IL103817A0 - Method and intermediates for the preparation of prolineboronic acid esters - Google Patents

Method and intermediates for the preparation of prolineboronic acid esters

Info

Publication number
IL103817A0
IL103817A0 IL103817A IL10381792A IL103817A0 IL 103817 A0 IL103817 A0 IL 103817A0 IL 103817 A IL103817 A IL 103817A IL 10381792 A IL10381792 A IL 10381792A IL 103817 A0 IL103817 A0 IL 103817A0
Authority
IL
Israel
Prior art keywords
intermediates
preparation
acid esters
prolineboronic acid
prolineboronic
Prior art date
Application number
IL103817A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL103817A0 publication Critical patent/IL103817A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL103817A 1991-11-22 1992-11-20 Method and intermediates for the preparation of prolineboronic acid esters IL103817A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79614891A 1991-11-22 1991-11-22
US93619892A 1992-08-26 1992-08-26

Publications (1)

Publication Number Publication Date
IL103817A0 true IL103817A0 (en) 1993-04-04

Family

ID=27121696

Family Applications (1)

Application Number Title Priority Date Filing Date
IL103817A IL103817A0 (en) 1991-11-22 1992-11-20 Method and intermediates for the preparation of prolineboronic acid esters

Country Status (17)

Country Link
EP (1) EP0641347A1 (enExample)
JP (1) JPH07501078A (enExample)
CN (1) CN1073946A (enExample)
AU (1) AU661362B2 (enExample)
CA (1) CA2123128A1 (enExample)
CZ (1) CZ124494A3 (enExample)
FI (1) FI942345A0 (enExample)
HU (1) HUT67937A (enExample)
IL (1) IL103817A0 (enExample)
MX (1) MX9206628A (enExample)
NO (1) NO941905L (enExample)
NZ (1) NZ245207A (enExample)
PT (1) PT101079A (enExample)
SI (1) SI9200332A (enExample)
SK (1) SK59294A3 (enExample)
TW (1) TW232697B (enExample)
WO (1) WO1993010127A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
WO1999016864A1 (en) 1997-09-29 1999-04-08 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
JP2002513762A (ja) 1998-05-04 2002-05-14 ポイント セラピューティクス， インコーポレイテッド 造血刺激
EP1084129B1 (en) 1998-06-05 2003-01-22 Point Therapeutics, Inc. Cyclic boroproline compounds
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
AU2001233622A1 (en) * 2000-02-25 2001-09-03 Novo-Nordisk A/S Inhibition of beta cell degeneration
AU2003218969A1 (en) * 2002-02-01 2003-09-02 Probiodrug Ag Modulation of t lymphocytes using dp iv inhibitors
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7317109B2 (en) 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
DK1689757T3 (en) 2003-11-12 2014-12-08 Sino Med Internat Alliance Inc HETEROCYCLIC DRY ACID COMPOUNDS
US7767828B2 (en) 2003-11-12 2010-08-03 Phenomix Corporation Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
KR20170104639A (ko) 2003-11-17 2017-09-15 노파르티스 아게 디펩티딜 펩티다제 ⅳ 억제제의 용도
HRP20211766T1 (hr) 2004-01-20 2022-02-18 Novartis Ag Formulacija i postupak izravne kompresije
WO2005105817A2 (en) * 2004-04-27 2005-11-10 Wyeth Coupling process for generating reactive boron­ containing derivatives of n-substituted pyrrole-2­ carbonitriles to produce biaryls
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
CA2606785A1 (en) 2005-05-19 2006-11-23 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1331835C (zh) * 2005-10-18 2007-08-15 武汉大学 光活性β－羟基酮的制备方法
WO2007100374A2 (en) 2005-12-19 2007-09-07 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof
ATE487940T1 (de) 2006-04-11 2010-11-15 Arena Pharm Inc Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
ES2585114T3 (es) * 2008-06-17 2016-10-03 Millennium Pharmaceuticals, Inc. Compuestos de ésteres boronato y composiciones farmacéuticas de los mismos
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
JP2013523819A (ja) 2010-04-06 2013-06-17 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012135570A1 (en) 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US9523687B2 (en) 2014-02-28 2016-12-20 Institut Pasteur Levels of CXCL 10/IP-10 forms and soluble CD26/DPPIV activity as early predictive biomarkers for HIV/SIV associated mucosal inflammation and progression towards AIDS
CA2949517A1 (en) 2014-05-20 2015-11-26 Millennium Pharmaceuticals, Inc. Boron-containing proteasome inhibitors for use after primary cancer therapy
WO2016144862A1 (en) 2015-03-09 2016-09-15 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
WO2018162722A1 (en) 2017-03-09 2018-09-13 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Dpp-4 inhibitors for use in treating bone fractures
KR20200036808A (ko) 2017-04-03 2020-04-07 코히러스 바이오사이언시스, 인크. 진행성 핵상 마비 치료를 위한 PPARγ 작용제
CN108047257B (zh) * 2017-12-17 2020-03-13 沧州普瑞东方科技有限公司 一种手性n-boc-吡咯烷-2-硼酸的制备工艺
EA202091962A1 (ru) * 2018-02-20 2020-11-06 Оцука Фармасьютикал Ко., Лтд. Способ производства 4-боронфенилаланина
CN110452258B (zh) * 2019-09-03 2021-01-01 上海馨远医药科技有限公司 一种二肽缬氨酸硼脯氨酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935493A (en) * 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
WO1991016339A1 (en) * 1990-04-14 1991-10-31 New England Medical Center Hospitals, Inc. Inhibitors of dipeptidyl-aminopeptidase type iv
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry

Also Published As

Publication number Publication date
HUT67937A (en) 1995-05-29
NO941905D0 (no) 1994-05-20
MX9206628A (es) 1993-05-01
CA2123128A1 (en) 1993-05-27
CN1073946A (zh) 1993-07-07
AU3136893A (en) 1993-06-15
CZ124494A3 (en) 1995-07-12
JPH07501078A (ja) 1995-02-02
TW232697B (enExample) 1994-10-21
AU661362B2 (en) 1995-07-20
SI9200332A (en) 1993-06-30
FI942345A7 (fi) 1994-05-20
EP0641347A1 (en) 1995-03-08
WO1993010127A1 (en) 1993-05-27
HU9401350D0 (en) 1994-08-29
SK59294A3 (en) 1995-02-08
NO941905L (no) 1994-07-14
NZ245207A (en) 1994-07-26
FI942345A0 (fi) 1994-05-20
PT101079A (pt) 1994-02-28

Similar Documents

Publication Publication Date Title
IL103817A0 (en) Method and intermediates for the preparation of prolineboronic acid esters
GB9508497D0 (en) Process for the preparation of clavulanic acid
EP0512211A3 (en) Process for the preparation of substituted malonic ester anilides and malonic acid monoanilides
FI940874A0 (fi) Menetelmä maitohapon ja maitohappoestereiden valmistamiseksi
EP0569823A3 (en) Process for the preparation of 2,5-di-phenylamino terephthalic acid and its dialkyl esters
PT82436A (en) Process for the preparation of 7-amino-3-propenylcephalosporanic acid and esters thereof
IL115594A (en) Preparation of alpha-tertiary carboxylic acid esters
PL308300A1 (en) Method of hydroxycarbonylating pentenic acids
EP0498509A3 (en) Method of preparation of amino acid esters
ZA927686B (en) A method for the preparation of 2-hydroxymandelic acids and 2-hydroxybenzaldehydes
EP0560158A3 (en) Process for the preparation of beta-aminoacrylic acid esters
EP0453841A3 (en) Process for the preparation of esters of 1-alcoxyhexatriene-2-carboxylic acid
GB2152932B (en) Process and intermediates for the preparation of alkoxyvincaminic acid esters and alkoxyapovincaminic acid esters
EP0538685A3 (en) Process for the preparation of vinyloxycarboxylic acid esters
HU9301617D0 (en) New thio-semicarbazone acid esters
PL292785A1 (en) Method of obtaining antranilic acid
GR861285B (en) Method for the preparation of 2-thiochromenyliden-acetoxic esters
IL105369A0 (en) Process and intermediates for the preparation of 2-amino-5-methyl-pyridine
EP0437187A3 (en) Process for the preparation of esters of hydroxyphenylpropanoic acid
GB9424595D0 (en) Process for the preparation of clavulanic acid
PL295870A1 (en) Method of obtaining z-2-methyl-2-butenic acid
PL294819A1 (en) Method of obtaining 2-methyl-4-chlorophenyloxyacetic acid
PL294671A1 (en) Method of obtaining thiazolydin-4-carboxylic acid
PL293135A1 (en) Method of obtaining monorphtalic acid
PL292213A1 (en) Method of obtaining acetic acid