H-1,3-dihydrobenzimidazol-2-one

514. (+)-(1S,5R,6S)엑소-1-[2-[6-(4-클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-3-에틸-2H-1,3-디히드로벤즈이미다졸-2-온514. (+)-(1S, 5R, 6S) exo-1- [2- [6- (4-chlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -3- Ethyl-2H-1,3-dihydrobenzimidazol-2-one

515. (+)-(1S,5R,6S)엑소-1-[2-[6-(4-클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-3-n-프로필-2H-1,3-디히드로벤즈이미다졸-2-온515. (+)-(1S, 5R, 6S) exo-1- [2- [6- (4-chlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -3- n-propyl-2H-1,3-dihydrobenzimidazol-2-one

516. (+)-(1S,5R,6S)엑소-2-[2-[6-(4-클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-3,3-디메틸-2,3-디히드로-1,2-벤즈이소티아졸 1,1-디옥시드516. (+)-(1S, 5R, 6S) exo-2- [2- [6- (4-chlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -3, 3-dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

517. (+)-(1S,5R,6S)엑소-2-[2-[6-(4-클로로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-2,3-디히드로-1,2-벤즈이소티아졸 1,1-디옥시드517. (+)-(1S, 5R, 6S) exo-2- [2- [6- (4-chlorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -2, 3-dihydro-1,2-benzisothiazole 1,1-dioxide

518. (+)-(1S,5R,6S)엑소-2-[2-[6-(4-플루오로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-3,3-디메틸-2,3-디히드로-1,2-벤즈이소티아졸 1,1-디옥시드518. (+)-(1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -3 , 3-dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

519. (+)-(1S,5R,6S)엑소-2-[2-[6-(4-플루오로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-3,3-디에틸-2,3-디히드로-1,2-벤즈이소티아졸 1,1-디옥시드519. (+)-(1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -3 , 3-diethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

520. (+)-(1S,5R,6S)엑소-2-[2-[6-(4-플루오로페닐)-3-아자비시클로[3.2.0]헵탄-3-일]에틸]-2,3-디히드로-1,2-벤즈이소티아졸 1,1-디옥시드520. (+)-(1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] heptan-3-yl] ethyl] -2 , 3-dihydro-1,2-benzisothiazole 1,1-dioxide

Claims (4)

중추신경계 질환 치료용 약제의 제조를 위한, 하기 화학식 Ⅰ의 N-치환 3-아자비시클로알칸 유도체 및 이들 유도체와 생리학적으로 허용되는 산과의 염의 용도.Use of N-substituted 3-azabicycloalkane derivatives of Formula I and salts of these derivatives with physiologically acceptable acids for the manufacture of a medicament for the treatment of central nervous system diseases. <화학식 Ⅰ><Formula I> 상기 식에서,Where B는 이중 결합을 함유할 수 있는 4-, 5- 또는 6-원 고리이며,B is a 4-, 5- or 6-membered ring which may contain double bonds, R1은 각각 할로겐 원자, C1-4알킬, 트리플루오로메틸, 히드록실, C1-4알콕시, 아미노, 모노메틸아미노, 디메틸아미노, 시아노 또는 니트로기에 의하여 단일치환 또는 이치환되거나, 치환되지 않은 페닐, 나프틸, 페난트릴 또는 티에닐기이고,R 1 is monosubstituted or disubstituted or substituted by a halogen atom, C 1-4 alkyl, trifluoromethyl, hydroxyl, C 1-4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro group, respectively Phenyl, naphthyl, phenanthryl or thienyl groups, n은 0, 1, 2, 3 또는 4의 수이며,n is a number of 0, 1, 2, 3 or 4, R2는 1개 또는 2개의 할로겐 원자에 의하여 치환되거나, 치환되지 않은 나프틸기이거나, 또는 하기의 라디칼들 중 하나이다:R 2 is an unsubstituted naphthyl group, substituted by one or two halogen atoms, or one of the following radicals: (상기 식에서,(Wherein R3은 수소 원자, 히드록실기이거나, 또는 불소, 염소 또는 브롬 원자에 의하여 치환되거나, 치환되지 않은 페닐 라디칼이고,R 3 is a hydrogen atom, a hydroxyl group, or a phenyl radical substituted or unsubstituted by a fluorine, chlorine or bromine atom, R4는 수소 원자이거나, 또는R 4 is a hydrogen atom, or R3및 R4는 함께 산소 원자이고,R 3 and R 4 together are oxygen atom, R5는 각각 불소, 염소 또는 브롬 원자에 의하여, 또는 히드록실, 니트로, 아미노, C1-4알카노일아미노, C1-4알킬아미노, C1-4알킬 또는 메톡시기에 의하여 단일치환 또는 이치환되거나, 치환되지 않은 페닐, 나프틸 또는 티에닐기이며,R 5 is mono- or di-substituted by fluorine, chlorine or bromine atoms, or by hydroxyl, nitro, amino, C 1-4 alkanoylamino, C 1-4 alkylamino, C 1-4 alkyl or methoxy groups Or an unsubstituted phenyl, naphthyl or thienyl group, R6은 수소 원자 또는 메틸기이고,R 6 is a hydrogen atom or a methyl group, R7은 각각 불소, 염소 또는 브롬 원자에 의하여, 또는 C1-4알킬, 히드록실, 메톡시, 니트로, 시아노, 트리플루오로메틸, 아미노 또는 디-C1-4알킬아미노기에 의하여 단일치환 또는 이치환되거나, 치환되지 않은 페닐, 나프틸, 벤조푸릴, 벤조티에닐, 티에닐, 인돌릴, N-메틸인돌릴 또는 인데닐기이거나, 또는 C3-7시클로알킬기이고,R 7 is monosubstituted by fluorine, chlorine or bromine atoms, or by C 1-4 alkyl, hydroxyl, methoxy, nitro, cyano, trifluoromethyl, amino or di-C 1-4 alkylamino groups, respectively Or a di-substituted or unsubstituted phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl group, or a C 3-7 cycloalkyl group, R8은 수소 원자, 또는 불소 또는 염소 원자, 또는 C1-4알킬, 메톡시 또는 아미노기이며,R 8 is a hydrogen atom or a fluorine or chlorine atom or a C 1-4 alkyl, methoxy or amino group, R9는 수소 원자 또는 메틸기이며,R 9 is a hydrogen atom or a methyl group, R10은 수소 원자 또는 메틸기이거나, 또는R 10 is a hydrogen atom or a methyl group, or R9와 R10은 고리 탄소 원자와 함께 스피로시클로프로판 고리를 형성하고,R 9 and R 10 together with the ring carbon atom form a spirocyclopropane ring, R11은 수소 원자, 히드록실, C1-C4알킬 또는 C1-C4알콕시기이거나, 인접한 탄소 원자와 함께 C=O- 또는 C=S기를 형성하고,R 11 is a hydrogen atom, hydroxyl, a C 1 -C 4 alkyl or a C 1 -C 4 alkoxy group or together with adjacent carbon atoms forms a C═O— or C═S group, X 및 Y는 탄소 원자, CH, CH2, NH 또는 C1-C4알킬-N기, 또는 질소 원자이고,X and Y are carbon atoms, CH, CH 2 , NH or C 1 -C 4 alkyl-N groups, or nitrogen atoms, Z는 직접 결합, CO기, CS기이거나, 또는 수소 원자가 히드록실, 아미노 또는 C1-C4알콕시기에 의하여 또는 할로겐 원자에 의하여 치환될 수 있는 CH 또는 CH2기이고,Z is a direct bond, a CO group, a CS group, or a CH or CH 2 group where the hydrogen atom may be substituted by a hydroxyl, amino or C 1 -C 4 alkoxy group or by a halogen atom, A는 수소 원자, 히드록실, 아미노, 메르캅토, C1-C4알킬아미노, 디-C1-C4알킬아미노, C1-C4알킬티오 또는 C1-C4알콕시기이거나, 인접한 탄소 원자와 함께 C=O기를 형성하거나, 또는A is a hydrogen atom, hydroxyl, amino, mercapto, C 1 -C 4 alkylamino, di-C 1 -C 4 alkylamino, C 1 -C 4 alkylthio or C 1 -C 4 alkoxy group, or an adjacent carbon Form a C═O group with an atom, or A는 이중 결합을 비연속적으로 1개 또는 2개 함유할 수 있고 CH 또는 CH2기 중 하나가 질소 또는 황 원자에 의하여 또는 NH 또는 N-CH3기에 의하여 대체될 수 있는, Y에 결합된 C3-C4알킬렌기이고, 이와 같은 A 함유 고리는 불소 또는 염소 원자에 의하여, 또는 메틸, 메톡시, 니트로 또는 아미노기에 의하여 단일 치환되고, 상기 고리가 벤젠 고리인 경우, 이 고리는 불소 또는 염소 원자 또는 메틸, 트리플루오로메틸, 니트로, 히드록실, 메톡시, 아미노, 모노메틸 또는 디메틸아미노기에 의하여 단일치환, 이치환, 또는 삼치환될 수 있으며,A is a C bonded to Y, which may contain one or two double bonds discontinuously and one of the CH or CH 2 groups may be replaced by a nitrogen or sulfur atom or by an NH or N-CH 3 group. A 3 -C 4 alkylene group, such an A containing ring is mono-substituted by a fluorine or chlorine atom or by a methyl, methoxy, nitro or amino group, and when the ring is a benzene ring, the ring is fluorine or chlorine Mono-, di-, or tri-substituted by an atom or a methyl, trifluoromethyl, nitro, hydroxyl, methoxy, amino, monomethyl or dimethylamino group, X-, Y- 및 Z-함유 고리는 1번 질소 원자에서 C1-C4알킬, 알릴 또는 벤질기를가질 수 있으며, 이중 결합을 비연속적으로 1개 내지 3개 함유할 수 있다).X-, Y- and Z-containing rings may have a C 1 -C 4 alkyl, allyl or benzyl group at nitrogen atom 1 and may contain 1 to 3 double bonds discontinuously). 제1항에 있어서, 중독성 질환 치료용 약제의 제조를 위한 용도.Use according to claim 1 for the manufacture of a medicament for the treatment of addictive diseases. 제1항 또는 제2항에 있어서, 코카인 중독 치료용 약제의 제조를 위한 용도.Use according to claim 1 or 2 for the manufacture of a medicament for the treatment of cocaine poisoning. 제1항 또는 제2항에 있어서, 암페타민 및 암페타민계 물질에 대한 중독 억제용 약제의 제조를 위한 용도.Use according to claim 1 or 2 for the preparation of a medicament for inhibiting addiction to amphetamine and amphetamine-based substances.
KR1020017006445A 1998-11-24 1999-11-12 Use of N-Substituted Azabicycloalkane Derivatives for Treating Diseases of the Central Nervous System KR20010080535A (en)

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