SK59294A3 - Method of making a prolineboronate ester - Google Patents

Method of making a prolineboronate ester Download PDF

Info

Publication number
SK59294A3
SK59294A3 SK592-94A SK59294A SK59294A3 SK 59294 A3 SK59294 A3 SK 59294A3 SK 59294 A SK59294 A SK 59294A SK 59294 A3 SK59294 A3 SK 59294A3
Authority
SK
Slovakia
Prior art keywords
formula
pinanediol
group
compound
ester
Prior art date
Application number
SK592-94A
Other languages
English (en)
Slovak (sk)
Inventor
Roger Snow
Terence A Kelly
Julian Adams
Simon Coutts
Clark Perry
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of SK59294A3 publication Critical patent/SK59294A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK592-94A 1991-11-22 1992-11-19 Method of making a prolineboronate ester SK59294A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79614891A 1991-11-22 1991-11-22
US93619892A 1992-08-26 1992-08-26
PCT/US1992/009845 WO1993010127A1 (en) 1991-11-22 1992-11-19 Method for making a prolineboronate ester

Publications (1)

Publication Number Publication Date
SK59294A3 true SK59294A3 (en) 1995-02-08

Family

ID=27121696

Family Applications (1)

Application Number Title Priority Date Filing Date
SK592-94A SK59294A3 (en) 1991-11-22 1992-11-19 Method of making a prolineboronate ester

Country Status (17)

Country Link
EP (1) EP0641347A1 (enExample)
JP (1) JPH07501078A (enExample)
CN (1) CN1073946A (enExample)
AU (1) AU661362B2 (enExample)
CA (1) CA2123128A1 (enExample)
CZ (1) CZ124494A3 (enExample)
FI (1) FI942345A0 (enExample)
HU (1) HUT67937A (enExample)
IL (1) IL103817A0 (enExample)
MX (1) MX9206628A (enExample)
NO (1) NO941905L (enExample)
NZ (1) NZ245207A (enExample)
PT (1) PT101079A (enExample)
SI (1) SI9200332A (enExample)
SK (1) SK59294A3 (enExample)
TW (1) TW232697B (enExample)
WO (1) WO1993010127A1 (enExample)

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JP2002513762A (ja) 1998-05-04 2002-05-14 ポイント セラピューティクス， インコーポレイテッド 造血刺激
EP1084129B1 (en) 1998-06-05 2003-01-22 Point Therapeutics, Inc. Cyclic boroproline compounds
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
AU2001233622A1 (en) * 2000-02-25 2001-09-03 Novo-Nordisk A/S Inhibition of beta cell degeneration
AU2003218969A1 (en) * 2002-02-01 2003-09-02 Probiodrug Ag Modulation of t lymphocytes using dp iv inhibitors
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7317109B2 (en) 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
DK1689757T3 (en) 2003-11-12 2014-12-08 Sino Med Internat Alliance Inc HETEROCYCLIC DRY ACID COMPOUNDS
US7767828B2 (en) 2003-11-12 2010-08-03 Phenomix Corporation Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
KR20170104639A (ko) 2003-11-17 2017-09-15 노파르티스 아게 디펩티딜 펩티다제 ⅳ 억제제의 용도
HRP20211766T1 (hr) 2004-01-20 2022-02-18 Novartis Ag Formulacija i postupak izravne kompresije
WO2005105817A2 (en) * 2004-04-27 2005-11-10 Wyeth Coupling process for generating reactive boron­ containing derivatives of n-substituted pyrrole-2­ carbonitriles to produce biaryls
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
CA2606785A1 (en) 2005-05-19 2006-11-23 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1331835C (zh) * 2005-10-18 2007-08-15 武汉大学 光活性β－羟基酮的制备方法
WO2007100374A2 (en) 2005-12-19 2007-09-07 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof
ATE487940T1 (de) 2006-04-11 2010-11-15 Arena Pharm Inc Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
ES2585114T3 (es) * 2008-06-17 2016-10-03 Millennium Pharmaceuticals, Inc. Compuestos de ésteres boronato y composiciones farmacéuticas de los mismos
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
JP2013523819A (ja) 2010-04-06 2013-06-17 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012135570A1 (en) 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
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WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
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WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US9523687B2 (en) 2014-02-28 2016-12-20 Institut Pasteur Levels of CXCL 10/IP-10 forms and soluble CD26/DPPIV activity as early predictive biomarkers for HIV/SIV associated mucosal inflammation and progression towards AIDS
CA2949517A1 (en) 2014-05-20 2015-11-26 Millennium Pharmaceuticals, Inc. Boron-containing proteasome inhibitors for use after primary cancer therapy
WO2016144862A1 (en) 2015-03-09 2016-09-15 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
WO2018162722A1 (en) 2017-03-09 2018-09-13 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Dpp-4 inhibitors for use in treating bone fractures
KR20200036808A (ko) 2017-04-03 2020-04-07 코히러스 바이오사이언시스, 인크. 진행성 핵상 마비 치료를 위한 PPARγ 작용제
CN108047257B (zh) * 2017-12-17 2020-03-13 沧州普瑞东方科技有限公司 一种手性n-boc-吡咯烷-2-硼酸的制备工艺
EA202091962A1 (ru) * 2018-02-20 2020-11-06 Оцука Фармасьютикал Ко., Лтд. Способ производства 4-боронфенилаланина
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WO1991016339A1 (en) * 1990-04-14 1991-10-31 New England Medical Center Hospitals, Inc. Inhibitors of dipeptidyl-aminopeptidase type iv
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry

Also Published As

Publication number Publication date
HUT67937A (en) 1995-05-29
NO941905D0 (no) 1994-05-20
MX9206628A (es) 1993-05-01
CA2123128A1 (en) 1993-05-27
CN1073946A (zh) 1993-07-07
AU3136893A (en) 1993-06-15
IL103817A0 (en) 1993-04-04
CZ124494A3 (en) 1995-07-12
JPH07501078A (ja) 1995-02-02
TW232697B (enExample) 1994-10-21
AU661362B2 (en) 1995-07-20
SI9200332A (en) 1993-06-30
FI942345A7 (fi) 1994-05-20
EP0641347A1 (en) 1995-03-08
WO1993010127A1 (en) 1993-05-27
HU9401350D0 (en) 1994-08-29
NO941905L (no) 1994-07-14
NZ245207A (en) 1994-07-26
FI942345A0 (fi) 1994-05-20
PT101079A (pt) 1994-02-28

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