SK51072006A3 - 3-(((4-fenyl)-piperazín-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2H- indol-2-ónové deriváty a s nimi súvisiace zlúčeniny na liečenie ochorení centrálneho nervového systému - Google Patents
3-(((4-fenyl)-piperazín-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2H- indol-2-ónové deriváty a s nimi súvisiace zlúčeniny na liečenie ochorení centrálneho nervového systému Download PDFInfo
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- SK51072006A3 SK51072006A3 SK5107-2006A SK51072006A SK51072006A3 SK 51072006 A3 SK51072006 A3 SK 51072006A3 SK 51072006 A SK51072006 A SK 51072006A SK 51072006 A3 SK51072006 A3 SK 51072006A3
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- Slovakia
- Prior art keywords
- dihydro
- indol
- ethyl
- piperazin
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- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0400957A HU0400957D0 (en) | 2004-05-11 | 2004-05-11 | Piperazinbe derivatives of dialkyl oxindoles |
| HU0500464A HUP0500464A3 (en) | 2005-05-05 | 2005-05-05 | Piperazine derivatives of dialkyl-oxindoles |
| PCT/HU2005/000052 WO2005109987A2 (fr) | 2004-05-11 | 2005-05-11 | Nouveaux derives piperazine d'oxindoles de dialkyle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK51072006A3 true SK51072006A3 (sk) | 2007-05-03 |
Family
ID=89986001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK5107-2006A SK51072006A3 (sk) | 2004-05-11 | 2005-05-11 | 3-(((4-fenyl)-piperazín-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2H- indol-2-ónové deriváty a s nimi súvisiace zlúčeniny na liečenie ochorení centrálneho nervového systému |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7786129B2 (fr) |
| EP (1) | EP1776339B1 (fr) |
| JP (1) | JP2007537229A (fr) |
| KR (1) | KR20070011594A (fr) |
| AT (1) | ATE435204T1 (fr) |
| AU (1) | AU2005244389B2 (fr) |
| BG (1) | BG109771A (fr) |
| CA (1) | CA2565514A1 (fr) |
| CZ (1) | CZ2006777A3 (fr) |
| DE (1) | DE602005015223D1 (fr) |
| DK (1) | DK1776339T3 (fr) |
| EA (1) | EA014236B1 (fr) |
| ES (1) | ES2329388T3 (fr) |
| HR (2) | HRP20060404A2 (fr) |
| IL (1) | IL179029A (fr) |
| MX (1) | MXPA06013069A (fr) |
| NO (1) | NO20065659L (fr) |
| NZ (1) | NZ551547A (fr) |
| PL (1) | PL1776339T3 (fr) |
| PT (1) | PT1776339E (fr) |
| RS (1) | RS20060623A (fr) |
| SI (1) | SI1776339T1 (fr) |
| SK (1) | SK51072006A3 (fr) |
| WO (1) | WO2005109987A2 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| EP2789338A3 (fr) | 2007-11-15 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Dérivé de pyridine condensé et son utilisation |
| HUP0900071A2 (en) * | 2009-02-06 | 2010-10-28 | Egis Gyogyszergyar Nyilvanosan | Optically active 3-[(phenyl-piperazin-1-yl)alkyl]-3-alkyl-oxindole derivatives influencing the central nervous system and pharmaceutical compositions containing them |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2635104B1 (fr) | 1988-08-03 | 1992-04-30 | Synthelabo | Derives d'indolone, leur preparation et leur application en therapeutique |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| WO1998008816A1 (fr) | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
| US20070232662A1 (en) | 2004-05-11 | 2007-10-04 | Egis Gyogyszergyar Rt. | Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders |
| DK1751106T3 (da) * | 2004-05-11 | 2009-03-09 | Egis Gyogyszergyar Nyrt | Piperazinderivater af alkyloxindoler |
-
2005
- 2005-05-11 CZ CZ20060777A patent/CZ2006777A3/cs unknown
- 2005-05-11 US US11/596,473 patent/US7786129B2/en not_active Expired - Fee Related
- 2005-05-11 AU AU2005244389A patent/AU2005244389B2/en not_active Ceased
- 2005-05-11 WO PCT/HU2005/000052 patent/WO2005109987A2/fr active Application Filing
- 2005-05-11 ES ES05779909T patent/ES2329388T3/es active Active
- 2005-05-11 RS RSP-2006/0623A patent/RS20060623A/sr unknown
- 2005-05-11 SI SI200530785T patent/SI1776339T1/sl unknown
- 2005-05-11 DE DE602005015223T patent/DE602005015223D1/de active Active
- 2005-05-11 PL PL05779909T patent/PL1776339T3/pl unknown
- 2005-05-11 JP JP2007512537A patent/JP2007537229A/ja not_active Ceased
- 2005-05-11 DK DK05779909T patent/DK1776339T3/da active
- 2005-05-11 MX MXPA06013069A patent/MXPA06013069A/es active IP Right Grant
- 2005-05-11 SK SK5107-2006A patent/SK51072006A3/sk not_active Application Discontinuation
- 2005-05-11 CA CA002565514A patent/CA2565514A1/fr not_active Abandoned
- 2005-05-11 KR KR1020067026024A patent/KR20070011594A/ko not_active Application Discontinuation
- 2005-05-11 EA EA200602083A patent/EA014236B1/ru not_active IP Right Cessation
- 2005-05-11 EP EP05779909A patent/EP1776339B1/fr active Active
- 2005-05-11 NZ NZ551547A patent/NZ551547A/en unknown
- 2005-05-11 PT PT05779909T patent/PT1776339E/pt unknown
- 2005-05-11 AT AT05779909T patent/ATE435204T1/de active
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2006
- 2006-11-02 IL IL179029A patent/IL179029A/en not_active IP Right Cessation
- 2006-11-20 HR HR20060404A patent/HRP20060404A2/xx not_active Application Discontinuation
- 2006-12-06 NO NO20065659A patent/NO20065659L/no not_active Application Discontinuation
- 2006-12-11 BG BG109771A patent/BG109771A/bg unknown
-
2009
- 2009-09-22 HR HR20090504T patent/HRP20090504T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1776339T3 (pl) | 2009-12-31 |
| HRP20090504T1 (hr) | 2009-10-31 |
| WO2005109987A9 (fr) | 2007-03-29 |
| ATE435204T1 (de) | 2009-07-15 |
| IL179029A0 (en) | 2007-03-08 |
| BG109771A (bg) | 2008-05-30 |
| RS20060623A (en) | 2008-09-29 |
| US20070232619A1 (en) | 2007-10-04 |
| DK1776339T3 (da) | 2009-11-02 |
| AU2005244389A1 (en) | 2005-11-24 |
| EA014236B1 (ru) | 2010-10-29 |
| JP2007537229A (ja) | 2007-12-20 |
| EP1776339B1 (fr) | 2009-07-01 |
| EA200602083A1 (ru) | 2007-06-29 |
| HRP20060404A2 (en) | 2007-04-30 |
| WO2005109987A3 (fr) | 2006-05-04 |
| IL179029A (en) | 2011-11-30 |
| SI1776339T1 (sl) | 2009-12-31 |
| NZ551547A (en) | 2010-06-25 |
| ES2329388T3 (es) | 2009-11-25 |
| CZ2006777A3 (cs) | 2007-03-14 |
| DE602005015223D1 (de) | 2009-08-13 |
| AU2005244389B2 (en) | 2011-09-01 |
| CA2565514A1 (fr) | 2005-11-24 |
| PT1776339E (pt) | 2009-09-16 |
| WO2005109987A2 (fr) | 2005-11-24 |
| MXPA06013069A (es) | 2007-03-30 |
| KR20070011594A (ko) | 2007-01-24 |
| US7786129B2 (en) | 2010-08-31 |
| EP1776339A2 (fr) | 2007-04-25 |
| NO20065659L (no) | 2007-01-29 |
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Legal Events
| Date | Code | Title | Description |
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| FC9A | Refused patent application |