CZ20011796A3 - Use of N-substituted azabicycloalkane derivatives for treating central nervous system disorders - Google Patents

Use of N-substituted azabicycloalkane derivatives for treating central nervous system disorders Download PDF

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CZ20011796A3
CZ20011796A3 CZ20011796A CZ20011796A CZ20011796A3 CZ 20011796 A3 CZ20011796 A3 CZ 20011796A3 CZ 20011796 A CZ20011796 A CZ 20011796A CZ 20011796 A CZ20011796 A CZ 20011796A CZ 20011796 A3 CZ20011796 A3 CZ 20011796A3
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azabicyclo
exo
ethyl
fluorophenyl
heptyl
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Rainer Munschauer
Gerd Steiner
Gerhard Gross
Martin Traut
Liliane Unger
Hans-Jürgen Teschendorf
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Basf Aktiengesellschaft
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula (I), wherein B, R<1>, R<2> and n have the meanings given in the description, for combating diseases of addiction and other diseases of the central nervous system.

Description

Použití N-substituovaných azabicykloalkanových derivátů pro léčení poruch centrálního nervového systémuUse of N-substituted azabicycloalkane derivatives for the treatment of central nervous system disorders

Oblast technikyTechnical field

Tento vynález se týká použití N-substituovaných azabicykloalkanových derivátů pro léčení poruch centrálního nervového systému.The present invention relates to the use of N-substituted azabicycloalkane derivatives for the treatment of central nervous system disorders.

Dosavadní stav technikyBACKGROUND OF THE INVENTION

N-Substituované azabicykloalkanové dervity jsou již známé jako neuroleptika (WO 95/13279, WO 95/15327, WO 96/04272, US patent č. 5 475 105, US patent č. 5 521 209, US patent č. 5 616 705 a US patent č. 5 753 690). Bylo také nalezeno, že tyto substance jsou také vhodné pro potlačování návykových poruch a jiných poruch centrálního nervového systému.N-substituted azabicycloalkane dervites are already known as neuroleptics (WO 95/13279, WO 95/15327, WO 96/04272, US Patent No. 5,475,105, US Patent No. 5,521,209, US Patent No. 5,616,705, and U.S. Patent No. 5,753,690). It has also been found that these substances are also useful for suppressing addictive disorders and other central nervous system disorders.

Podstata vynálezuSUMMARY OF THE INVENTION

Tento vynález skýtá použití N-substituovanýchThe present invention provides the use of N-substituted

3-azabicykloalkanových derivátů obecného vzorce I3-azabicycloalkane derivatives of the general formula I

ve kterém znamená 4-, 5 - nebo 6-členný kruh, který může obsahovat dvojnou vazbu,wherein it is a 4-, 5- or 6-membered ring which may contain a double bond,

R1 je fenylová, naftylová, fenanthrylová nebo thienylová skupina, v každém případě nesubstituovaná nebo mononebo disubstituovaná atomy halogenu, alkylovými skupinami s 1 až 4 atomy uhlíku, trifluormethylovými skupinami, hydroxyskupinami, alkoxyskupinami s 1 až 4 atomy uhlíku, aminoskupinami, monomethylaminoskupinami, dimethylaminoskupinami, kyanoskupinami nebo nitroskupinami, n je číslo 0, 1, 2, 3 nebo 4 aR 1 is phenyl, naphthyl, phenanthryl or thienyl, in each case unsubstituted or mono- or disubstituted with halogen atoms, C 1 -C 4 alkyl, trifluoromethyl, hydroxy, C 1 -C 4 alkoxy, amino, monomethylamino, dimethylamino n is 0, 1, 2, 3 or 4; and cyano or nitro;

R2 je naftylová skupina, která je nesubstituovaná nebo substituovaná jedním nebo dvěma atomy halogenu, nebo jedním z následujících zbytkůR 2 is naphthyl which is unsubstituted or substituted by one or two halogen atoms, or one of the following radicals

kde r3 je atom vodíku, hydroxyskupina nebo fenylová skupina, která je nesubstituovaná nebo substituovaná atomem fluoru, chloru nebo bromu,wherein r 3 is a hydrogen atom, a hydroxy group or a phenyl group which is unsubstituted or substituted by a fluorine, chlorine or bromine atom,

R4 je atom vodíku neboR 4 is hydrogen or

R3 a R4 tvoří dohromady atom kyslíku,R 3 and R 4 together form an oxygen atom,

R5 je fenylová, naftylová nebo thienylová skupina, každá z nich je nesubstituovaná nebo mono- nebo disubstituovaná atomy fluoru, chloru nebo bromu, nebo hydroxyskupinami, nitroskupinami, aminoskupinami, alkanoylaminoskupinami s 1 až 4 atomy uhlíku, alkylaminoskupinami s 1 až 4 atomy uhlíku, alkylovými skupinami s 1 až 4 atomy uhlíku nebo methoxyskupinami,R 5 is phenyl, naphthyl or thienyl, each of which is unsubstituted or mono- or disubstituted by fluorine, chlorine or bromine atoms, or by hydroxy, nitro, amino, C 1 -C 4 alkanoylamino, C 1 -C 4 alkylamino, (C 1 -C 4) alkyl or methoxy

R6 je atom vodíku nebo methylová skupina,R 6 is a hydrogen atom or a methyl group,

R7 je fenylová, naftylová, benzofurylová, benzo • · thienylová, thienylová, indolylová, N-methylindolylová nebo indenylová skupina, v každém případě nesubstituovaná nebo mono- nebo disubstituovaná atomy fluoru, chloru nebo bromu, nebo alkylovými skupinami s 1 až 4 atomy uhlíku, hydroxyskupinami, methoxyskupinami, nitroskupinami, kyanoskupinami, trifluormethylovými skupinami, aminoskupinami, dialkylaminoskupinami s 1 až 4 atomy uhlíku v každé alkylové části, nebo je cykloalkylová skupina se 3 až 7 atomy uhlíku,R 7 is phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, thienyl, indolyl, N-methylindolyl or indenyl, in each case unsubstituted or mono- or disubstituted with fluorine, chlorine or bromine atoms or C 1 -C 4 alkyl groups , hydroxy, methoxy, nitro, cyano, trifluoromethyl, amino, dialkylamino of 1 to 4 carbon atoms in each alkyl moiety, or is cycloalkyl of 3 to 7 carbon atoms,

R8 je atom vodíku, atom fluoru nebo atom chloru, alkylová skupina s 1 až 4 atomy uhlíku, methoxyskupina nebo aminoskupina,R 8 is hydrogen, fluoro or chloro, C 1 -C 4 alkyl, methoxy or amino,

R9 je atom vodíku nebo methylová skupina aR 9 is hydrogen or methyl and

R10 je atom vodíku nebo methylová skupina nebo r9 a R10 dohromady s atomem uhlíku kruhu tvoří spirocyklopropanový kruh,R 10 is a hydrogen atom or a methyl group, or R 9 and R 10 together with the ring carbon atom form a spirocyclopropane ring,

R11 je atom vodíku, hydroxyskupina, alkylová skupina s 1 až 4 atomy uhlíku nebo alkoxyskupina s 1 až 4 atomy uhlíku, nebo dohromady se sousedícím atomem uhlíku tvoří skupinu vzorce C=0- nebo skupinu vzorce C=S-,R ( 11) is hydrogen, hydroxy, (C1-C4) -alkyl or (C1-C4) alkoxy, or together with an adjacent carbon atom forms a group of formula C = O- or a group of formula C = S-,

X a Y jsou atomy uhlíku, skupiny vzorce CH, CH2, NH nebo alkyl-N-skupina s 1 až 4 atomy uhlíku nebo atomy dusíku,X and Y are carbon atoms, CH, CH 2 , NH or C 1-4 alkyl or N-alkyl,

Z je přímá vazba, skupina vzorce CO, skupina vzorce • 9Z is a direct bond, a group of formula CO, a group of formula • 9

CS, skupina vzorce CH nebo skupina vzorce CH2, kde atom vodíku může být nahrazen hydroxyskupinou, aminoskupinou, alkoxyskupinou s 1 až 4 atomy uhlíku nebo atomem halogenu, aCS, CH or CH 2 , wherein the hydrogen atom may be replaced by hydroxy, amino, C 1 -C 4 alkoxy or halogen, and

A je atom vodíku, hydroxyskupina, aminoskupina, merkaptoskupina, alkylaminoskupina s 1 až 4 atomy uhlíku, dialkylaminoskupina s 1 až 4 atomy uhlíku v každé alkylové části, alkylthioskupina s 1 až 4 atomy uhlíku nebo alkoxyskupina s 1 až 4 atomy uhlíku, nebo dohromady se sousedícím atomem uhlíku tvoří skupinu vzorce C=0, neboA is hydrogen, hydroxy, amino, mercapto, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino in each alkyl moiety, C 1 -C 4 alkylthio or C 1 -C 4 alkoxy, or together an adjacent carbon atom forms a group of formula C = O, or

A je na Y-vázaná alkylenová skupina se 3 nebo 4 atomy uhlíku, která může obsahovat jednu nebo dvě nekumulované dvojné vazby a kde jedna ze skupin CH nebo CH2 může být nahrazena atomem dusíku nebo atomem síry nebo skupinou NH nebo skupinou N-CH3 a kde kruh je bud' monosubstituován atomem fluoru, chloru nebo methylovou skupinou, methoxyskupinou, nitroskupinou nebo aminoskupinou, nebo v případě benzenového kruhu, tento kruh může být mono-, di- nebo trisubstituován atomy fluoru nebo chloru nebo methylovými skupinami, trifluormethylovými skupinami, nitroskupinami, hydroxyskupinami, methoxyskupinami, aminoskupinami, monomethylovými skupinami nebo dimethylaminoskupinami, a kde kruh obsahující X, Y a Z na atomu dusíku v poloze 1 může nést alkylovou skupinu s 1 až 4 atomy uhlíku, allylovou skupinu nebo benzylovou skupinu a může obsahovat 1 až 3 nekumulované dvojné vazby,A is a Y-linked alkylene group having 3 or 4 carbon atoms, which may contain one or two non-accumulated double bonds and wherein one of the CH or CH 2 groups may be replaced by a nitrogen or sulfur atom or an NH group or an N-CH 3 group and wherein the ring is either monosubstituted by fluorine, chlorine or methyl, methoxy, nitro or amino, or in the case of a benzene ring, the ring may be mono-, di- or trisubstituted by fluorine or chlorine atoms or methyl, trifluoromethyl, nitro , hydroxy, methoxy, amino, monomethyl or dimethylamino groups, and wherein the ring containing X, Y and Z at the 1-position nitrogen atom may carry an alkyl group having 1 to 4 carbon atoms, an allyl group or a benzyl group and may contain 1 to 3 double bonds,

a jejich solí s fyziologicky přijatelnými kyselinami, pro výrobu léčiva pro potlačování návyku, pro léčení poruch koncentrace (poruchy nedostatku pozornosti), hyperaktivity u dětí (poruchy nedostatku pozornosti v důsledku hyperaktivity) , učení a ochablosti paměti (poškození kognitivní funkce).and their salts with physiologically acceptable acids, for the manufacture of a medicament for suppressing addiction, for treating concentration disorders (attention deficit disorders), hyperactivity in children (attention deficit hyperactivity disorders), learning and memory weakness (cognitive impairment).

Použití podle tohoto vynálezu se týká všech návykových poruch, pokud jsou způsobeny odejmutím substance nebo jiných návykových poruch, jako například závislosti na hrách. Substancemi vytvářejícími návyk mohou být:The use according to the invention relates to all addictive disorders as far as they are caused by the withdrawal of a substance or other addictive disorders, such as addiction to games. Addictive substances can be:

opioidy, například morfin nebo heroin, nikotin, alkohol, substance, které vzájemně reagují s komplexem benzodiazepinového receptoru, sedativy nebo transkvilizéry, například benzodiazepiny.opioids, for example morphine or heroin, nicotine, alcohol, substances that interact with a benzodiazepine receptor complex, sedatives or transquillizers, for example benzodiazepines.

Možné substance vytvářející návyk podle tohoto vynálezu jsou zvláště kokain nebo amfetamin a substance podobné amfetaminu.Possible addictive substances according to the invention are in particular cocaine or amphetamine and amphetamine-like substances.

Sloučeniny obecného vzorce I se mohou používat jak ve formě svých racemátů, tak svých optických isomerů.The compounds of the formula I can be used in the form of both their racemates and their optical isomers.

Pro nové indikace se sloučeniny mohou podávat obvyklým způsobem orálně nebo parenterálně, intravenózně nebo intramuskulárně.For new indications, the compounds may be administered orally or parenterally, intravenously or intramuscularly in the usual manner.

Dávka závisí na věku, stavu a hmotnosti pacienta a na typu podávání. Obecně denní dávka aktivní sloučeniny je mezi • · asi 1 a 100 mg/kg tělesné hmotnosti v případě orálního podávání a mezi 0,1 a 10 mg/kg tělesné hmotnosti v případě parenterálního podávání.The dose depends on the age, condition and weight of the patient and the type of administration. Generally, the daily dose of active compound is between about 1 and 100 mg / kg body weight for oral administration and between 0.1 and 10 mg / kg body weight for parenteral administration.

Sloučeniny se mohou používat ve formách obvyklých pro farmaceutické podání, v pevné nebo kapalné formě, například jako tablety, tablety povlečené filmem, kapsle, prášky, granule, tablety povlečné cukrem, čípky, roztoky, masti, krémy a spreje. Ty se vyrábějí obvyklým způsobem. K tomuto účelu se aktivní sloučeniny mohou zpracovávat s obvyklými farmaceutickými pomocnými látkami, jako jsou pojivá tablet, plniva, konzervační látky, látky napomáhající rozpadu tablet, regulátory toku, plastifikátory, zvlhčovači látky, dispergátory, emulgátory, rozpouštědla, látky zpomalující uvolňování, antioxidanty a/nebo propelenty (srovnej H. Sucker a kol., Pharmazeutische Technologie, Thieme-Verlag, Stuttgart (1978)). Výsledné formy pro podávání obvykle obsahují aktivní sloučeninu v množství od 1 do 99 % hmotnostních.The compounds may be used in forms customary for pharmaceutical administration, in solid or liquid form, for example, as tablets, film-coated tablets, capsules, powders, granules, sugar-coated tablets, suppositories, solutions, ointments, creams and sprays. These are produced in the usual manner. For this purpose, the active compounds can be formulated with conventional pharmaceutical auxiliaries such as binding tablets, fillers, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, release retardants, antioxidants and / or or propellants (cf. H. Sucker et al., Pharmazeutische Technologie, Thieme-Verlag, Stuttgart (1978)). The resulting administration forms usually contain the active compound in an amount of from 1 to 99% by weight.

Příklady provedení vynálezuDETAILED DESCRIPTION OF THE INVENTION

Následující sloučeniny se mohou uvést jako příklady sloučenin obecného vzorce I.The following compounds may be exemplified as compounds of formula I.

1. 1-(4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-1. 1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] -

-(3-heptyl)]butan-l-on,- (3-heptyl)] butan-1-one,

2. 1-fenyl-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-hepty1) ] butan-1-on,2. 1-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

3. 1-(4-fluorfenyl)-4-[exo-6,7-difenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,3. 1- (4-Fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

• · • · • · • · • · • · • • • 9 • • • 9 • 9 • · • · • 9 • · • · • • · • • · ·· • · ·· • · 9 9 • 9 9 9 • 9 • · • · ·· • · • · ·· • · · · • • • · · · • • • · · • · • · • · · • · • · • • ··· • • ··· • · • · · • · • 9 • · • · · • · • 9 • • 9 •999 • • 9 • 999

. 1-(4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan,. 1- (4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane,

5. l-fenyl-2-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethan-l-on,5. 1-phenyl-2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethan-1-one;

6. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-hepty1)]butan,6. 1- (4-Fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane;

7. l-(4-fluorfenyl)-4-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,7. 1- (4-Fluorophenyl) -4- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;

8. l-(4-fluorfenyl)-4-[exo-6-o-fluorfenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-on,8. 1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;

9. 1-(4-fluorfenyl)-4-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,9. 1- (4-Fluorophenyl) -4- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

10. 1-(4-fluorfenyl)-4-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,10. 1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

11. 1-(4-fluorfenyl)-4-[exo-6-p-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,11. 1- (4-Fluorophenyl) -4- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

12. l-(4-fluorfenyl)-4-[exo-6-m,p-dichlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,12. 1- (4-Fluorophenyl) -4- [exo-6-m, p-dichlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

13. l-(4-fluorfenyl)-4-[exo-6-m,p-dimethoxyfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan-l-on,13. 1- (4-Fluorophenyl) -4- [exo-6-m, p-dimethoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

14. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on, • ·14. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

15. 1-fenyl-4~[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan-l-on,15. 1-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

16. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-hepty1)]butan,16. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane;

17. l-(4-fluorfenyl)-4-[exo-6-p-nitrofenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan-l-on,17. 1- (4-Fluorophenyl) -4- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

18. 1-(4-fluorfenyl)-4-[exo-6-m-nitrofenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-on,18. 1- (4-Fluorophenyl) -4- [exo-6-m-nitrophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;

19. 1-(4-fluorfenyl)-4-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,19. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

20. 1-(4-fluorfenyl)-4-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,20. 1- (4-Fluorophenyl) -4- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-one;

21. 1-(4-fluorfenyl)-4-[exo-6-(3-thienyl)-3-azabicyklo— [3,2,0]-(3-heptyl)]butan-l-on,21. 1- (4-Fluorophenyl) -4- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;

22. l-(4-fluorfenyl)-4-[exo-6-(3-pyridyl)-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-on,22. 1- (4-Fluorophenyl) -4- [exo-6- (3-pyridyl) -3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;

23. 1-(4-fluorfenyl)-3-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]propan-l-on,23. 1- (4-Fluorophenyl) -3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] propan-1-one;

24. 1-(bis-4-fluorfenyl)-4-[exo-6-p-f luorf enyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan,24. 1- (bis-4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butane;

25. 1-(bis-4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-hepty1)]butan,25. 1- (bis-4-fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butane;

4 4 • 4 4 4 • 4 • 4 • 4 .·· · 4 * λ . ·· · 4 * λ «· «· 44 44 • 4 • 4 • · • · 4 > 4> • 4 • 4 • 4 • 4 • 4 • 4 • 4 • 4 • ••4 4 • •• 4 4 • · 4 4 φ • · 4 4 φ 4 4 • 4 • 4 4 • 4 • 4 4 4 4 4 4 4 4 4 4 4 4 4 · 4 · • · 4 • · 4 • 4 • 4 • 4 • 4 4 •••4 4 ••• 4

26. 1-(4-fluorfenyl)-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,26. 1- (4-Fluorophenyl) -4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;

27. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,27. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;

28. 1- (4-fluorfenyl)-4-[exo-6,7-difenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,28. 1- (4-Fluorophenyl) -4- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;

29. l-fenyl-4-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,29. 1-phenyl-4- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;

30. l-fenyl-4-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,30. 1-phenyl-4- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butan-1-ol;

31. 1-(4-fluorfenyl)-4-[exo-6-o-fluorfenyl-3-azabicyklo- [3,2,0]-(3-heptyl)]butan-l-ol,31. 1- (4-Fluorophenyl) -4- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-ol;

32. 1-(4-fluorfenyl)-4-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,32. 1- (4-Fluorophenyl) -4- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-ol;

33. 1-(4-fluorfenyl)-4-[exo-6-p-trifluormethylfenyl-3azabicyklo[3,2,0]-(3-heptyl)]butan-l-ol,33. 1- (4-Fluorophenyl) -4- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-ol;

34. l-(4-fluorfenyl)-4-[exo-6-p-aminofenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butan-l-on,34. 1- (4-Fluorophenyl) -4- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] (3-heptyl)] butan-1-one;

35. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propyl]-4-fluorbenzamid,35. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -4-fluorobenzamide;

36. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propyl]benzamid,36. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] propyl] benzamide;

• · 4 · • · • · 4 · • · • • 4 · • • 4 · ·· • · • · ·· • · • · • ·« • · « 4· • · 5 · • · ·> ♦ « ·> ♦ « • « • « • •44 • • 44 • · · • · · ♦ · ♦ · • · ·· • · ·· • • • • • 4 • · • 4 • · • «·* • «· * • · · • · ·· • · · • · ·· • • ·*·· • • · * ··

37. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl)-4-fluorbenzamid,37. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl) -4-fluorobenzamide;

38. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl)benzamid,38. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl) benzamide,

39. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-N-methyl-4-fluorbenzamid,39. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methyl-4-fluorobenzamide,

40. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-N-methylbenzamid,40. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methylbenzamide,

41. N-[2-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl)-N-methyl-4-isopropylbenzamid,41. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methyl-4-isopropylbenzamide,

42. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl]-4-chlorbenzamid,42. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -4-chlorobenzamide,

43. N-[2-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-43. N- [2- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3,2,0] -

-(3-heptyl)]ethyl)-4-chlorbenzamid,- (3-heptyl) ethyl) -4-chlorobenzamide,

44. N-[3-[exo-6—fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl]-3-methoxybenzamid,44. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -3-methoxybenzamide;

45. N-[3-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propylJ-3-nitrobenzamid,45. N- [3- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -3-nitrobenzamide,

46. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl)-4-fluorbenzamid,46. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] propyl] -4-fluorobenzamide,

47. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))propyl]benzamid,47. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) propyl] benzamide,

48. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-4-fluorbenzamid,48. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -4-fluorobenzamide,

49. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl]benzamid,49. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] benzamide,

50. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-N-methyl-4-fluorbenzamid,50. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -N-methyl-4-fluorobenzamide,

51. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-N-methylbenzamid,51. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -N-methylbenzamide;

52. N—[2 —[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl]-N-methyl-4-isopropylbenzamid,52. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -N-methyl-4-isopropylbenzamide,

53. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl]-4-chlorbenzamid,53. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -4-chlorobenzamide,

54. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]propyl]-3-methoxybenzamid,54. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl] -3-methoxybenzamide,

55. N-[3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))propyl]-3-nitrobenzamid,55. N- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) propyl] -3-nitrobenzamide,

56. N-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl]-4-chlorbenzamid,56. N- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -4-chlorobenzamide;

57. N-[2-(exo-6-o-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-4-chlorbenzamid,57. N- [2- (exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)) ethyl] -4-chlorobenzamide,

58. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-2-hydroxybenzamid,58. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2-hydroxybenzamide;

• ·• ·

59. N-[2-[exo-6-m-hydroxyfenyl-3-azabicyklo[3,2,0]—(3— -hepty1)]ethyl]-4-chlorbenzamid,59. N- [2- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-chlorobenzamide,

60. exo-3-n-butyl-6-fenyl-3-azabicyklo[3,2,0]heptan,60. exo-3-n-butyl-6-phenyl-3-azabicyclo [3.2.0] heptane,

61. exo-3-methyl-6-fenyl-3-azabicyklo[3,2,0]heptan,61. exo-3-methyl-6-phenyl-3-azabicyclo [3.2.0] heptane;

2. exo-3-methyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,2. Exo-3-methyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;

63. exo-3-n-propyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,63. exo-3-n-propyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;

64. exo-3-methyl-6,7-difenyl-3-azabicyklo[3,2,0]heptan ,64. exo-3-methyl-6,7-diphenyl-3-azabicyclo [3.2.0] heptane;

65. exo-3-n-propyl-6-m-hydroxyfenyl-3-azabicyklo[3,2,0]heptan,65. exo-3-n-propyl-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] heptane;

66. exo-3-allyl-6-m-methoxyfenyl-3-azabicyklo[3,2,0]heptan,66. exo-3-allyl-6-m-methoxyphenyl-3-azabicyclo [3.2.0] heptane;

67. exo-3-(3,4-dimethoxy)fenethyl-6-fenyl-3-azabicyklo[3,2,0]heptan,67. exo-3- (3,4-dimethoxy) phenethyl-6-phenyl-3-azabicyclo [3.2.0] heptane;

68. exo-3-(3,4-dimethoxy)fenethyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,68. exo-3- (3,4-dimethoxy) phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;

69. exo-3-(3,4-dihydroxy)fenethy1-3-azabicyklo[3,2,0]heptan,69. exo-3- (3,4-dihydroxy) phenethyl-3-azabicyclo [3.2.0] heptane;

70. exo-3-fenethyl-6-p-fluorfenyl-3-azabicyklo[3,2,0]heptan,70. exo-3-phenethyl-6-p-fluorophenyl-3-azabicyclo [3.2.0] heptane;

71. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ] ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,71. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,

• ·• ·

72. ( + ) —6—β—[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)-3-yl]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-οη,72. (+) -6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl) -3-yl] ethyl-7-methyl-5H-thiazolo [ 3,2-a] pyrimidin-5-one,

73. (-)-6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3, 2,0]-(3-heptyl)-3-yl]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-οη,73. (-) - 6-β- [Exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) -3-yl] ethyl-7-methyl-5H-thiazolo [ 3,2-a] pyrimidin-5-one,

74. 6-β-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,74. 6-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he,

75. 6-β-[exo-6,7-difenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,75. 6-β- [exo-6,7-diphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,

76. 6-β-[exo-6,7-bis-(p-fluorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)-3-yl]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,76. 6-β- [exo-6,7-bis- (p-fluorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl) -3-yl] ethyl-7-methyl-5H- thiazolo [3,2-a] pyrimidin-5-one,

77. 6-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,77. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,

78. 6-β-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-78. 6-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one;

79. 6-β-[exo-6-m-hydroxyfenyl-3-azabicyklo[3, 2,0]-(3-79. 6-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one;

80. 6—β—[2—[exo-6-p-aminofenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,80. 6-β- [2- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

81. 6-β-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,81. 6-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,

82. 82. 6-p-[exo-6-p-methoxyfenyl-3-azabicyklo[3,2,0)-(3- -heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a)pyrimidin-5-on, 6-p- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] - (3- -heptyl) ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one; 83 . 83. 6—β-[exo-6-p—nitrofenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-β- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] (3-heptyl)) ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he, 84 . 84. 6-p-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-p- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he, 85. 85. 6-β-[exo-6-p-hydroxyfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl-7-methyl-5H-thiazolo[3,2-a)pyrimidin-5-on, 6-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he, 86 . 86. 6-β-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he, 87 . 87. 6-β-[exo-6-(p-terc.-butylfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-β- [exo-6- (p-tert-butylphenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a pyrimidin-5-one, 88 . 88. 6-β-[endo-6-(p-terc.-butylfenyl)-3-azabicyklo[3,2,0)-(3- -heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-β- [endo-6- (p-tert-butylphenyl) -3-azabicyclo [3.2.0] - (3- -heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one; 89 . 89. 6-β-[θχο-6-(3,4-dichlorfenyl)-3-azabicyklo[3,2,0)-(3- -heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidiTi-5-on, 6-β- [θχο-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] - (3- -heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one; 90 . 90. 6-β-[exo-6-(3,4-dimethoxyfenyl)-3-azabicyklo[3,2,0]- -(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-β- [exo-6- (3,4-dimethoxyphenyl) -3-azabicyclo [3.2.0] - - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one, 91. 91. 6-β-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0)-(3-heptyl) ]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on, 6-β- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine-5- he,

92. 6-β-[exo-6-(3,4-dihydroxyfenyl)-3-azabicyklo[3,2,0]-92. 6-β- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] -

-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-aJpyrimidin-5-on,- (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

93. 6-β-[exo-6-(o-fluorfenyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,93. 6-β- [exo-6- (o-fluorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

94. 6-β-[exo-6-(3-thienyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a)pyrimidin-5-on,94. 6-β- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl-7-methyl-5H-thiazolo [3,2-a) pyrimidin-5-one,

95. 6-β-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,95. 6-β- [exo-6- (5-chloro- (2-thienyl)) - 3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-5H-thiazolo [ 3,2-a] pyrimidin-5-one,

96. 6-β - [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-on,96. 6-β - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [3, 2-a] pyrimidin-5-one,

97. 6-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-aJpyrimidin-5-on,97. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-2,3-dihydro-5H-thiazolo [3, 2-pyrimidin-5-one,

98. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,3,7-trimethyl-5H-thiazolo[3,2-a] j)yrimidin-5-on,98. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,3,7-trimethyl-5H-thiazolo [3,2- (a) (j) yrimidin-5-one;

99. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-5H-thiazolo[3,2-a]pyrimidin-5-on,99. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

100. 6^-[exo-6-fenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-5H-thiazolo[3,2-a]pyrimidin-5-on,100. 6- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

101. 7-β—[exo-6—p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,101. 7-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,

102. 7-β-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,102. 7-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1] 3] thiazin-6-one,

103. 7”p-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,103. 7 'p- [Exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,

104. 7-β-[exo-6-p-chlorfenyl-3-azabicyklo[ 3,2,0 ] - (3-heptyl)]ethy1-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,104. 7-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,

105. 7-3-[exo-6-p-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,105. 7-3- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,

106. 7-β-[exo-6-m-hydroxyfenyl-3-azabicyklo[3,2/0]-(3-heptyl)]ethyl-8-methyl-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on,106. 7-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-8-methyl-2H, 6H-pyrimido [2,1-b] [1,3] thiazin-6-one,

107. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,107. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

108. (+)-3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethy1-2,4-(1H,3H)chinazolindion,108. (+) - 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

109. (-)-3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl-2,4-(1H,3H)chinazolindion,109. (-) - 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

110. 3-β-(exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)] ethyl-2,4-(1H,3H)chinazolindion,110. 3-β- (exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

111. 3-β-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethy1-2,4-(1H,3H)chinazolindion,111. 3-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

112. 3-β-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ] 18 ethyl-2,4-(1H,3H)chinazolindion,112. 3-β- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 18 ethyl-2,4- (1H, 3H) quinazolinedione,

113. 3-p-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,113. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

114. 3-p-[exo-6-p-hydroxyfenyl-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,114. 3-β- [exo-6-p-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

115. 3-β-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,115. 3-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

116. 3“3-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-116. 3 '3- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

117. 3-β- [exo-6-p-nitrofenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,117. 3-β- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

118. 3-β-[endo-6-p-nitrofenyl-3-azabicyklo[3,2,0]-(3-118. 3-β- [endo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-

-hepty1)]ethyl-2,4-(1H,3H)chinazolindion,-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

119. 3-β-[exo-6—m-hydroxyfenyl-3-azabicyklo[3,2,0]-(3-119. 3-β- [exo-6-m-hydroxyphenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

120. 3-β-[exo-6-p-aminofenyl-3-azabicyklo[ 3,2,0 ] - (3-heptyl) ]ethyl-2,4-(1H,3H)chinazolindion,120. 3-β- [exo-6-p-aminophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

121. 3^-[exo-6-p-jodfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-2,4-(1H,3H)chinazolindion,121. 3- [exo-6-p-iodophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

122. 3-β-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-122. 3-β- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] -

-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

123. 3-β-[βχο-6-(3,4-dichlorfenyl)-3-azabicyklo[3,2,0]19123. 3-β- [βχο-6- (3,4-dichlorophenyl) -3-azabicyclo [3.2.0] 19

-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

124. 3-β-[exo-6-(3,4-dihydroxyfenyl)-3-azabicyklo[3,2,0]-124. 3-β- [exo-6- (3,4-dihydroxyphenyl) -3-azabicyclo [3.2.0] -

-(3-heptyl)]ethyl-2,4-(lH,3H)chinazolindion,- (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

125. 3-β-[exo-6-(3,5-dichlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,125. 3-β- [exo-6- (3,5-dichlorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

126. 3-β-[θΧθ-6-ο-ίluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,126. 3-β- [θΧ-6-ο-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

127. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-8-methyl-2,4-(1H,3H)chinazolindion,127. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methyl-2,4- (1H, 3H) quinazolinedione,

128. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-chlor-2,4-(1H,3H)chinazolindion,128. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-chloro-2,4- (1H, 3H) quinazolinedione,

129. 3-β - [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-fluor-2,4-(1H,3H)chinazolindion,129. 3-β - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-fluoro-2,4- (1H, 3H) quinazolinedione,

130. 3-β-[exo-6—p-fluorfenyl-3—azabicyklo[3,2,0]-(3-heptyl)]ethyl-5-chlor-2,4-(1H,3H)chinazolindion,130. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5-chloro-2,4- (1H, 3H) quinazolinedione,

131. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-fluor-2,4-(1H,3H)chinazolindion,131. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-fluoro-2,4- (1H, 3H) quinazolinedione,

2. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-6-methyl-2,4-(1H,3H)chinazolindion,2. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-methyl-2,4- (1H, 3H) quinazolinedione,

133. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-8-methoxy-2,4-(lH,3H)chinazolindion,133. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-8-methoxy-2,4- (1H, 3H) quinazolinedione,

134. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]- ethyl-6-trifluormethyl-2,4-(1H,3H)chinazolindion,134. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-trifluoromethyl-2,4- (1H, 3H) quinazolinedione,

135. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-7-nitro-2,4-(1H,3H)chinazolindion,135. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-nitro-2,4- (1H, 3H) quinazolinedione,

136. 3-β - [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-nitro-2,4-(lH,3H)chinazolindion,136. 3-β - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-nitro-2,4- (1H, 3H) quinazolinedione,

137. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-amino-2,4-(1H,3H)chinazolindion,137. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-amino-2,4- (1H, 3H) quinazolinedione,

138. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-amino-2,4-(1H,3H)chinazolindion,138. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-amino-2,4- (1H, 3H) quinazolinedione,

139. 3-β-[exo—6-p-fluorfenyl-3—azabicyklo[3,2,0]-(3-heptyl)]ethyl-6-hydroxy-2,4-(1H,3H)chinazolindion,139. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6-hydroxy-2,4- (1H, 3H) quinazolinedione,

140. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-5-chlor-2,4-(1H,3H)chinazolindion,140. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-5-chloro-2,4- (1H, 3H) quinazolinedione,

141. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6,7-dimethoxy-2,4-(1H,3H)chinazolindion,141. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7-dimethoxy-2,4- (1H, 3H) quinazolinedione ,

142. 3^-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6,8-dichlor-2,4-(1H,3H)chinazolindion,142. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-6,8-dichloro-2,4- (1H, 3H) quinazolinedione,

143. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-6,7,8-trimethoxy-2,4-(1H,3H)chinazolindion,143. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7,8-trimethoxy-2,4- (1H, 3H) ) quinazolindione,

144. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3, 2,0 ] - (3-heptyl)]ethyl-1-methy1-2,4-(1H,3H)chinazolindion,144. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-1-methyl-2,4- (1H, 3H) quinazolinedione,

5. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]21 ethyl-1-ethy1-2,4-(1H,3H)chinazolindion,5. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 21 ethyl-1-ethyl-2,4- (1H, 3H) quinazolinedione,

• · • · • · • · • • • • • · • · • · • · • · • · • · • · * · * · • • • · • · • • • • • • • · • · < < ·· ··

·· » * φ · • ♦ · · • · · · · • · · · ··· ·· ·«··· • •

146. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-l-allyl-2,4-(1H,3H)chinazolindion,146. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1-allyl-2,4- (1H, 3H) quinazolinedione,

147. 3-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-l-benzyl-2,4-(1H,3H)chinazolindion,147. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1-benzyl-2,4- (1H, 3H) quinazolinedione,

148. 3-gamma-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]propyl-2,4-(1H,3H)chinazolindion,148. 3-gamma- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] propyl-2,4- (1H, 3H) quinazolinedione,

149. 3-S-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]butyl-2,4-(1H,3H)chinazolindion,149. 3-S- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] butyl-2,4- (1H, 3H) quinazolinedione,

150. 3-β-[exo-6-(2-thienyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,150. 3-β- [exo-6- (2-thienyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

151. 3-β - [exo-6-(5-chlor-2-thienyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,151. 3-β - [exo-6- (5-chloro-2-thienyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione ,

152. 3-β-[exo-6-(3-thienyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,4-(1H,3H)chinazolindion,152. 3-β- [exo-6- (3-thienyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

153. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-lH-thieno[3,2-d]pyrimidin-2,4-dion,153. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1H-thieno [3,2-d] pyrimidine-2,4- dion,

154. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-lH-thieno[2,3-d]pyrimidin-2,4-dion,154. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1H-thieno [2,3-d] pyrimidine-2,4- dion,

155. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-lH-thieno[3,4-d]pyrimidin-2,4-dion,155. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1H-thieno [3,4-d] pyrimidine-2,4- dion,

156. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]22156. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 22

ethyl-l-methyl-ΙΗ,3H-pyrido[2,3-d]pyrimidin-2,4-dion,ethyl-1-methyl-ΙΗ, 3H-pyrido [2,3-d] pyrimidine-2,4-dione,

157. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-3H-chinazolin-4-on,157. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-3H-quinazolin-4-one,

158. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methoxy-3H-chinazolin-4-on,158. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methoxy-3H-quinazolin-4-one,

159. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on-dihydrochlorid,159. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-on-dihydrochloride,

160. 3^-[exo-6-fenyl-3-azabicyklo[ 3,2,0]-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,160. 3- [exo-6-phenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one ,

161. 3-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl- 2-methyl-4H-pyrido [ 1,2-a ] pyriinidin-4-on,161. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-on,

162. 3-β-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,162. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [1,2-a] pyrimidine- 4-on,

163. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,163. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,6-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,

164. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-164. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-2,7-dimethyl-4H-pyrido[l,2-a]pyrimidin-4-on,-heptyl)] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one;

165. 3^-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-165. 3 R - [Exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on, • ·. · ·· · · ·9·-heptyl)] ethyl-2,8-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one; · ·· · · · · ·

9 9 9 9 9 9 9 · 999 9 9 9 9 9 9 · 99

9 9 9 9 9 9 9 9· • 9999999 9 9 99 999 9 9 9 9 9 9 9 • 9999999 9 9 99 99

9 99 999 99999 9. 9 99 999 99999 9

166. 3-β- [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3—166. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,-heptyl)] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one;

167. 3-8-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,167. 3-8- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,6,8-trimethyl-4H-pyrido [1,2- a] pyrimidin-4-one,

168. 3-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,168. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,

169. 3-β-[exo-6-o-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,169. 3-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,7-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,

170. 3-β-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)Jethyl-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,170. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl) ethyl-2,8-dimethyl-4H-pyrido [1,2-a] pyrimidin-4 -he,

171. 3-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-on,171. 3-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,9-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one,

172. 3-8-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,172. 3-8- [exo-6- (5-chloro- (2-thienyl)) - 3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrido [ 1,2-a] pyrimidin-4-one,

173. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,173. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7,8,9-tetrahydro-2-methyl-4H- pyrido [1,2-a] pyrimidin-4-one,

174. 3—β — [exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl) ] ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a] pyrimidin-4-on,174. 3-β - [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-6,7,8,9-tetrahydro-2-methyl-4H- pyrido [1,2-a] pyrimidin-4-one,

175. 3-β-[exo—6-p—methoxyfenyl-3-azabícyklo[3,2,0]-(3-heptyl)]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,175. 3-β- [exo-6-p-methoxyphenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-6,7,8,9-tetrahydro-2-methyl-4H- pyrido [1,2-a] pyrimidin-4-one,

176. 3-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl-2-methyl-4H-pyrimido[1,2-a]pyrimidin-4-on,176. 3-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-4H-pyrimido [1,2-a] pyrimidine- 4-on,

177. 3~3~[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methyl-7-chlor-4H-pyrimido[1,2-a]pyrimidin-4-on,177. 3- [3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-7-chloro-4H-pyrimido [1,2- a] pyrimidin-4-one,

178. 6-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-7-methyl-lH,5H-imidazo[l,2-a]pyrimidin-5-on,178. 6-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-7-methyl-1H, 5H-imidazo [1,2-a] pyrimidin-5-one,

179. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methy1-7,8-dihydro-4H,6H-pyrrolo[1,2-a]pyrimidin-4-on,179. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methyl-7,8-dihydro-4H, 6H-pyrrolo [ 1,2-a] pyrimidin-4-one,

180. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methylbenzimidazol,180. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methylbenzimidazole,

181. l-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethylbenzimidazol,181. 1- [beta] - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylbenzimidazole,

182. l-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2,3-dihydrobenzimidazol-2-on,182. 1- [beta] - [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2,3-dihydrobenzimidazol-2-one;

3. 2-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ] methylbenzimidazol,3. 2- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methylbenzimidazole;

184. 3-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethylindol, teplota tání 193 až 195 °C (hydrochlorid) ,184. 3-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylindole, m.p. 193-195 ° C (hydrochloride),

185. 3-β - [2-(exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]—(3— -heptyl))ethylindol,185. 3-β - [2- (exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)) ethylindole,

186. 3-β-[exo-6-fenyl-3-azabicyklo[3,2,0]—(3-heptyl)]ethylindol , teplota tání 104 až 105 °C (hydrochlorid),186. 3-β- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylindole, m.p. 104-105 ° C (hydrochloride),

187. 3-β-[exo-6-m-methoxyfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethylindol,187. 3-β- [exo-6-m-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethylindole,

188. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methyl-3,4-dihydrochinazolin-4-on,188. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,

189. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methyl-3,4-dihydrochinazolin-4-thion,189. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazoline-4-thione,

190. 2-[exo-6-fenyl-3-azabicyklo(3,2,0]-(3-heptyl)Jmethyl-3,4-dihydrochinazolin-4-on,190. 2- [exo-6-phenyl-3-azabicyclo (3.2.0) - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,

191. 2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]methyl-3,4-dihydrochinazolin-4-on,191. 2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,

192. 2-[exo-6-o-methoxyfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]methyl-3,4-dihydrochinazolin-4-on,192. 2- [exo-6-o-methoxyphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-3,4-dihydroquinazolin-4-one,

193. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))methyl-4-hydroxy-6-methylpyrimidin,193. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) methyl-4-hydroxy-6-methylpyrimidine,

194. 6- [exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]methyl-2-methyl-4-hydroxypyrimidin,194. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyl-2-methyl-4-hydroxypyrimidine,

5. 6-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl) ]methyluracil, * ·5. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] methyluracil;

196. 6-[exo-6-fenyl-3-azabicyklo[3,2,0]-(3-heptyl)Jmethyluracil,196. 6- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl) -methyluracil,

197. 6-[exo-6-p-fluorfenyl-3-azabicyklo[3, 2,0 ] - (3-heptyl)]-1,2,3,4-tetrahydro-l,3-dimethyl-2,4-dioxopyrimidin,197. 6- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] -1,2,3,4-tetrahydro-1,3-dimethyl-2,4 -dioxopyrimidine,

198. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidin,198. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-6-methyl-2; 4-dioxopyrimidine,

199. 5-β—[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-l,6-dimethyl-2,4-dioxopyrimidin,199. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-1,2,3,4-tetrahydro-1,6-dimethyl- 2,4-dioxopyrimidine,

200. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-3,6-dimethyl-2,4-dioxopyrimidin,200. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-3,6-dimethyl- 2,4-dioxopyrimidine,

201. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-3,6-dimethyl-2,4-dithiopyrimidin,201. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-3,6-dimethyl- 2,4-dithiopyrimidine,

202. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0}—(3-heptyl)]ethyl-1,2,3,4-tetrahydro-l,3,6-trimethyl-2,4-dioxopyrimidin,202. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0} - (3-heptyl)] ethyl-1,2,3,4-tetrahydro-1,3,6- trimethyl-2,4-dioxopyrimidine,

203. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-1,2,3,4-tetrahydro-6-amino-l-methyl-2,4-dioxopyrimidin,203. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-1,2,3,4-tetrahydro-6-amino-1- methyl-2,4-dioxopyrimidine,

204. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-2-amino-6-methyl-4(3H)pyrimidinon, • · * · · ♦ «· ·· « ♦ « ·♦·«- · · 9 · • · · · >·· · · · • · ···· · · « » · · « · ·· · · · *·· · · ··· ·204. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-amino-6-methyl-4 (3H) pyrimidinone; * · - 9 - - - - 9 9 •>> 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 ·· · · ··· ·

5. 5—β-Cexo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-amino-3,6-dimethyl-4(3H)pyrimidinon,5. 5-β-Cexo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-amino-3,6-dimethyl-4 (3H) pyrimidinone;

206. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethy1-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,206. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

207. 5-p-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3-ethyl-6-methyl-4(3H)pyrimidinon,207. 5-p- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3-ethyl-6-methyl-4 (3H) pyrimidinone,

208. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-amino-3-ethyl-6-methyl-4(3H)pyrimidinon,208. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-amino-3-ethyl-6-methyl-4 (3H) pyrimidinone,

209. 5-β- [exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,209. 5-β- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

210. 5^-[exo-6-m-chlorfenyl-3-azabicyklo[3, 2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,210. 5 '- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

211. 5-β-[exo-6-o-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,211. 5-β- [exo-6-o-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

212. 5^-[exo-6-p-trifluormethylfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H ) pyrimidinon,212. 5 '- [exo-6-p-trifluoromethylphenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

213. 5^-[exo-6-p-kyanfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon ,213. 5 '- [exo-6-p-cyanophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

214. 5-β-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,214. 5-β- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

215. 5^-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]28 ethyl-2-methylamino-4-methoxy-6-methylpyrimidin,215. 5 - [[exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] 28 ethyl-2-methylamino-4-methoxy-6-methylpyrimidine,

216. 3-3-(exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,O]-(3-oktyl)]ethyl-2,4-(1H,3H)chinazolindion,216. 3-3- (exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2,4- (1H) (3H) quinazolinedione,

217. 3-β-[endo-6-fenyl-7-methyl-1,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-2,4-(lH,3H)chinazolindion,217. 3-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2,4- (1H) (3H) quinazolinedione,

218. 3-β-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,218. 3-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione,

219. 3-β-[exo-6-p-trifluormethylfenyl-7-methyl-l,5-cis-3,7diazabicyklo[3,3,0)-(3-oktyl)]ethyl-6-fluor-2,4-(1H,3H)chinazolindion,219. 3-β- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-6-fluoro-2, 4- (1H, 3H) quinazolinedione,

220. 3-β-[exo-6-m-chlorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,220. 3-β- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione,

221. 3-β-[exo-6-p-methoxyfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-6-methyl-2,4-(1H,3H)chinazolindion,221. 3-β- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-6-methyl- 2,4- (1H, 3H) quinazolinedione,

222. 5-β-[exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl))ethyl-2-methylamino-3,6-dimethyl-4(3H)-pyrimidinon,222. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl)) ethyl-2-methylamino-3, 6-Dimethyl-4 (3H) -pyrimidinone

223. 5-β-[exo-6-p-fluorfenyl-7-methyl-1,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dinethyl-4(3H)pyrimidinon,223. 5-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino- 3,6-Dinethyl-4 (3H) pyrimidinone

224. 1-β-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl))ethyl-2(3H)benzimidazolon,224. 1-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)) ethyl-2 (3H) benzimidazolone,

225. 5-β-[exo-6-p-nitrofenyl-7-methyl-l,5-cis-3,7-diazabicyklo £3,3,0j — (3-oktyl)]ethyl-2-methylamino-3,6-dimethyl -4(3H)pyrimidinon,225. 5-β- [exo-6-p-nitrophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] -3- (3-octyl)] ethyl-2-methylamino-3 6-dimethyl-4 (3H) pyrimidinone

226. 5-β-[exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)-pyrimidinon,226. 5-β- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino-3, 6-Dimethyl-4 (3H) -pyrimidinone

227. 5-p-[endo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)-pyrimidinon,227. 5-β- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino-3, 6-Dimethyl-4 (3H) -pyrimidinone

228. 3-β-[exo-6-p-fluorfenyl-7-methyl-l,5-CÍS-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,228. 3-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2-methyl- 4H-pyrido [1,2-a] pyrimidin-4-one,

229. ΐ-β-[exo-6-p-fluorfenyl-7-methyl-l,5-CÍS-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethylindolin-2-on,229. ΐ-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethylindolin-2-one,

230. 6-β-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-7-methyl-5H-thiazolo- [3,2-a]pyrimidin-5-on,230. 6-β- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-7-methyl- 5H-thiazolo- [3,2-a] pyrimidin-5-one,

231. l-p-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl-2(lH)chinolon,231. 1- [beta] - [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2 (1H) quinolone,

232. 3-β-[7-fenyl-1,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)] ethyl-2,4-(lH,3H)chinazolindion,232. 3-β- [7-phenyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

233. 3-3-[7-p-fluorfenyl-l,5-cis-3,7-diazabicyklo[3,3,0]-233. 3-3- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] -

-(3-oktyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-octyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

234. 5-β-[7-p-fluorfenyl-1,5-cis-3,7-diazabicyklo[3,3,0]-234. 5-β- [7-p-fluorophenyl-1,5-cis-3,7-diazabicyclo [3.3.0] -

Φ · · · · φ· *Φ · · · φ · *

Φ · · '* ♦ · ·· • · · » · · a · ·· • »····»> · · ♦ ·· · • > · φφφφ·· φφ φ φφ μφ φφ φφφφA · * ♦ a a a a a a a a · φ · · · · · · · · ·

- 30 -(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3Η)pyrimidinon,- 30- (3-octyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3 ') pyrimidinone,

235. 3^-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-2,4-(1H,3H)chinazolindion,235. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

236. 3-β-[exo-6-fenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-2,4-(1H,3H)chinazolindion,236. 3-β- [exo-6-phenyl-3-azabicyclo [3.1.0] - (3-hexyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

237. 3-β-[6,6-difenyl-3-azabicyklo[3,1,0]-(3-hexyl)Jethyl-2,4-(1H,3H)chinazolindion,237. 3-β- [6,6-diphenyl-3-azabicyclo [3.1.0] - (3-hexyl) ethyl-2,4- (1H, 3H) quinazolinedione,

238. 5-β-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,238. 5-β- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] - (3-hexyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

239. 6-β-[exo-6-m-chlorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,239. 6-β- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] - (3-hexyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidine- 5-on,

240. 3-p-[6-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)y1)]ethyl-2,4-(1H,3H)chinazolindion,240. 3-p- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octenyl))] ethyl-2,4- (1H, 3H) quinazolinedione,

241. 5-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinon,241. 5-β- [6-p-Fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone

242. 6-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(6okten)y1)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,242. 6-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octenyl))] ethyl-7-methyl-5H-thiazolo [3] , 2-a] pyrimidin-5-one,

3 . 1—β— [ 6-fenyl-1,5-cis-3-azabicyklo[ 3,3,0 ] - (3-( 6-ok-ten)yl)]ethyl-2(3H)benzimidazolon,3. 1-β- [6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-oc-ten) yl)] ethyl-2 (3H) benzimidazolone,

244. l-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(631244. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (631)

-okten)y1)]ethylindolin-2-on,ethyl-indolin-2-one,

245. 1—β — [6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-(6-okten)yl)]ethyl-2(lH)chinolon,245. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2 (1H) quinolone,

246. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)- (3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,246. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione ,

247. 5-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,247. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl-2-methylamino-3,6-dimethyl- 4 (3H) pyrimidinone

248. 6^-[exo-6-fenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,248. 6- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] (3-octyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

249. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-249. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethylindolin-2-on,- (3-octyl)] ethylindolin-2-one,

250. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-250. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethyl-2(lH)chinolon,- (3-octyl)] ethyl-2 (1H) quinolone,

251. 3-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-251. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl))ethyl-2,4-(1H,3H)chinazolindion,- (3-octyl) ethyl-2,4- (1H, 3H) quinazolinedione,

252. 5-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo(3,3,0]-252. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo (3.3.0) -

-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3-octyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

53. 6-β-[endo-fenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-oktyl) ]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,53. 6-β- [endo-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

54. l-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3 y 0)-54. L-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3 y 0) -

-(3-oktyl)]ethylindolin-2-on,- (3-octyl)] ethylindolin-2-one,

255. l-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-255. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethyl-2(1H)chinoIon,- (3-octyl)] ethyl-2 (1H) quinone,

256. 3-β—[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-256. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethy1-2,4-(1H,3H)chinazolindion,- (3-octyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

257. 5-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-257. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3-octyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

258. 6-β-[exo-7-fenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,258. 6-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl-7-methyl-5H-thiazolo [3,2- (a) pyrimidin-5-one,

259. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-259. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethylindolin-2-on,- (3-octyl)] ethylindolin-2-one,

260. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-260. 1-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethyl-2(lH)chinolon,- (3-octyl)] ethyl-2 (1H) quinolone,

261. 3-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-261. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

262. 5^-[endo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[4,3,0]-262. 5 - [- endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4,3,0] -

-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

263. 3-β-[endo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-263. 3-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-

-nonyl)]ethyl-2,4-(lH,3H)chinazolindion,-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

264. 5-β-[endo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,264. 5-β- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 ( 3H) pyrimidinone,

265. 3-β-[endo-6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo- [4,3,Ο]-(3-nonyl)]ethyl-2,4-(1Η,3Η)chinazolindion,265. 3-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.1] - (3-nonyl)] ethyl-2,4- (1Η, 3Η) quinazolindione,

266. 5-β-[endo-6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]—(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-266. 5-β- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-

-4(3H)pyrimidinon,-4 (3H) pyrimidinone

267. 3-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,267. 3-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2,4- ( 1H, 3H) quinazolinedione,

268. 5-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-268. 5-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-(7-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,- (3- (7-Nonen) yl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

269. l-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2(3H)benzimidazolon,269. 1- [beta] - [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2 (3H) benzimidazolone ,

270. 1-β-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethylindolin-2-on,270. 1-β- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethylindolin-2-one,

271. 3-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethyl-2, 4-(1H,3H)chinazolindion,271. 3-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,

272. 5-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-272. 5-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-(6-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl—4(3H)pyrimidinon,- (3- (6-nonen) yl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

3. 3-β-[6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethyl-2,4-(1Η,3H)chinazolindion,3. 3-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolindione,

274. 5—β—[6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)- yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon, ·· » ·· * φφ φφ • · · φ φ φ φ · φ · φ • · φ · · φ · ·· · • · φ··· φ φ φ · · · · · φ φ φ φ φ φ φ · φ φφ · ·· φφφ φφ φφφφ274. 5-β- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) -yl)] ethyl-2-methylamino-3,6- dimethyl-4 (3H) pyrimidinone, · φ • · · · · • • • • • · • • • • • · · · Φ · · · · · · · · · ·

275. 3-β-[6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]—(3—(6-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,275. 3-β- [6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,

276. 5-β-[6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,276. 5-β- [6-p-Trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone

277. 1—β— [6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-277. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-(6-nonen)yl)]ethyl-2(3H)benzimidazolon,- (3- (6-nonen) yl)] ethyl-2 (3H) benzimidazolone,

278. l-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(6-nonen)yl)]ethylindolin-2-on,278. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethylindolin-2-one,

279. l-β-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-279. 1-β- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-(6-nonen)yl)]ethyl-2(lH)chinolon,- (3- (6-nonen) yl)] ethyl-2 (1H) quinolone,

280. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2,4-(1H,3H)chinazolidon,280. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2,4- ( 1H, 3H) quinazolidone,

281. 5-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinon,281. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2-methylamino-3 6-dimethyl-4 (3H) pyrimidinone

282. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2-methyl-4H-pyrido[l,2-a]pyrimidin-4-on,282. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2-methyl-4H -pyrido [1,2-a] pyrimidin-4-one,

283. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl-2(lH)chinolon,283. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2 (1H) quinolone ,

284. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-284. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-(7-nonen)yl)]ethyl-2(3H)benzimidazolon,- (3- (7-nonen) yl)] ethyl-2 (3H) benzimidazolone,

285. 1-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-285. 1-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-(7-nonen)yl)]ethylindolin-2-on,- (3- (7-Nonen) yl)] ethylindolin-2-one,

286. 3-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)y1)]ethyl-2,4-(1H,3H)chinazolindion,286. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,

287. 5-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)y1)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,287. 5-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonenyl))] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone

288. 3-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-288. 3-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nony1)]ethyl-2,4-(1H,3H)chinazolindion,- (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

289. 5-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,289. 5-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl- 4 (3H) pyrimidinone

290. 3-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2,4-(1H,3H)chinazolindion,290. 3-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione,

291. 5-β-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,291. 5-β- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 ( 3H) pyrimidinone,

292. 6—β—[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-292. 6-β- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on,- (3-Nonyl)] ethyl-7-methyl-5H-thiazolo [3,2-a] pyrimidin-5-one,

293. l-β-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2(3H)benzimidazolon,293. 1- [beta] - [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2 (3H) benzimidazolone,

294. 1-β-[βχο-6-ρ-ίluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-294. 1-β- [βχο-6-β-fluorophenyl-1,5-cis-3-azabicyclo [4,3,0] -

-(3-nonyl)]ethylindolin-2-on, ·· · *9 · ··9* • · 9 9 9 9 99**9 * 9 · · ··· ··· · 9 · · · 9 9 · 9 ·· 9· ··· *··*9* ·· · ·» ··· ♦♦ ··*·- (3-nonyl)] ethylindolin-2-one, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9 · 9 ··· 9 · ··· * ·· * 9 * ·· · »··· ♦♦ ·· * ·

295. 1—β —[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-295. 1-β - [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl-2(lH)chinolon, .296. 3-β-(exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,- (3-nonyl)] ethyl-2 (1H) quinolone, 296. 3-β- (exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolindione,

297. 5-β-[exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,297. 5-β- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2-methylamino-3,6 -Dimethyl-4 (3H) pyrimidinone

298. 3-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,298. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2,4- ( 1H, 3H) quinazolinedione,

299. 5-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H) pyrimidinon,299. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl-2-methylamino-3 6-dimethyl-4 (3H) pyrimidinone

300. 3-β-[7-p-fluorfenyl-3-azabicyklo[4,3,0]-(3-(1-nonen)yl)]ethyl-2,4-(1H,3H)chinazolindion,300. 3-β- [7-p-fluorophenyl-3-azabicyclo [4.3.0] - (3- (1-nonen) yl)] ethyl-2,4- (1H, 3H) quinazolinedione,

301. 5-β-[7-fenyl-3-azabicyklo[4,3,0]-(3-(1-nonen)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,301. 5-β- [7-phenyl-3-azabicyclo [4.3.0] - (3- (1-nonen) yl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone ,

302. 5-β-[7-p-fluorfenyl-3-azabicyklo[4,3,0]]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,302. 5-β- [7-p-fluorophenyl-3-azabicyclo [4.3.0]] ethyl-2-methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

303. 3-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2,4-(1H,3H)chinazolindion,303. 3-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2,4- (1H, 3H) quinazolinedione ,

304. 5-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-304. 5-β- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)— pyrimidinon,- (3-nonyl)] ethyl-2-methylamino-3,6-dimethyl-4 (3H) -pyrimidinone,

305. l-β- [exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2(3H)benzimidazolon,305. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2 (3H) benzimidazolone,

306. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethylindolin-2-on,306. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethylindolin-2-one,

307. l-β-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl-2(lH)chinolon,307. 1- [beta] - [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl-2 (1H) quinolone,

308. 3—β—[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]—(3—(6-okten)yl)]ethyl-2,4-(1H,3H)chinazolindion,308. 3-β- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2 4- (1H, 3H) quinazolinedione,

309. 5-β-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]—(3—(6-okten)yl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,309. 5-β- [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-2 - methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

310. 3-β-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0 ] (3-oktyl)]ethyl-2,4-(1H,3H)chinazolindion,310. 3-β- [Exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl-2,4 - (1H, 3H) quinazolinedione,

311. 5-β-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl-2-methylamino-3,6-dimethyl-4(3H)pyrimidinon,311. 5-β- [Exo / endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl-2- methylamino-3,6-dimethyl-4 (3H) pyrimidinone,

312. l-β-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]—(3—(6-okten)yl)]ethylindolin-2-on,312. 1- [beta] - [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethylindolin-2 -he,

313. 6-β-[6-fenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-(6-okten)yl)]ethyl-7-methyl-5H-thiazolo[3,2-a ] pyrimidin-5-on, • ·313. 6-β- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl-7-methyl -5H-thiazolo [3,2-a] pyrimidin-5-one;

314. N-[2-[exo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]-4-fluorbenzamid,314. N- [2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl] -4-fluorobenzamide,

315. N-[2-[endo-6-fenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]-4-fluorbenzamid,315. N- [2- [endo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] -4-fluorobenzamide,

316. N-[2-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]-4-fluorbenzamid,316. N- [2- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] -4- fluorobenzamide,

317. N-[2-[exo—6—p—trifluormethylfenyl-7—methyl-1,5-cis—3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]benzamid,317. N- [2- [exo-6-p-trifluoromethylphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,

318. N-2-[exo-6-m-chlorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]ethyl]benzamid,318. N-2- [exo-6-m-chlorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,

319. N-[2-[exo-6-p-methoxyfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl]-4-chlorbenzamid,319. N- [2- [exo-6-p-methoxyphenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl] -4- chlorobenzamide,

320. N-[2-[exo-6-fenyl-7-methyl-1,5-cis-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen-l-karboxamid,320. N- [2- [exo-6-phenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene-1-carboxamide ,

321. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-7-methyl-l,5-cis-3,7-diazabicyklo[3,3,0)-(3-oktyl)]butan-l-on,321. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] butan-1-one,

322. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-7-methyl-1,5—cis—3,7-diazabicyklo[3,3,0]-(3-oktyl)]butan-l-ol,322. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-7-methyl-1,5-cis-3,7-diazabicyclo [3.3.0] - (3-octyl)] butan-1-ol,

323. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]benzamid,323. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] benzamide,

324. l-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-324. 1- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl]naftalen, . .1 • ·- (3-nonyl)] ethyl] naphthalene,. .1 • ·

iand

325. 1- (4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-on,325. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-one,

326. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-ol,326. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-ol,

327. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]- ( 3-nony 1) ] ethyl ] -2- (N-methy1) aminobenzamid,327. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -2- (N-methyl) aminobenzamide,

328. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,328. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -5-chloro- (2-thienyl) ) Carboxamide

329. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]inden-3-karboxamid,329. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] indene-3-carboxamide,

330. N-[2-[exo-6-fenyl-l,5-cis-3-azabicyklo(4,3,0]-(3-nonyl)]ethyl]-4-fluorbenzamid,330. N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] (3-nonyl)] ethyl] -4-fluorobenzamide,

331. N-[2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]naftalen-l-karboxamid,331. N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] (3-nonyl)] ethyl] naphthalene-1-carboxamide,

332. 1-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]naftalen,332. 1- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] naphthalene,

333. l-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]butan-l-on,333. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] butane -l-he,

334. N-[2-[exo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]benzamid,334. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] benzamide,

335. N-[2-[exo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[4,3 ,0]-(3-(7-nonen)yl)]ethyl]inden-3-karboxamid, • ·335. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] indene-3- carboxamide, •

.J { ..J {.

336 . 336 N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl))ethyl]naftalen-l-karboxamid, N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl) ethyl] naphthalene-1-carboxamide, 337 . 337. N-[2-[exo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(7- -nonen)yl)]ethyl]-4-fluorbenzamid, N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] &lt; / RTI &gt; non-enyl) ethyl] -4-fluorobenzamide, 338 . « 338. « N-[2-[exo-6-fenyl-l,5-cis-3-azabicyklo[4,3,0)-(3-(7-nonen)yl)]ethyl]-3-chlor-l-benzo-(2-thienyl)karboxamid, N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] -3-chloro-1-benzo - (2-thienyl) carboxamide, 339. 339. l-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)y1)]ethyl]naftalen, 1- [2- [6-p-Fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen-yl)] ethyl] naphthalene, 340. 340. 1-(4-fluorfenyl)-4-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]butan-l-on, 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] butan-1-one , 341. 341. 1-(4-fluorfenyl)-4-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]butan-l-ol, 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] butan-1-ol , 342 . 342. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl)-2-(N-methyl)aminobenzamid, N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] -2- (N-methyl) aminobenzamide, 343 . 343. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl]-5-chlor-(2-thienyl)karboxamid, N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] -5-chloro- (2- thienyl) carboxamide, 344. 344. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)y1)]ethyl]benzamid, N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen-yl)] ethyl] benzamide, 345. 345. N-[2-[6-fenyl-l,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl]-3-chlor-l-benzo-(2-thienyl)karboxamid, N- [2- [6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] -3-chloro-1-benzo- ( 2-thienyl) carboxamide,

346. N-[2-[6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo-346. N- [2- [6-p-Trifluoromethylphenyl-1,5-cis-3-azabicyclo-

[4,3,0)-(3-(6-nonen)yl)]ethyl]naftalen-l-karboxamid,[4,3,0] - (3- (6-nonen) yl)] ethyl] naphthalene-1-carboxamide,

347. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl]inden-3-karbonimid,347. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] indene-3-carbonimide,

348. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(6-nonen)yl)]ethyl]naftalen-l-karboxamid,348. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (6-nonen) yl)] ethyl] naphthalene-1-carboxamide,

349. 1-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-nonyl)]ethylJnaftalen,349. 1- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] naphthalene,

350. 1-(4-fluorfenyl)-4-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-on,350. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-one,

351. 1-(4-fluorfenyl)-4-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-nonyl))butan-l-ol,351. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)) butan-1-ol,

352. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]-2-(N-methyl)aminobenzamid,352. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] - 2- (N-methyl) aminobenzamide,

353. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethylJbenzamid,353. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] benzamide,

354. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0)-354. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,- (3-nonyl)] ethyl] -5-chloro- (2-thienyl) carboxamide,

355. N-[2-[endo-6-fenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-nonyl)]ethyl]-4-fluorbenzamid,355. N- [2- [endo-6-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -4-fluorobenzamide,

356. N-[2—[endo-6-p-trifluormethylfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl))ethyl]inden-3-karboxamid,356. N- [2- [endo-6-p-trifluoromethylphenyl-1,5-cis-3-azabicyclo [4.3.0] (3-nonyl) ethyl] indene-3-carboxamide,

357. 2-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]42 • · : :357. 2- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] 42

• 9• 9

V ♦ • » t ί·· · • · · ·· · ϊ .: t.· • fc ·· « · 9 9 9 ····♦ ♦ t t:: t t t t t t t t t t t t t t t t t

-(3-(7-nonen) yl) ]ethyl]naftalen,- (3- (7-Nonen) yl)] ethyl] naphthalene,

358. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]benzamid,358. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] benzamide,

359. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]-2-(N-methyl)aminobenzamid,359. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] -2- ( N-methyl) aminobenzamide,

360. N-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(7-nonen)yl)]ethyl]naftalen-l-karboxamid,360. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (7-nonen) yl)] ethyl] naphthalene-1- carboxamide,

361. 1-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]naftalen,361. 1- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] naphthalene,

362. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]butan-l-on,362. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] butane -l-he,

363. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]benzamid,363. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] benzamide,

364. N-[2-[exo-7-p-fluorfenyl—1,5-cis—3—azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]-5-chlor-(2-thienyl)karboxamid,364. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] -5-chloro - (2-thienyl) carboxamide,

365. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]-3-chlor-l-benzo-(2-thienyl )karboxamid,365. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] -3-chloro -1-benzo- (2-thienyl) carboxamide,

366. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0)-(3-(8-nonen)y1)]ethyl]inden-3-karboxamid,366. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonene) yl] ethyl] indene-3-carboxamide,

367. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]naftalen-l-karboxamid, »· · · · • t I · · • ·····*· · • · » · · «· * ··367. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] naphthalene-1-carboxamide, · I I I I I I I I I I I I I I I I I I

368. 1-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-(8-nonen)yl)]ethyl]naftalen,368. 1- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3- (8-nonen) yl)] ethyl] naphthalene,

369. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-on,369. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-one,

370. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]butan-l-ol, ♦370. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] butan-1-ol; ♦

371. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-371. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl]-2-(N-methyl)aminobenzamid,- (3-nonyl)] ethyl] -2- (N-methyl) aminobenzamide,

372. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]benzamid,372. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] benzamide,

373. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,373. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] -5-chloro- (2-thienyl) ) Carboxamide

374. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-374. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] -

-(3-nonyl)]ethyl]naftalen-l-karboxamid,- (3-nonyl)] ethyl] naphthalene-1-carboxamide,

375. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[4,3,0]-(3-nonyl)]ethyl]inden-3-karboxamid,375. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [4.3.0] - (3-nonyl)] ethyl] indene-3-carboxamide,

376. l-[2-[6-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)yl)]ethyl]naftalen,376. 1- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] naphthalene,

77. 1-(4-fluorfenyl)-4-[6-p-fluorfenyl-1,5-cis-3-azabi cyklo[3,3,O]-(3-(6-okten)yl)]butan-l-on,77. 1- (4-Fluorophenyl) -4- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] butane- l-he,

378. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-(6-okten)y1)]ethyl]benzamid,378. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octenyl)] - ethyl] benzamide,

379. N-[2-[6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-(6-okten)yl)]ethyl]naftalen-l-karboxamid,379. N- [2- [6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] naphthalene-1-carboxamide,

380. l-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen,380. 1- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene,

381. 1-(4-fluorfenyl)-4-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]butan-l-ol,381. 1- (4-fluorophenyl) -4- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] butan-1-ol,

382. N-[2-[exo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl)benzamid,382. N- [2- [exo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl) benzamide,

383..N-[2-[exo-6—fenyl—1,5—cis-3-azabicyklo[3,3,0)-(3-oktyl)]ethyl]naftalen-l-karboxamid,383..N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene-1-carboxamide,

384. N-[2-[exo-6-fenyl-l,5-cis-3-azabicyklo[3,3,0)-(3-oktyl)]ethyl]inden-3-karboxamid,384. N- [2- [exo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] indene-3-carboxamide,

385. 1-[2-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen,385. 1- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene,

386. l-(4-fluorfenyl)-4-[endo-6-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-oktyl)]butan-l-on,386. 1- (4-fluorophenyl) -4- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] butan-1-one,

387. N-[2-[endo-6-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]benzamid,387. N- [2- [endo-6-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,

388. N-[2-[endo-6-fenyl-1,5-cis-3-azabicyklo[3,3,0)-(3-oktyl)]ethyl]naftalen-l-karboxamid,388. N- [2- [endo-6-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene-1-carboxamide,

389. l-[2-[exo-7-p-fluorfenyl-l,5-cis-3-azabicyklo[3,3,0]-389. 1- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] -

-(3-oktyl)]ethyl)naftalen, ·- (3-octyl)] ethyl) naphthalene,

· · • · *· ·

• ♦ 1 • i ·• ♦ 1 • i ·

390. 1-(4-fluorfenyl)-4-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]butan-l-on,390. 1- (4-fluorophenyl) -4- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] butan-1-one,

391. N-[2-[exo-7-p-fluorfenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]benzamid,391. N- [2- [exo-7-p-fluorophenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] benzamide,

392. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen-l-karboxamid,392. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] (3-octyl)] ethyl] naphthalene-1-carboxamide,

393. N-[2-[exo-7-fenyl-1,5-cis-3-azabicyklo[3,3,0]-(3-oktyl)]ethyl]inden-3-karboxamid,393. N- [2- [exo-7-phenyl-1,5-cis-3-azabicyclo [3.3.0] - (3-octyl)] ethyl] indene-3-carboxamide,

394. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl]-4-fluorbenzamid,394. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -4-fluorobenzamide,

395. N-[2-[exo-6—fenyl-3-azabicyklo[3,l,0]-(3-hexyl)]ethyl]-5-chlor-(2-thienyl)karboxamid,395. N- [2- [exo-6-phenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -5-chloro (2-thienyl) carboxamide,

396. N-[2-[6 ,6-difenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl]-(1-naftyl)karboxamid,396. N- [2- [6,6-Diphenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] - (1-naphthyl) carboxamide,

397. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,1,0]-(3-hexyl)]ethyl]-3-chlor-l-benzo-(2-thienyl)karboxamid,397. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -3-chloro-1-benzo (2-thienyl) carboxamide ,

398. N-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,1,0]-(3-hexyl) ]ethyl]-4-chlorbenzamid,398. N- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.1.0] (3-hexyl)] ethyl] -4-chlorobenzamide,

399. l-[2-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicykLo[3,3,0]-(3-(6-okten)yl)jethylnaftalen,399. 1- [2- [6-p-Fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl) ethylnaphthalene,

400. N-[2-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicykLo- [3,3,0]-(3-(6-okten)yl)]ethyl]benzamid,400. N- [2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl ] benzamide,

• · • · • · · • · · 9 ·9 9 · 9 • · • · • · • · « ♦ · 9 9 · * «♦ · 9 9 · * 9· · · 1 · · 9 · · · 1 · · • · • · «··· 0 · · «··· 0 · · • ♦ · 1 • » * • 1 · 1 • »* • • • · • · 9 9 9 9 9 9 • • ♦ 9 ♦ 9 • • • 99 · · • 100 · · • 9 9 9 • 9 9 9

401. N-[2—[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo- [3,3,0]-(3-(6-okten)yl)]ethyl]naftalen-l-karboxamid,401. N- [2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl ] Naphthalene-1-carboxamide

402. N-[2-[6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0)-(3-(6-okten)yl)]ethyl]inden-3-karboxamid,402. N- [2- [6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] indene-3-carboxamide,

403. 1-[2-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-oktyl)]ethyl]naftalen,403. 1- [2- [Exo-endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3-octyl)] ethyl] naphthalene ,

404. N-[2-[exo/endo-6-p-fluorfenyl-1,5-cis-8-oxa-3,7-diazabicyklo [ 3 ,3,0]-(3-oktyl)]ethylJbenzamid,404. N- [2- [exo-endo-6-p-fluorophenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] (3-octyl)] ethyl] benzamide,

405. l-[2-[6-fenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-405. 1- [2- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] -

-(3-(6-okten)yl)]ethyl]naftalen,- (3- (6-octenyl)) ethyl] naphthalene,

406. N-[2-[6-fenyl-1,5-cis-8-oxa-3,7-diazabicyklo[3,3,0]-(3-(6-okten)yl)]ethylJbenzamid,406. N- [2- [6-phenyl-1,5-cis-8-oxa-3,7-diazabicyclo [3.3.0] - (3- (6-octen) yl)] ethyl] benzamide,

407. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]benzosulfonamid,407. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzosulfonamide,

408. N-[2-[exo-6-fenyl-3-azabicyklo[ 3,2,0 J - (3-heptyl)]ethyl]benzosulfonamid,408. N- [2- [exo-6-phenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzosulfonamide,

409. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]-N-methylbenzosulfonamid,409. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -N-methylbenzosulfonamide,

410. N-[2-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo[3,2,0]-410. N- [2- [exo-6- (5-chloro-2-thienyl)] - 3-azabicyclo [3.2.0] -

-(3-heptyl)]ethyl]-4-fluorbenzosulfonamid,- (3-heptyl)] ethyl] -4-fluorobenzosulfonamide,

411. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-1fenoxypropan,411. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1-phenoxypropane,

• · • · 9 9 • · • · « « • · • · • 9 • 9 • • • • • • • · • · * · * · » « »« 9 9 * * • • • · • · ♦ · ♦ · 1 1 9 9 9 9 • • • • ···· · ···· · • * • * * * • · 1 • · 1 * * • • • • 1 1 • · • · • 1 • 1 9 9 9 9 9 9 • · · • · · • · • · • · • · • •

412. 2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl) ]-l-p-fluorfenoxyethan,412. 2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] -1-p-fluorophenoxyethane,

413. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-l-(l-naftyloxy)propan,413. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1- (1-naphthyloxy) propane,

414. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]—(3-heptyl)]-l-p-terc.-butylfenoxypropan,414. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1-p-tert-butylphenoxypropane,

415. 3-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-415. 3- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] -

-1-p-fluorfenoxypropan,-1-p-fluorophenoxypropane

416. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-416. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-

-hepty1)]ethyl]thiobenzamid,-heptyl) ethyl] thiobenzamide,

417. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fluorthiobenzamid,417. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-fluorothiobenzamide,

418. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-418. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl]-4-chlorthiobenzamid,-heptyl) ethyl] -4-chlorothiobenzamide,

419. O-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]benzoát,419. O- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] benzoate,

420. O-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fluorbenzoát,420. O- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-fluorobenzoate,

421. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-ΙΗ-benzo[ c, d ]indol-2-on,421. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indol-2-one,

422. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-422. N- [2- [exo-6-p-chloro-phenyl-3-azabicyclo [3.2.0] - (3-

-heptyl)]ethyl]-ΙΗ-benzo[c,d]indol-2-on, • *-heptyl) ethyl] -ΙΗ-benzo [c, d] indol-2-one;

423. N-[2-[exo-6-m-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-ΙΗ-benzo[c,d]indol-2-on,423. N- [2- [exo-6-m-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indol-2-one,

424. N-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]-ΙΗ-benzo[ c, d ]indol-2-on,424. N- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indol-2-one,

425. 3,3-dimethyl-l-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]indolin-2-on,425. 3,3-dimethyl-1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,

426. 3,3-dimethyl-l-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,426. 3,3-dimethyl-1- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,

427. 3,3-dimethyl-l-[2-[exo-6-m-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,427. 3,3-dimethyl-1- [2- [exo-6-m-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,

428. 1-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-3,3,5-trimethylindolin-2-on,428. 1- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3,3,5-trimethylindolin-2-one,

429. 3,4-dichlor-N-[2-[exo-6-p-nitrofenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]benzamid,429. 3,4-dichloro-N- [2- [exo-6-p-nitrophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

430. 2,5-difluor-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]benzamid,430. 2,5-difluoro-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] benzamide,

431. 2-amino-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo- [3,2,0]-(3-hepty1)]ethyl]benzamid,431. 2-amino-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

432. 2-amino-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]benzamid,432. 2-amino-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

433. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-2-methylaminobenzamid,433. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2-methylaminobenzamide,

• • a and 4 4 r» r » • • a a and a 9 9 9 9 • • • • • * • * • a • a * ♦ * ♦ • • ♦ ♦ • • • • • · • · • 4 • 4 9 9 • 1 • 1 * * • • • · · * • · · * A 4 A 4 4 4 4 4 • a * • a * • • • • 9 9 • • • • 9 9 • • a w and w a and • • « « • • 4 · 4 · a a a a and a • * • * ti · ti · a and

434. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-heptyl))ethyl]-2-methylaminobenzamid,434. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] -2-methylaminobenzamide,

435. 3-amino-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl]benzamid,435. 3-amino-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

436. 4-amino-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl]benzamid,436. 4-amino-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

437. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]thiofen-2-karboxamid,437. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] thiophene-2-carboxamide,

438. 5-chlor-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl))ethyl)thiofen-2-karboxamid,438. 5-chloro-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] thiophene-2-carboxamide,

439. 5-chlor-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-439. 5-chloro-N- [2- [exo-6-p-chloro-phenyl-3-azabicyclo [3.2.0] -

-(3-heptyl)]ethyl)thiofen-2-karboxamid,- (3-heptyl) ethyl) thiophene-2-carboxamide,

440. 5-chlor-N-[2-[exo-6-(5-chlor-(2-thienyl))-3-azabicyklo- [3,2,0)-(3-heptyl)]ethyl)thiofen-2-karboxamid,440. 5-chloro-N- [2- [exo-6- (5-chloro- (2-thienyl)) - 3-azabicyclo [3.2.0] (3-heptyl)] ethyl) thiophene- 2-carboxamide,

441. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl)benzo[b)furan-2-karboxamid,441. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] benzo [b] furan-2-carboxamide,

442. 3-chlor-N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-442. 3-chloro-N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0]

-(3-heptyl)]ethyl]benzo[b]thiofen-2-karboxamid,- (3-heptyl)] ethyl] benzo [b] thiophene-2-carboxamide,

443. 3-chlor-N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0)-443. 3-chloro-N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] &lt; / RTI &gt;

-(3-heptyl))ethyl]benzo[b]thiofen-2-karboxamid,- (3-heptyl) ethyl] benzo [b] thiophene-2-carboxamide,

444. 3-chlor-N-[2-[exo-6-p-nitrofenyl-3-azabicyklo[3,2,0]-444. 3-chloro-N- [2- [exo-6-p-nitrophenyl-3-azabicyclo [3,2.0] -

-(3-heptyl)]ethyl)benzo[b]thiofen-2-karboxamid,- (3-heptyl)] ethyl) benzo [b] thiophene-2-carboxamide,

445. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]inden-3-karboxamid,445. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indene-3-carboxamide,

446. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]inden-3-karboxamid,446. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indene-3-carboxamide,

447. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]cyklopropankarboxamid,447. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] cyclopropanecarboxamide,

448. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]cyklopentankarboxamid,448. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] cyclopentanecarboxamide,

449. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3, 2,0]-(3-hepty1)]ethyl]cyklopentankarboxamid,449. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3,2.0] - (3-heptyl)] ethyl] cyclopentanecarboxamide,

450. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]cyklohexankarboxamid,450. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] cyclohexanecarboxamide,

451. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl)cyklohexankarboxamid,451. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl) ethyl] cyclohexanecarboxamide,

452. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]naftalen-l-karboxamid,452. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] naphthalene-1-carboxamide,

453. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indol-2-karboxamid,453. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] indole-2-carboxamide,

454. N-[2-[exo-6-p-chlorfenyl-3-azabicyklo[3, 2,0]-(3-heptyl)]ethyl]indol-3-karboxamid,454. N- [2- [exo-6-p-chlorophenyl-3-azabicyclo [3.2.0] (3-heptyl)] ethyl] indole-3-carboxamide,

455. exo-6-p-fluorfenyl-3-[2-(1-naftyl)ethyl] -3-azabicyklo[3,2,0]heptan,455. exo-6-p-fluorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,

456. exo-6-p-chlorfenyl-3-[2-(1-naftyl)ethyl] -3-azabicyklo[3,2,O]heptan,456. exo-6-p-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,

457. exo-6-m-chlorfenyl-3-[2-(l-naftyl)ethyl]-3-azabicyklo[3,2,0 Jheptan,457. exo-6-m-chlorophenyl-3- [2- (1-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,

458· exo-6-(5-chlor-(2-thienyl))-3-[2-(1-naftyl)ethyl)-3-azabicyklo[3,2,0Jheptan,458 · exo-6- (5-chloro- (2-thienyl)) - 3- [2- (1-naphthyl) ethyl) -3-azabicyclo [3.2.0] heptane,

459. exo-6-p-fluorfenyl-3-[2-(2-naftyl)ethyl]-3-azabicyklo[3,2,0]heptan,459. exo-6-p-fluorophenyl-3- [2- (2-naphthyl) ethyl] -3-azabicyclo [3.2.0] heptane,

460. exo-6-p-fluorfenyl-3-[l-naftylmethyl]-3-azabicyklo[3,2,0]heptan,460. exo-6-p-fluorophenyl-3- [1-naphthylmethyl] -3-azabicyclo [3.2.0] heptane,

461. exo-6-p-fluorfenyl-3-[2-naftylmethyl]-3-azabicyklo- [3,2,0Jheptan,461. exo-6-p-fluorophenyl-3- [2-naphthylmethyl] -3-azabicyclo [3.2.0] heptane,

462. 4-[6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-1-(2-thienyl)butan-l-on,462. 4- [6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] - 1- (2-thienyl) butan-1-one,

463. 4-[6-p-chlorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]-l- (2-thienyl)butan-l-on,463. 4- [6-p-chlorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] -1- (2-thienyl) butan-1-one,

464. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fenylpyrrolidin-2-on,464. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-phenylpyrrolidin-2-one,

465. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]benzoxazolin-2-on,465. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzoxazolin-2-one,

66. N-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0J-(3-hepty1)]ethyl]isoindolinon,66. N- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0- (3-heptyl)] ethyl] isoindolinone,

4 4 ·· · 4 4 4 » 4 4 4 4 · φ · · 4 4 4 a 4 4 • 4 4 4 · • 4 4 ··4 4 ·· 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4

467. 1-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indazol,467. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indazole,

468. 1-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-1,8-naftalensultam,468. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1,8-naphthalenesultam,

469. 4-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-l,4-benzoxazin-3-on,469. 4- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1,4-benzoxazin-3-one,

470. 1-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]chinoxalin-2(1H)-on,470. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] quinoxalin-2 (1H) -one,

471. 1—[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,471. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,

472. l-[2-[exo-6-p-fluorfenyl-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]spiro[cyklopropan-1',3-indolin-2-on],472. 1- [2- [exo-6-p-fluorophenyl-3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] spiro [cyclopropan-1 ', 3-indolin-2-one] ,

473. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-3H-pyrimidin-4-on,473. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3H- pyrimidin-4-one,

474. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3H-pyrimidin-4-on,474. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -3H- pyrimidin-4-one,

475. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(5-chlor-1-naftyl)-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-3H-pyrimidin-4-on,475. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl -3H-pyrimidin-4-one

476. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3H-pyrimidin-4-on,476. 3,6-dimethyl-2-methylamino-5- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl -3H-pyrimidin-4-one

477. 3,6-dimethyl-2-methylamino-5-[2-[exo-6-(9-fenanthryl)-3-477. 3,6-Dimethyl-2-methylamino-5- [2- [exo-6- (9-phenanthryl) -3-

-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-3H-pyrimidin-4-on,-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3H-pyrimidin-4-one,

478. 7-methyl-6-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]—(3— -heptyl)]ethyl]-5H-thiazolo[3,2-a]pyrimidin-5-on,478. 7-Methyl-6- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -5H-thiazolo [3,2] -a] pyrimidin-5-one,

479. 3-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-1H,3H-chinazolin-2,4-dion,479. 3- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2,4-dione,

480. 3-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-1H,3H-chinazolin-2,4-dion,480. 3- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2,4-dione,

481. 6-fluor-3-[2-(exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-hepty1)]ethyl]-1H,3H-chinazolin-2,4-dion,481. 6-fluoro-3- [2- (exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2, 4-dione,

482. 3-[2-[exo-6-(5-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-lH,3H-chinazolin-2,4-dion,482. 3- [2- [exo-6- (5-chloro-2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H, 3H-quinazoline-2, 4-dione,

483. 3-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on,483. 3- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -2-methyl-4H-pyrido [1,2- a] pyrimidin-4-one,

484. 1-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-2(1H)chinolon,484. 1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2 (1H) quinolone,

485. 1—[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]indolin-2-on,485. 1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] indolin-2-one,

86. 1-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl) ]ethyl]-2(3H)benzimidazolon,86. 1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2 (3H) benzimidazolone,

487. 1-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl) ] ethyl]-3-methyl-2(3H)benzimidazolon,487. 1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -3-methyl-2 (3H) benzimidazolone,

488. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl) ] - 54 - ethyl]benzamid,488. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] - 54-ethyl] benzamide,

489. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl]benzamid,489. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

490. N- [2-[exo-6-(5-chlor-1-naftyl)-3-azabicyklo[3,2,0]-490. N- [2- [exo-6- (5-chloro-1-naphthyl) -3-azabicyclo [3,2,0] -

-(3-heptyl)]ethyl]benzamid,- (3-heptyl)] ethyl] benzamide,

491. 3-[2-(1-naftyl)ethyl]-exo-6-(1-naftyl)-3-azabicyklo[3,2,0]heptan,491. 3- [2- (1-naphthyl) ethyl] -exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] heptane,

492. 3-[2-(1-naftyl)ethyl]-exo-6-(2-naftyl)-3-azabicyklo[3,2,O]heptan,492. 3- [2- (1-naphthyl) ethyl] -exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] heptane,

493. 1-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl]-ΙΗ-benzo[c,d]indol-2-on,493. 1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-benzo [c, d] indole-2- he,

494. 1-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,O]-(3-heptyl)]ethyl]-lH-benzo[c,d]indol-2-on,494. 1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -1H-benzo [c, d] indole-2- he,

495. 3,3-dimethyl-l-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-l,3-dihydroindol-2-on,495. 3,3-dimethyl-1- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -1,3-dihydroindole- 2-on,

496. 3,3-dimethyl-l-[2-[exo-6-(2-naftyl)-3-azabicyklo- [3,2,O]-(3-heptyl)]ethyl]-l,3-dihydroindol-2-on,496. 3,3-dimethyl-1- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -1,3-dihydroindole -2-on,

497. 3,3-dimethyl-l-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-l,3-dihydroindol-2—on,497. 3,3-dimethyl-1- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -1, 3-dihydroindol-2-one,

498. 5-chlor-N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-498. 5-chloro-N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3,2,0] -

-(3-heptyl)]ethyl]-2-thiofenkarboxamid,- (3-heptyl)] ethyl] -2-thiophenecarboxamide,

499. 5-chlor-N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]• 9 9499. 5-chloro-N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] • 9 9

- 55 -(3-heptyl)]ethyl]-2-thiofenkarboxamid,- 55 - (3-heptyl)] ethyl] -2-thiophenecarboxamide,

500. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-4-fluorbenzamid,500. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-fluorobenzamide,

501. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-4-nitrobenzamid,501. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -4-nitrobenzamide,

502. N-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0)-(3-hepty1)]ethyl]benzamid,502. N- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

503. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-4-methoxybenzamid,503. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-methoxybenzamide,

504. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]-4-hydroxybenzamid,504. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] -4-hydroxybenzamide,

505. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethylJ-3,4-dichlorbenzamid,505. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3,4-dichlorobenzamide,

506. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]naftalen-l-karboxamid,506. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] naphthalene-1-carboxamide,

507. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]naftalen-l-karboxamid,507. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] naphthalene-1-carboxamide,

508. N-[2-[exo-6-(9-fenanthryl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl]benzamid,508. N- [2- [exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] benzamide,

509. 1-[2-[exo-6-(6-chlor-2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl))ethyl)-lH-benzo[c,d]indol-2-on,509. 1- [2- [exo-6- (6-chloro-2-naphthyl) -3-azabicyclo [3.2.0] (3-heptyl) ethyl] -1H-benzo [c, d] indol-2-one,

510. 1-[2-[exo-6-(9-fenanthryl)-3-azabicyklo[3,2,0]- 56 -(3-hepty1)]ethyl]-ΙΗ-benzo[c,d]indol-2-on,510. 1- [2- [exo-6- (9-phenanthryl) -3-azabicyclo [3.2.0] -5- (3-heptyl)] ethyl] -4-benzo [c, d] indole- 2-on,

511. N-[2-[exo-6-(1-naftyl)-3-azabicyklo[ 3,2,0 ] - (3-heptyl)]ethyl]isoindolinon,511. N- [2- [exo-6- (1-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] isoindolinone,

512. N-[2-[exo-6-(2-naftyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]isoindolinon,512. N- [2- [exo-6- (2-naphthyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] isoindolinone,

513. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-3-methyl-2H-l,3-dihydrobenzimidazol-2-on,513. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3 - methyl-2H-1,3-dihydrobenzimidazol-2-one,

514. (+)-(lS,5R,6S)exo-l-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)Jethyl]-3-ethyl-2H-l,3-dihydrobenzimidazol-2-on,514. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl) -ethyl] -3- ethyl-2H-1,3-dihydrobenzimidazol-2-one,

515. (+)-(1S,5R,6S)exo-1-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3-n-propyl-2H-l,3-dihydrobenzimidazol-2-on,515. (+) - (1S, 5R, 6S) exo-1- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3 -n-propyl-2H-1,3-dihydrobenzimidazol-2-one,

516. (+)-(1S,5R,6S)exo-2-[2-[6-(4-chlorfenyl)-3-azabicyklo[3,2,0]-(3-heptyl)]ethyl]-3,3-dimethyl-2,3-dihydro-l, 2benzisothiazol-1,1-dioxid,516. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -3 3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide,

517. (+)-(lS,5R,6S)exo-2-[2-[6-(4-chlorfenyl) -3-azabicyklo[3,2,0]—(3-heptyl)]ethyl]-2,3-dihydro-l,2-benzisothiazol-1,1-dioxid,517. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-chloro-phenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl] -2 3-dihydro-1,2-benzisothiazole-1,1-dioxide,

518. (+)-(lS,5R,6S)exo-2-[2-[6-(4-fluorfenyl)-3-azabicyklo- [3,2,0]-(3-heptyl)]ethyl]-3,3-dimethyl-2,3-dihydro-l, 2benzisothiazol-1,1-dioxid,518. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] (3-heptyl)] ethyl] - 3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide,

519. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorfenyl)-3-azabicyklo• · • 9 • 9· • 999519. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo] -9-9-9999

999·· ·9 [3,2,0)-(3-heptyl)]ethyl)-3,3-diethyl-2,3-dihydro-l,2benzisothiazol-1,1-dioxid a999 ··· 9 [3,2,0) - (3-heptyl)] ethyl) -3,3-diethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide and

520. (+)-(1S,5R,6S)exo-2-[2-[6-(4-fluorfenyl)-3-azabicyklo[3,2,0)-(3-heptyl)]ethyl)-2,3-dihydro-l,2-benzisothiazol-1,1-dioxid.520. (+) - (1S, 5R, 6S) exo-2- [2- [6- (4-fluorophenyl) -3-azabicyclo [3.2.0] - (3-heptyl)] ethyl) -2 1,3-dihydro-1,2-benzisothiazole-1,1-dioxide.

Gesř(a republika Geser (and Republic

Claims (4)

1. Použití N-substituovaných 3-azabicykloalkanových derivátů obecného vzorce IUse of N-substituted 3-azabicycloalkane derivatives of the general formula I IrIr B znamená 4-, 5 - nebo 6-členný kruh, který může obsahovat dvojnou vazbu,B represents a 4-, 5- or 6-membered ring which may contain a double bond, R1 je fenylová, naftylová, fenanthrylová nebo thienylová skupina, v každém případě nesubstituovaná nebo mononebo disubstituovaná atomy halogenu, alkylovými skupinami s 1 až 4 atomy uhlíku, trifluormethylovými skupinami, hydroxyskupinami, alkoxyskupinami s 1 až 4 atomy uhlíku, aminoskupinami, monomethylaminoskupinami, dimethylaminoskupinami, kyanoskupinami nebo nitroskupinami, n je číslo 0, 1, 2, 3 nebo 4 aR 1 is phenyl, naphthyl, phenanthryl or thienyl, in each case unsubstituted or mono- or disubstituted with halogen atoms, C 1 -C 4 alkyl, trifluoromethyl, hydroxy, C 1 -C 4 alkoxy, amino, monomethylamino, dimethylamino n is 0, 1, 2, 3 or 4; and cyano or nitro; R2 je naftylová skupina, která je nesubstituovaná nebo substituovaná jedním nebo dvěma atomy halogenu, nebo jedním z následujících zbytkůR 2 is naphthyl which is unsubstituted or substituted by one or two halogen atoms, or one of the following radicals R3 R3 0 0 zR8 zR 8 Í---R5 , - I --- R5, - II — NR6--C--R7 II - NR 6 - C - R 7 — NR6--so2—- NR 6 --so 2 - R4 R 4
- 59 • · · • · · • · · · • · ···· · • · · ·· ·- 59 · · · · · · · · · · · · · · · · · · · · · · · · · · R3 je atom vodíku, hydroxyskupina nebo fenylová skupina, která je nesubstituovaná nebo substituovaná atomem fluoru, chloru nebo bromu,R 3 is a hydrogen atom, a hydroxy group or a phenyl group which is unsubstituted or substituted by a fluorine, chlorine or bromine atom, R4 je atom vodíku neboR 4 is hydrogen or R3 a R4 tvoří dohromady atom kyslíku, • 9R 3 and R 4 together form an oxygen atom; - 60 R5 je fenylová, naftylová nebo thienylová skupina, každá z nich je nesubstituovaná nebo mono- nebo disubstituovaná atomy fluoru, chloru nebo bromu, nebo hydroxyskupinami, nitroskupinami, aminoskupinami, alkanoylaminoskupinami s 1 až 4 atomy uhlíku, alkylaminoskupinami s 1 až 4 atomy uhlíku, alkylovými skupinami s 1 až 4 atomy uhlíku nebo methoxyskupinami,- 60 R 5 is phenyl, naphthyl or thienyl, each of which is unsubstituted or mono- or disubstituted by fluorine, chlorine or bromine, or hydroxyl, nitro, amino, alkanoylamino having 1-4 carbon atoms, alkylamino having 1-4 carbon carbon, (C 1 -C 4) alkyl or methoxy groups, R6 je atom vodíku nebo methylová skupina,R 6 is a hydrogen atom or a methyl group, R7 je fenylová, naftylová, benzofurylová, benzothienylová, thienylová, indolylová, N-methylindolylová nebo indenylová skupina, v každém případě nesubstituovaná nebo mono- nebo disubstituovaná atomy fluoru, chloru nebo bromu, nebo alkylovými skupinami s 1 až 4 atomy uhlíku, hydroxyskupinami, methoxyskupinami, nitroskupinami, kyanoskupinami , trifluormethylovými skupinami, aminoskupinami, dialkylaminoskupinami s 1 až 4 atomy uhlíku v každé alkylové části, nebo je cykloalkylová skupina se 3 až 7 atomy uhlíku,R 7 is phenyl, naphthyl, benzofuryl, benzothienyl, thienyl, indolyl, N-methylindolyl or indenyl, in each case unsubstituted or mono- or disubstituted by fluorine, chlorine or bromine atoms, or by C 1 -C 4 alkyl, hydroxy, methoxy, nitro, cyano, trifluoromethyl, amino, dialkylamino of 1 to 4 carbon atoms in each alkyl moiety, or is cycloalkyl of 3 to 7 carbon atoms, R8 je atom vodíku, atom fluoru nebo atom chloru, alkylová skupina s 1 až 4 atomy uhlíku, methoxyskupina nebo aminoskupina, r9 je atom vodíku nebo methylová skupina aR 8 is hydrogen, fluoro or chloro, C 1 -C 4 alkyl, methoxy or amino, R 9 is hydrogen or methyl; and R10 je atom vodíku nebo methylová skupina nebo r9 a R10 dohromady s atomem uhlíku kruhu tvoří spirocyklopropanový kruh,R 10 is a hydrogen atom or a methyl group, or R 9 and R 10 together with the ring carbon atom form a spirocyclopropane ring, 4 44 4 4 «4 « - 61 R11 je atom vodíku, hydroxyskupina, alkylová skupina s 1 až 4 atomy uhlíku nebo alkoxyskupina s 1 až 4 atomy uhlíku, nebo dohromady se sousedícím atomem uhlíku tvoří skupinu vzorce C=O- nebo skupinu vzorce C=S-, jsou atomy uhlíku, skupiny vzorce CH, CH2, NH nebo alkyl-N-skupina s 1 až 4 atomy uhlíku nebo atomy dusíku, je přímá vazba, skupina vzorce CO, skupina vzorce CS, skupina vzorce CH nebo skupina vzorce CH2, kde atom vodíku může být nahrazen hydroxyskupinou, aminoskupinou, alkoxyskupinou s 1 až 4 atomy uhlíku nebo atomem halogenu, a je atom vodíku, hydroxyskupina, aminoskupina, merkaptoskupina, alkylaminoskupina s 1 až 4 atomy uhlíku, dialkylaminoskupina s 1 až 4 atomy uhlíku v každé alkylové části, alkylthioskupina s 1 až 4 atomy uhlíku nebo alkoxyskupina s 1 až 4 atomy uhlíku, nebo dohromady se sousedícím atomem uhlíku tvoří skupinu vzorce C=0, nebo je na Y-vázaná alkylenová skupina se 3 nebo 4 atomy uhlíku, která může obsahovat jednu nebo dvě nekumulované dvojné vazby a kde jedna ze skupin CH nebo CH2 může být nahrazena atomem dusíku nebo atomem síry nebo skupinou NH nebo skupinou N-CH3 a kde kruh je buď monosubstituován atomem fluoru, chloru nebo methylovou skupinou, methoxyskupinou, nitroskupinou nebo aminoskupinou, nebo v případě benzenového kruhu, tento kruh může být mono-, di- nebo trisubstituován ·· · · • · · · • · · • · · atomy fluoru nebo chloru nebo methylovými skupinami, trifluormethylovými skupinami, nitroskupinami, hydroxyskupinami, methoxyskupinami, aminoskupinami, monomethylovými skupinami nebo dimethylaminoskupinami, a kde kruh obsahující X, Y a Z na atomu dusíku v poloze 1 může nést alkylovou skupinu s 1 až 4 atomy uhlíku, allylovou skupinu nebo benzylovou skupinu a může obsahovat 1 až 3 nekumulované dvojné vazby, a jejich solí s fyziologicky přijatelnými kyselinami, pro výrobu léčiva pro léčení poruch centrálního nervového systému.- R 11 is hydrogen, hydroxy, C 1 -C 4 alkyl or C 1 -C 4 alkoxy, or taken together with an adjacent carbon atom to form C = O- or C = S-, are atoms carbon, CH, CH 2 , NH, or C 1 -C 4 alkyl-N-is a direct bond, CO, CS, CH or CH 2 wherein hydrogen can be replaced by hydroxy, amino, C 1 -C 4 alkoxy or halogen, and is hydrogen, hydroxy, amino, mercapto, C 1 -C 4 alkylamino, C 1 -C 4 dialkylamino, alkylthio C 1 -C 4 or C 1 -C 4 alkoxy, or together with an adjacent carbon atom, form a group of formula C = O, or is a C 3 -C 4 alkylene group which may be contain one or two non-cumulated double bonds, and wherein one of the groups CH or CH 2 may be replaced by a nitrogen or sulfur atom or NH or N-CH 3, and wherein the ring is either monosubstituted by fluorine, chlorine, methyl, methoxy, nitro or amino, or in the case of a benzene ring, the ring may be mono-, di- or trisubstituted by fluorine or chlorine atoms or by methyl, trifluoromethyl, nitro, hydroxy, methoxy groups , amino, monomethyl or dimethylamino groups, and wherein the ring containing X, Y and Z at the 1-position nitrogen atom may carry a C 1 -C 4 alkyl, allyl or benzyl group and may contain 1 to 3 non-accumulated double bonds, and their salts with physiologically acceptable acids, for the manufacture of a medicament for the treatment of central nervous disorders system. 2. Použití podle nároku 1 pro výrobu léčiva pro léčení návykových poruch.Use according to claim 1 for the manufacture of a medicament for the treatment of addictive disorders. 3. Použití podle nároku 1 nebo 2 pro výrobu léčiva pro léčení návyku na kokain.Use according to claim 1 or 2 for the manufacture of a medicament for the treatment of cocaine addiction. 4. Použití podle nároku 1 nebo 2 pro výrobu léčiva pro potlačování návyku na amfetaminu a substancích podobných amfetaminu.Use according to claim 1 or 2 for the manufacture of a medicament for suppressing addiction to amphetamine and amphetamine-like substances.
CZ20011796A 1998-11-24 1999-11-12 Use of N-substituted azabicycloalkane derivatives for treating central nervous system disorders CZ20011796A3 (en)

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